Claims
- 1. An opthalmic non-irritating iodine anti-infective medicament liquid for treating the eye comprising an iodide-oxidizing peroxidase selected from the group consisting of horseradish peroxidase, lactoperoxidase, myleroperoxidase and soybean-peroxidase, a source of hydrogen peroxide and an iodide source in an admixture with water having a molar ratio of hydrogen peroxide to iodide of between about 0.5 and 4.0 and a maximum concentration of hydrogen peroxide of 0.015% such that free molecular iodine is the principle iodine species generated in the admixture with said admixture having a maximum concentration of hydrogen peroxide of 0.015% such that free molecular iodine is the principle iodine species generated in the admixture and represents a minimum of at least 25% of the total concentration of iodine species on a molar basis with said admixture having a maximum concentration of thiosulfate titratable iodine of 650 ppm and wherein said medicament further comprises a buffer agent to maintain the pH thereof at between pH 4.5 and pH 7.1.
- 2. An opthalmic non-irritating iodine medicament as defined in claim 1 wherein said free molecular iodine is in a range of between 5 and 330 ppm.
- 3. An opthalmic non-irritating iodine medicament as defined in claim 2 wherein said pH is maintained between 6.0 to 7.1.
- 4. An opthalmic non-irritating iodine medicament as defined in claim 3 wherein said buffering agent is selected from the group consisting of glycine, phthalate acid, citric acid, phosphate, borate, barbituric acid, glutaric acid, dimethylglutarate, acetic acid, sodium acetate, succinic acid-sodium succinate, cacodylic acid, sodium hydrogen maleate, sodium bicarbonate or other agents that yield carbonate anion is solution, imidazole and the following buffers known to one skilled in the art as Good buffers Tris (tris(hydroxymethyl)aminoethane), MES (2-�N-morpholino!ethanesulfonic acid), BIS-TRIS (bis�2-hydroxyethyl!imino-tris�hydroxymethyl!methane; 2-bis�2-hydroxyethyl!amino-2- �hydroxymethyl!-1,3-propanediol), ADA (N-�2-acetamido!-2-iminodiacetic acid; N-�carbamoylmethyl!iminodiacetic acid), ACES ((2-�(2-amino-2-oxoethyl)amino!ethanesulfonic acid; N-�2-acetamido!-2-aminoethane-sulfonic acid) and PIPES (piperaine-N, N'-bis�2-ethanesulfonic acid! and 1,4-piperazinediethanesulfonic acid).
FIELD OF THE INVENTION
The present invention is a continuation in part of Ser. No. 08/551,478 filed Jan. 1, 1995 now U.S. Pat. No. 5,639,481, which is a continuation in part of Ser. No. 08/324391 filed Oct. 17, 1994, abandoned, and relates generally to the enzymatic formation of a non-toxic and non-irritating germicidal iodine based microbicide which will inactive pathogenic organisms that are contaminants in and on mammalian ocular tissue.
US Referenced Citations (6)
Foreign Referenced Citations (3)
Number |
Date |
Country |
307376 |
Mar 1989 |
EPX |
447582 |
Sep 1991 |
EPX |
9605730 |
Feb 1996 |
WOX |
Non-Patent Literature Citations (1)
Entry |
Rawn. "Biochemistry". (1993) (Harper and Row: NY), pp. 229-233. |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
551478 |
Jan 1995 |
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Parent |
324391 |
Oct 1994 |
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