Patent Grant
10426336
The following description is provided to assist the understanding of the reader. None of the information provided or references cited is admitted to be prior art.
Optical coherence tomography (OCT) is an imaging technique. OCT imaging techniques are often used in a medical setting. The techniques are capable of producing three dimensional images from within optical scattering samples, such as biological tissue. In other words, light scattered by a sample can be detected in order to form an image of the sample. When imaging a sample, parts of the sample below its surface can be imaged. Examples of biological tissue that may be imaged using OCT include coronary arteries, skin, and an eye. In another example, OCT may be used for art conservation to analyze layers of a painting.
OCT is often accomplished with the use of an interferometer. An interferometer utilizes light that is reflected back from a sample and a reference light. The reference light is generally configured to travel a similar distance as light that is reflected back from the sample. The light from the sample and the reference light can be combined in such a way that gives rise to an interference pattern. That is, the light from the sample and the reference light will either constructively or destructively interfere with each other. The level of interference that occurs indicates the reflectivity of areas of the sample, such that structures within the sample may be identified and imaged.
In an embodiment, the present technology provides an improved optical coherence tomography (OCT) system combining two wavelengths capable, for example, of simultaneously imaging the anterior chamber and retina of an eye. In an illustrative embodiment, the OCT system includes a first light source configured to emit a first beam having a first wavelength. The OCT system further includes a second light source configured to emit a second beam having a second wavelength. The OCT system further includes an interferometer. The first beam and the second beam are configured to be directed into the interferometer. The interferometer includes a reference path and an interferometer sample path. The OCT system further includes a first beam splitter configured to divide, from an output of the interferometer sample path the first beam into a first sample path, and the second beam into a second sample path. The OCT system further includes a second beam splitter configured to combine the first beam and the second beam into a common axis.
An illustrative method includes emitting, by a first light source, a first beam having a first wavelength. The method also includes emitting, by a second light source, a second beam having a second wavelength. The method also includes directing the first beam and the second beam into an interferometer. The interferometer includes a reference path and an interferometer sample path. The method also includes dividing, by a first beam splitter from an output of the interferometer sample path the first beam into a first sample path, and the second beam into a second sample path. The method also includes combining, by a second beam splitter, the first beam and the second beam into a common axis.
The foregoing summary is illustrative only and is not intended to be in any way limiting. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features will become apparent by reference to the following drawings and the detailed description.
The foregoing and other features of the present disclosure will become more fully apparent from the following description and appended claims, taken in conjunction with the accompanying drawings. Understanding that these drawings depict only several embodiments in accordance with the disclosure and are, therefore, not to be considered limiting of its scope, the disclosure will be described with additional specificity and detail through use of the accompanying drawings.
In the following detailed description, reference is made to the accompanying drawings, which form a part hereof. In the drawings, similar symbols typically identify similar components, unless context dictates otherwise. The illustrative embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented here. It will be readily understood that the aspects of the present disclosure, as generally described herein, and illustrated in the figures, can be arranged, substituted, combined, and designed in a wide variety of different configurations, all of which are explicitly contemplated and make part of this disclosure.
Described herein is an improved optical coherence tomography (OCT) system combining two wavelengths capable, for example, of simultaneously imaging the anterior chamber and retina of an eye.
Imaging the anterior chamber of an eye utilizes a different optical configuration than imaging for the retina of an eye. For the anterior chamber of the eye, a beam scan may be generally perpendicular to the sample (or cornea) and the beam has a shallow focus. When imaging the retina, a beam can be refracted by the eye itself, so a beam scan may be convergent with a collimated larger beam size for deep focusing in the eye. In other words, a beam used to scan the retinal area of the eye must enter the eye at a different angle than a beam used to scan the anterior chamber of the eye. Advantageously, the system and methods disclosed herein can image both the anterior chamber and the retina of an eye simultaneously by superimposing two light paths of different wavelength ranges suitable for eye imaging into one path. Such a configuration advantageously can reduce insertion loss of a combiner.
Further, the methods and systems disclosed herein can utilize a single detector and interferometer to detect two imaging ranges. Previously, systems have utilized multiple interferometers and multiple photo-detectors in order to image two samples at once. The methods and systems disclosed herein use a single interferometer and photo-detector, greatly decreasing the cost, complexity, and size of an OCT system designed to scan multiple samples at once.
The methods and systems disclosed herein advantageously also do not utilize complex mechanisms to adjust the focus and incidence angle of a single beam in order to realize multiple imaging ranges. Previously, systems may have used a single light source for scanning two different samples. However, such systems utilized complex switchable or adjustable lenses to adjust a single beam in order to switch between multiple imaging ranges. Such a configuration is complex, has many moving parts, and may be quite large. Further, such a configuration may not allow simultaneous and real time imaging of multiple imaging ranges. The methods and systems disclosed herein advantageously reduces the number of components utilized for multiple imaging ranges and allows for simultaneous and real time imaging of multiple imaging ranges. For example, the systems and methods disclosed herein can achieve real time imaging of two imaging ranges, such as an anterior chamber of an eye and the retinal area of an eye.
In an illustrative embodiment, two light sources are used to emit two beams with different wavelengths (or different bands of wavelength). In one embodiment, a wavelength swept source may be utilized to emit the two different beams. The output of the two light sources are combined into an interferometer. The interferometer includes a reference path and a sample path. The sample path is a path through which the beams are transmitted to be reflected off the sample (e.g., an eye). The reference path is a separate path through which the beams are reflected to have the same optical length as the sample path, such that the interferometer can generate an accurate image of the sample.
The sample path is output from the interferometer, and a first beam splitter splits the sample path into a first sample path and a second sample path. On a return path (when light from the sample paths is reflected or backscattered), the first beam splitter acts as a combiner, re-combining the first beam and the second beam into a common axis. In an embodiment, the first and second sample paths share a single common lens system, and the first beam in the first sample path is introduced into the middle of the common lens system. The first sample path is for a beam having (or band approximately around) a wavelength of 1,300 nanometers (nm). The second sample path is for a beam having (or band approximately around) a wavelength of 1,060 nanometers. In alternative embodiments, different wavelengths or bands of wavelengths may be used for the first and second beams (and subsequently the first and second sample paths).
The first and second sample paths are divided by a first dichroic mirror (the first beam splitter) at the root of the sample path of the interferometer. Such a dichroic mirror is specially configured to have transmission characteristics that reflect or transmit the light of the first beam and let the light of the second beam pass through (see discussion of
The second sample path is configured with a scan mirror positioned at a focal point of a first lens of the common two lens system. The two lens system, in this embodiment, is in a 4f configuration. In alternative embodiments, the lens system may have more or less than two lenses, and may be in other configurations that the 4f configuration.
The second beam passes through the second lens resulting in a collimated beam configured for convergent scanning such that the second beam can scan the retinal area of the eye. In other words, the second sample path has a lens system with a collimating beam and a convergent scanning pattern relative to the sample. The collimating beam is focused at the retinal area after passing through the eye lens system and can be scanned across the retinal area because of convergent scanning before entering the eye. Accordingly, the path length of the second beam that scans the retinal area will be longer than the path length of the first beam that scans the anterior chamber of the eye. The difference between the first sample path length and the second sample path length can be an optical length equivalent to the axial length of a human eye. The second path also includes a second scan mirror for imaging the retinal area. The second scan mirror is located at the focal point of the first lens of the two lens system.
Light from the first beam that passes through the first sample path is introduced into the second lens of the two lens system by having a second beam splitter (here a dichroic mirror) positioned between the second lens and a focal point of the first lens. Here, the second beam splitter acts as a combiner, combining the first and second beams onto the same common axis. The scan mirror for the first sample path is positioned at a focal point of the second lens on the reflected path from the second beam splitter. When the first and second beams are reflected or backscattered from the sample, the second beam splitter splits the first and second beams back into the first and second sample paths, respectively. The first sample path and the first beam are configured to focus the beam such that the beam scans perpendicular to the anterior chamber position of the eye. In other words, the first sample path has a lens system with a divergent beam and lateral scanning pattern that is perpendicular to the sample.
When imaging the anterior chamber and the retinal area of the eye, the swept light sources (first and second light sources) are simultaneously and alternately modulated (see discussion below of
The detector can detect and analyze the received signals alternately for different time slots based on the two different wavelengths (or wavelength bands) of the first beam and the second beam. In other words, the detector can detect each of the reflected first and second beams that correspond with the two different imaging ranges. A processor decomposes the two imaging ranges into two images by selecting specific time slots of the detected signal. The processor may also control when the two light sources are swept so that the processor knows the specific time slots of the detected signal for each imaging range. In other words, the processor will recognize the first imaging range when the first beam is emitted to image the sample, and the processor will recognize the second imaging range when the second beam is emitted to image the sample.
Accordingly, the two wavelength ranges can provide anterior chamber and retinal area imaging of an eye simultaneously by superimposing two light paths into one, minimizing insertion loss of a combiner. Further, the system utilizes one single set of a detector and an interferometer that can be shared for both imaging ranges. This advantageously allows for a compact system that provides real time imaging of both the anterior chamber and retinal area of the eye.
The second beam 140 is emitted by the second light source 110 and has a second wavelength. The first beam 148 and the second beam 140 are combined and directed into an interferometer 115. The interferometer includes a reference path 128 and an interferometer sample path 170. The reference path 128 is shown by an arrow 130. The first beam 148 and the second beam 140 from the first light source 105 and the second light source 110 pass through the interferometer 115 to a mirror 125. The mirror 125 here is a half-mirror that reflects some of the light that hits it, but not all light. Accordingly, some of the first beam 148 and the second beam 140 are reflected into the reference path 128. The reference path 128 includes two different paths that correspond with a first sample path length and a second sample path length. That is, the reference path 128 will change depending on which part of the sample is being imaged (and subsequently which sample path is being utilized).
Accordingly, when the first sample path is being utilized with the first beam 148 to measure an anterior segment of an eye 156, the reference path 128 is longer, and the light is reflected off of a mirror 132 and a mirror 134. When the second sample path is being utilized with the second beam 140 to measure a retinal area of the eye 156, a path length switch 135 is activated to shorten the reference path 128, which corresponds to the difference in path length between the first sample path and the second sample path. In an alternative embodiment, the reference path 128 (and the shortened reference path when the path length switch 135 is activated) may be variable in order to provide depth scanning of the eye 156. In an alternative embodiment, instead of having a path length switch 135, the difference in path length between a reference path for the first beam 148 and a reference path for the second beam 140 may be pre-adjusted or predetermined in order to have relative offset/non-offset of depth ranges between the anterior chamber and retinal areas of the eye.
When the first beam 148 or the second beam 140 are reflected back from the first sample, they are reflected by the mirror 125 into the interferometer sample path 170. The interferometer sample path 170 is indicated by an arrow 160. The light in the interferometer sample path is reflected by a mirror 165. At a mirror 172 (here a half-mirror), the light from the reference path 128 and the interferometer sample path 170 are combined and are received by a balanced photo-detector 120, from which two images of the sample can be generated.
The first beam 148 and the second beam 140 output from the interferometer 115 arrive at a beam splitter 136. The beam splitter 136 divides the first beam 148 into a first sample path and the second beam 140 into a second sample path. To do so, the beam splitter 136 reflects or transmits the wavelength band of the first beam 148 but does not reflect or transmit the wavelength band of the second beam 140 (see discussion of
Accordingly, the first beam 148 is reflected into a first sample path to mirrors 125, 150, and 152 subsequently. After reflecting off of the mirror 152, the first beam 148 is reflected off of a scan mirror 154. The scan mirror 154 is configured to be at a focal point of a lens 155. The scan mirror 154 is also configured to direct the first beam 148 onto a beam splitter 145, which in turn reflects or transmits the first beam 148 into the lens 155. The beam splitter 145 is configured to recombine the first beam 148 on a common axis 143 as the second beam 140, which will be discussed more below. The first sample path therefore causes the first beam 148 to be a divergent beam with a lateral scanning pattern perpendicular to the sample, such that an anterior chamber of the eye 156 may be imaged. Any light of the first beam 148 that is backscattered and/or reflected can return to the interferometer along the same first sample path until it is recombined with the second beam 140 at the beam splitter 136. Backscattered and/or reflected light is split at the beam splitter 145 on the return path.
After passing through the beam splitter 136, the second beam 140 passes through the second sample path. This includes being reflected off of a mirror 146 and onto a scan mirror 142, which is configured to be at a focal point of a lens 144. The lens 144 and the lens 155, in this embodiment, are configured to be in a 4f configuration. The second beam 140 passes through the lens 144 and passes through the beam splitter 145 (see
The second beam 140 also passes through the lens 155 such that the second beam 140 is a collimating beam with a convergent scanning pattern to scan the retinal area of the sample. Any light from the second beam 140 that is reflected or backscattered passes back through the second sample path where it will be recombined with the first beam 148 at the beam splitter 136.
The graph 200 has a first vertical axis related to transmittance. In other words, the higher the transmittance, the more light will pass through the beam splitter without being reflected. The horizontal axis is wavelength. Accordingly, the beam splitter has higher or lower transmittance depending on the wavelength of the light incident on the beam splitter. Here, the properties of a given beam splitter are shown by a line 205. For reference, a first wavelength band 210 and a second wavelength band 215 are also shown on the graph 200. Accordingly, light in the first wavelength band 210 (e.g., around 1,060 nanometers) is largely transmitted through the beam splitter, as demonstrated by
The first beams 305 of the first sample may yield backscattered or reflected signals 315. The second beams 310 may yield backscattered or reflected signals 320. As an example, the reflected signals 315 may correspond to imaging of an anterior chamber via a first sample path as discussed above with respect to
The foregoing description of illustrative embodiments has been presented for purposes of illustration and of description. It is not intended to be exhaustive or limiting with respect to the precise form disclosed, and modifications and variations are possible in light of the above teachings or may be acquired from practice of the disclosed embodiments.
While certain embodiments have been illustrated and described, it should be understood that changes and modifications can be made therein in accordance with ordinary skill in the art without departing from the technology in its broader aspects as defined in the following claims.
The embodiments, illustratively described herein may suitably be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein. Thus, for example, the terms “comprising,” “including,” “containing,” etc. shall be read expansively and without limitation. Additionally, the terms and expressions employed herein have been used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the claimed technology. Additionally, the phrase “consisting essentially of” will be understood to include those elements specifically recited and those additional elements that do not materially affect the basic and novel characteristics of the claimed technology. The phrase “consisting of” excludes any element not specified.
The present disclosure is not to be limited in terms of the particular embodiments described in this application. Many modifications and variations can be made without departing from its spirit and scope, as will be apparent to those skilled in the art. Functionally equivalent methods and compositions within the scope of the disclosure, in addition to those enumerated herein, will be apparent to those skilled in the art from the foregoing descriptions. Such modifications and variations are intended to fall within the scope of the appended claims. The present disclosure is to be limited only by the terms of the appended claims, along with the full scope of equivalents to which such claims are entitled. It is to be understood that this disclosure is not limited to particular methods, reagents, compounds compositions or biological systems, which can of course vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting.
As will be understood by one skilled in the art, for any and all purposes, particularly in terms of providing a written description, all ranges disclosed herein also encompass any and all possible subranges and combinations of subranges thereof. Any listed range can be easily recognized as sufficiently describing and enabling the same range being broken down into at least equal halves, thirds, quarters, fifths, tenths, etc. As a non-limiting example, each range discussed herein can be readily broken down into a lower third, middle third and upper third, etc. As will also be understood by one skilled in the art all language such as “up to,” “at least,” “greater than,” “less than,” and the like, include the number recited and refer to ranges which can be subsequently broken down into subranges as discussed above. Finally, as will be understood by one skilled in the art, a range includes each individual member.
All publications, patent applications, issued patents, and other documents referred to in this specification are herein incorporated by reference as if each individual publication, patent application, issued patent, or other document was specifically and individually indicated to be incorporated by reference in its entirety. Definitions that are contained in text incorporated by reference are excluded to the extent that they contradict definitions in this disclosure.
Other embodiments are set forth in the following claims.
This application is a U.S. national phase application under 35 U.S.C. § 371 of International Application No. PCT/US2016/035012, which claims priority to U.S. Provisional Application No. 62/169,230, filed Jun. 1, 2015, each of which is incorporated herein by reference in its entirety.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/US2016/035012 | 5/31/2016 | WO | 00 |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2016/196463 | 12/8/2016 | WO | A |
| Number | Name | Date | Kind |
|---|---|---|---|
| 4466699 | Droessler et al. | Aug 1984 | A |
| 5022745 | Zayhowski et al. | Jun 1991 | A |
| 5319668 | Luecke | Jun 1994 | A |
| 5372135 | Mendelson et al. | Dec 1994 | A |
| 5430574 | Tehrani | Jul 1995 | A |
| 5537162 | Hellmuth et al. | Jul 1996 | A |
| 5561523 | Blomberg et al. | Oct 1996 | A |
| 5979760 | Freyman et al. | Nov 1999 | A |
| 5982963 | Feng et al. | Nov 1999 | A |
| 6070093 | Oosta et al. | May 2000 | A |
| 6111645 | Tearney et al. | Aug 2000 | A |
| 6134003 | Tearney et al. | Oct 2000 | A |
| 6160826 | Swanson et al. | Dec 2000 | A |
| 6275718 | Lempert | Aug 2001 | B1 |
| 6282011 | Tearney et al. | Aug 2001 | B1 |
| 6373632 | Flanders | Apr 2002 | B1 |
| 6421164 | Tearney et al. | Jul 2002 | B2 |
| 6485413 | Boppart et al. | Nov 2002 | B1 |
| 6501551 | Tearney et al. | Dec 2002 | B1 |
| 6556853 | Cabib et al. | Apr 2003 | B1 |
| 6564087 | Pitris et al. | May 2003 | B1 |
| 6725073 | Motamedi et al. | Apr 2004 | B1 |
| 7099358 | Chong | Aug 2006 | B1 |
| 7231243 | Tearney et al. | Jun 2007 | B2 |
| 7323680 | Chong | Jan 2008 | B2 |
| 7324214 | De Groot et al. | Jan 2008 | B2 |
| 7352783 | Chong | Apr 2008 | B2 |
| 7382809 | Chong et al. | Jun 2008 | B2 |
| 7388891 | Uehara et al. | Jun 2008 | B2 |
| 7400410 | Baker et al. | Jul 2008 | B2 |
| 7414779 | Huber et al. | Aug 2008 | B2 |
| 7428057 | De Lega et al. | Sep 2008 | B2 |
| 7489713 | Chong et al. | Feb 2009 | B2 |
| 7701588 | Chong | Apr 2010 | B2 |
| 7725169 | Boppart et al. | May 2010 | B2 |
| 7835010 | Morosawa et al. | Nov 2010 | B2 |
| 7865231 | Tearney et al. | Jan 2011 | B2 |
| 7869057 | De Groot | Jan 2011 | B2 |
| 7884945 | Srinivasan et al. | Feb 2011 | B2 |
| 7961312 | Lipson et al. | Jun 2011 | B2 |
| 8036727 | Schurman et al. | Oct 2011 | B2 |
| 8115934 | Boppart et al. | Feb 2012 | B2 |
| 8315282 | Huber et al. | Nov 2012 | B2 |
| 8405834 | Srinivasan et al. | Mar 2013 | B2 |
| 8427649 | Hays | Apr 2013 | B2 |
| 8500279 | Everett et al. | Aug 2013 | B2 |
| 8625104 | Izatt et al. | Jan 2014 | B2 |
| 8690328 | Chong | Apr 2014 | B1 |
| 8690330 | Hacker et al. | Apr 2014 | B2 |
| 9163930 | Buckland et al. | Oct 2015 | B2 |
| 9335154 | Wax | May 2016 | B2 |
| 9851433 | Sebastian | Dec 2017 | B2 |
| 20020163948 | Yoshida et al. | Nov 2002 | A1 |
| 20040036838 | Podoleanu | Feb 2004 | A1 |
| 20050171438 | Chen et al. | Aug 2005 | A1 |
| 20050201432 | Uehara et al. | Sep 2005 | A1 |
| 20050213103 | Everett et al. | Sep 2005 | A1 |
| 20060105209 | Thyroff et al. | May 2006 | A1 |
| 20060109872 | Sanders | May 2006 | A1 |
| 20060215713 | Flanders et al. | Sep 2006 | A1 |
| 20070040033 | Rosenberg | Feb 2007 | A1 |
| 20070076217 | Baker et al. | Apr 2007 | A1 |
| 20070081166 | Brown et al. | Apr 2007 | A1 |
| 20070133647 | Daiber | Jun 2007 | A1 |
| 20070141418 | Ota et al. | Jun 2007 | A1 |
| 20070263226 | Kurtz et al. | Nov 2007 | A1 |
| 20070291277 | Everett et al. | Dec 2007 | A1 |
| 20080097194 | Milner | Apr 2008 | A1 |
| 20080269575 | Iddan | Oct 2008 | A1 |
| 20090022181 | Atkins et al. | Jan 2009 | A1 |
| 20090079993 | Yatagai | Mar 2009 | A1 |
| 20090103050 | Michaels et al. | Apr 2009 | A1 |
| 20090169928 | Nishimura et al. | Jul 2009 | A1 |
| 20090247853 | Debreczeny | Oct 2009 | A1 |
| 20090268020 | Buckland et al. | Oct 2009 | A1 |
| 20090290613 | Zheng et al. | Nov 2009 | A1 |
| 20100110171 | Satake | May 2010 | A1 |
| 20100157308 | Xie | Jun 2010 | A1 |
| 20100246612 | Shimizu | Sep 2010 | A1 |
| 20100253908 | Hammer | Oct 2010 | A1 |
| 20100284021 | Hacker | Nov 2010 | A1 |
| 20110112385 | Aalders | May 2011 | A1 |
| 20110228218 | Hauger et al. | Sep 2011 | A1 |
| 20110235045 | Koerner | Sep 2011 | A1 |
| 20110255054 | Hacker et al. | Oct 2011 | A1 |
| 20110299034 | Walsh et al. | Dec 2011 | A1 |
| 20120013849 | Podoleanu | Jan 2012 | A1 |
| 20120026466 | Zhou et al. | Feb 2012 | A1 |
| 20120133950 | Suehira | May 2012 | A1 |
| 20120136259 | Milner et al. | May 2012 | A1 |
| 20120188555 | Izatt et al. | Jul 2012 | A1 |
| 20130265545 | Buckland et al. | Oct 2013 | A1 |
| 20140051952 | Reichgott et al. | Feb 2014 | A1 |
| 20140111774 | Komine | Apr 2014 | A1 |
| 20140228681 | Jia et al. | Aug 2014 | A1 |
| 20140268163 | Milner et al. | Sep 2014 | A1 |
| 20140293290 | Kulkarni | Oct 2014 | A1 |
| 20140336479 | Ando | Nov 2014 | A1 |
| 20150348287 | Yi et al. | Dec 2015 | A1 |
| 20160178346 | Kulkarni | Jun 2016 | A1 |
| 20170090031 | Bondy et al. | Mar 2017 | A1 |
| 20180088236 | Eichenholz et al. | Mar 2018 | A1 |
| 20180128594 | Lee et al. | May 2018 | A1 |
| Number | Date | Country |
|---|---|---|
| 10 2011 114 797 | Apr 2013 | DE |
| 2006-202543 | Aug 2006 | JP |
| 2008-188047 | Aug 2008 | JP |
| 2010-172538 | Aug 2010 | JP |
| WO-2012075126 | Jun 2012 | WO |
| WO-2013168149 | Nov 2013 | WO |
| WO-2015121756 | Aug 2015 | WO |
| WO-2017176901 | Oct 2017 | WO |
| Entry |
|---|
| Changho Chong, et al. “Large Coherence Length Swept Source for Axial Length Measurement of the Eye.” Applied Optics 48:10 (2009): D145-150. |
| Chowdhury, Md Koushik et al., Challenges & Countermeasures in Optical Noninvasive Blood Glucose Detection, International Journal of Innovative Research in Science, Engineering and Technology vol. 2, Issue 1, Jan. 2013 (6 pages). |
| Dai et al., “Optical coherence tomography for whole eye segment imaging,” Optics Express, vol. 20, No. 6 (2012) pp. 6109-6115. |
| Dhalla et al., “Simultaneous swept source optical coherence tomography of the anterior segment and retina using coherence revival,” Optics Letters, vol. 37 No. 11, Jun. 1, 2012, pp. 1883-1885. |
| English Translation of the International Search Report and Written Opinion on International Application No. PCT/EP2009/009189, dated Apr. 6, 2010, 12 pages. |
| F. Lexer et al., “Wavelength-tuning interferometry of intraocular distances,” Applied Optics, vol. 36, No. 25, pp. 6548-6553 (Sep. 1, 1997). |
| Fainman, Y. et al., “Nanophotonics for Information Systems,” Information Optics and Photonics (T. Fournel and B. Javidi eds., Springer New York, 2010) pp. 13-37. |
| International Preliminary Report on Patentability and Written Opinion on International Application No. PCT/US2015/032726 dated Dec. 8, 2016(7 pages). |
| International Preliminary Report on Patentability in corresponding application PCT/US2016/035012 dated Dec. 14, 2017. |
| International Preliminary Report on Patentability in corresponding international application No. PCT/US2015/019299 dated Sep. 22, 2016. |
| International Preliminary Report on Patentability in corresponding international application No. PCT/US2015/032727 dated Dec. 8, 2016. |
| International Preliminary Report on Patentability in International appln. No. PCT/IB2015/000808. |
| International Search Report and Written Opinion dated Aug. 26, 2015 for PCT/US15/32727 (8 pages). |
| International Search Report and Written Opinion in corresponding application No. PCT/US2016/035012 dated Aug. 18, 2016. |
| International Search Report and Written Opinion in International Application No. PCT/US2015/19299 dated Nov. 2, 2015 (10 pages). |
| International Search Report and Written Opinion in PCT/IB2015/000808 dated Oct. 20, 2015 (12 pages). |
| Jeong et al., “Spectral-domain OCT with dual illumination and interlaced detection for simultaneous anterior segment and retina imaging,” Optics Express, vol. 20, Issue 17, pp. 19148-19159 (2012). |
| Jia et al., Split-Spectrum Amplitude-Decorrelation Angiography with Optical Coherence Tomography, Optics Express, vol. 20 No. 4, Feb. 9, 2012, pp. 4710-4725. |
| Lexer et al., “Wavelength-tuning interferometry of intraocular distances”, Applied Optics, vol. 36, No. 25, Sep. 1, 1997, pp. 6548-6553. |
| Mariampillai et al., Speckle Variance Detection of Microvasculature Using Swept-Source Optical Coherence Tomography, Optics Letters, vol. 33 No. 13, Jul. 1, 2008, pp. 1530-1532. |
| Nankivil et al.,“Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe,” OSA Nov. 1, 2015; vol. 6, No. 11; DOI:10.1364/BOE.6.004516; Biomedical Optics Express 4516-4528. |
| Non-Final Rejection on U.S. Appl. No. 14/723,325 dated Dec. 7, 2017. |
| Notice of Allowance on U.S. Appl. No. 15/202,925 dated Feb. 13, 2018 (9 pages). |
| P. Tayebati et al., “Microelectromechanical tunable filter with stable half symmetric cavity,” Electronics Letters, vol. 34, No. 20, pp. 1967-1968 (Oct. 1, 1998). |
| Poddar, et al., “Non-Invasive Glucose Monitoring Techniques: A Review and Current Trends,” Oct. 31, 2008, pp. 1-47. |
| Sarlet, G. et al., “Wavelength and Mode Stabilization of Widely Tunable SG-DBR and SSG-DBR Lasers,” IEEE Photonics Technology Letters, vol. 11, No. 11, Nov. 1999, pp. 1351-1353. |
| Segawa, Toru et al., “Semiconductor Double-Ring-Resonator-Coupled Tunable Laser for Wavelength Routing,” IEEE Journal of Quantum Electronics, vol. 45, No. 7, Jul. 2009, pp. 892-899. |
| Sergie Ortiz, et al. “Corneal Topography From Spectral Optical Coherence Tomography (SOCT).” Biomedical Optics Express 2:12, (2011):3232-3247. |
| U.S. Notice of Allowance dated Dec. 6, 2013. |
| U.S. Notice of Allowance on U.S. Appl. No. 14/601,945 dated Sep. 13, 2016. |
| U.S. Notice of Allowance on U.S. Appl. No. 14/613,644 dated Nov. 7, 2016. |
| U.S. Notice of Allowance on U.S. Appl. No. 14/613,644 dated Nov. 18, 2016. |
| U.S. Notice of Allowance on U.S. Appl. No. 14/641,200 dated Jul. 12, 2016. |
| U.S. Office Action dated Sep. 12, 2013. |
| U.S. Office Action dated Aug. 19, 2015. |
| U.S. Office Action on U.S. Appl. No. 14/601,945 dated Mar. 2, 2016. |
| U.S. Office Action on U.S. Appl. No. 14/613,644 dated Jun. 8, 2016. |
| U.S. Office Action on U.S. Appl. No. 14/641,200 dated Mar. 14, 2016. |
| U.S. Office Action on U.S. Appl. No. 14/641,200 dated Dec. 7, 2015. |
| U.S. Office Action on U.S. Appl. No. 14/723,325 dated Nov. 18, 2016. |
| U.S. Office Action on U.S. Appl. No. 14/723,325 dated Apr. 24, 2017. |
| U.S. Office Action on U.S. Appl. No. 15/202,925 dated Jul. 27, 2017. |
| Chopra et al., Topographical Thickness of the Skin in the Human Face, Aesthetic Surgery Journal, vol. 35(8), 2015, pp. 1007-1013. |
| Final Office Action on U.S. Appl. No. 15/630,654 dated Sep. 12, 2018. |
| Non-Final Office Action on U.S. Appl. No. 14/723,325 dated Jan. 29, 2019. |
| Non-Final Office Action on U.S. Appl. No. 15/086,520 dated Aug. 6, 2018. |
| Non-Final Office Action on U.S. Appl. No. 15/611,515 dated Oct. 5, 2018. |
| Non-Final Office Action on U.S. Appl. No. 15/648,239 dated Jun. 6, 2018. |
| U.S. Office Action on U.S. Appl. No. 14/723,325 dated Apr. 19, 2019. |
| U.S. Office Action on U.S. Appl. No. 15/630,654 dated Apr. 4, 2018. |
| International Search Report and Written Opinion in PCT/US2019/027671 dated Jul. 1, 2019. |
| Number | Date | Country | |
|---|---|---|---|
| 20180206716 A1 | Jul 2018 | US |
| Number | Date | Country | |
|---|---|---|---|
| 62169230 | Jun 2015 | US |
