Claims
- 1. A process for preparing an optically active alcohol compound represented by the formula: ##STR50## wherein X represents --COO--, --OCO--, --CH.sub.2 O-- or --OCH.sub.2 --; A represents an alkyl or alkoxyl group having 1 to 20 carbon atoms; l and m each represents a number of 1 or 2, and * indicates asymmetric carbon atom,
- which comprises asymmetrically hydrolyzing by using an esterase having the ability to hydrolyze only one of the enantiomers of a dl-ester represented by the formula: ##STR51## wherein A, X, l and m are as defined above, and R' represents a lower alkyl group.
- 2. The process according to claim 1, wherein the esterase is the one derived from a microorganism.
- 3. The process according to claim 2, wherein the microorganism is the one belonging to the genus Pseudomonas or Arthrobacter.
- 4. The process according to claim 1, wherein the asymmetric hydrolysis is carried out in a buffer solution.
- 5. The process according to claim 4, wherein the buffer solution is of a concentration of 0.05 to 2 mol/l.
- 6. The process according to claim 1, wherein the asymmetric hydrolysis is carried out at a temperature of 10.degree. to 60.degree. C.
- 7. The process according to claim 4, wherein the asymmetric hydrolysis is carried out in the presence of an organic solvent.
- 8. The process according to claim 7, wherein the organic solvent is toluene, chloroform, methyl isobutyl ketone or dichloromethane.
- 9. The process according to claim 1 wherein X is --COO-- or --OCO--.
- 10. The process according to claim 2 wherein X is --COO-- or --OCO--.
- 11. The process according to claim 3 wherein X is --COO-- or --OCO--.
- 12. The process according to claim 4 wherein X is --COO-- or --OCO--.
- 13. The process according to claim 5 wherein X is --COO-- or --OCO--.
- 14. The process according to claim 6 wherein X is --COO-- or --OCO--.
- 15. The process according to claim 7 wherein X is --COO-- or --OCO--.
- 16. The process according to claim 8 wherein X is --COO-- or --OCO--.
Priority Claims (3)
Number |
Date |
Country |
Kind |
62-69485 |
Mar 1987 |
JPX |
|
62-132600 |
May 1987 |
JPX |
|
62-170030 |
Jul 1987 |
JPX |
|
Parent Case Info
This is a division of application Ser. No. 08/136,827, filed Oct. 18, 1993, now U.S. Pat. No. 5,338,484 which in turn is a division of Ser. No. 07/986,871, filed Dec. 4, 1992 (now U.S. Pat. No. 5,274,168), which in turn is a continuation of Ser. No. 07/589,500, filed Nov. 9, 1990, (now abandoned), which in turn is a division of Ser. No. 07/170,409, filed Mar. 18, 1988 (now U.S. Pat. No. 5,002,693).
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Entry |
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Divisions (3)
|
Number |
Date |
Country |
Parent |
136827 |
Oct 1993 |
|
Parent |
986871 |
Dec 1992 |
|
Parent |
170409 |
Mar 1988 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
589500 |
Nov 1990 |
|