Claims
- 1. A one component tissue adhesive in solid form having as active substances when reconstituted in 1 ml of solution:
- 65-115 mg of human fibrinogen,
- 40-80 U of factor XIII,
- 1-50 IU of PPSB (prothrombin factors) based on factor II (prothrombin),
- 0.01-50 IU of antithrombin III,
- 0.1-5 mmol/l of calcium ions, and
- 1-10,000 KIU of aprotinin,
- wherein the ratio of said active substances is such that there is no premature coagulation of said adhesive during preparation, and such that coagulation is initiated on contact with a wound surface.
Priority Claims (1)
Number |
Date |
Country |
Kind |
36 22 642.4 |
Jul 1986 |
DEX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/835,118, filed Feb. 14, 1992, now abandoned, which is a continuation of Ser. No. 07/069,199, filed Jul. 2, 1987, now abandoned.
US Referenced Citations (9)
Foreign Referenced Citations (2)
Number |
Date |
Country |
0103196 |
Aug 1982 |
EPX |
0085923 |
Jan 1983 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Bang, et al., Thrombosis and Bleeding Disorders, Academic Press (1971), p. 236. |
Continuations (2)
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Number |
Date |
Country |
Parent |
835118 |
Feb 1992 |
|
Parent |
69199 |
Jul 1987 |
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