Claims
- 1. Compound selected from compounds, and their pharmaceutically acceptable salts, of the group consisting of 5-[(4-phenylbutyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile and 5-[(5-phenylpentyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile.
- 2. Compound of claim 1 which is 5-[(4-phenylbutyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile, or a pharmaceutically acceptable salt thereof.
- 3. Compound of claim 1 which is 5-[(5-phenylpentyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile, or a pharmaceutically acceptable salt thereof.
- 4. A pharmaceutical composition comprising a therapeutically-effective amount of a calcium channel blocking compound and a pharmaceutically-acceptable carrier or diluent, said calcium channel blocking compound selected from 5-[(4-phenylbutyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile and 5-[(5-phenylpentyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile, or a pharmaceutically acceptable salt thereof.
- 5. The composition of claim 4 wherein said compound is 5-[(4-phenylbutyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile, or a pharmaceutically acceptable salt thereof.
- 6. The composition of claim 4 wherein said compound is 5-[(5-phenylpentyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile, or a pharmaceutically acceptable salt thereof.
- 7. A therapeutic method for treating hypertension, said method comprising administering to a hypertensive patient a therapeutically-effective amount of a compound selected from 5-[(4-phenylbutyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile and 5-[(5-phenylpentyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile, or a pharmaceutically acceptable salt thereof.
- 8. The method of claim 7 wherein said compound is 5-[(4-phenylbutyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile or, or a pharmaceutically acceptable salt thereof.
- 9. The method of claim 7 wherein said compound is 5-[(5-phenylpentyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile, or a pharmaceutically acceptable salt thereof.
RELATED CASES
This is a continuation of application Ser. No. 040,824, filed Mar. 31, 1993, now abandoned, which is a continuation of 07/811,450, filed Dec. 19, 1992, now abandoned, which is a continuation of 07/638,006 filed Jan. 5, 1991, now abandoned, which is a continuation of application Ser. No. 07/454,341 filed Dec. 21, 1989, now abandoned.
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Continuations (4)
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Number |
Date |
Country |
Parent |
40824 |
Mar 1993 |
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Parent |
811450 |
Dec 1992 |
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Parent |
638006 |
Jan 1991 |
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Parent |
454341 |
Dec 1989 |
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