Claims
- 1. A 12 to 30 nucleotide-unit long oligodeoxynucleotide comprising at least one 5-substituted uracil or cytosine, where the 5-substituent is a C.sub.3-6 n-alkyl group, a vinyl group, a butenyl group, an ethynyl group or a C.sub.4-12 n-1-alkynyl group, with the proviso that the uracil moiety may not be substituted with an n-alkyl group or a C.sub.8-12 n-1-alkynyl group.
- 2. An oligodeoxynucleotide as claimed in claim 1, in which one or more of the phosphodiester moieties are replaced by phosphorothioate or phosphorodithioate moieties.
- 3. An oligodeoxynucleotide as claimed in claim 1, in which one or more of the phosphodiester moieties are replaced by phosphorothioate moieties of R- or S-configuration.
Priority Claims (1)
Number |
Date |
Country |
Kind |
93 000164 |
Jan 1994 |
HUX |
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Parent Case Info
This application is a continuation in part of 08/492,043, filed Sep. 21, 1995 and now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5484908 |
Froehler et al. |
Jan 1996 |
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Non-Patent Literature Citations (3)
Entry |
Kim, S. "The Influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex tormation," FEBS vol. 314 (1) pp. 29-32 Dec. 1992. |
Xodo, et al "Effect of 5-metlylcytosine on the stability of triple stranded DNA -a thermodynamic study," NAR vol. 19(20) 1991 pp. 5625-5631. |
Froeitzer et al "0ligodeoxynucleotides containing C-5 Propyne Analogs of 2'-Deoxyuridine and 2' Deoxycytidine," Tetrahedron Letters. vol. 33(37) pp. 5307-5310 1992. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
492043 |
Sep 1995 |
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