1. Field of the Invention
The present invention relates to an object information acquiring apparatus.
2. Description of the Related Art
Development of a photoacoustic tomography apparatus (object information acquiring apparatus) for medical purposes using a short pulse oscillation laser is progressing (Manohar et al, “Region-of-interest breast studies using the Twente Photoacoustic Mammoscope (PAM)” Proc. Of SPIE, Vol. 6437, 643702). Photoacoustic tomography (PAT) is a technique for forming images by irradiating a pulse laser (at several tens to several hundred nano-seconds) onto a measurement segment, receiving a photoacoustic wave generated in the segment using a probe, and processing the acquired receive signals. The PAT allows analysis of biological functions by the spectral measurement based on the absorption coefficient of the biological tissue.
To generate short pulse light used for measuring an acoustic wave, a laser using a Q switch is used. Q switch oscillation is a technique to oscillate a high output and short pulse laser light by controlling a Q value of the resonator performance index, which is a half-width function of an oscillation pulse. The laser oscillation in this case is called giant pulse oscillation.
An apparatus that acquires object information by irradiating laser light based on the laser oscillation using such a Q switch has been proposed (Japanese Patent Application Laid-Open No. 2013-89680).
However in the case of a laser apparatus using a Q switch, anomalous emission such as pre-lasing occurs when characteristics of the apparatus are unstable. One challenge is to detect and decrease the anomalous emission such as pre-lasing. Because of the anomalous emission, an acoustic wave signal is generated from the biological tissue. This acoustic wave signal, due to the anomalous emission, becomes noise when an acoustic signal is analyzed, interrupting the acquisition of accurate biological information (object information). Further, the pulse width of one giant pulse disperses, and a desired acoustic wave signal cannot be acquired. Moreover, generation of anomalous emission such as pre-lasing is strongly correlated with ambient temperature of the laser apparatus. However if generation of anomalous emission such as pre-lasing is suppressed by controlling the temperature of the laser apparatus, the object information acquiring apparatus becomes large, and manufacturing cost increases.
With the foregoing in view, it is an object of the present invention to provide an object information acquiring apparatus where influence of anomalous emission is minimized.
To achieve the object, the present invention uses the following configuration. In other words, an object information acquiring apparatus, comprising: a laser light source configured to irradiate laser light onto an object; a detector configured to detect a part of the laser light from the laser light source; a receiver configured to receive an acoustic wave that propagate from the object, based on the irradiation of the laser light; and an acquisition unit configured to acquire information relating to the object, based on a reception result of the receiver and a detection result of the detector, wherein the detector detects anomalous emission from the laser light source.
The present invention also uses a following configuration. In other words, an object information acquiring apparatus, comprising: a laser light source configured to irradiate laser light onto an object; a detector configured to detect a part of the laser light from the laser light source; a determination unit configured to determine whether anomalous emission is included in the laser light, based on the detection result of the detector; a receiver configured to receive an acoustic wave that propagate from the object, based on the irradiation of the laser light; and an acquisition unit configured to acquire information relating to the object, based on a reception result of the receiver and a determination result of the determination unit.
The present invention also uses a following configuration. In other words, an object information acquiring apparatus, comprising: a laser light source configured to irradiate laser light onto an object; a detector configured to detect a part of the laser light from the laser light source; a receiver configured to receive an acoustic wave that propagate from the object, based on the irradiation of the laser light; and an acquisition unit configured to acquire information relating to the object, based on a reception result of the receiver and a detection result of the detector, wherein the acquisition unit acquires information on the object using the reception result of the receiver, excluding a reception result, which is acquired when the detection result of the detector indicates anomalous emission.
As mentioned above, the present invention can provide an object information acquiring apparatus where influence of anomalous emission is minimized.
Further features of the present invention will become apparent from the following description of exemplary embodiments with reference to the attached drawings.
Embodiments of the present invention will now be described with reference to the drawings. As a rule, a same composing element is denoted with a same reference number, for which redundant description is omitted. Calculation expressions, calculation procedures or the like to be described in detail herein below should be appropriately changed depending on the configuration of the apparatus to which the present invention is applied and various conditions, and are not intended to limit the scope of the invention to the following description.
An object information acquiring apparatus of the present invention includes an apparatus utilizing a photoacoustic effect, which receives an acoustic wave generated in an object by irradiating light (electromagnetic wave) such as near infrared, onto the object, and acquires the object information as image data. In the case of the apparatus utilizing the photoacoustic effect, the object information to be acquired refers to the generation source distribution of the acoustic wave generated by light irradiation, the initial sound pressure distribution in the object, the absorption density distribution or absorption coefficient distribution of light energy derived from the initial sound pressure distribution, or the substance concentration distribution constituting the tissue. Examples of the substance concentration distribution are: an oxygen saturation distribution; a total hemoglobin concentration distribution; and an oxy/deoxy hemoglobin concentration distribution.
Characteristic information, which is the object information at a plurality of locations, may be acquired as two-dimensional or three-dimensional characteristic distribution. The characteristic distribution can be generated as image data that indicates the characteristic information inside the object. The acoustic wave referred to in the present invention is typically an ultrasound wave, that includes a sound wave and a light-induced ultrasound wave. An acoustic wave generated by the photoacoustic effect is called a photoacoustic wave or a light-induced ultrasound wave. An acoustic detector (e.g. probe) receives an acoustic wave generated or reflected inside the object.
In actual anomalous emission, the total output is lower than a giant pulse emission. Therefore a sensor, of which sensitivity and temporal resolution are very high, must be used to detect only an anomalous emission by resolving the emission with respect to time. This means that the sensor becomes expensive. Further, in the case of pre-lasing, which is an example of anomalous emission, the period from the start of generation of the oscillation to sending a Q switch OFF signal for starting the generation of a giant pulse is short, several nanoseconds to several tens of nanoseconds. In practical terms, it is very difficult to negate generating the oscillation of a giant pulse during this short period. Techniques to solve these problems will now be described herein below.
The object information acquiring apparatus 101 is an apparatus to acquire information inside the object 111 using a photoacoustic wave signal. A part of the energy of the light propagated inside the object 111 is absorbed by an absorber (sound source), such as hemoglobin in blood. Then the acoustic wave signal 117 is generated by the thermal expansion of the light absorber, and the acoustic wave signal 117 propagates inside the object. The propagating acoustic wave signal 117 is converted into the electric signal 118 by a probe disposed in the acoustic wave receiver 105, and is transferred to the acoustic wave signal processing unit 106, which is an acquisition unit (an acquisition device). The electric signal 118 is converted into optical characteristic value distribution information or the like inside the object 111 by the acoustic wave signal processing unit 106, and becomes object information. The generated object information includes the optical characteristic value distribution and absorption coefficient distribution, as well as initial sound pressure distribution, substance concentration and oxygen saturation based thereon. Image data for displaying an image reconstructed based on this information can also be included.
The laser light source 102 provides light that is transmitted through a biological body, which is the object 111, so as to appropriately transmit a photoacoustic signal generated by a measurement target, such as hemoglobin in a blood vessel. To increase the signal accuracy of the photoacoustic signal, that is the acoustic wave signal 117, light having high power must propagate to the object 111. The laser light is used for this reason. Furthermore, the light must reach the measurement target hemoglobin or the like without being absorbed in the object 111 very much, hence the wavelength of the light that can easily propagate in the object 111 is limited, and light having a 500 nm to 1200 nm wavelength characteristic in particular is used. For this, an alexandrite laser or a titanium sapphire laser is preferably used. Furthermore, in order to improve the signal accuracy of the acoustic wave signal 117, a pulse light with short pulse width, several tens to several hundreds of nanometers, is used for the laser light 115. To generate this laser light having high power and short pulse width, a laser that oscillates with giant pulses using the Q switch is preferably used. The laser light source 102 may be integrated into the object information acquiring apparatus 101, or may be installed externally.
The light transmission optical system 103 has a function to propagate light from the laser light source 102 to the light irradiation optical system 104. Distance is generated between the laser light source 102 and the light irradiation optical system 104 depending on the configuration. Because of this distance, the laser light 115 spreads. Therefore in order to suppress this spreading, lenses or the like are disposed on the optical path of the laser light 115. If the lenses or the like cannot be disposed on a straight line because of the positional relationship of the laser light source 102 and the light irradiation optical system 104, the traveling direction of the laser light 115 is adjusted by disposing a reflection mirror or the like. Thereby the laser light is guided to a desired location. If necessary, the laser light is guided to a timing trigger which measures a light transmission timing that is required by the acoustic wave signal processing unit 106, or to such a measurement apparatus as a laser light sensor 107 of the present invention. For this purpose, the branch mirror 108 is disposed on the optical path and the branched light is guided to these measurement apparatuses. Optical fibers may be used for some part of the light transmission in the light transmission optical system 103.
The light irradiation optical system 104 forms the irradiation light 116 from the laser light 115 propagated by the light transmission optical system 103, and irradiates the light 116 onto a measurement target segment in the object 111. For this, the light irradiation optical system 104 plays a role of transforming the light quantity distribution of the laser light 115 to an appropriate light quantity distribution for the object 111, such as spreading the laser light 115. The light irradiation optical system 104 includes a lens and a diffusion plate in order to form the irradiation light 116 by expanding or diffusing the laser light 115 appropriately, so that the acoustic wave signal 117 is ideally acquired and the irradiation amount to the object 111 (biological body) does not exceed a specified value.
The acoustic wave receiver 105 has a probe that receives the acoustic wave signal 117. The probe receives the acoustic wave signal 117 which is generated on the surface, inside of the biological body or the like by the pulsed light (irradiation light 116), and converts the acoustic wave into an analog electric signal 118. The probe can be any probe that can receive an acoustic wave signal, such as a probe using piezoelectric phenomena, a probe using the resonance of light, or a probe using the change in electrostatic capacitance. The probe of this embodiment is typically a probe where a plurality of reception elements (e.g. piezoelectric elements) are one-dimensionally or two-dimensionally disposed, or are spirally disposed on the base of a bowl-shaped fixed component. If such multi-dimensionally arrayed elements are used, the acoustic wave signal 117 can be simultaneously received at a plurality of locations. As a result, the measurement time can be shortened. And to increase a number of measurement locations by a probe, the probe may be scanned so as to receive the acoustic wave signal 117 at a plurality of locations. The acoustic wave signal 117 received by the probe is converted into the electric signal 118, and is then used for generating the characteristic information by the acoustic wave signal processing unit 106.
The acoustic wave signal processing unit 106 is constituted by an information processor, such as a computer, and circuits, and processes and computes the electric signal 118. The acoustic wave signal processing unit 106 includes a conversion unit, such as an A/D convertor, which coverts an electric signal acquired by the probe (analog signal) into a digital signal. It is preferable that the conversion unit can simultaneously process a plurality of signals. Thereby the time required to generate an image (image reconstruction) can be decreased. The converted digital signal is stored in memory in the acoustic wave signal processing unit 106. The acoustic wave signal processing unit 106 generates object information, such as optical characteristic value distribution, using the data or the like stored in this memory, by back projection in a time domain, for example.
An excitation unit (an excitation device) 204, a laser medium 205 and a Q switch 206 are disposed inside the resonator. The laser controller 211 controls the voltage that is applied to the excitation unit 204 and the Q switch 206. The excitation unit 204 uses a flash lamp or a semiconductor laser, and if a rod type laser medium 205 is used, the excitation unit 204 optically excites the laser medium 205 from the side surface. For the Q switch 206, Pockels cells, which are optical crystals of potassium dihydrogen phosphate (KDP), potassium deuterium phosphate (DKDP) or the like, are used. Pockels cells are elements where the refractive index changes with anisotropy in proportion to the electric field strength, and the polarizing direction of the transmitted light rotates. Therefore Pockels cells are widely used to acquire giant pulsed light, of which oscillation pulse width is small and output intensity is high. Although the pulse width is different depending on the type of laser medium, resonator length and optical resonance state, a 100 ns or less pulse width is acquired. If Nd:YAG crystals or alexandrite crystals are used for the laser medium, the configuration in
Particularly in the case of a solid-state laser that uses a rod type laser medium, if anomalous emission/oscillation such as pre-lasing is generated in a center area of the rod where excitation efficiency is high, a giant pulse oscillation is continuously generated triggered by this oscillation, concentrated at the center. As a result, strong oscillation having a special intensity distribution, which is described later, is generated. As a Q switch, a device that induces refractive index anisotropy of Pockels cells or the like in the electric field is used to change the polarizing direction of the reciprocating light. The resonance is suppressed using this characteristic of the Q switch. If an optical shutter to suppress such resonance is used, the polarizing state of the giant pulse light and the polarizing state of the anomalous emission such as pre-lasing differ. The characteristic of the Q switch is utilized in an example described later.
The laser light sensor 107 disclosed in the present invention does not detect only feeble emission when the Q switch is ON (resonance suppression period). In other words, the laser light sensor 107 acquires oscillation intensity such that both the feeble emission, which is an anomalous emission such as pre-lasing, and the giant pulse oscillation, which is emitted triggered by feeble transmission (pre-lasing) after the Q switch is turned OFF, are included on the time axis. The laser light sensor 107 outputs a signal in accordance with the acquired intensity in the detection result to the determination unit 123 in
A method for controlling the object information acquiring apparatus or the laser apparatus included therein in the case when anomalous emission such as pre-lasing is generated will be described. If a cause of generating anomalous emission such as pre-lasing is presumed, a control method for minimizing this cause is introduced, or a method of stopping the object information acquiring apparatus or the laser apparatus included therein is used. A case when the cause is presumed and retraceable, such as a case when a member constituting the Q switch is a member of which refractive index anisotropy is changed by applying voltage, as in the case of Pockels cells, is considered. In this case, the optimum voltage to be applied to Pockels cells may be shifted by the influence of temperature or the like of the laser apparatus. As a result, anomalous emission such as pre-lasing may be generated. In such a case, generation of anomalous emission such as pre-lasing can be suppressed by changing the voltage to be applied to the Pockels cells as a control of the laser apparatus. By disposing such a control mechanism, a stable object information acquiring apparatus can be provided. If the anomalous emission such as pre-lasing is accidently generated due to the unstable operation of the Q switch or the like, information, to identify whether the emission is an emission that includes anomalous emission such as pre-lasing or an emission that does not include anomalous emission such as pre-lasing, is also included in the output data. Then if only the acoustic wave signals acquired by the emission which does not include anomalous emission such as pre-lasing is used for image reconstruction, then noise of the reconstructed image can be removed. It is also possible to output, along with the reconstructed image, information that the image was constructed based on the laser light where anomalous emission such as pre-lasing was generated.
Now
The range of the emission energy (range where intensity of laser light 115 is distributed) when the emission energy including both the anomalous emission such as pre-lasing and the giant pulse is acquired, disperses. However this energy is observed concentrating in a range that is about φ2 mm (range of which element addresses are −20 to 20), which is narrower than the range of φ5 mm where the giant pulse is generated (a part of the range where the intensity of the laser light 115 is distributed). When the anomalous emission such as pre-lasing is generated, the total of the emission energy observed by each element remains 300 mJ. In other words, this is the same as the total emission energy of the typical giant pulses observed by each element in
A criteria is set in the determination unit 123 to determine whether anomalous emission such as pre-lasing is generated or not in a laser having such an emission energy distribution characteristic. In other words, a criteria is set so as to determine that anomalous emission such as pre-lasing is generated if an average value, calculated by dividing the total energy of each element in the φ2 mm range by a total number of elements in the φ2 mm range, is 0.25 mJ or more. Thereby anomalous emission such as pre-lasing is accurately detected. In other words, the determination unit 123 compares the determination threshold, which is a predetermined value, with the average value based on the detected result by the laser light sensor 107a. Then, if the average value exceeds the determination threshold in the comparison result, the determination unit 123 determines that anomalous emission such as pre-lasing is generated, and outputs this determination result 119. If the average value does not exceed the determination threshold in the comparison result, on the other hand, the determination unit 123 determines that anomalous emission such as pre-lasing is not generated, and outputs this determination result 119. Possible output destinations are the acoustic wave signal processing unit 106 and the laser light source 102.
The determination unit 123 is a single block in
In a laser having this emission energy distribution characteristic, it was determined whether anomalous emission such as pre-lasing is generated or not by monitoring the energy in the φ2 mm range, and anomalous emission such as pre-lasing was detected accurately. Moreover, one of the causes of the generation of anomalous emission such as pre-lasing is the rise in temperature of the laser system. Therefore, the control function to suppress the generation of anomalous emission such as pre-lasing by the laser controller dropping the air conditioning temperature of the laser system by 0.1° C. was included. Thereby an object information acquiring apparatus that suppresses the destabilization of the giant pulses was created. Further, by using the above-mentioned sensor configuration, the generation of anomalous emission such as pre-lasing was easily detected, even when the time resolution of the laser light sensor 107 is not very high.
Since a configuration other than the sensor 107b can be the same as Example 1, an object information acquiring apparatus, where the influence of anomalous emission such as pre-lasing is minimized, can be provided. Further, cost reduction can be expected because accuracy is similar to the laser light sensor 107a of Example 1, and a number of photo acceptance units is less than that of the laser light sensor 107a.
The configuration is not limited to this, and signals based on the intensity of the laser light 115 acquired by the elements in the φ2 mm range, out of the photo acceptance unit 109a of the laser light sensor 107a of Example 1, may be integrated by wiring or the like. And the signals acquired by the photo acceptance unit 109a outside φ2 mm range are not used. Thereby an effect similar to the laser light sensor 107b of Example 2 can be demonstrated.
Using this configuration, anomalous emission such as pre-lasing is accurately detected and the image is reconstructed after omitting data acquired based on the laser light including anomalous emission such as pre-lasing. As a result, an object information acquiring apparatus that can acquire accurate data can be created.
By including this laser light sensor unit 126, the object information acquiring apparatus can reconstruct an image with omitting predetermined data. Predetermined data here refers to data acquired by a laser light 115 that includes anomalous emission such as pre-lasing. This laser light sensor 107d can be an inexpensive undivided single element sensor 109d, hence the object information acquiring apparatus having this sensor 109d can also be created at low cost.
Further, unlike Example 1, the determination unit 123, to determine whether anomalous emission such as pre-lasing is generated or not, is not required. That is, it is unnecessary to determine whether anomalous emission such as pre-lasing is generated or not, because the polarizing plate 110 that transmits only anomalous emission such as pre-lasing is disposed. In other words, anomalous emission can be detected only by determining on whether the sensor 109d detected the light or not. This detection result (detection content) is outputted to the acoustic wave signal processing unit 106 and the laser light source 102. The object information is acquired based on this output. Therefore the object information acquiring apparatus can be manufactured easily and at low cost.
<Modifications>
The description on each example is merely an example to describe the present invention, and the present invention can be embodied by appropriately making changes or combinations within a range that does not depart from the true spirit of the invention. The above-mentioned processing and means of the present invention can be freely combined as long as technical inconsistencies are not generated. Various characteristics of the present invention are not limited to the above examples, but can be widely applied. The object information acquiring apparatuses according to Example 1 to Example 6 can be implemented using, for example, an information processor having a CPU, memory or the like, that operate according to programs (software). Instead each composing element of the object information acquiring apparatus may be constituted by hardware, such as circuits, that can input/output and compute information.
<Comparative Technique>
This means that the laser light sensor 124 of the single element sensor according to this comparative technique cannot determine anomalous emission such as pre-lasing. Therefore in the case of an object information acquiring apparatus using the sensor of this comparative technique, accurate data on the object information cannot be acquired. On the other hand, according to each example of the present invention, an object information acquiring apparatus which can detect anomalous emission such as pre-lasing, and acquire an accurate image where the influence of anomalous emission such as pre-lasing is minimized, can be provided, as described above.
Embodiment(s) of the present invention can also be realized by a computer of a system or apparatus that reads out and executes computer executable instructions (e.g., one or more programs) recorded on a storage medium (which may also be referred to more fully as a ‘non-transitory computer-readable storage medium’) to perform the functions of one or more of the above-described embodiment(s) and/or that includes one or more circuits (e.g., application specific integrated circuit (ASIC)) for performing the functions of one or more of the above-described embodiment(s), and by a method performed by the computer of the system or apparatus by, for example, reading out and executing the computer executable instructions from the storage medium to perform the functions of one or more of the above-described embodiment(s) and/or controlling the one or more circuits to perform the functions of one or more of the above-described embodiment(s). The computer may comprise one or more processors (e.g., central processing unit (CPU), micro processing unit (MPU)) and may include a network of separate computers or separate processors to read out and execute the computer executable instructions. The computer executable instructions may be provided to the computer, for example, from a network or the storage medium. The storage medium may include, for example, one or more of a hard disk, a random-access memory (RAM), a read only memory (ROM), a storage of distributed computing systems, an optical disk (such as a compact disc (CD), digital versatile disc (DVD), or Blu-ray Disc (BD)™), a flash memory device, a memory card, and the like.
While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions.
This application claims the benefit of Japanese Patent Application No. 2014-127527, filed on Jun. 20, 2014, which is hereby incorporated by reference herein in its entirety.
Number | Date | Country | Kind |
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2014-127527 | Jun 2014 | JP | national |