Claims
- 1. A method for the controlled sustained release of an ophthalmic drug into the eye over a period of time which comprises:
- a. inserting an elongated device having a body of a polymeric material in the form of a rod or tube containing an ophthalmic drug into the upper or lower fornix so as to anchor said device into position therein, wherein said polymeric material is a material which is subject to swelling in a liquid environment, said device being sufficiently flexible to allow it to bend along the curvature of the eye within the upper or lower fornix upon being positioned so that the longitudinal axis of said device is generally parallel to the transverse diameter of the eyeball, said device being of a size and configuration such that, upon insertion into the upper or lower fornix, the device does not extend onto any visible portion of the eyeball, said device being independent of movement of the eye and remaining out of the field of vision so as to be well retained in place and imperceptible by a patient over a prolonged period of use;
- b) allowing the device to swell so that it locks into place in the fornix as it grows in size such that the length of the device is at least 8 mm and the diameter does not exceed 1.9 mm; and
- c) allowing said device to remain in the upper or lower fornix for drug release during said period of time, whereby the device when inserted into the upper or lower fornix can be retained therein for more than seven days.
- 2. The method of claim 1 wherein a device is employed having dimensions which initially are smaller than the desired final dimensions, so that the device is assisted in locking into place as the device increases in size after insertion into the fornix.
- 3. The method of claim 1 wherein a release modifier is employed during manufacture of said device and which includes the further step of adjusting the ratio of drug to release modifier during manufacture of said device to affect the rate of liquid diffusion into the device.
- 4. The method of claim 1 wherein said polymeric material is a silicone-containing material.
- 5. The method of claim 1 wherein said polymeric material is liquid silicone rubber.
- 6. The method of claim 1 wherein the length of the device is from 8 to 25 mm for use in the lower fornix to suit the eyes of different sizes such as infants, children and adults.
- 7. The method of claim 1 wherein the length of the device is from 8 to 35 mm for use in the upper fornix to suit the eyes of different sizes such as infants, children, and adults.
- 8. The method of claim 1 wherein the diameter of the device is from 0.5 to 1.9 mm to suit the eyes of different sizes such as infants, children, and adults.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8623661 |
Oct 1986 |
GBX |
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9026888 |
Dec 1990 |
GBX |
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BACKGROUND OF THE INVENTION
This is a division of application Ser. No. 243,915 filed May 17, 1994 which is a division of application Ser. No. 083,303 filed Jun. 29, 1993, now U.S. Pat. No. 5,322,691, which is a continuation-in-part of application Ser. No. 944,438 filed Sep. 14, 1992 which is a division of application Ser. No. 626,001 filed Dec. 12, 1990, now U.S. Pat. No. 5,147,647, which is a continuation-in-part of application Ser. No. 500,093 filed Mar. 21, 1990, which is a continuation of application Ser. No. 330,959 filed Mar. 29, 1989 which is a continuation of application Ser. No. 104,045 filed Oct. 1, 1987.
US Referenced Citations (10)
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts Assession No. 119:278624. |
Divisions (3)
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Number |
Date |
Country |
Parent |
243915 |
May 1994 |
|
Parent |
083303 |
Jun 1993 |
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Parent |
626001 |
Dec 1990 |
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Continuations (3)
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Number |
Date |
Country |
Parent |
397771 |
Mar 1995 |
|
Parent |
330959 |
Mar 1989 |
|
Parent |
104045 |
Oct 1987 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
944438 |
Sep 1992 |
|
Parent |
500093 |
Mar 1990 |
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