Claims
- 1. Compounds of general formula ##STR67## wherein R.sup.1 is a member selected from the group consisting of (a1) an unsubstituted at most binuclear aryl group having 6 to 10 carbon atoms, and (a2) a group as in (a1) but substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen, phenyl, carboxyl, cyano, nitro and hydroxy groups,
- (b) a 5- to 6-membered heteroaromatic ring containing one heteroatom which is selected from the group consisting of nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus and the non-heteroatoms of the ring are carbon atoms; and
- R.sup.2 is a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms;
- R.sup.3 is hydrogen, hydroxy, alkanoyloxy or nicotinoyloxy; and
- R.sup.4 and R.sup.5 are the same or different and each is a member selected from the group consisting of hydrogen, halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and
- X is nitrogen or methine; and
- physiologically acceptable acid addition salts thereof.
- 2. Compounds of general formula ##STR68## wherein R.sup.1 is a member selected from the group consisting of unsubstituted phenyl or phenyl substituted by at least one halogen atom;
- R.sup.2 is a member selected from the group consisting of hydrogen or alkyl having up to 3 carbon atoms;
- R.sup.3 is a member selected from the group consisting of hydrogen or hydroxy or nicotinoyloxy;
- R.sup.4 and R.sup.5 are members independently selected from the group consisting of hydrogen, halogen and methyl; and
- X is nitrogen;
- and physiologically acceptable acid addition salts thereof.
- 3. Compounds of general formula ##STR69## wherein R.sup.1 is a member selected from the group consisting of
- (a1) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms; and
- (a2) a group as in (a1) but substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen, phenyl, carboxyl, cyano, nitro and hydroxy groups,
- (b) a 5- to 6-membered heteroaromatic ring containing one heteroatom which is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus and the nonheteroatoms of the ring are carbon atoms;
- R.sup.2 is a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms;
- R.sup.3 is a member selected from the group consisting of alkanoyloxy of one to six carbon atoms and nicotinoyloxy; and
- R.sup.4 and R.sup.5 are the same or different and each is a member selected from the group consisting of hydrogen, halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and
- X is nitrogen or methine; and physiologically acceptable acid addition salts thereof.
- 4. O-{3-[4-(2-Chlorophenyl)-piperazino]-2-hydroxy-propyl}-4-chlorobenzaldoxime and physiologically acceptable acid addition salts thereof.
- 5. O-{3-[4-(2,6-Dimethylphenyl)-piperazino]-2-hydroxypropyl}-4-chlorobenzaldoxime and physiologically acceptable acid addition salts thereof.
- 6. Compounds of general formula: ##STR70## wherein R.sup.1 is a member selected from the group consisting of: (a1) an unsubstituted at most binuclear aryl group having 6 to 10 carbon atoms,
- (a2) a group as in (a1) but substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen, phenyl, carboxyl, cyano, nitro and hydroxy groups,
- R.sup.2 is a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; and
- R.sup.3 is hydrogen, hydroxy, alkanoyloxy or nicotinoyloxy; and
- R.sup.4 and R.sup.5 are the same or different and each is a member selected from the group consisting of hydrogen, halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and
- X is nitrogen or methine; and
- physiologically acceptable acid addition salts thereof.
- 7. A pharmaceutical composition for decrease of blood cholesterol comprising an effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier or excipient.
- 8. The composition of claim 7 wherein the composition contains between 1 and 1,000 milligrams of compound of claim 1 per dosage unit.
- 9. A pharmaceutical composition for decrease of blood triglyceride level comprising an effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier or excipient.
- 10. The composition of claim 9 wherein the composition contains between 1 and 1,000 milligrams of compound of claim 1 per dosage unit.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2658762 |
Dec 1976 |
DEX |
|
Parent Case Info
This is a continuation of copending application Ser. No. 864,004, filed Dec. 23, 1977, now abandoned.
US Referenced Citations (7)
Foreign Referenced Citations (1)
Number |
Date |
Country |
842968 |
Aug 1960 |
GBX |
Continuations (1)
|
Number |
Date |
Country |
Parent |
864004 |
Dec 1977 |
|