Claims
- 1. Optically active or racemic prostaglandins of the formula ##STR41## wherein: R is a hydrogen atom, a C.sub.1 -C.sub.12 alkyl group or a cation of a pharmaceutically acceptable base;
- R.sub.2 and R.sub.3, taken together, form an oxo group;
- the symbol represents a single or a double bond, wherein, when the symbol is a double bond, R.sub.1 is a hydrogen atom and when the symbol is a single bond, R.sub.1 is hydroxy;
- one of R.sub.4 and R.sub.5 is hydroxy and the other is hydrogen;
- R.sub.6 and R.sub.7 are independently hydrogen or C.sub.1 -C.sub.4 alkyl;
- n is zero, 1, 2 or 3; and
- R.sub.8 is a radical ##STR42## wherein m is 1, 2, 3, 4 or 5 and W is --CH.sub.2 --, or R.sub.8 is tetrahydrofuryl; 1-adamantyl; 2-nor-bornyl; 2-bicyclo[2,2,2]octyl; or 4-t.butyl-cyclohexyl.
- 2. A compound as claimed in claim 1 wherein R is C.sub.1 -C.sub.12 alkyl.
- 3. The compound of claim 2 wherein R is methyl.
- 4. A compound selected from the group consisting of:
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-cyclohexyl-prost-5-en-13-ynoic acid;
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-(2'-bicyclo-[2,2,2]-octyl)-prost-5-en-13-ynoic acid;
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-cycloheptyl-prost-5-en-13-ynoic acid;
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-cyclohexyl-16S-methyl-prost-5-en-13-ynoic acid;
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-(2'-nor-bornyl)-prost-5-en-13-ynoic acid;
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-(1'-adamantyl)-prost-5-en-13-ynoic acid;
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-(2'-tetrahydro-furyl)-prost-5-en-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-(2'-nor-bornyl)-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-(1'-adamantyl)-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-cyclopentyl-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-cyclohexyl-16R-methyl-prost-5-en-13-ynoic acid;
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-cyclohexyl-16(S,R)-methyl-prost-5-en-13-ynoic acid;
- 5c-9-oxo-11.alpha.,15S-dihydroxy-20,19,18-trinor-17-(4'-tert. butyl)-cyclohexyl-prost-5-en-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-cyclohexyl-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-(2'bicyclo-[2,2,2]-octyl)-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-cycloheptyl-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-cyclohexyl-16S-methyl-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-cyclohexyl-16R-methyl-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-cyclohexyl-16(S,R)-methyl-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-(4'tert. butyl)-cyclohexyl-prosta-5,10-dien-13-ynoic acid;
- 5c-9-oxo-15S-hydroxy-20,19,18-trinor-17-(2'-tetrahydro-furyl)-prosta-5,10-dien-13-ynoic acid.
- 5. The C.sub.1 -C.sub.12 alkyl esters of the compound of claim 4.
- 6. The methyl esters of the compound of claim 4.
- 7. The pharmaceutically acceptable salts of the compound of claim 4.
- 8. A pharmaceutical composition having antiulcer or luteolytic activity comprising, as the active ingredient, an effective amount of the compound of claim 1 together with a pharmaceutically acceptable carrier or diluent.
Priority Claims (1)
Number |
Date |
Country |
Kind |
27654 A/74 |
Sep 1974 |
ITX |
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CROSS-REFERENCE TO RELATED APPLICATIONS
This is a continuation of our copending application Ser. No. 835,288, filed Sept. 21, 1977, now abandoned which in turn is a continuation of Ser. No. 734,629 filed Oct. 21, 1976 now abandoned, which is a divisional of application Ser. No. 603,015, filed Aug. 8, 1975, now U.S. Pat. No. 4,035,415.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3884909 |
Schaub |
May 1975 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
603015 |
Aug 1975 |
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Continuations (2)
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Number |
Date |
Country |
Parent |
835288 |
Sep 1977 |
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Parent |
734629 |
Oct 1976 |
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