Claims
- 1. A process for preparing an optically active tri-substituted methane compound having, as substituents, an aromatic ring group and a phenyl group having a hydroxyl group at the ortho- or para-position, which is characterized by allowing a phenol compound unsubstituted at the ortho- or/and para-position to react with an optically active secondary carbinol compound having an aromatic ring group at the .alpha.-position in the presence of tri-substituted phosphine and diazodicarboxylate or diazodicarboxamide.
- 2. A process as claimed in claim 1, in which said phenol compound is unsubstituted at the ortho-position and said optically active tri-substituted methane compound has, as one of its substituents, a phenyl group having hydroxyl group at the ortho-position.
- 3. A process as claimed in claim 1, in which said phenol compound is a compound represented by the formula ##STR19## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, respectively, stand for a hydrogen atom or a group which does not take part in the reaction, and adjacent two groups of them may be combined with each other to form a ring together with the carbon atom on the benzene ring to which they bond; said optically active secondary carbinol compound is a compound represented by the formula: ##STR20## wherein Q stands for an aromatic ring group, R stands for a group which does not take part in the reaction, C means an asymmetric carbon atom and said optically active tri-substituted methane compound is a compound represented by the formula: ##STR21## wherein each symbol is of the same meaning as defined above.
- 4. A process as claimed in claim 3, wherein at least two of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are groups other than hydrogen.
- 5. A process as claimed in claim 3, wherein each of R.sup.1 and R.sup.2 is a group other than hydrogen.
- 6. A process as claimed in claim 1, in which said tri-substituted phosphine is a compound represented by the formula R.sub.3.sup.6 P (wherein R.sup.6 stands for a C.sub.1 -C.sub.8 alkyl group or an optionally substituted phenyl group.
- 7. A process as claimed in claim 1, in which diazodicarboxylate and diazodicarboxamide are compounds represented by the formula, R.sup.7 --CO--N.dbd.N--CO--R.sup.8, wherein R.sup.7 and R.sup.8 independently stand for a lower alkoxy group, a di-lower alkylamino group or a cyclic amino group.
Priority Claims (2)
Number |
Date |
Country |
Kind |
4-177043 |
Jul 1992 |
JPX |
|
5-130296 |
Jun 1993 |
JPX |
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Parent Case Info
This application is a division of application Ser. No. 08/085,166, filed Jul. 2, 1992, (now U.S. Pat. No. 5,354,913).
US Referenced Citations (5)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0171251 |
Dec 1992 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Mitsunbu, Synthesis, 1981 pp. 1-28. |
Divisions (1)
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Number |
Date |
Country |
Parent |
85166 |
Jul 1993 |
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