Claims
- 1. A compound which is 3-methyl-5-[3-(4,4-diphenylpiperid-1-yl)-propyl](+)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate or a salt thereof.
- 2. The compound of claim 1 which is (+)-1,4-dihydro-2,6-dimethyl-4,(3-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-methyl-5-[3-(4,4-diphenylpiperid-1-yl)-propyl] ester-hydrochloride.
- 3. A medicament composition containing from 0.1 to 95 per cent by weight of a pharmacologically-acceptable compound of claim 1 suitable excipient.
- 4. A compound according to claim 1 which is pharmacologically acceptable.
- 5. A pharmacologically-acceptable salt of claim 4.
- 6. A process for the treatment of hypertension, of coronary cardiac diseases, of peripheral and cerebral circulatory disturbances and of diseases due to an increased retention of water or sodium, which comprises administering an effective amount of compound of claim 4 to a patient afflicted with at least one such condition.
- 7. A process for the prophylaxis of hypertension, of coronary cardiac diseases, of peripheral and cerebral circulatory disturbances and of diseases due to an increased retention of water or sodium, which comprises administering an effective amount of compound of claim 4 to a patient subject to at least one such condition.
Priority Claims (3)
Number |
Date |
Country |
Kind |
04653/84 |
Sep 1984 |
CHX |
|
04652/84 |
Sep 1984 |
CHX |
|
01263/86 |
Mar 1986 |
CHX |
|
RELATED APPLICATION
This application is a continuation-in-part of application Ser. No. 781,808, (now USP 4,707,486) filed Sept. 30, 1985. The entire disclosure of that parent application is incorporated herein by reference.
US Referenced Citations (12)
Foreign Referenced Citations (5)
Number |
Date |
Country |
117416 |
Sep 1984 |
EPX |
1950394 |
Apr 1970 |
DEX |
1668029 |
Jul 1971 |
DEX |
2003112 |
Jul 1971 |
DEX |
8402132 |
Jun 1984 |
WOX |
Non-Patent Literature Citations (3)
Entry |
Shibanuma et al., Chem. Pharm. Bull., 28(9), 2809-2812 (1980). |
Poindexter et al., CA 106: 32841y. |
Jaunin et al., CA, 105: 60534y. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
781808 |
Sep 1985 |
|