Claims
- 1. An ophthalmic composition comprising an oil-in-water emulsion including an oily component, an aqueous component, and a surfactant component including a first surfactant, a second surfactant and a third surfactant, wherein each of the surfactants is different from the other surfactant.
- 2. The ophthalmic composition of claim 1 wherein the emulsion is a self-emulsifying emulsion.
- 3. The ophthalmic composition of claim 1 wherein each surfactant includes a hydrophobic constituent and a hydrophilic constituent, the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in chemical structure, and the hydrophilic constituent of the second surfactant and the hydrophilic constituent of the third surfactant are substantially similar in chemical structure.
- 4. The ophthalmic composition of claim 1 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in overall length in fully extended conformation.
- 5. The ophthalmic composition of claim 1 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar to a hydrophobic constituent of the oily component.
- 6. The ophthalmic composition of claim 1 wherein the hydrophobic constituent of the third surfactant is shorter in overall length in fully extended conformation than the hydrophobic constituents of the first and second surfactants by an equivalent length of about 3 to about 10 methylene groups.
- 7. The ophthalmic composition of claim 1 wherein the first surfactant is a polyoxyalkylene alkylene ether.
- 8. The ophthalmic composition of claim 1 wherein the second surfactant is a polyalkylene oxide ether of an alkyl alcohol.
- 9. The ophthalmic composition of claim 1 wherein the third surfactant is a polyalkylene oxide ether of an alkylphenol.
- 10. The ophthalmic composition of claim 1 wherein the first surfactant is a polyoxyethylene oleyl ether, the second surfactant is a polyethylene oxide ether of stearyl alcohol, and the third surfactant is a polyethylene oxide ether of nonylphenol.
- 11. The ophthalmic composition of claim 1 wherein the oily component comprises mineral oil.
- 12. The ophthalmic composition of claim 1 wherein the composition is sterilized by filtering.
- 13. An ophthalmic composition comprising an oil-in-water emulsion including an oily component, an aqueous component, and a surfactant component including a first surfactant, a second surfactant and a third surfactant, each surfactant includes a hydrophobic constituent and a hydrophilic constituent, the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in chemical structure, and the hydrophilic constituent of the second surfactant and the hydrophilic constituent of the third surfactant are substantially similar in chemical structure.
- 14. The ophthalmic composition of claim 13 wherein the emulsion is a self-emulsifying emulsion.
- 15. The ophthalmic composition of claim 13 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in overall length in fully extended conformation.
- 16. The ophthalmic composition of claim 13 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar to a hydrophobic constituent of the oily component.
- 17. The ophthalmic composition of claim 13 wherein the hydrophobic constituent of the third surfactant is shorter in overall length in fully extended conformation than the hydrophobic constituent of the first and second surfactants by an equivalent length of about 3 to about 10 methylene groups.
- 18. The ophthalmic composition of claim 13 wherein the first surfactant is a polyoxyalkylene alkylene ether.
- 19. The ophthalmic composition of claim 13 wherein the second surfactant is a polyalkylene oxide ether of an alkyl alcohol.
- 20. The ophthalmic composition of claim 13 wherein the third surfactant is a polyalkylene oxide ether of an alkylphenol.
- 21. The ophthalmic composition of claim 13 wherein the first surfactant is a polyoxyethylene oleyl ether, the second surfactant is a polyethylene oxide ether of stearyl alcohol, and the third surfactant is a polyethylene oxide ether of nonylphenol.
- 22. The ophthalmic composition of claim 13 wherein the oily component comprises mineral oil.
- 23. The ophthalmic composition of claim 13 wherein the composition is sterilized by filtering.
- 24. An ophthalmic composition comprising a therapeutic component and an oil-in-water emulsion including an oily component, an aqueous component and a surfactant component including a first surfactant, a second surfactant and a third surfactant, wherein each of the surfactants is different from the other surfactants.
- 25. The ophthalmic composition of claim 24 wherein the emulsion is a self-emulsifying emulsion.
- 26. The ophthalmic composition of claim 24 wherein the therapeutic component is present in an amount effective to provide a therapeutic effect to a patient in response to the composition being administered to an eye of the patient.
- 27. The ophthalmic composition of claim 24 wherein the therapeutic component is selected from the group consisting of antibacterial substances, antihistaminics, decongestants, anti-inflammatories, non-steroid anti-inflammatory drugs, miotics, anticholinergics, mydriatics, antiglaucoma drugs, antiparasitic drugs, anti-protozoal drugs, antiviral drugs, carbonic anhydrase inhibitors, anti-fungal drugs, anesthetic agents, ophthalmic diagnostic drugs, ophthalmic agents used as adjuncts in surgery, chelating agents, immunosuppressive agents and mixtures thereof.
- 28. The ophthalmic composition of claim 24 wherein the therapeutic component is selected from the group consisting of quinoxalines, quinoxaline derivatives, timolol, timolol derivatives, pilocarpine, pilocarpine derivatives and mixtures thereof.
- 29. The ophthalmic composition of claim 24 wherein each surfactant includes a hydrophobic constituent and a hydrophilic constituent, the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in chemical structure and the hydrophilic constituent of the second surfactant and the hydrophilic constituent of the third surfactant are substantially similar in chemical structure.
- 30. The ophthalmic composition of claim 24 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in overall length in fully extended conformation.
- 31. The ophthalmic composition of claim 24 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar to a hydrophobic constituent of the oily component.
- 32. The ophthalmic composition of claim 24 wherein the hydrophobic constituent of the third surfactant is shorter in overall length in fully extended conformation than the hydrophobic constituent of the first and second surfactants by an equivalent length of about 3 to about 10 methylene groups.
- 33. The ophthalmic composition of claim 24 wherein the first surfactant is a polyoxyalkylene alkylene ether.
- 34. The ophthalmic composition of claim 24 wherein the second surfactant is a polyalkylene oxide ether of an alkyl alcohol.
- 35. The ophthalmic composition of claim 24 wherein the third surfactant is a polyalkylene oxide ether of an alkylphenol.
- 36. The ophthalmic composition of claim 24 wherein the first surfactant is a polyoxyethylene oleyl ether, the second surfactant is a polyethylene oxide ether of stearyl alcohol, and the third surfactant is a polyethylene oxide ether of nonylphenol.
- 37. The ophthalmic composition of claim 24 wherein the oily component comprises mineral oil.
- 38. The ophthalmic composition of claim 24 wherein the composition is sterilized by filtering.
- 39. An ophthalmic composition comprising a therapeutic component, and an oil-in-water emulsion including an oily component, an aqueous component and a surfactant component including a first surfactant, a second surfactant and a third surfactant, each surfactant includes a hydrophobic constituent and a hydrophilic constituent, the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in chemical structure, and the hydrophilic constituent of the second surfactant and the hydrophilic constituent of the third surfactant are substantially similar in chemical structure.
- 40. The ophthalmic composition of claim 39 wherein the emulsion is a self-emulsifying emulsion.
- 41. The ophthalmic composition of claim 39 wherein the therapeutic component is present in an amount effective to provide a therapeutic effect to a patient in response to the composition being administered to an eye of the patient.
- 42. The ophthalmic composition of claim 39 wherein the therapeutic component is selected from the group consisting of antibacterial substances, antihistaminics, decongestants, anti-inflammatories, non-steroid anti-inflammatory drugs, miotics, anticholinergics, mydriatics, antiglaucoma drugs, antiparasitic drugs, anti-protozoal drugs, antiviral drugs, carbonic anhydrase inhibitors, anti-fungal drugs, anesthetic agents, ophthalmic diagnostic drugs, ophthalmic agents used as adjuncts in surgery, chelating agents, immunosuppressive agents and mixtures thereof.
- 43. The ophthalmic composition of claim 39 wherein the therapeutic component is selected from the group consisting of quinoxalines, quinoxaline derivatives, timolol, timolol derivatives, pilocarpine, pilocarpine derivatives and mixtures thereof.
- 44. The ophthalmic composition of claim 39 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in overall length in fully extended conformation.
- 45. The ophthalmic composition of claim 39 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar to a hydrophobic constituent of the oily component.
- 46. The ophthalmic composition of claim 39 wherein the hydrophobic constituent of the third surfactant is shorter in overall length in fully extended conformation than the hydrophobic constituent of the first and second surfactants by an equivalent length of about 3 to about 10 methylene groups.
- 47. The ophthalmic composition of claim 39 wherein the first surfactant is a polyoxyalkylene alkylene ether.
- 48. The ophthalmic composition of claim 39 wherein the second surfactant is a polyalkylene oxide ether of an alkyl alcohol.
- 49. The ophthalmic composition of claim 39 wherein the third surfactant is a polyalkylene oxide ether of an alkylphenol.
- 50. The ophthalmic composition of claim 39 wherein the first surfactant is a polyoxyethylene oleyl ether, the second surfactant is a polyethylene oxide ether of stearyl alcohol, and the third surfactant is a polyethylene oxide ether of nonylphenol.
- 51. The ophthalmic composition of claim 39 wherein the oily component comprises mineral oil.
- 52. The ophthalmic composition of claim 39 wherein the composition is sterilized by filtering.
- 53. A method of preparing an ophthalmic composition comprising:
providing an oily component to a temperature above a melting temperature of the oily component; combining a surfactant component with the oily component to form an admixture, wherein the surfactant component includes a first surfactant, a second surfactant and a third surfactant, and each of the surfactants is different from the other surfactants; and combining the admixture with an aqueous phase to form an oil-in-water emulsion.
- 54. The method of claim 53 wherein the oil-in-water emulsion formed is a self-emulsifying emulsion.
- 55. The method of claim 53 wherein each surfactant includes a hydrophobic constituent, and a hydrophilic constituent, the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in chemical structure and the hydrophilic constituent of the second surfactant and the hydrophilic constituent of the third surfactant are substantially similar to each other.
- 56. The method of claim 53 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar in overall length in fully extended conformation.
- 57. The method of claim 53 wherein the hydrophobic constituent of the first surfactant and the hydrophobic constituent of the second surfactant are substantially similar to a hydrophobic constituent of the oily component.
- 58. The method of claim 53 wherein the hydrophobic constituent of the third surfactant is shorter in overall length in fully extended conformation than the hydrophobic constituent of the first and second surfactants by an equivalent length of about 3 to about 10 methylene groups.
- 59. The method of claim 53 wherein the combining of the surfactant component with the oily component is effective to dissolve the surfactant component in the oily phase.
- 60. The method of claim 53 wherein the first surfactant is a polyoxyalkylene alkylene ether, the second surfactant is a polyalkylene oxide ether of an alkyl alcohol, and the third surfactant is a polyalkylene oxide ether of an alkylphenol.
- 61. The method of claim 53 wherein the oily component comprises mineral oil.
- 62. The method of claim 53 further comprising sterilizing the oil-in-water emulsion by filtering the oil-in-water emulsion.
- 63. The method of claim 53 further comprising combining a therapeutic component with the oil-in-water emulsion.
- 64. A method comprising administering the composition of claim 1 to an eye of a subject in an amount effective to provide at least one benefit to the eye.
- 65. A method comprising administering the composition of claim 13 to an eye of a subject in an amount effective to provide at least one benefit to the eye.
- 66. A method comprising contacting a contact lens with the composition of claim 1 in an amount and at conditions effective to provide at least one benefit to the contact lens or to the wearer of the contact lens.
- 67. A method comprising contacting a contact lens with the composition of claim 13 in an amount and at conditions effective to provide at least one benefit to the contact lens or to the wearer of the contact lens.
- 68. A method comprising administering the composition of claim 24 to an eye of a subject in an amount effective in providing a desired therapeutic effect to the subject.
- 69. A method comprising administering the composition of claim 39 to an eye of a subject in an amount effective in providing a desired therapeutic effect to the subject.
- 70. A method comprising contacting a contact lens with a composition comprising an oil-in-water emulsion, the contacting being effective in providing the contact lens with at least one benefit selected from the group consisting of lubricating the contact lens, preventing dehydration of the contact lens and preventing protein deposition on the contact lens.
RELATED APPLICATION
[0001] This application claims the benefit of U.S. Provisional Application Serial No. 60/353,050 filed Jan. 30, 2002, the disclosure of which is incorporated in its entirety herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60353050 |
Jan 2002 |
US |