The invention relates to an ophthalmic set for myopia progression control.
In the present description, the phrases myopia progression control, myopia progression slowing-down and myopia progression reduction are used with equivalent meanings.
Myopia progression has been established through many observations and well documented for several years, although its cause(s) is (are) still subject to doubts and research. Myopia progression is the fact that for one person, his/her myopia increases with time at a rate which almost did not exist before. Kids are the most concerned with myopia progression, and it is thus a major issue for humanity to address this problem. Artificial light, in particular that produced by screens or LEDs, is suspected as being a cause for myopia progression, but the actual biological phenomena and mechanisms which lead to myopia progression remain at hypothesis level.
Several principles and methods have already been proposed for myopia progression control, including those now mentioned.
One of these methods consists in adding to spectacle lenses or contact lenses used for correcting myopia microlenses that focus part of light at a distance in front of the retina, in addition to the light that is focused on the retina for allowing sharp vision to the wearer who is equipped with these spectacle or contact lenses.
Another method consists in adding to the spectacle lenses or contact lenses used for correcting myopia aspherical microlenses that produce light volumes at a distance in front of the retina, again in addition to the light that is focused on the retina for producing the sharp image.
Still another method consists in adding to the spectacle lenses or contact lenses used for correcting myopia diffusing elements which reduce the vision contrast of the wearer.
Still other methods implement progressive addition lenses which provide power addition to compensate for the lag of accommodation, or bifocal prismatic lenses for producing both the power addition and a prism effect.
All these methods are based on lenses that are designed for modifying wavefronts of the light that enters the eyes of the wearer, or modifying wavefronts of part of this light.
Further methods are based on other principles, such as administering atropine to the subject, or wearing rigid contact lenses during nights for modifying the shape of the cornea.
But all these methods turn out not to be efficient enough in many cases for myopia progression control, so that new solutions are still required or even combinations of solutions.
Studies have been performed recently that suggest a role of the choroid in myopia progression. A thinning of the choroid is associated with a long-term length increase of the eyeball, which leads to myopia increase. In addition, it has been recently observed that light may enhance choroid thinning. This would be due to biological circadian cycles, either local in the eyes or central for the person or even both. The wavelength range from 440 nm (nanometer) to 520 nm, corresponding to blue-green colours, is the one implied in central circadian regulation (with melanopsin absorption peaking at 480 nm) and is suspected playing a role for myopia progression. Another spectral range, from 560 nm to 600 nm and corresponding to amber light, also seems to play a role with myopia progression, but in a lesser extent compared to blue-green light.
Starting from this situation, one object of the present invention consists in providing new means for allowing myopia progression control, which are more efficient than those known from prior art.
Another object of the invention is that such means are easy for the user, without causing vision discomfort.
For meeting at least one of these objects or others, a first aspect of the present invention proposes an ophthalmic set for myopia progression control, which comprises spectral filtering means arranged for being effective on light that enters a user's eye, these spectral filtering means being such that the ophthalmic set has a vision transmission value higher than 70% when assessed with CIE Standard Illuminant D65, and an average transmission value assessed over the spectral range from 460 nm to 510 nm, or 440 nm to 520 nm, that is equal to or less than 50%, preferably less than 30%, whereby the spectral filtering means are efficient for slowing-down a myopia progression of the user.
The ophthalmic set of the invention being based on spectral filtering capability, it operates in a way different than the devices known from prior art for controlling myopia progression. Indeed, the invention ophthalmic set addresses directly the amount of light that plays a role in myopia progression instead of modifying focus features of this light.
In a known manner, the vision transmission value commonly referred to as Tv takes into account spectral sensitivity features of the human eye, in addition to spectral features of the Illuminant D65. This vision transmission value Tv is such as defined in the standard NF EN 1836 and corresponds to the wavelength range from 380 nm to 780 nm.
Preferably, the spectral filtering means may be further such that the ophthalmic set has another average transmission value assessed over the other spectral range from 560 nm to 600 nm, that is equal to or less than 70%, preferably less than 50%. Indeed, light with wavelength values between 560 nm and 600 nm also participates in myopia progression, although in a lesser extent than light in the wavelength ranges 460 nm-510 nm and 440 nm-520 nm. In addition, filtering out light simultaneously in both ranges 460 nm-510 nm, or 440 nm-520 nm, and 560 nm-600 nm improves color balancing, and thus improves color rendering for the user.
In preferred embodiments of the invention, the ophthalmic set may further comprise wavefront modifying means adapted to modify wavefronts of the light that enters the user's eye also for slowing down, by an own efficiency of such wavefront modifying means, the myopia progression of the user. The wavefront modifying means are combined with the spectral filtering means within the invention ophthalmic set so that the spectral filtering means and the wavefront modifying means are effective simultaneously on the light that enters the user's eye. Thus, respective efficiencies of the wavefront modifying means and spectral filtering means for slowing-down myopia progression are combined for the user of the ophthalmic set. Increased efficiency is thus obtained compared to devices designed only for modifying the light wavefronts. For such preferred embodiments, the wavefront modifying means may comprise one of the following:
In particular, when the wavefront modifying means comprise light-diffusing elements, the ophthalmic set may have one of the following arrangements:
Alternatively, when the wavefront modifying means comprise microlenses, these microlenses may be of refractive type, in particular unifocal or bifocal refractive-type microlenses, or diffractive type, in particular pi-Fresnel microlenses.
For some of the preferred embodiments, the wavefront modifying means may advantageously comprise a spectacle lens, and the spectral filtering means may comprise one among:
For others of the preferred embodiments, the wavefront modifying means may comprise a contact lens, and the spectral filtering means may comprise one among:
Generally for the invention, the ophthalmic set may further comprise at least one among:
In this way, the invention ophthalmic set is further efficient for controlling myopia progression, since it can match the circadian rhythm of the phenomena and mechanisms which lead to the myopia progression. Indeed, the inventors have observed that light with wavelength values between 460 nm and 510 nm, or between 440 nm and 520 nm, participates more in myopia progression at evening time. Preferably, when the alert means are adapted for informing the user to equip himself with the spectral filtering means, or with the spectral filtering means combined with the wavefront modifying means, at fixed period before bedtime, this fixed period may be comprised between 1 hour and 6 hours, preferably comprised between 2 hours and 4 hours.
Alternatively, when the ophthalmic set comprises the light-measurement means for measuring the intensity of ambient light, the alert means being then coupled to the light-measurement means for informing the user to equip himself with the spectral filtering means, or with the spectral filtering means combined with the wavefront modifying means, when the intensity of ambient light becomes less than the threshold, this threshold may be comprised between 300 Lux and 1000 Lux, preferably between 500 Lux and 1000 Lux. Indeed, such light intensity threshold corresponds to natural light dimming as occurring in the evenings.
In other possible invention embodiments, the spectral filtering means may be electrochromic means capable of switching between a blue-blocking state where the average transmission value of the ophthalmic set, assessed over the spectral range from 460 nm to 510 nm, or 440 nm to 520 nm, is equal to or less than 50%, and a clear state where this average transmission value is higher than 50%. Then the ophthalmic set may comprise again light-measurement means adapted for measuring the intensity of ambient light, and control means coupled to the light-measurement means. For such other embodiments, the control means are arranged for switching the electrochromic means into the blue-blocking state when the intensity of ambient light becomes less than a threshold. This threshold may be again comprised between 300 Lux and 1000 Lux, preferably between 500 Lux and 1000 Lux.
A second aspect of the invention proposes a process for maintaining vision comfort to a person, in particular to a child, when this process comprises providing this person with the ophthalmic set of the first invention aspect, and the person using the ophthalmic set in daily life.
These and other features of the invention will be now described with reference to the appended figures, which relate to preferred but not-limiting embodiments of the invention.
For clarity sake, element sizes which appear in these figures do not correspond to actual dimensions or dimension ratios. Also, same reference numbers which are indicated in different ones of these figures denote identical elements of elements with identical function.
Although the embodiments of the invention now described with reference to
T(460 nm-510 nm)=( 1/50)·∫460510T(λ)·dλ
where the wavelength values λ are expressed in nanometers, the summation interval is from 460 nm to 510 nm, and the spectral transmission values T(λ) are expressed in %. Alternatively, the blue-green wavelength interval may be extended to 440 nm-520 nm, so that the equation for the average blue-green transmission value can be also:
T(440 nm-520 nm)=( 1/80)·∫440520T(λ)·dλ
According to the invention, at least one of T(460 nm-510 nm) and T(440 nm-520 nm) is equal to or less than 50%, preferably less than 30%.
The visual transmission, as commonly denoted Tv, is assessed using the Illuminant D65 as defined in the standards known in the art. It thus takes into account the sensitivity of the human eye. Tv is calculated according to the following equation:
Tv=∫380 nm780 nmT(λ)·E(λ)·V(λ)·dλ/∫380 nm780 nmE(λ)·V(λ)·dλ
where E(λ) describes the spectral intensity of CIE Standard Illuminant D65, and V(λ) describes the spectral sensitivity of human eye. According to the invention, Tv is higher than 70%.
Optionally, another average transmission value may be assessed for the menses 1 and 2, over the further spectral range from 560 nm to 600 nm which corresponds to amber light. Such average amber transmission value is calculated according to:
T(560 nm-600 nm)=( 1/40)·∫560600T(λ)·dλ
The spectral filtering features which are used in the invention may be obtained by incorporating one or more light-absorbing dyes in a material of base parts of the lenses 1 and 2. Alternatively, such dyes may be contained in films which are covering at least one face of each lens 1, 2. These dyes are selected for providing each lens with the above spectral filtering features. The Man skilled in the art knows how to select light-absorbing dyes from spectral features thereof as provided by chemical suppliers, and how to adjust dye concentrations within the material(s) of the lenses 1, 2 for obtaining desired transmission values. Appropriate dyes for obtaining the spectral features recited above are provided in WO 2019/238648. The diagram of
The lenses 1 and 2 with such spectral filtering features are efficient for avoiding choroid thinning, and therefore for slowing down myopia progression for the spectacle wearer. Since the blue-green range, corresponding to 460 nm-510 nm or 440 nm-520 nm, is the most important range in the visible light for the choroid thickness variations, the capability of the lenses 1 and 2 to reduce selectively the light intensity in the blue-green range is essential for obtaining myopia progression slowing-down.
Because the other spectral range from 560 nm to 600 nm, corresponding to amber colour, has been also observed with effect on the choroid thickness variations, the dyes may be advantageously further selected for being also light-absorbing between 560 nm and 600 nm, preferably in a way to provide the lenses 1 and 2 with average amber transmission value of less than 70%, preferably less than 50%. In addition to strengthening the efficiency for myopia progression control as produced by the light reduction in the first range 460 nm-510 nm, the additional light reduction in the second range 560 nm-600 nm improves the colour balancing. Colour rendering is improved in this way for the wearer through the lenses 1 and 2, when compared to the light reduction only in 460 nm-510 nm.
It is further possible to add at least one antireflecting coating on each lens 1, 2, in particular for reflecting blue light in the wavelength range 430 nm-465 nm. Such reflection is efficient for protecting the user's eyes against light with short wavelengths as emitted by display screens and LED-based devices. Antireflecting coatings suitable for this purpose are described in EP 2 602 655 for example.
In preferred embodiments of the invention, the spectral filtering means recited above may be combined within each of the spectacle lenses 1, 2 with wavefront modifying means also suitable for slowing down myopia progression. In this way a combined efficiency is obtained for myopia progression slowing-down, which is higher than efficiency as resulting from addition of the separated respective effects of the spectral filtering means and wavefront modifying means.
Actually, the microlenses 21 tend to reduce the visual acuity of the wearer, because they disrupt the point spread function, commonly referred to as SPF, of the myopia compensating function of the lenses 1 and 2. But due to the chromatism of the material of the base eyeglass, and also that of the eyes, the blue portion of the visible range mainly participates in the peripheral area of the spot that constitutes the image of a point-source of white light on the wearer's retina. Therefore, reducing the intensity of the blue-green light as provided by the spectral filtering means involved in the invention reduces the diameter of the image spot. Improvement of the wearer's visual acuity is thus obtained, when compared to the lens provided with the microlenses but without the spectral filtering means. It is also possible modifying the microlenses in order to increase their efficiency for myopia progression control, while maintaining constant the wearer's visual acuity thanks to the effect of the spectral control means on the full spectrum point spread function. For example, a surface-concentration of the microlenses may be further increased in the peripheral area of each spectacle lens in this way.
Further embodiments of the invention may be obtained by replacing the microlenses 21 of refractive type as just described, either unifocal, bifocal or aspherical, with other types of microlenses, including of diffractive type, such as pi-Fresnel microlenses.
Actually, the light-diffusing elements 31 cause back-scattering of part of the light that originates from the surroundings of the wearer, so that cosmetic issues may arise for an observer who looks at the spectacles. Indeed, each of the wearer's eyes may appear blurred to the observer through the spectacle lenses 1,2 due to the back-scattered light. Therefore, reducing the intensity of the blue-green light that is back-scattered by the light-diffusing elements 31 improves the cosmetic aspect of the lenses. It is thus advantageous to apply the coating 22 that contains the absorbing dyes above the light-diffusing elements 31 on the front surface S1, so that the coating 22 absorbs part of the back-scattered light.
Other embodiments of the invention may be obtained by arranging the light-diffusing elements on the rear surface of the base eyeglass, i.e. on the wearer's side of the eyeglass. For example, a layer may be deposited on this rear surface of the base eyeglass, which is light-diffusing in the range 440 nm-520 nm. Then, the dyes that absorb in the same wavelength range may be either incorporated within the same layer, or within an additional layer intermediate between the light-diffusing layer and the base eyeglass on the rear surface of this latter, or within the base eyeglass itself, or within an additional layer which is arranged on the front surface of the base eyeglass.
Further embodiments of the invention may be obtained by combining the spectral filtering means for blue-green light reduction with other wavefront modifying means such as eyeglasses of progression addition type or bifocal prismatic type.
It is also possible to combine spectacles provided with the spectral filtering means for blue-green light reduction with administration of atropine to the wearer and myopia compensation, for obtaining improved myopia progression control.
Still further embodiments of the invention may have one of the following configurations, in addition to the spectacle eyeglasses being provided with the wavefront modifying means:
In other possible embodiments of the invention, the wavefront modifying means may be provided by contact lenses to be worn by the user, and the dyes responsible for the blue-green light reduction may be incorporated in either the contact lenses, or in eyeglasses of spectacles to be worn in addition to the contact lenses.
In addition, it has been observed that light with wavelength values in the range 440 nm-520 nm that enters the eyes in the morning causes choroid thickening, whereas light with same wavelength values but received in the evenings causes choroid thinning. This would be due to biological circadian cycles, both local in each eye and central for the person. The wavelength range 440 nm-520 nm corresponding to blue-green colour appears as the most important part of the visible light for myopia progression related to circadian cycles. The other spectral range 560 nm-600 nm corresponding to amber light also seems to play a role with myopia progression related to circadian cycles, but in a lesser extent compared to blue-green light. The invention improvements which are now described are designed for matching such circadian cycles, for further increasing the efficiency in controlling myopia progression.
The spectacles of
In other possible embodiments of the control means, they may incorporate at least one ambient light sensor which may be accommodated in the spectacle frame 10, as indicated by reference 5. This light sensor performs measurements of the ambient light level as existing in the surroundings of the wearer and supplies the measurement results to a wireless communication unit also accommodated in the spectacle frame 10. Then the measurement results are retransmitted to the smartphone 40. For such operation, the smartphone 40 may be wireless connected to the communication unit of the spectacle frame 10. Then, the alert for the user to equip with the spectacles may be issued by the smartphone 40 once the ambient light intensity becomes lower than a threshold, thereby indicating evening time. Such threshold may be set to 750 Lux, for example.
Other possible embodiments may be based on electrochromic technology, to allow the user to wear the spectacles permanently. The spectacle lenses may be provided with dioptric power and/or astigmatism for compensating a user's ametropia. Electrochromic technology makes it possible to activate temporarily spectral filtering means, for example selectively during 3 hours before bedtime. To this end, the spectacle lenses 1 and 2 are provided with respective electrochromic devices across their whole optical areas. Electrochromic compounds are selected to provide a clear state with average blue-green transmission value that is higher than 50%, and a blue-blocking state with the average blue-green transmission value that is less than 50%. The spectacle frame 10 accommodates batteries 4 suitable for causing switching of the electrochromic devices from clear state to blue-blocking state, and also the reverse operation. Control means 3, also accommodated in the spectacle frame 10, are configured to trigger switching of the electrochromic devices from clear state to blue-blocking state in the evening, when natural dimming of the ambient light reaches the threshold. Such embodiments based on electrochromic technology may be combined with the ambient light sensor(s) 5 and/or smartphone application as before. One advantage of combining the electrochromic technology with an ambient light sensor is that the spectacles can be autonomous for producing myopia progression control, without requiring a smartphone. The batteries 4 and the control means 3 may be accommodated in the temples 11 and 12 of the frame 10, for example.
According to an improvement of the electrochromic-based embodiments, the transition from clear state to blue-blocking state may be soft, with a progressive evolution of the light transmission between both states. This avoids discomfort caused by sudden switch. Indeed, soft transition may not be detected by the spectacle wearer, since it may be partially compensated for by his pupil variations.
Invention embodiments different from those described above may be obtained, in particular regarding the actual implementation of the spectral filtering means and/or wavefront modifying means. For example, the spectral filtering means may be comprised of at least one interferential filter, possibly with a multi-layered filter structure, instead of using light-absorbing dyes. Using combinations of dyes and interferential filter is also possible. Generally, one will understand that combinations of such spectral filtering means with wavefront modifying means of any type may also be used.
Number | Date | Country | Kind |
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21305270.7 | Mar 2021 | EP | regional |