Patent Grant
12082926
The present disclosure relates to devices, methods, and systems for monitoring a subject's physiological information. More specifically, the present disclosure relates to noninvasive measurement of the physiological information using multiple sources of data derived from an optical sensor.
Hospitals, nursing homes, and other patient care facilities typically include patient monitoring devices in the facility. Patient monitoring devices can include sensors, processing equipment, and displays for obtaining and analyzing a medical patient's physiological parameters such as blood oxygen saturation level, respiratory rate, pulse, and a myriad of other parameters, such as those monitored on commercially available patient monitors from Masimo Corporation of Irvine, California. Clinicians, including doctors, nurses, and other medical personnel, use the physiological parameters and trends of those parameters obtained from patient monitors to diagnose illnesses and to prescribe treatments. Clinicians also use the physiological parameters to monitor patients during various clinical situations to determine whether to adjust the level of medical care given to patients.
Patient monitoring can be achieved through spectroscopic analysis using, for example, a pulse oximeter. A pulse oximeter generally includes one or more light sources transmitting optical radiation into or reflecting off through a portion of the body, for example a finger, a hand, a foot, a nose, an earlobe, or a forehead. One or more photo detection devices detect the light after interaction with tissue of the portion of the body, and output one or more detector signals responsive to the detected attenuated light. One or more signal processing devices process the detector signals and output a measurement indicative of a physiological parameter or characteristic, such as oxygen saturation (SpO2), pulse rate, a plethysmograph waveform, perfusion index (PI), pleth variability index (PVI), methemoglobin (MetHb), carboxyhemoglobin (CoHb), total hemoglobin (tHb), blood glucose, etc., and a display may display any one or any combination of the foregoing parameters individually, in groups, in trends, as combinations, or as an overall wellness or other index. An example of such an oximeter is described in U.S. Pat. No. 9,323,176, filed May 27, 1999, entitled “Stereo Pulse Oximeter,” now U.S. Pat. No. 6,334,065, the disclosure of which is hereby incorporated by reference in its entirety.
For purposes of summarizing the disclosure, certain aspects, advantages and novel features of the inventions have been described herein. It is to be understood that not necessarily all such advantages can be achieved in accordance with any particular embodiment of the inventions disclosed herein. Thus, the inventions disclosed herein can be embodied or carried out in a manner that achieves or optimizes one advantage or group of advantages as taught herein without necessarily achieving other advantages as can be taught or suggested herein.
Disclosed herein are devices (also referred to herein as “sensors”) that can include multiple detectors and/or multiple emitters that are arranged and/or spatially configured such that the devices can obtain measurements that relate to different path lengths or different tissue geometries. Such configurations can improve determinations of physiological parameters with respect to accuracy, reliability, or robustness, for example by reducing the likelihood of a total measurement error. Any of the devices described herein can be secured to various portions of a subject's body. For example, any of the devices described herein can be secured to a digit of the subject, such as a finger, a toe, or another portion of the subject's body, such as an ear, nose, arm, wrist, among others. Accordingly, although some implementations of the present disclosure describe devices configured to secure to a finger of a user, the present disclosure is not so limited. Any of the devices described herein can be configured to interact with other devices via mechanical and/or electrical connection and/or via wired and/or wireless communication methods. Any of the devices described herein can be configured to determine one or more physiological parameters of a subject based on, for example, signals generated from one or more sensors (for example, an optical sensor) of the device, and/or any of the devices described herein can be configured to communicate with a separate device to facilitate determination of such one or more physiological parameters by such separate device. Any of the devices described herein can be utilized for noninvasive determination of one or more physiological parameters.
Disclosed herein is a noninvasive physiological sensor configured to attach to a finger of a user, the noninvasive physiological sensor comprising: a body portion configured to be secured to the finger of the user; a first emitter configured to emit light of one or more wavelengths into tissue of the finger of the user when the noninvasive physiological sensor is in use, wherein the first emitter is operably positioned by the body portion at a first side of the finger when the body portion is secured to the finger; and a plurality of detectors, each of the plurality of detectors configured to detect at least a portion of the emitted light after attenuation by the tissue of the finger of the user when the noninvasive physiological sensor is in use, wherein each of the plurality of detectors is configured to generate at least one signal responsive to the detected light, and wherein the plurality of detectors comprises: a first detector operably positioned by the body portion at a second side of the finger that is opposite the first side of the finger when the body portion is secured to the finger such that the first detector and the first emitter are substantially aligned with one another; and a second detector operably positioned by the body portion at a third side of the finger when the body portion is secured to the finger such that the second detector is offset approximately 90 degrees from the first emitter with respect to an axis extending through at least a portion of the body portion.
In some implementations: the noninvasive physiological sensor further comprises a second emitter configured to emit light of one or more wavelengths into the tissue of the finger of the user when the noninvasive physiological sensor is in use; and the second emitter is operably positioned by the body portion at a fourth side of the finger that is opposite the third side of the finger when the body portion is secured to the finger such that the second emitter is offset approximately 90 degrees from the first emitter with respect to said axis extending through at least the portion of the body portion. In some implementations, the second emitter is operably positioned by the body portion such that the second emitter is offset approximately 180 degrees from the second detector with respect to said axis extending through at least the portion of the body portion. In some implementations, the first emitter and the second emitter are configured to be selectively activated such that only one of the first and second emitters is emitting light at a given time.
In some implementations, said axis extends through a center of a cross-section of the body portion. In some implementations, the first emitter and the plurality of detectors are operably positioned by the body portion along a plane of a cross-section of the body portion when secured to the finger of the user. In some implementations, said body portion is configured such that, when secured to the finger of the user, said axis extends along at least a portion of a longitudinal axis of the finger. In some implementations, said first emitter is the only emitter of the noninvasive physiological sensor.
In some implementations, the body portion is configured to be transitioned from a first configuration when not secured to the finger of the user to a second configuration when secured to the finger of the user, and wherein the first and second configurations are different. In some implementations, the body portion is configured to be substantially flat when in the first configuration. In some implementations, the body portion is configured such that, when in the second configuration, the body portion is wrapped around the finger of the user. In some implementations, when the body portion is in said second configuration, a cross-section of the body portion is rounded.
In some implementations, in the plurality of detectors further comprises a third detector operably positioned by the body portion at a fourth side of the finger when the body portion is secured to the finger such that the third detector is offset approximately 90 degrees from the first emitter with respect to said axis extending through said at least the portion of the body portion. In some implementations, the third detector is operably positioned by the body portion at the fourth side of the finger when the body portion is secured to the finger such that the third detector is offset approximately 180 degrees from the second detector with respect to said axis extending through at least the portion of the body portion.
In some implementations, the first emitter and the plurality of detectors are in communication with a monitoring device configured to: control operation of the first emitter; receive said at least one signal generated by each of the plurality of detectors; and determine one or more physiological parameters based on said at least one signal generated by each of the plurality of detectors. In some implementations, the one or more physiological parameters comprises at least one of oxygen saturation, pulse rate, and glucose. In some implementations, the noninvasive physiological sensor further comprises a cable connected to the body portion and configured to transmit said at least one signal generated by each of the plurality of detectors to said monitoring device. In some implementations, said monitoring device is configured to attach to a wrist of the user. In some implementations, said monitoring device is configured to wirelessly transmit said determined one or more physiological parameters. In some implementations, said noninvasive physiological sensor is configured to wirelessly transmit said at least one signal from each of the plurality of detectors to said monitoring device.
In some implementations, said noninvasive physiological sensor is configured to determine one or more physiological parameters based on said at least one signal generated by each of the plurality of detectors. In some implementations, the first side of the finger comprises a nail-bed of the finger.
Disclosed herein is a noninvasive physiological sensor configured to attach to a finger of a user, the noninvasive physiological sensor comprising: a body portion configured to be secured to the finger of the user; a first emitter configured to emit light of one or more wavelengths into tissue of the finger of the user when the noninvasive physiological sensor is in use, wherein the first emitter is operably positioned by the body portion at a first side of the finger when the body portion is secured to the finger; a second emitter configured to emit light of one or more wavelengths into the tissue of the finger of the user when the noninvasive physiological sensor is in use, wherein the second emitter is operably positioned by the body portion at a second side of the finger that is opposite the first side of the finger when the body portion is secured to the finger; and a plurality of detectors, each of the plurality of detectors configured to detect at least a portion of the emitted light after attenuation by the tissue of the finger of the user when the noninvasive physiological sensor is in use, wherein each of the plurality of detectors is configured to generate at least one signal responsive to the detected light, and wherein the plurality of detectors comprises: a first detector operably positioned by the body portion at the second side of the finger when the body portion is secured to the finger such that the first detector is spaced from the second emitter by a first distance, wherein the first detector and the first emitter are configured to operate in a first transmissive mode and wherein the first detector and the second emitter are configured to operate in a first reflectance mode; and a second detector operably positioned by the body portion at the second side of the finger when the body portion is secured to the finger such that the second detector is spaced from the second emitter by a second distance that is greater than the first distance, wherein the second detector and the first emitter are configured to operate in a second transmissive mode and wherein the second detector and the second emitter are configured to operate in a second reflectance mode.
In some implementations, the body portion is configured to be transitioned from a first configuration when not secured to the finger of the user to a second configuration when secured to the finger of the user, and wherein the first and second configurations are different. In some implementations, when the body portion is in the first configuration, the first detector, the second detector, and the second emitter are aligned with one another. In some implementations, the body portion is configured to be substantially flat when in the first configuration. In some implementations, the body portion is configured such that, when in the second configuration, the body portion is wrapped around the finger of the user. In some implementations, when the body portion is in the second configuration, a cross-section of the body portion is rounded.
In some implementations, said first and second reflectance modes are configured to operate simultaneously. In some implementations, only one of said first and second reflectance modes are configured to operate at a given time. In some implementations, said first and second transmissive modes are configured to operate simultaneously. In some implementations, only one of said first and second transmissive modes are configured to operate at a given time. In some implementations, the first and second reflective modes are configured to operate simultaneously with one another and with the first and second transmissive modes.
In some implementations, the first side of the finger comprises a nail-bed of the finger. In some implementations, the second emitter and the plurality of detectors are operably positioned by the body portion along a plane that is substantially parallel to at least one of a first axis extending through at least a portion of the body portion when secured to the finger and a second axis extending along at least a portion of the finger when the body portion is secured to the finger. In some implementations: at least a portion of the light emitted by the first emitter is transmitted through the tissue of the finger and detected by the first detector and the second detector; and at least a portion of the light emitted by the second emitter is reflected by the tissue of the finger and detected by the first detector and the second detector.
In some implementations, the first and second emitters and the plurality of detectors are in communication with a monitoring device configured to: control operation of the first and second emitters; receive said at least one signal generated by each of the plurality of detectors; and determine one or more physiological parameters based on said at least one signal generated by each of the plurality of detectors. In some implementations, one or more physiological parameters comprises at least one of oxygen saturation, pulse rate, and glucose. In some implementations, the noninvasive physiological sensor further comprises a cable connected to the body portion and configured to transmit said at least one signal generated by each of the plurality of detectors to said monitoring device. In some implementations, said monitoring device is configured to attach to a wrist of the user. In some implementations, said monitoring device is configured to wirelessly transmit said determined one or more physiological parameters. In some implementations, said noninvasive physiological sensor is configured to wirelessly transmit said at least one signal from each of the plurality of detectors to said monitoring device.
Disclosed herein is a noninvasive physiological sensor configured to attach to a finger of a user, the noninvasive physiological sensor comprising: a body portion configured to be secured to the finger of the user; a first emitter configured to emit light of one or more wavelengths into tissue of the finger of the user when the noninvasive physiological sensor is in use, wherein the first emitter is operably positioned by the body portion at a first side of the finger when the body portion is secured to the finger; and a plurality of detectors, each of the plurality of detectors configured to detect at least a portion of the emitted light after attenuation by the tissue of the finger of the user when the noninvasive physiological sensor is in use, wherein each of the plurality of detectors is configured to generate at least one signal responsive to the detected light, and wherein the plurality of detectors comprises: a first detector operably positioned by the body portion at a second side of the finger that is opposite the first side of the finger when the body portion is secured to the finger such that the first detector is offset approximately 180 degrees from the first emitter with respect to an axis extending through at least the portion of the body portion; and a second detector operably positioned by the body portion at the second side of the finger when the body portion is secured to the finger such that the second detector is aligned with but spaced from the first detector by a first distance.
In some implementations, the first and second detectors are configured to concurrently operate in a transmissive mode with the first emitter. In some implementations, said first emitter is the only emitter of the noninvasive physiological sensor. In some implementations, the body portion does not operably position any emitters at the second side of the finger when the body portion is secured to the finger. In some implementations: the plurality of detectors comprises a third detector operably positioned by the body portion at the second side of the finger when the body portion is secured to the finger such that the third detector is aligned with but spaced from the first detector by a second distance and aligned with but spaced from the second detector by a third distance that is greater than the second distance. In some implementations, the first, second, and third detectors are configured to concurrently operate in said transmissive mode with the first emitter. In some implementations, said first and second distances are equal.
In some implementations, the body portion is configured to be transitioned from a first configuration when not secured to the finger of the user to a second configuration when secured to the finger of the user, and wherein the first and second configurations are different. In some implementations, when the body portion is in the first configuration, the first detector, the second detector, and the first emitter are aligned with one another. In some implementations, the body portion is configured to be substantially flat when in the first configuration. In some implementations, the body portion is configured such that, when in the second configuration, the body portion is wrapped around the finger of the user. In some implementations, when the body portion is in the second configuration, a cross-section of the body portion is rounded.
In some implementations, the first emitter and the plurality of detectors are in communication with a monitoring device configured to: control operation of the first emitter; receive said at least one signal generated by each of the plurality of detectors; and determine one or more physiological parameters based on said at least one signal generated by each of the plurality of detectors. In some implementations, the one or more physiological parameters comprises at least one of oxygen saturation, pulse rate, and glucose. In some implementations, the noninvasive physiological sensor further comprises a cable connected to the body portion and configured to transmit said at least one signal generated by each of the plurality of detectors to said monitoring device. In some implementations, said monitoring device is configured to attach to a wrist of the user. In some implementations, said monitoring device is configured to wirelessly transmit said determined one of more physiological parameters. In some implementations, said noninvasive physiological sensor is configured to wirelessly transmit said at least one signal from each of the plurality of detectors to said monitoring device. In some implementations, said noninvasive physiological sensor is configured to determine one or more physiological parameters based on said at least one signal generated by each of the plurality of detectors. In some implementations, the first side of the finger comprises a nail-bed of the finger.
Disclosed herein is a noninvasive physiological sensor configured to attach to a finger of a patient, the sensor comprising: a first emitter configured to emit light and configured to be positioned on or around a nail-bed of the finger when the sensor is in use; and a plurality of detectors, wherein each of the plurality of detectors is configured to detect at least some of the light after attenuation by tissue of the patient and generate at least one signal responsive to the detected light. The plurality of detectors can comprise: a first detector configured to be positioned opposite the first emitter relative to the finger when the sensor is in use, and a second detector configured to be positioned on a side of the finger when the sensor is in use such that the second detector is offset about 90 degrees from the first emitter with respect to a longitudinal axis of the finger.
The plurality of detectors can further comprise a third detector configured to be positioned opposite the second detector relative to the finger when the sensor is in use such that the third detector is offset about 90 degrees from the first emitter with respect to the longitudinal axis of the finger. The sensor can further comprise a second emitter configured to be positioned opposite the second detector relative to the finger when the sensor is in use such that the second emitter is offset about 90 degrees from the first emitter with respect to the longitudinal axis of the finger. The first emitter and the second emitter can be selectively activated so that only one of the first emitter or the second emitter is emitting light at a given time. In some variants, said about 90 degrees is between 80 and 100 degrees, between 87 and 93 degrees, between 89 and 91 degrees, or exactly 90 degrees.
In some variants, the first emitter is activated for a first quarter cycle, the second emitter is activated for a third quarter cycle, and the first emitter and the second emitter are off for a second quarter cycle and a fourth quarter cycle. In some variants, a particular path length of the light detected by a particular one of the plurality of detectors is different from a path length of the light detected by all other ones of the plurality of detectors. When the sensor is attached to the patient, the emitter and the plurality of detectors can be configured to be located on a same 2D plane. When the sensor is attached to the finger of the patient, the first emitter, the second emitter, and the plurality of detectors can be located on a same 2D plane. The plurality of detectors can be communicatively coupled to a patient monitor and the patient monitor can be configured to: receive the signals generated by the plurality of detectors; and determine a physiological parameter based at least in part on at least one of the received signals. In some variants, the patient monitor receives the signals as a time-division-multiplexed signal. The physiological parameter can comprise at least one of total hemoglobin, oxygen saturation, pulse rate, a plethysmograph waveform, perfusion index, pleth variability index, methemoglobin, carboxyhemoglobin, or glucose. The sensor can comprise a wearable apparatus, a fingertip sleeve configured to couple to the finger, tape for securing the sensor to the finger, an L-shaped sensor, and/or a tape sensor. In some variants, none of the plurality of detectors are positioned on a knuckle of the patient when the sensor is in use.
Disclosed herein is a noninvasive physiological sensor comprising: an emitter configured to emit light; a detector configured to detect the light after attenuation by tissue of a patient and generate at least one signal corresponding to the detected light; and a motorized component configured to move the emitter along a longitudinal axis of a finger of the patient when the sensor is in use, wherein, responsive to receiving a first command signal, the motorized component moves the emitter from a first position on a nail-side of the finger to a second position off the nail-side of the finger. The detector can be configured to be positioned opposite the emitter relative to the finger when the sensor is in use. The detector can be configured to be positioned on a side of the finger when the sensor is in use such that the detector is offset 90 degrees from the emitter with respect to the longitudinal axis of the finger. In some variants, the emitter moves relative to the detector. The motorized component can be further configured to move the detector along the longitudinal axis of the finger when the sensor is in use, and the motorized component can be configured to receive a second command signal from a controller, wherein, responsive to receiving said second command signal, the motorized component moves the detector along the longitudinal axis of the finger. Responsive to receiving a second command signal, the motorized component can move the emitter from the second position to the first position. Responsive to receiving a third command signal, the motorized component can move the emitter from the second position to a third position, wherein the third position is different from the first position.
The emitter can be configured to emit light at each of the first position and the second position. In some variants, a path length of the light detected by the detector when the emitter is at the first position is different from a path length of the light detected by the detector when the emitter is at the second position. The detector can be communicatively coupled to a patient monitor and the patient monitor can be configured to: receive the at least one signal generated by the detector; and determine a physiological parameter based at least in part on the received at least one signal. The physiological parameter can comprise at least one of total hemoglobin, oxygen saturation, pulse rate, a plethysmograph waveform, perfusion index, pleth variability index, methemoglobin, carboxyhemoglobin, or glucose. The sensor can comprise a wearable apparatus, a fingertip sleeve configured to couple to the finger, tape for securing the sensor to the finger, an L-shaped sensor, and/or a tape sensor. In some variants, none of the plurality of detectors are positioned on a knuckle of the patient when the sensor is in use.
Disclosed herein is a noninvasive physiological sensor configured to attach to a finger of a user, the sensor comprising: a first emitter configured to emit light and configured to be positioned on or around a first side of the finger when the sensor is in use; a second emitter configured to emit light and configured to be positioned on or around a second side of the finger when the sensor is in use; and a plurality of detectors, wherein each of the plurality of detectors is configured to detect at least some of the light emitted by the first and second emitters after attenuation by tissue of the finger, each of the plurality of detectors further configured to generate at least one signal responsive to the detected light. The plurality of detectors can comprise: a first detector configured to be positioned on the second side of the finger when the sensor is in use; and a second detector configured to be positioned on the second side of the finger and adjacent to the first detector when the sensor is in use.
The first side of the finger can comprise a nail-bed of the finger. The second side of the finger can be opposite the first side of the finger. The first side can be a top portion of the finger and the second side can be a bottom portion of the finger. The first detector, the second detector, and the second emitter can be aligned along a plane with one another when the sensor is in use, said plane being parallel to a longitudinal axis of the finger. The first emitter and the first detector or the second detector can be aligned along a plane that is orthogonal to a longitudinal axis of the finger. The light emitted by the first emitter can be transmitted through the tissue of the finger and detected by the first detector and the second detector, and the light emitted by the second emitter can be reflected by the tissue of the finger and detected by the first detector and the second detector. The generated signals can be associated with transmittance and reflectance of the light emitted by the first emitter and the second emitter. In some variants, the first detector is offset from the first emitter by a first degree amount with respect to a longitudinal axis of the finger, and the second detector is offset from the first emitter by a second degree amount with respect to a longitudinal axis of the finger. The first emitter and the second emitter can be selectively activated so that only one of the first emitter or the second emitter is emitting light at a given time.
In some variants, the first emitter is activated for a first quarter cycle, the second emitter is activated for a third quarter cycle, and the first emitter and the second emitter are off for a second quarter cycle and a fourth quarter cycle. In some variants, a particular path length of the light detected by a particular one of the plurality of detectors is different from a path length of the light detected by all other ones of the plurality of detectors. The plurality of detectors can be communicatively coupled to a patient monitor and the patient monitor can be configured to: receive the signals generated by the plurality of detectors; and determine a physiological parameter based at least in part on at least one of the received signals. In some variants, the patient monitor receives the signals as a time-division-multiplexed signal. The physiological parameter can comprise at least one of total hemoglobin, oxygen saturation, pulse rate, a plethysmograph waveform, perfusion index, pleth variability index, methemoglobin, carboxyhemoglobin, or glucose. The sensor can comprise a wearable apparatus, a fingertip sleeve configured to couple to the finger, tape for securing the sensor to the finger, an L-shaped sensor, and/or a tape sensor. In some variants, none of the plurality of detectors are positioned on a knuckle of the patient when the sensor is in use.
Various embodiments will be described hereinafter with reference to the accompanying drawings. These embodiments are illustrated and described by example only, and are not intended to limit the scope of the disclosure. In the drawings, similar elements have similar reference numerals.
Although certain embodiments and examples are described below, those of skill in the art will appreciate that the disclosure extends beyond the specifically disclosed embodiments or uses and obvious modifications and equivalents thereof. Thus, it is intended that the scope of the disclosure herein disclosed should not be limited by any particular embodiments described below.
There are many sources of potential measurement error introduced to pulse oximetry systems. Some such sources of error include the pulse oximetry system's electronic components, including emitters and detectors, as well as chemical and structural physiological differences between patients. Another source of measurement error is the particular tissue geometry of a measurement site.
To address these or other problems, a sensor can include multiple emitters or multiple detectors that are arranged and/or spatially configured such that the sensor can generate signals that relate to different path lengths and/or different tissue geometries. In this way, the sensor can reduce the likelihood of a measurement error caused by a particular tissue geometry, thereby improving the accuracy, reliability, and/or robustness of the sensor. Additionally or alternatively, the sensor can include improved accuracy, reliability, or robustness by using any of various arbitration techniques to select or to combine estimations from the various signals (for example, generated by any one of a plurality of detectors of a sensor), or to determine a confidence parameter.
The monitoring device 80 can include a sensor interface 81 and a processor 82. The sensor 100 can provide a stream of data to the monitoring device 80. For example, the sensor 100 can provide a stream of data to the sensor interface 81 and/or to the processor 82 (for example, via the sensor interface 81). The sensor 100 can be connected to the sensor interface 81 via a wired or wireless connection. An output of the sensor interface 81 can be fed into the processor 82 in a raw or partially processed data form. Partially processed sensor data can be demodulated, filtered, or otherwise processed to prepare the data for use by the processor 82 to calculate measurements of one or more physiological parameters. Partially processing the sensor data can include generating basic ratios of wavelengths in a multi-wavelength system. The processor 82 can include one or more hardware or software signal processors. Partial processing can include, for example, a low or high pass filter or other preprocessing steps typically performed in a signal acquisition system.
The unprocessed or partially processed streams of data from the sensor 100 can be combined by the processor 82 into combined sensor data. The combined sensor data can include a plurality of features of the signals from the sensor 100, such as amplitude, phase, AC value, DC value, or others. Measurement site or body tissue information can be provided to the processor 82 as independent features. The processor 82 can produce one or more measurements of a physiological parameter based on the combined sensor data. The plurality of features of the signals can be mapped onto empirical data, which can provide estimates of physiological parameter measurements. The additional independent features of the measurement site or body tissue information can provide more combinations of features and improve the estimation of the physiological parameters. The combinations of features can be linear or can include high-ordered combinations. The processor 82 can analyze from the combined sensor data various features, such as a ratiometric value, such as ratios of attenuated light of one wavelength to attenuated light of another wavelength, or combinations of features, including non-normalized features, data from bulk absorption or peripheral absorption signals, or others. The sensor 100 and monitoring device 80 can be utilized to obtain a physiological parameter or characteristic, such as oxygen saturation (SpO2), pulse rate, a plethysmograph waveform, perfusion index (PI), pleth variability index (PVI), methemoglobin (MetHb), carboxyhemoglobin (CoHb), total hemoglobin (tHb), blood glucose, among other things.
The sensor 100 can be or comprise one or more emitters (such as one, two, three, four, five, or six or more emitters) and/or one or more detectors (such as one, two, three, four, five, or six or more detectors) which can be utilized to obtain information indicative of one or more physiological parameters. For example, with reference to
The DSP 85 can communicate with and/or control the emitter 110 via drivers 83, and the DSP 85 can communicate with the detector 112 via a front end 84. For example, the emitter 110 can emit light, and the detector 112 can sense at least a portion of the light after it interacts with tissue of a subject and can generate one or more signals indicative of the sensed light. The generated signal(s) can be indicative of an intensity of light reflected, refracted, scattered, absorbed, or transmitted at a tissue site. The drivers 83 can convert digital control signals into analog drive signals capable of driving the emitter 110 to illuminate the tissue site. Light emitted by the emitter 110 can have an infrared (IR), near infrared (NIR), red, ultra-violet (UV), visible, or other wavelength. The detector 112 can generate one or more composite analog light intensity signals responsive to light detected by the detector 112 after attenuation, reflection, refraction, scattering, absorption, etc., at the tissue site. The emitter 110 and detector 112 can be positioned at various locations on or around a tissue site when the sensor 100 is in use. For example, when the tissue site is a finger, toe, wrist, or the like, the emitter 110 or the detector 112 can be positioned on a top side, on a bottom side, or on the right and/or left sides of the finger when the sensor 100 is in use.
The front end 84 can convert the one or more composite analog light intensity signals from the detector 112 into digital data and input the digital data into the DSP 85. The digital data from the front end 84 can correspond to and/or be indicative of at least one of a plurality of physiological parameters such as any of those described herein. For example, the digital data from the front end 84 can be representative of a change in the absorption of particular wavelengths of light as a function of the changes in the tissue site resulting from pulsing blood.
The DSP 85 can include one or more data or signal processors configured to execute one or more programs for determining physiological parameters from input data. The DSP 85 can perform operations that include calculating and/or outputting one or more physiological measurements. In some cases, the DSP 85 can receive multiple signals from the sensor 100. For example, the sensor 100 may include a multi-emitter, multi-detector, and/or movable arrangement, such as any of those described herein. In some such cases, the DSP 85 can obtain multiple signals, determine an estimation of a physiological parameter for each, some, or all received signals, and can use any of various arbitration techniques to select or to combine the estimations, or to determine a confidence parameter. The operations performed by the DSP 85 can be implemented in software, firmware or other form of code or instructions, or logic or other hardware, or a combination of the above.
The DSP 85 can compare or analyze one or more of the determined parameters (for instance, at least two of the determined parameters or one determined parameter and a previous or model parameter) to adjust how a parameter is measured or calculated to make the measured parameter more accurate or reliable, to adjust a sensor to make the measured parameter more accurate or reliable, to calculate, derive or determine an accuracy or a confidence value of a measured parameter, to isolate a parameter, or to determine another parameter based on the one or more parameters.
The user interface 86a can include a numerical or graphical display that provides readouts of measures or parameters, trends and bar graphs of measures or parameters, visual indications of measures or parameters, visual indicators like LEDs of various colors that signify measurement magnitude, or device management interfaces, which can be generated by LEDs, LCDs, or CRTs, for example. The user interface 86a can include an audible output device that provides readouts or audible indications of measures or parameters. The user interface 86a can include one or more input devices like a keypad, touch screen, pointing device, voice recognition device, and computer that can be used to supply control or configuration data, such as initialization settings, from the user interface 86a to an instrument manager. In some implementations, the user interface 86a can be an interface for devices as well as users.
The controls 86b can be outputs to medical equipment, such as drug administration devices, ventilators, or fluid IVs, so as to control the amount of administered drugs, ventilator settings, or the amount of infused fluids. The monitoring device 80 can use the controls 86b to automatically treat a patient (for instance, provide fluid to the patient, provide medication to the patient, turn on a fan to cool the patient, or adjust a temperature of a room to heat or cool the patient) in response to determining that the patient may benefit from treatment.
The transceiver 86c can transmit information via an antenna about operation of the monitoring device 80 to an electronic device or receive control or configuration data for operating the monitoring device 80. The transceiver 86c can, for example, communicate via a computer network or intermediary device or directly with the electronic device using electromagnetic radiation. The transceiver 86c can be configured to wirelessly communicate with a separate device. As another example, the transceiver 86c can be configured to wirelessly transmit processed and/or unprocessed physiological information obtained by the sensor 100 and/or monitoring device 80. The transceiver 86c can be configured to use any of a variety of wireless protocols, such as Wi-Fi (802.11x), Bluetooth®, ZigBee®, Zwave®, cellular telephony, infrared, near field communication (NFC), RFID, satellite transmission, proprietary protocols, combinations of the same, and the like.
The memory device 86d can be used to store information about operation of the monitoring device 80. This information can, for example, include readouts of measures or parameters, trends and bar graphs of measures or parameters, visual indications or indicators. The memory device 86d can be used to store data such as information obtained from the sensor 100 and/or determined by the monitoring device 80 based on such information. The memory device 86d can be or include, including without limitation, dynamic and/or static random access memory (RAM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), and the like.
One or more of the components relating to signal acquisition or processing (for example, front end 84, drivers 83, DSP 85, etc.) can be incorporated into one or more connecting cables, the sensor itself, or are otherwise closer to the sensor sites. As such, the monitoring device 80 can include primarily the input or output device 86. In addition, some of the components are illustrated as separate units but can be combined. By reducing the number of components included in the monitoring device 80, the monitoring device 80 can be smaller in size or more portable, which can be more convenient for home or spot-check use. Although not illustrated in
The emitter 110 can be a light-emitting diode (LED). The emitter(s) 110 can each emit light of the same or different wavelengths. The emitter(s) 110 can emit light of different wavelengths in sequence with only one emitter emitting light at a given time, thereby forming a pulse sequence. For example, the emitter(s) 110 can be modulated or selectively activated so that only one emitter 110 (or a subset of emitters) is emitting light at a given time. For example, a first emitter can be activated for a first quarter cycle and off for the remaining three-quarters cycle; and a second emitter can be activated for a third quarter cycle and off for the remaining three-quarters cycle. In this way, the emitters can be cycled on and off alternately, in sequence, with each only active for a quarter cycle and with a quarter cycle separating the active times. Alternative activation sequences for the emitter(s) 110 may be used to provide a time-multiplexed signal from the detector 112 allowing separation of emitter signals.
The detector 112 can include one or more photodetectors, photodiodes, phototransistors, or the like. Details of an exemplary photodetector that can be utilized for detector 112 are described in U.S. Pat. No. 9,277,880, the disclosure of which is incorporated by reference herein in its entirety. The detector 112 can detect the light emitted by the emitter 110 after the light is attenuated by tissue of the tissue site 5. The detector 112 can generate an electrical signal based on the detected light from the emitter(s) 110. The detector 112 can detect the light from the emitter(s) 110 after the light is attenuated by tissue, for example, between the detector(s) 112 and the emitter(s) 110. Such tissue can be located at a measurement site, such as a cephalic site. Additionally or alternatively, the measurement site can be a peripheral site. The detector(s) 112 can generate an electrical signal based on the detected light from the emitter(s) 110. The signals of the sensor 100 can be provided to the processor 82 (for example, via the sensor interface 81) for processing and determining measurements of physiological parameters.
The signals of the sensor 100 (such as the signal of the emitted light from the emitter(s) 110 and the signal of the detected light from the detector(s) 112) can be fed into the processor 82. The processor 82 can process raw or minimally processed data to generate one or multiple measurements or estimations of physiological parameters. The processor 82 can additionally or alternatively process an output of one detector independently of the output of another detector to produce two measurements of the physiological parameter respectively. For example, the processor 82 may determine an estimation of a physiological parameter for each detector signal such that the number of physiological parameter estimates corresponds to the number of detector(s) 112. As another example, the processor 82 may combine sensor data from at least two detector signals to determine an estimation of a physiological parameter.
The processor 82 can determine a final measurement of the physiological parameter based on one or more signals from one sensor 100 or one or more signals from multiple sensors 100. The final measurement can be an average, weighted average, linear combination, etc. of those measurements, or others. The signal processor can also compare the single measurement from the combined data with the measurements from the individual sensors to obtain additional information about the patient.
Although the monitoring device 80 of system 10 of
Any of the sensors discussed herein, such as sensor 200, 300, 400, 500, 600, 700, 800, and/or 900 can include any of the features described above with respect to sensor 100, and any of sensor 200, 300, 400, 500, 600, 700, 800, and/or 900 can be configured to interact with a monitoring device such as monitoring device 80 in a manner similar or identical as discussed above with respect to sensor 100 and monitoring device 80.
Any of the sensors discussed herein, such as sensor 100, 200, 300, 400, 500, 600, 700, 800, and/or 900 can be utilized in systems, sensor assemblies, and/or devices similar or identical to those discussed in U.S. Pat. Pub. No. 2020/0138288, the disclosure of which is incorporated by reference herein in its entirety.
Some of the figures of the present disclosure illustrate various emitters and/or detectors of sensors in dotted lines to better illustrate surrounding portions of the sensor or portions of a subject's body proximate the sensor. In various implementations of sensors described herein, the emitter(s) and/or detector(s) can be positioned on interior portions, exterior portions, and/or within (for example, within a thickness of) the sensor (for example, of a body portion of the sensor).
There are many sources of potential measurement error introduced to pulse oximetry systems. Some such sources of error include the pulse oximetry system's electronic components, including emitters and detectors, as well as chemical and structural physiological differences between subjects (e.g., patients). Another source of measurement error is the particular tissue geometry of a measurement site. For example, the particular tissue geometry can affect the scattering of photons as the photons pass through the subject's tissue (arterial blood) and arrive at the sensor's light detector. To improve the accuracy or reliability, a system can obtain multiple estimations of the physiological parameter and can use any of various arbitration techniques to select or to combine the estimations, or to determine a confidence parameter.
As described, the sensors described herein can include an emitter and a detector. The emitter can emit light into tissue of a patient and the detector can receive the light after it has been attenuated by the tissue. Beer's Law relates the attenuation of light to properties of a material. In particular, Beer's law states that absorbance of a material is proportional to the concentrations of the attenuating species in the material sample. The relationship between these parameters is expressed in Equation 1 below:
A=ε*b*c (Equation 1)
where A is the absorbance of the material at a given wavelength of light, ε is the molar absorptivity or extinction coefficient (L mol−1 cm−1), unique to each molecule and varying with wavelength, b is the length of the light path through the material (cm) (generally referred to as path length), and c is the concentration of an analyte of interest (mol L−1).
In general, the path length corresponding to a particular emitter/detector pair varies based on the geometry of the tissue that is illuminated, as well as the distance between or orientation of the emitter and detector. Consequently, different emitter/detector pairs typically obtain measurements associated with different path length. Similarly, the path length associated with an emitter/detector pair will likely change if the position of the emitter or detector is changed relative to the tissue site. In some cases, arranging or configuring the sensor to obtain measurements that relate to different path lengths and/or different tissue geometries can reduce the likelihood of a measurement error across all measurements, thereby improving the accuracy, reliability, or robustness of the sensor.
Systems, methods, and devices disclosed herein can improve the accuracy, reliability, and/or robustness of physiological parameter estimations by measuring light of diverse path lengths. For example, a system can include multiple sensors that are placed at different measurement sites, such as on different fingers or different portions of the same finger. Some implementations of monitoring systems disclosed herein can simultaneously or concurrently receive measurements from multiple measurement sites. As another example, a particular sensor may include multiple emitters and/or multiple detectors, which can be utilized to obtain measurements corresponding to different path lengths. As another example, a particular sensor or component thereof may be configured to move to alternate positions to vary the path length associated with its measurements.
In some implementations, a sensor can include an emitter and a plurality of detectors and the sensor can output signals corresponding to varying path lengths of light detected by each of the detectors. The path length between each of the detectors and the emitter can be different depending on the arrangement of the detectors in the sensor, and such differential path length can result in variable output signals from each of the detected based on detected light. The sensor, and/or a monitoring device connected to the sensor, can use the signals generated by the detectors to determine estimations of a physiological parameter. In this way, at least some of the different estimations of a physiological parameter can correspond to different path lengths, which can improve the accuracy, reliability, and/or robustness of a physiological parameter determination. For example, using any of various arbitration techniques, the sensor, and/or a monitoring device connected to the sensor, can select or combine the estimations or can determine a confidence parameter associated with an estimation. Furthermore, systems, methods, or devices disclosed herein can utilize particular distances, angles, or spatial configurations between a set of detectors and/or between an emitter and a particular detector to further improve an accuracy, reliability, and/or robustness of physiological parameter determinations.
With reference to
The spacing between or the arrangement of the detectors 212a, 212b, 212c and/or the emitter 210 can vary across implementations of the sensor 200. In some cases, the detectors 212a, 212b, 212c and/or the emitter 210 can be positioned or spaced (e.g., circumferentially) to maximize a difference between the tissues sampled by each of the detectors 212a, 212b, 212c. In some cases, the detectors 212a, 212b, 212c can be equally spaced at least partially around the tissue site when the sensor 200 is in use, for example, when the body portion 201 is secured to a finger. For example, the detectors 212a, 212b, 212c can be equally spaced from each other and/or the emitter 210 when the sensor 200 is in use. In some cases, the detectors 212a, 212b, 212c can be unequally spaced about the tissue site when the sensor 200 is in use. For example, the arrangement or spatial distribution of emitter 210 and the detectors 212 can be random or arbitrary.
As mentioned above, the sensor 200 can include and operably position an emitter 210 and multiple detectors 212a, 212b, 212c around a tissue site (e.g., a fingertip). For example, the sensor 200 can include a body portion 201 that can arrange the emitter 210 and the detectors 212a, 212b, 212c circumferentially around a perimeter of a cross-section through the fingertip and/or through the body portion 201 when the sensor 200 is in use. The relative positions and/or arrangement of the emitter 210 and detectors 212a, 212b, 212c can be described with respect to an axis extending through the body portion 201 or a portion thereof when the body portion 201 is secured to a portion of the subject's body (e.g., a finger) and/or when the body portion 201 is not secured to a portion of the subject's body. Additionally or alternatively, the relative positions and/or arrangement of the emitter 210 and detectors 212a, 212b, 212c can be described with respect to a longitudinal axis 30 (e.g., angular displacement with respect to rotation about a longitudinal axis 30) of the tissue site (e.g., a fingertip). In the figures, axis 30 is also referenced as a “Z” axis and shown along with mutually orthogonal “X” and “Y” axes (also labeled 34 and 32 respectively). For instance, in the example of
Although the emitter 210 and detectors 212a, 212b, 212c are illustrated as being spaced (circumferentially) approximately 90 degrees from each other relative to the longitudinal axis 30 (e.g., as shown in
In some implementations, detectors 212a, 212c that are positioned at similar angle magnitudes (e.g., 90 degrees) relative to the emitter 210 (circumferentially) about longitudinal axis 30 can capture similar tissue geometry. For instance, detectors 212a, 212c on either side of (e.g., right and left side) the subject's fingertip 7 can capture similar tissue geometry. In some cases, such detectors 212a, 212c positioned at similar angle magnitudes relative to the emitter 210 on either side that capture similar geometry may be used to determine a single physiological parameter.
In some implementations, sensor 200 includes and/or is configured to connect to a cable 203. Cable 203 can facilitate communication between sensor 200 and a separate device, such as a monitoring device similar or identical to monitoring device 80 discussed above. However, in some implementations, sensor 200 does not include a cable, for example, where sensor 200 is configured to wirelessly communicate with separate devices.
As discussed above, sensor 200 can be configured to secure to a finger of a subject and/or another portion of the subject's body. As also discussed above, sensor 200 can include a body portion 201 that can secure the sensor 200 at least partially to a portion of the subject's body and that can operably position emitter 210 and detectors 212a, 212b, 212c. In some implementations, body portion 201 is a sleeve that can slide and/or be otherwise positioned over a portion of the subject's body (e.g., a finger). In some implementations, body portion 201 is configured to be wrapped around a portion of the subject's body. For example, in some implementations, sensor 200 is a tape sensor. As another example, in some implementations, portions of the body portion 201 are configured to wrap around a subject's finger and secure to other portions of the body portion 201.
To secure the sensor 200 to a subject's finger, the finger can be positioned over the first portion 201a, the second portion 201b can be wrapped around a tip of the finger, and portions of the first and second portions 201a, 201b can be secured to one another, for example, via adhesive securement and/or mechanical securement (for example, via hook and loop fastener type engagement). In such manner, body portion 201 can be transitioned from a first configuration where it is flat and/or not secured to the finger (see
It is to be understood that sensor 200 can be secured to a finger in a variety of ways. For example, body portion 201 can be secured to a finger such that the emitter 210 is positioned at a top side or a bottom side of the finger and detector 212b is positioned at a top side or a bottom side of the finger. In some cases, the sensor 200 (for example, body portion 201) can be sized and/or shaped such that, when positioned over a fingertip, sensor 200 (for example, body portion 201) does not cover the subject's knuckles.
In this example, the detectors 312a, 312b, 312c are operably positioned by a body portion 301 of the sensor 300 to be generally aligned with respect to each other along a bottom side of the subject's fingertip 7 and each are circumferentially offset approximately 180 degrees from the emitter 310 with respect to the longitudinal axis 30 when the sensor 300 is in use (and/or with respect to an axis extending through at least a portion of body portion 301). The detectors 312a, 312b, 312c can be spaced apart from one another along a length of body portion 301 of the sensor 300, for example, as shown in
Sensor 300 can include a body portion 301 that can be similar or identical to body portion 201 of sensor 200. In some implementations, body portion 301 is a sleeve that can slide and/or be otherwise positioned over a portion of the subject's body (e.g., a finger). In some implementations, body portion 301 is configured to be wrapped around a portion of the subject's body. For example, in some implementations, sensor 300 is a tape sensor. As another example, in some implementations, portions of the body portion 301 are configured to wrap around a subject's finger and secure to other portions of the body portion 301.
To secure the sensor 300 to a subject's finger, the finger can be positioned over the first portion 301a, the second portion 301b can be wrapped around a tip of the finger, and portions of the first and second portions 301a, 301b can be secured to one another, for example, via adhesive securement and/or mechanical securement (for example, via hook and loop fastener type engagement). In such manner, body portion 301 can be transitioned from a first configuration where it is flat and/or not secured to the finger (see
It is to be understood that sensor 300 can be secured to a finger in a variety of ways. For example, body portion 301 can be secured to a finger such that the emitter 310 is positioned at a top side or a bottom side of the finger and detectors 312a, 312b, 312c are positioned at a top side or a bottom side of the finger. In some cases, the sensor 300 (for example, body portion 301) can be sized and/or shaped such that, when positioned over a fingertip, sensor 300 (for example, body portion 301) does not cover the subject's knuckles.
Although
With reference to
With reference to
As can be understood based on the location and arrangement of the emitters 410a, 410b, 510a, 510b and detectors 412a, 412b, 412c, 512a, 512b, 512c in sensors 400, 500, either of sensors 400, 500 can be configured to facilitate either or both of transmittance and reflectance type pulse oximetry. For example, emitter 410a and detector 412a of sensor 400 can be positioned on a same side of a finger and can be operated in a reflectance mode where at least a portion of the light emitted by emitter 410a is detected by detector 412a after reflecting from at least a portion of the subject's tissue. Further, emitter 410b and detector 412a can be positioned on opposite sides of the finger (for example, top and bottom sides of the finger) and can be operated in a transmittance mode where at least a portion of the light emitted by emitter 410b is detected by detector 412a after being transmitted through at least a portion of the subject's tissue. Sensor 400 can be configured to operate in such transmittance and reflectance modes concurrently or non-concurrently. Emitters 510a, 510b and detector 512a can operate in a similar or identical manner as described above with respect to sensor 400.
It is to be understood that sensors 400, 500 can be secured to a finger in a variety of ways. For example, body portion 401 can be secured to a finger such that the emitter 410a and detector 412a are positioned at a top side or a bottom side of the finger and emitter 410b is positioned at a top side or a bottom side of the finger. As another example, body portion 501 can be secured to a finger such that the emitter 510a and detector 512a are positioned at a top side or a bottom side of the finger and emitter 510b is positioned at a top side or a bottom side of the finger. Although not illustrated in
As described with respect to sensors 200, 300 of
Although illustrated in a conventional elongated surface with opposing wings style/shape, an artisan will recognize from the disclosure herein that the sensors 400, 500 shown in
With continued reference to
During use, the L-shaped sensor 600 can be wrapped around a subject's anatomy, such as a foot, a hand, a finger, an ear or a toe, among other locations. In an example in which the subject's anatomy is a finger, the L-shaped sensor 600 can be wrapped such that the emitter 610 is positioned on a nail-bed of the finger, a first detector 612a is positioned on the bottom of the fingertip opposite the emitter 610 relative to the fingertip, a second detector 612b is positioned on the bottom of the fingertip and spaced from the first detector 612a, a third detector 612c is positioned on a side of the fingertip and circumferentially offset approximately 90 degrees from the emitter 610 with respect to a longitudinal axis of the finger, and a fourth detector 612d is positioned on a side of the fingertip opposite the third detector 612c relative to the finger and circumferentially offset approximately 90 degrees from the emitter 610 with respect to a longitudinal axis of the finger.
After a portion of the subject's anatomy (e.g., finger) has been positioned relative to the emitter 610 and detectors 612a, 612b, 612c, 612d, the second sensor tape 602 can be wrapped around the finger or a portion thereof. When wrapped around the finger, the second sensor tape 604 may extend from the sensor end 606 to the free end 608 and can be secured to nearby skin and/or to sensor tape 602. For example, when wrapped around the finger, a first portion of the length of an adhesive side of the second sensor tape 602 can directly contact the subject's skin and a second portion of the length of the adhesive side of the sensor tape 602 can substantially contact the non-adhesive side of the sensor tape 602. The sensor tape advantageously reduces motion-induced electrical noise by positioning and securing the emitter 610 and the detectors 612a, 612b, 612c, 612d to the subject's skin, thereby minimizing movements of the sensor 600 relative to the subject due to subject's movement.
The spacing between and/or the arrangement of the detectors 612a, 612b, 612c, 612d and/or the emitter 610 can vary across embodiments of the sensor 600. In some cases, the detectors 612a, 612b, 612c, 612d and/or the emitter 610 can be positioned or spaced to maximize a difference between the tissues sampled by each of the detectors 612a, 612b, 612c, 612d when the sensor 600 is in use. In some cases, the detectors 612a, 612b, 612c, 612d can be equally circumferentially spaced at least partially around the tissue site when the sensor 600 is in use. For example, the detectors 612a, 612b, 612c, 612d can be equally circumferentially spaced from each other and/or the emitter 610 when the sensor 600 is in use. In some cases, the detectors 612a, 612b, 612c, 612d can be unequally circumferentially spaced about the tissue site when the sensor 600 is in use. For example, the arrangement or spatial distribution of emitter 610 and the detectors 612a, 612b, 612c, 612d can be random or arbitrary. In some cases, the distances between the detectors 612a, 612b, 612c, 612d can change based on a size of the measurement site.
Similar to the multi-detector arrangements described herein, a sensor that includes multiple emitters can output signals corresponding to varying path lengths, which can improve the accuracy, reliability, and/or robustness of physiological parameter determination.
Sensor 700 can include a body portion 701 that can secure to and/or around a tissue site and can include and/or operably position the emitters 710a, 710b and detectors 712a, 712b. Body portion 701 can be similar or identical to any of body portions 201, 301, 401, or 501 discussed above. Sensor 700 can include and/or be configured to connect to a cable that can be similar or identical to cables 203, 303 of sensors 200, 300.
The spacing between and/or the arrangement of the detectors 712a, 712b, emitter 710a, and/or emitter 710b can vary across embodiments. For example, the emitters 710a, 710b and/or detectors 712a, 712b can be positioned or spaced to maximize a difference between the tissues sampled by each of the detectors 712a, 712b when the sensor 700 is in use. In some cases, the emitters 710a, 710b and detectors 712a, 712b can be equally circumferentially spaced at least partially around the tissue site when the sensor 600 is in use. Alternatively, in some cases, the emitters 710a, 710b and detectors 712a, 712b can be unequally circumferentially spaced about the tissue site when the sensor 600 is in use. For example, the arrangement or spatial distribution of the emitters 710a, 710b and detectors 712a, 712b can be random or arbitrary.
The relative position or arrangement of the emitters 710a, 710b and detectors 712a, 712b can be described with respect to a longitudinal axis 30 of the tissue site (e.g., angular displacement with respect to rotation about a longitudinal axis 30). For instance, with reference to
Although the emitters 710a, 710b and detectors 712a, 712b are illustrated as being circumferentially spaced approximately 90 degrees from each other relative to the longitudinal axis 30 in
To facilitate variations in path lengths associated with transmitted and/or reflected light in tissue of the subject detected by detectors 712a, 712b, emitters 710a, 710b can be modulated and/or selectively activated so that only one of emitter 710a or emitter 710b is emitting light at a given time. In this way, the sensor 700 can generate several light paths and associated measurements, such as a first light path from emitter 710a to detector 712a, a second light path from emitter 710a to detector 712b, a third light path from emitter 710b to detector 712a, and/or a fourth light path from emitter 710b to detector 712b. In some implementations, emitter 710a can be activated for a first quarter cycle and off for the remaining three-quarters cycle and emitter 710b can be activated for a third quarter cycle and off for the remaining three-quarters cycle. In this way, the emitters 710a, 710b can be cycled on and off alternately, in sequence, with each only active for a quarter cycle and with a quarter cycle separating the active times. In some cases, additional measurements can be generated by activating both of emitters 710a, 710b for a period of time. Alternative activation sequences for the emitters 710a, 710b may be used in some cases, which can provide a time multiplexed signal from the detector 712a and/or 712b allowing separation of emitter signals.
The detectors 712a, 712b can generate one or more electrical signals corresponding to detected light after attenuation through tissue. In cases where emitters 710a, 710b are each activated for a period of time, the detectors 712a, 712b can be utilized to form a time-division-multiplexed (TDM) signal. This TDM signal can be coupled to a monitoring device. In some implementations, emitter 710a is configured to emit red light and emitter 710b is configured to emit infrared light, and the sensor 700 can be configured to facilitate obtaining a time multiplexed signal from the detectors 712a, 712b allowing separation of red and infrared signals and determination and removal of ambient light levels in downstream signal processing.
Sensor 700 can include a body portion 701 that can be similar or identical to body portion 201, 301, 401, 501 of sensor 200, 300, 400, 500, respectively. In some implementations, body portion 701 is a sleeve that can slide and/or be otherwise positioned over a portion of the subject's body (e.g., a finger). In some implementations, body portion 701 is configured to be wrapped around a portion of the subject's body. For example, in some implementations, sensor 700 is a tape sensor (such as shown in
To secure the sensor 700 to a subject's finger, the finger can be positioned over the first portion 701a, the second portion 701b can be wrapped around a tip of the finger, and portions of the first and second portions 701a, 701b can be secured to one another, for example, via adhesive securement and/or mechanical securement (for example, via hook and loop fastener type engagement). In such manner, body portion 701 can be transitioned from a first configuration where it is flat and/or not secured to the finger (see
It is to be understood that sensor 700 can be secured to a finger in a variety of ways. For example, body portion 701 can be secured to a finger such that the emitter 710a and detector 712b are positioned at a top side or a bottom side of the finger and detector 712a and emitter 710b are positioned at right or left sides of the finger. In some cases, the sensor 700 (for example, body portion 701) can be sized and/or shaped such that, when positioned over a fingertip, sensor 700 (for example, body portion 701) does not cover the subject's knuckles.
In some cases, an emitter or detector of a sensor, or the sensor itself, can be enabled for manual or automated movement to alternate positions, for example relative to a tissue site of a subject and/or relative to various components of the sensor. Similar to the multi-detector or multi-emitter arrangements described herein, such a sensor can be configured to output multiple signals corresponding to varying path lengths. For example, the sensor can be utilized for a first measurement at a first location and can be utilized for a second measurement at a second location.
In some cases, the entire sensor 800 is configured to be moveable. In some cases, only a portion of the sensor 800 is configured to be moveable. For example, in some cases, an emitter 810 is movable, while a detector 812 is not. As another example, a detector 812 can be movable while an emitter 810 is not.
The sensor 800, or portions thereof, can be manually moved, for example by a user. In some such cases, the sensor 800 can include a position changer 809, such as a wheel, knob, button, switch, slider, rail, etc. For example, a user could place the sensor 800 at a first position (for example, position A) and then move it to a second position (for example, position B) by interacting with the position changer 809. In some cases, a display or other indication can prompt the user to cause the sensor 800 to move to the second position and/or can display readings after measurements are complete.
Additionally or alternatively, the sensor 800, or portions thereof, may be configured to be moved by an automated or motorized arrangement. For example, a position changer 809 can be configured to interact with and move the sensor 800, automatically, as desired or required. The position changer 809 can vary across embodiments. For example, the position changer 809 can include, but is not limited to, a motor, actuator, micro-motor, or solenoid actuator arrangement. In some such cases, motion control can be software programmed. The number of positions of sensor 800 can vary across embodiments and can be fixed or variable. For example, in some cases, the sensor 800 can be configured to move within a limited range of motion between alternate positions. Similar to any of the other sensors described herein, the sensor 800 can output signals corresponding to varying path lengths. For example, the sensor 800 may be configured to obtain a measurement at each of a plurality of positions of the sensor 800, thereby obtaining measurements at different tissue geometries. In some implementations, sensor 800 includes a body portion and/or cable, each of which can be similar or identical to any of the body portions and/or cables discussed elsewhere herein.
The emitters 910a, 910b and detectors 912a, 912b are shown in dotted lines in
To secure the sensor 900 to a subject's finger, the finger can be positioned over the first portion 901a, the second portion 901b can be wrapped around a tip of the finger, and portions of the first and second portions 901a, 901b can be secured to one another, for example, via adhesive securement and/or mechanical securement (for example, via hook and loop fastener type engagement). In such manner, body portion 901 can be transitioned from a first configuration where it is flat and/or not secured to the finger (see
It is to be understood that sensor 900 can be secured to a finger in a variety of ways. For example, body portion 901 can be secured to a finger such that the emitter 910a is positioned at a top side or a bottom side of the finger and emitter 910b and detectors 912a, 912b are positioned at a top side or a bottom side of the finger. In some cases, the sensor 900 (for example, body portion 901) can be sized and/or shaped such that, when positioned over a fingertip, sensor 900 (for example, body portion 901) does not cover the subject's knuckles.
In some implementations, as illustrated in
In some implementations, the emitters 910a, 910b may emit light in an alternating fashion such that the detectors 912a, 912b can detect the transmitted light and the reflected light. For example, when the emitter 910a emits light, the detectors 912a, 912b can detect light transmitted from the emitter 910a to the detectors 912a, 912b through tissue of the finger. When the emitter 910b emits light (for example, while the emitter 910a is turned off), the detectors 912a, 912b can detect light emitted by the emitter 910b and reflected by the tissue. In some implementations, one or more signals generated by the detectors 912a, 912b during a transmittance mode (for example, where only emitter 910a is active) are analyzed separately from one or more signals generated by the detectors 912a, 912b during a reflectance mode (for example, where only emitter 910b is active). In some implementations, for example, where the sensor 900 is configured to operate in transmittance and reflectance modes concurrently, signals generated by the detectors 912a, 912b that are based on light emitted from both of emitters 910a, 910b are analyzed together and/or are compared.
Utilizing both transmittance and reflectance pulse oximetry modes during operation (whether concurrently or non-concurrently) via multiple detectors and/or multiple emitters can advantageously allow the sensor 900 to generate signals that correspond to different path lengths and/or different tissue geometries. In some implementations, physiological measurements (for example, blood oxygen saturation) of a patient can be obtained using, for example, transmittance and reflectance operational modes. Accordingly, using both transmittance and reflectance can improve the accuracy, reliability, and/or robustness of a physiological sensor by reducing the likelihood of a measurement error (for example, compared to measurements made using just transmittance or just reflectance). Additionally, use of reflectance can increase the number of areas where a sensor may be placed on a subject.
Any of the sensors or portions thereof described herein can be integrated into an apparatus that can be worn by a subject. Such apparatus, which can be wearable by the subject, can be a sleeve (for example, fingertip sleeve, arm sleeve, wrist sleeve, leg sleeve, toe sleeve, and the like), a finger clip, an ear clip, an ear insert, a toe clip, a glove, a ring, a bracelet, a watch, an arm band, a sock, an ankle band, a wrap, or another apparatus that can be worn or attached to a subject.
Any of the sensors 200, 300, 400, 500, 600, 700, 800, and/or 900 can be configured to interact with a separate device (such as monitoring device 80) in a similar or identical manner as that described above with respect to sensor 100. Additionally, any of sensors 200, 300, 400, 500, 600, 700, 800, and/or 900 can include features of monitoring device 80 similar to that described with reference to sensor 100. For example, any of sensors 200, 300, 400, 500, 600, 700, 800, and/or 900 can be configured to determine one or more physiological parameters (for example, via a processor thereof) and/or to communicate (for example, wirelessly) with separate devices.
In various ones of the figures, emitter(s) and/or detector(s) may be represented by various shapes having various sizes. Such shapes and/or sizes are not intended to be limiting, however, and the relative sizes and/or shapes of any of the emitters and/or detectors shown in the figures are not intended to be limiting.
The term “and/or” herein has its broadest least limiting meaning which is the disclosure includes A alone, B alone, both A and B together, or A or B alternatively, but does not require both A and B or require one of A or one of B. As used herein, the phrase “at least one of” A, B, “and” C should be construed to mean a logical A or B or C, using a non-exclusive logical or.
The following description is merely illustrative in nature and is in no way intended to limit the disclosure, its application, or uses. For purposes of clarity, the same reference numbers will be used in the drawings to identify similar elements. It should be understood that steps within a method may be executed in different order without altering the principles of the present disclosure.
Features, materials, characteristics, or groups described in conjunction with a particular aspect, embodiment, or example are to be understood to be applicable to any other aspect, embodiment or example described herein unless incompatible therewith. All of the features disclosed in this specification (including any accompanying claims, abstract and drawings), or all of the steps of any method or process so disclosed, may be combined in any combination, except combinations where at least some of such features or steps are mutually exclusive. The protection is not restricted to the details of any foregoing embodiments. The protection extends to any novel one, or any novel combination, of the features disclosed in this specification (including any accompanying claims, abstract and drawings), or to any novel one, or any novel combination, of the steps of any method or process so disclosed.
While certain embodiments have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of protection. Indeed, the novel methods and systems described herein may be embodied in a variety of other forms. Furthermore, various omissions, substitutions and changes in the form of the methods and systems described herein may be made. Those skilled in the art will appreciate that in some embodiments, the actual steps taken in the processes illustrated or disclosed may differ from those shown in the figures. Depending on the embodiment, certain of the steps described above may be removed, others may be added. For example, the actual steps or order of steps taken in the disclosed processes may differ from those shown in the figures. Depending on the embodiment, certain of the steps described above may be removed, others may be added. For instance, the various components illustrated in the figures may be implemented as software or firmware on a processor, controller, ASIC, FPGA, or dedicated hardware. Hardware components, such as processors, ASICs, FPGAs, and the like, can include logic circuitry. Furthermore, the features and attributes of the specific embodiments disclosed above may be combined in different ways to form additional embodiments, all of which fall within the scope of the present disclosure.
User interface screens illustrated and described herein can include additional or alternative components. These components can include menus, lists, buttons, text boxes, labels, radio buttons, scroll bars, sliders, checkboxes, combo boxes, status bars, dialog boxes, windows, and the like. User interface screens can include additional or alternative information. Components can be arranged, grouped, displayed in any suitable order.
Although the present disclosure includes certain embodiments, examples and applications, it will be understood by those skilled in the art that the present disclosure extends beyond the specifically disclosed embodiments to other alternative embodiments or uses and obvious modifications and equivalents thereof, including embodiments which do not provide all of the features and advantages set forth herein. Accordingly, the scope of the present disclosure is not intended to be limited by the specific disclosures of preferred embodiments herein, and may be defined by claims as presented herein or as presented in the future.
Conditional language, such as “can,” “could,” “might,” or “may,” unless specifically stated otherwise, or otherwise understood within the context as used, is generally intended to convey that certain embodiments include, while other embodiments do not include, certain features, elements, or steps. Thus, such conditional language is not generally intended to imply that features, elements, or steps are in any way required for one or more embodiments or that one or more embodiments necessarily include logic for deciding, with or without user input or prompting, whether these features, elements, or steps are included or are to be performed in any particular embodiment. The terms “comprising,” “including,” “having,” and the like are synonymous and are used inclusively, in an open-ended fashion, and do not exclude additional elements, features, acts, operations, and so forth. Also, the term “or” is used in its inclusive sense (and not in its exclusive sense) so that when used, for example, to connect a list of elements, the term “or” means one, some, or all of the elements in the list. Further, the term “each,” as used herein, in addition to having its ordinary meaning, can mean any subset of a set of elements to which the term “each” is applied.
Conjunctive language such as the phrase “at least one of X, Y, and Z,” unless specifically stated otherwise, is otherwise understood with the context as used in general to convey that an item, term, etc. may be either X, Y, or Z. Thus, such conjunctive language is not generally intended to imply that certain embodiments require the presence of at least one of X, at least one of Y, and at least one of Z.
Language of degree used herein, such as the terms “approximately,” “about,” “generally,” and “substantially” as used herein represent a value, amount, or characteristic close to the stated value, amount, or characteristic that still performs a desired function or achieves a desired result. For example, the terms “approximately”, “about”, “generally,” and “substantially” may refer to an amount that is within less than 10% of, within less than 5% of, within less than 1% of, within less than 0.1% of, and within less than 0.01% of the stated amount. As another example, in certain embodiments, the terms “generally parallel” and “substantially parallel” refer to a value, amount, or characteristic that departs from exactly parallel by less than or equal to 15 degrees, 10 degrees, 5 degrees, 3 degrees, 1 degree, or 0.1 degree.
The scope of the present disclosure is not intended to be limited by the specific disclosures of preferred embodiments in this section or elsewhere in this specification, and may be defined by claims as presented in this section or elsewhere in this specification or as presented in the future. The language of the claims is to be interpreted broadly based on the language employed in the claims and not limited to the examples described in the present specification or during the prosecution of the application, which examples are to be construed as non-exclusive.
This application claims the benefit of priority under 35 U.S.C. § 119(e) to U.S. Patent Application No. 63/135,933, entitled “OPTICAL SENSOR WITH MULTIPLE DETECTORS OR MULTIPLE EMITTERS,” filed Jan. 11, 2021 and U.S. Patent Application No. 63/060,868, entitled “OPTICAL SENSOR WITH MULTIPLE DETECTORS OR MULTIPLE EMITTERS,” filed Aug. 4, 2020. All of the above-mentioned applications are incorporated by reference herein in their entireties. Any and all applications for which a foreign or domestic priority claim is identified in the Application Data Sheet as filed with the present application are hereby incorporated by reference under 37 CFR 1.57.
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| Entry |
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| US 2024/0016391 A1, 01/2024, Lapotko et al. (withdrawn) |
| Number | Date | Country | |
|---|---|---|---|
| 20220039707 A1 | Feb 2022 | US |
| Number | Date | Country | |
|---|---|---|---|
| 63135933 | Jan 2021 | US | |
| 63060868 | Aug 2020 | US |
