Claims
- 1. A compound of the formula (I): ##STR246## wherein A is a moiety selected from ##STR247## wherein (R) shows that the carbon atom has R-configuration; and (S) shows that the carbon atom has S-configuration, or a physiological acceptable salt thereof.
- 2. The compound of claim 1 which is (2R,3S)-2-(2-fluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-yl-methyl)oxirane, or its salt.
- 3. The compound of claim 1 which is (2R,3S)-2-(4-fluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-methyl)-oxirane, or its physiologically acceptable salt.
- 4. A process for preparing a compound of the formula (I'): ##STR248## or its physiologically acceptable salt, wherein (R) and (S) refer to a carbon having R-configuration and S-configuration respectively, which comprises
- (A) reacting a compound of the formula (IV): ##STR249## or its physiologically acceptable salt, wherein (R) is as defined above, with methanesulfonyl chloride in the presence of triethyl-amine to give a compound of the formula (I"): ##STR250## or its physiologically acceptable salt, wherein (R) is as defined above, (B) then reacting a compound of the formula (I") obtained as above with sodium methylate to give a compound of the formula (I'), or its physiologically acceptable salt.
Priority Claims (3)
Number |
Date |
Country |
Kind |
3-309069 |
Nov 1991 |
JPX |
|
4-019888 |
Feb 1992 |
JPX |
|
4-145510 |
Jun 1992 |
JPX |
|
Parent Case Info
This application is a divisional of Ser. No. 07/981,850 filed Nov. 24, 1992 now U.S. Pat. No. 5,371,100.
US Referenced Citations (8)
Foreign Referenced Citations (8)
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Oct 1984 |
EPX |
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EPX |
0131845 |
Jan 1985 |
EPX |
174769 |
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0195557 |
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421210 |
Apr 1991 |
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GBX |
Divisions (1)
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Number |
Date |
Country |
Parent |
981850 |
Nov 1992 |
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