Claims
- 1. A prostaglandin analog of formula VI ##STR2## wherein Y.sub.1 is trans--CH.dbd.CH--, --C.dbd.C--, --CH.sub.2 CH.sub.2 --, or cis--CH.dbd.CH--;
- wherein M.sub.1 is .alpha.-R.sub.5 :.beta.-OH or .alpha.-OH:R.sub.5, wherein R.sub.5 is hydrogen or methyl;
- wherein L.sub.1 is .alpha.-R.sub.3 :.beta.-R.sub.4, .alpha.-R.sub.4 :.beta.-R.sub.3, or a mixture of .beta.-R.sub.3 :.beta.-R.sub.4 and .alpha.-R.sub.4 :.beta.-R.sub.3 wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro;
- wherein g is 3, 4, or 5;
- wherein R.sub.7 is
- (1) phenoxy;
- (2) phenoxy substituted by one, 2 or 3 chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, with the proviso that not more than two substituents are other than alkyl;
- (3) phenyl;
- (4) phenyl substituted by one, two or three chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, with the proviso that not more than two substituents are other than alkyl;
- (5) phenylmethyl, phenylethyl, or phenylpropyl;
- (6) phenylmethyl, phenylethyl, or phenylpropyl substituted by one, 2 or 3 chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, with the proviso that not more than two substituents are other than alkyl; with the proviso that R.sub.7 is phenoxy or substituted phenoxy only when R.sub.3 and R.sub.4 are hydrogen or methyl, being the same or different; and
- wherein R.sub.1 is
- (a) hydrogen;
- (b) alkyl of one to 12 carbon atoms, inclusive;
- (c) cycloalkyl of 3 to 10 carbon atoms, inclusive;
- (d) aralkyl of 7 to 12 carbon atoms, inclusive;
- (e) phenyl;
- (f) phenyl substituted with one, 2, or 3 chloro or alkyl of one to 3 carbon atoms;
- (g) phenyl substituted in the para position by
- (i) --NH--CO--R.sub.25
- (ii) --CO--R.sub.26
- (iii) --O--CO--R.sub.27
- (iv) --CH.dbd.N--NH--CO--NH.sub.2
- wherein R.sub.25 is methyl, phenyl, acetamidophenyl, benzamidophenyl, or --NH.sub.2 ; R.sub.26 is hydroxy, methyl, phenyl, --NH.sub.2, or methoxy; and R.sub.27 is phenyl or acetamidophenyl; inclusive, or a pharmacologically acceptable salt thereof when R.sub.1 is hydrogen.
- 2. A prostaglandin analog according to claim 1, wherein R.sub.7 is phenyl or phenylalkyl or a substituted derivative thereof.
- 3. 5,6-trans-Didehydro-9-deoxy-9-methylene-17-phenyl-18,19,20-trinor-PGF.sub.1, a prostaglandin analog according to claim 2.
- 4. A prostaglandin analog according to claim 1, wherein R.sub.7 is phenoxy or substituted phenoxy.
- 5. 5,6-trans-Didehydro-9-deoxy-9-methylene-16-phenoxy-17,18,19,20-tetranor-PGF.sub.1, a prostaglandin analog according to claim 4.
CROSS REFERENCE TO RELATED APPLICATIONS
The present application is a divisional application of U.S. Ser. No. 035,144, filed May 1, 1979, now pending.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4118584 |
Bundy |
Oct 1978 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
35144 |
May 1979 |
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