In one aspect the disclosure relates to oral care compositions that make teeth whiter. In one aspect, the oral care compositions described herein comprise ascorbic acid derivatives as teeth whitening agents. In another aspect, the oral care compositions described herein are stable until use, reasonably priced, safe, easy to use, and do not require special apparatus or trained personnel to be applied.
Foods, tobacco, medication, drinks such as coffee, tea and red wine, stain teeth overtime. Whitening teeth can be achieved by using tooth whitening products. Oral care compositions and processes have been developed over the years to whiten teeth. Some of the most common oral care compositions for whitening teeth contain peroxide derivatives. Peroxide compounds can bleach teeth, remove stains and kill cariogenic bacteria. However, the lack of compound stability, the cost, the harshness to teeth and gums represents downsides of the available processes. Consumers are turning more and more towards “natural” ingredients within their oral care products. By “natural” ingredients it is to be understood as “naturally sourced” and “naturally derived” ingredients.
Therefore, there is a clear need for natural oral care compositions for teeth whitening, which are stable until use, reasonably priced, safe, easy to use, and which do not require special apparatus or trained personnel to be applied.
The present disclosure relates to oral care compositions for whitening teeth. The oral care compositions of the disclosure comprise reducing agents as teeth whitening agents. Traditional whitening agents are believed to act as oxidizing agents (accepting electrons) to bleach stains. Without being bound by theory, ascorbic acid and its derivatives are able to bleach stains by acting as reducing agents (losing electrons). In some aspects, the oral care compositions described herein comprise whitening agents in a buffered oral care composition providing protection from tooth erosion.
In one aspect, the oral care compositions of the disclosure do not comprise bleaching agents or whitening agents such as hydrogen peroxide or a hydrogen peroxide source, for example, urea peroxide, or metal chlorites or a peroxide salt or complex (for example, peroxyphosphate, peroxycarbonate, perborate, peroxysilicate), or persulfate salts (for example calcium peroxyphosphate, sodium perborate, sodium carbonate peroxide, sodium peroxyphosphate, and potassium persulfate), or a hydrogen peroxide polymer complex (for example, a peroxide-polyvinyl pyrrolidone polymer complex).
In one aspect, the oral care compositions of the disclosure comprise ascorbic acid derivatives as whitening agents. Ascorbic acid is a natural water-soluble vitamin, commonly known as vitamin C. Ascorbic acid exists as two enantiomers commonly denoted “I” (for “levo”) and “d” (for “dextro”). The “I” isomer is the one most often encountered. Ascorbic acid is also referred to as L (+)-ascorbic acid or 1-ascorbic acid.
In one aspect, the oral care composition of the disclosure comprises an ascorbic acid derivatives selected from the group consisting of: L-ascorbic acid, calcium ascorbate, calcium 1-ascorbate dihydrate, magnesium ascorbate, potassium ascorbate, magnesium L-ascorbyl phosphate (also referred to as: magnesium ascorbate phosphate or ascorbic acid phosphate magnesium salt), L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate, (+) sodium L-ascorbate, dehydro-1-(+)-ascorbic acid dimer, sodium ascorbyl phosphate (also referred to as: ascorbic acid phosphate sodium salt, sodium 1-ascorbyl phosphate, 2-phospho-L-ascorbic acid trisodium salt. L-ascorbic acid 2-phosphate trisodium salt or sodium L-ascorbyl-2-phosphate), ascorbic acid-2-glucoside, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl stearate, disodium ascorbyl sulfate, ascorbyl 6-palmitate and combinations thereof.
In one embodiment, the oral care composition of the disclosure is in the form selected from: a toothpaste, a dentifrice, a mouthwash, a mouth rinse, a topical oral gel and a denture cleanser. In another embodiment, the oral care composition of the disclosure is in the form selected from: dental strips, beads, ribbon toothpaste, varnish, dental floss, chewing gum, lozenges and toothpowder.
In yet a further aspect, the oral care compositions of the disclosure can comprise antiplaque agents, antigingivitis agents, antimalodor agents, antitartar agents, anticalculus agents, erosion prevention agents, and/or combinations thereof. Optionally, the oral care compositions of the disclosure may comprise abrasives, surfactants, viscosity and rheology modifiers, humectants, sweeteners, flavors, colorants, preservatives and/or combinations thereof. Optionally, the oral care composition of the disclosure comprises water. Optionally, the oral care compositions of the disclosure may comprise pigments, opacifiers, polymer complexes, surfactants, bicarbonate salts, pH modifying agents, foam modulators, thickening agents, antibacterial agents, anticariogenic agents, fluoride ion sources, stannous ion sources, zinc ion sources and/or combinations thereof.
In one aspect, the compositions of the disclosure contain a relatively high amount of sodium stearate. Without being bound by theory, the relatively high amounts of sodium stearate can help with the toothpaste discoloration that can take place with the presence of ascorbic acid derivatives (e.g., sodium ascorbyl phosphate or sodium and ascorbyl 6-palmitate).
In yet another aspect, the compositions of the disclosure, e.g., any of Composition 1.0 et seq., can be utilized in methods of removing surface enamel stains (e.g., not intrinsic stain removal). In one aspect, without being bound by theory, the phosphate salt on the ascorbic acid derivative can help lift the stain from the surface of the enamel while the fatty acid chain can help anchor the derivative to surface in order to perform this task.
It is to be understood that both the foregoing general description and the following detailed description of the disclosure, are exemplary and explanatory only and are not restrictive of the claimed disclosure.
As used herein, the use of the singular includes the plural unless specifically stated otherwise. As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. As used herein, the use of a compound comprising several isomers or stereoisomers, includes all the isomeric forms of that compound.
Unless stated otherwise, all percentages of the oral care composition components given in this specification are by weight based on a total oral care composition or formulation weight of 100%.
As used herein, an “oral care composition” refers to a composition for which the intended use includes oral care, oral hygiene, and/or oral appearance, or for which the intended method of use comprises administration to the oral cavity, and refers to compositions that are palatable and safe for topical administration to the oral cavity, and for providing a benefit to the teeth and/or oral cavity. The term “oral care composition” thus specifically excludes compositions which are highly toxic, unpalatable, or otherwise unsuitable for administration to the oral cavity. In some embodiments, an oral care composition is not intentionally swallowed, but is rather retained in the oral cavity for a time sufficient to affect the intended utility. The oral care compositions as disclosed herein may be used in nonhuman mammals such as companion animals (e.g., dogs and cats), as well as by humans. In some embodiments, the oral care compositions as disclosed herein are used by humans. Oral care compositions include, for example, dentifrice and mouthwash. In some embodiments, the disclosure provides mouthwash formulations.
As used herein, “orally acceptable” refers to a material that is safe and palatable at the relevant concentrations for use in an oral care formulation, such as a mouthwash or dentifrice.
As used herein, “orally acceptable carrier” refers to any vehicle useful in formulating the oral care compositions disclosed herein. The orally acceptable carrier is not harmful to a mammal in amounts disclosed herein when retained in the mouth, without swallowing, for a period sufficient to permit effective contact with a dental surface as required herein. In general, the orally acceptable carrier is not harmful even if unintentionally swallowed. Suitable orally acceptable carriers include, for example, one or more of the following: water, a thickener, a buffer, a humectant, a surfactant, an abrasive, a sweetener, a flavorant, a pigment, a dye, an anti-caries agent, an anti-bacterial, a whitening agent, a desensitizing agent, a vitamin, a preservative, an enzyme, and mixtures thereof.
The oral care composition is further defined as a product which, during the normal course of usage, is not for the purpose of systemic administration of particular therapeutic agents intentionally swallowed, but is rather retained in the oral cavity for a time sufficient to contact substantially all of the dental surfaces and/or oral tissues for the purposes of oral activity. Examples of such oral care compositions include, but are not limited to toothpaste, dentifrice, mouthwash, mouthrinse, topical oral gel, denture cleanser, dental strips, beads, varnish, dental floss, ribbon toothpaste, chewing gum, lozenges, toothpowder and the like.
As used herein, the term “toothpaste” refers to a paste, a gel, an emulsion, used on a toothbrush for cleaning the teeth. It is understood that a toothpaste for example will typically be diluted with water upon use, while a mouth rinse typically will not be.
As used herein, the term “dentifrice” refers to a paste, gel, or liquid formulations unless otherwise specified. The dentifrice composition may be in any desired form such as deep striped, surface striped, multi-layered, having the gel surrounding the paste, or any combination thereof. Alternatively, the oral care composition can be dual phase dispensed from a separated compartment dispenser.
As used herein, the terms “mouthwash” or “mouthrinse” refer to oral care compositions that are substantially liquid in character, such as a spray, or rinse. In such a preparation, the oral care composition typically has an aqueous phase comprising water or a water and alcohol mixture. Further, in various embodiments, the oral care composition includes a humectant and surfactant as described below. Generally, the weight ratio of water to alcohol is in the range of 1:1 to 20:1, preferably 3:1 to 10:1 and more preferably 4:1 to 6:1. The total amount of water and alcohol mixture in this type of preparation is typically in an amount from 70% by weight to 99.9% by weight of the preparation. In various embodiments, the alcohol is typically ethanol or isopropanol.
As used herein, the term “topical oral gel” refers to a mixture prepared and immediately transferred into a retaining tray, such as those used in holding whitening gels, and the person can wear the tray for an effective period of time. The teeth that are in contact with the mixture will be treated. For use with retaining trays, the mixture can be in the form of a low-viscosity liquid or a gel. In certain embodiments, the whitening agent of the disclosure is formulated in an oral care composition comprising crosslinked copolymer of polyacrylic acid (Carbopol® polymer), glycerin and water.
As used herein, the term “varnish” refers to a stock solution, or a mixture of stock solutions with water, applied to the teeth in a varnish formulation, e.g., wherein the gel can stay on the tooth for an extended period of time for effective treatment. When the oral care composition is in the form of a gel or a varnish, then the oral care composition of the present disclosure is a viscous liquid, preferably a gel, which maintains its consistency during storage enabling the product to be painted on the tooth surface with a soft applicator pen or brush. In certain embodiments, the whitening agent of the disclosure is formulated in an oral care composition comprising hydrophobic copolymers comprising at least one of octylacrylamide/acrylates/butylaminoethyl, methacrylate copolymer, VA/butyl maleate/isobornyl acrylate copolymer, acrylates/t-butylacrylamide copolymer, polyvinylpyrrolidone/vinyl acetate copolymer, triacontanyl polyvinylpyrrolidone copolymer, acrylates/dimethylaminoethyl methacrylate copolymer (sold under the name of Eudragit®), 2-propenoic acid 2-methyl-2-methylpropyl ester polymer with 2-propenoic acid and N-(1,1,3,3-tetramethylbutyl)-2-propenamide (sold under the name of DERMACRYL®), and/or combinations thereof.
As used herein, the term “denture cleanser” refers to a cleaner for dentures when they are out of the mouth. As used herein, the term “dental strips,” refers to disposable strips, which contain enamel safe whitening gel, placed directly to the teeth. As used herein, the term “tooth powder” refers to a powder for cleaning the teeth. As used herein, the term “ribbon toothpaste” refers to toothpaste dispensed in the form of a ribbon. As used herein, the term “active”, refers to compounds that, when applied to a target tissue, provide a benefit or improvement to the target tissue. The actives can be delivered in the form of any oral care formulations, for example toothpaste, transparent paste, gel, mouthwash, powder, cream, dental strip, spray, gum, or any other known in the art. The term “active” and “agent” are used interchangeably in this disclosure. As used herein, “tooth” or “teeth” refer to natural teeth, dentures, dental plates, fillings, caps, crowns, bridges, dental implants, and the like, and any other hard surfaced dental prosthesis either permanently or temporarily fixed within the oral cavity. As used herein, “whitening” refers to a change in visual appearance of a tooth, wherein the tooth has a brighter shade. As used herein, “applying” refers to any method by which the oral care composition of the disclosure is placed in contact with the tooth surface.
As used herein, one of skill in the art would appreciate that an “ascorbic acid salt” may be referred to by several names in the literature. As used herein, “ascorbic acid derivatives” of the disclosure comprise all the isomers, diastereomers and enantiomers of the cited compounds.
The disclosure provides for oral care compositions comprising whitening agents comprising ascorbic acid derivatives. Generally, ascorbic acid derivatives of the disclosure can any selected from the group consisting of: L-ascorbic acid, calcium ascorbate, calcium 1-ascorbate dihydrate, magnesium ascorbate, potassium ascorbate, magnesium L-ascorbyl phosphate L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate, (+) sodium L-ascorbate, dehydro-1-(+)-ascorbic acid dimer, sodium ascorbyl phosphate, ascorbic acid-2-glucoside, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl stearate, disodium ascorbyl sulfate, and ascorbyl 6-palmitate.
In one aspect, ascorbic acid derivatives of the disclosure are sodium ascorbyl phosphate and ascorbyl 6-palmitate. In another aspect, the content of ascorbic acid derivative in the oral care composition is from 0.5% by weight to 5% by weight of the total weight of the oral care composition. In some aspects, the content of the ascorbic acid derivative(s) in the oral care composition is about 0.5%, or about 0.75%, or about 1%, or about 1.25%, or about 1.5%, about 1.75%, or about 2%, or about 2.25%, or about 2.5%, or about 2.75%, or about 3%, or about 3.25%, or about 3.5%, or about 3.75%, or about 4%, or about 4.25%, or about 4.5%, or about 4.75%, or about 5% by weight of the total weight of the oral care composition.
In one embodiment, the disclosure provides an oral care composition for whitening teeth, wherein the composition comprises a whitening agent selected from sodium ascorbyl phosphate, ascorbyl 6-palmitate and combinations thereof. In one embodiment, the disclosure provides an oral care composition for whitening teeth, wherein the composition comprises a whitening agent which is sodium ascorbyl phosphate in an amount from 0.5% by weight to 5% by weight relative to the total oral care composition.
In one embodiment, the disclosure provides an oral care composition for whitening teeth, wherein the oral care composition comprises a whitening agent which is sodium ascorbyl phosphate, e.g., where sodium ascorbyl phosphate is in an amount from about 1.0% by weight to about 3.0% by weight relative to the total oral care composition. In one embodiment, the disclosure provides an oral care composition for whitening teeth, comprising a whitening agent which is sodium ascorbyl phosphate in an amount of about 1.5% by weight relative to the total oral care composition.
In one embodiment, the disclosure provides an oral care composition for whitening teeth, comprising a whitening agent which is sodium ascorbyl phosphate in an amount of about 2.5% by weight relative to the total oral care composition.
In one embodiment, the disclosure provides an oral care composition for whitening teeth, comprising a whitening agent which is ascorbyl 6-palmitate in an amount from 0.5% by weight to 5% by weight relative to the total oral care composition. In one embodiment, the disclosure provides an oral care composition for whitening teeth, comprising a whitening agent which is ascorbyl 6-palmitate in an amount of about 1.5% by weight relative to the total oral care composition. In one embodiment, the disclosure provides an oral care composition for whitening teeth, comprising a whitening agent which is ascorbyl 6-palmitate in an amount of about 2.5% by weight relative to the total oral care composition. In one embodiment, the disclosure provides an oral care composition for whitening teeth, comprising a whitening agent which is ascorbyl 6-palmitate in an amount from 1.0% by weight to 3.0% by weight relative to the total oral care composition.
In one aspect, the oral care compositions of the disclosure are free from peroxides or chemical whitening agents not being an ascorbic acid derivative.
In some embodiments, the oral care composition of the disclosure comprises a whitening agent, wherein the whitening agent comprises an ascorbic acid salt.
For example, in one aspect the oral care composition of the disclosure comprises one or more ascorbic acid salts selected from the group consisting: calcium ascorbate, calcium 1-ascorbate dihydrate, magnesium ascorbate, potassium ascorbate, magnesium L-ascorbyl phosphate L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate, (+) sodium L-ascorbate, dehydro-1-(+)-ascorbic acid dimer, sodium ascorbyl phosphate, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl stearate, disodium ascorbyl sulfate, and ascorbyl 6-palmitate.
In some embodiments, the oral care composition of the disclosure comprises a whitening agent, wherein the whitening agent comprises an ascorbic acid derivative selected from the group consisting: L-ascorbic acid, calcium ascorbate, calcium 1-ascorbate dihydrate, magnesium ascorbate, potassium ascorbate, magnesium L-ascorbyl phosphate L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate, (+) sodium L-ascorbate, dehydro-1-(+)-ascorbic acid dimer, sodium ascorbyl phosphate, ascorbic acid-2-glucoside, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl stearate, disodium ascorbyl sulfate and ascorbyl 6-palmitate.
In some embodiments, the oral care composition of the disclosure comprises a whitening agent, wherein the whitening agent comprises sodium ascorbyl phosphate. In some embodiments, the oral care composition of the disclosure comprises a whitening agent, wherein the whitening agent comprises sodium ascorbyl phosphate and comprises orally acceptable carriers.
In some embodiments, the oral care composition of the disclosure comprises sodium ascorbyl phosphate, orally acceptable carriers and further comprises one or more ingredients selected from the following: pH modifying agents, erosion prevention agents, foam modulators, thickening agents, flavoring agent, antibacterial agents, desensitizing agents, anticariogenic agents, fluoride ion sources, anticalculus agents, abrasives, stain prevention agents, antitartar agents, polymer complexes, surfactants, humectants and/or combinations thereof.
In some embodiments, the oral care composition of the disclosure comprises a whitening agent, wherein the whitening agent comprises ascorbyl 6-palmitate.
In some embodiments, the oral care composition of the disclosure comprises a whitening agent and orally acceptable carriers, wherein the whitening agent comprises ascorbyl 6-palmitate.
In some embodiments, the oral care composition of the disclosure comprises a whitening agent and orally acceptable carriers, wherein the whitening agent comprises ascorbyl 6-palmitate, and wherein the oral care composition further comprises one or more ingredients selected from the group consisting of: pH modifying agents, erosion prevention agents, foam modulators, thickening agents, flavoring agents, antibacterial agents, desensitizing agents, anticariogenic agents, fluoride ion sources, anticalculus agents, abrasives, stain prevention agents, antitartar agents, polymer complexes, surfactants, humectants and/or combinations thereof.
In still a further embodiments, the disclosure provides a method of utilizing an applicator to deliver the oral care composition of the disclosure, wherein the applicator is a pen and the pen is stored within an oral care implement. In some embodiments, the pen is removed from the oral care implement prior to application of the oral care composition to the tooth. In some embodiments, the oral care composition may be applied to the tooth after brushing. In some embodiments, the oral care composition may be applied to the tooth after brushing with the oral care implement.
In one embodiment, the present disclosure also provides methods for whitening a tooth surface using the oral care compositions according to the present disclosure. In one embodiment, the disclosure provides a method for whitening a tooth surface, comprising applying to the tooth surface a safe and effective amount of the oral care composition of the disclosure, wherein the oral care composition comprises a whitening agent and wherein the whitening agent comprises an ascorbic acid derivative.
In one embodiment, the disclosure provides a method for whitening a tooth surface, comprising applying to the tooth surface a safe and effective amount of the oral care composition of the disclosure, wherein the whitening agent and orally acceptable carriers, and wherein the whitening agent comprises an ascorbic acid derivative.
In further embodiments, the disclosure provides a method to whiten a surface of a tooth comprising applying an effective amount of an oral care composition described herein, to the oral cavity of a subject in need thereof.
In further embodiments, the disclosure provides a method to whiten a surface of a tooth comprising: contacting the surface of the tooth with the oral care composition of the disclosure, for the duration of time sufficient to whiten the surface of the tooth.
In further embodiments, the disclosure provides a method to whiten a surface of a tooth, comprising: contacting the surface of the tooth with an oral care composition comprising a whitening agent, and wherein the whitening agent is an ascorbic acid derivative.
In further embodiments, the disclosure provides a method to whiten a surface of a tooth, with an oral care composition comprising a whitening agent, and wherein the whitening agent is an ascorbic acid derivative selected from the group consisting of: L-ascorbic acid, calcium ascorbate, calcium 1-ascorbate dihydrate, magnesium ascorbate, potassium ascorbate, magnesium L-ascorbyl phosphate, L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate, sodium ascorbate, dehydro-1-(+)-ascorbic acid dimer, sodium ascorbyl phosphate, ascorbic acid-2-glucoside, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl stearate, disodium ascorbyl sulfate, ascorbyl 6-palmitate and/or combinations thereof.
In further embodiments, the disclosure is a method to whiten a surface of a tooth, with an oral care composition comprising a whitening agent, wherein the whitening agent is an ascorbic acid derivative, and wherein the oral care composition is free from other whitening agents, e.g., peroxides, percarbonate, peracid, peroxysulfate derivatives and/or combinations thereof.
In further embodiments, the disclosure provides a method to whiten a surface of a tooth, with an oral care composition comprising a whitening agent wherein the whitening agent is an ascorbic acid derivative, wherein the oral care composition further comprises one or more orally acceptable carrier(s).
In further embodiments, the disclosure provides a method to whiten a surface of a tooth comprising: contacting the surface of the tooth with an oral care composition, wherein the oral care composition comprises a whitening agent, wherein the whitening agent is an ascorbic acid derivative, and wherein the composition further comprises one or more ingredient selected from: abrasives, stain prevention agents, antitartar agents, anticalculus agents, polymer complexes, surfactants, humectants, pH modifying agents, foam modulators, thickening agents, flavoring agent, antibacterial agents, desensitizing agents, anticariogenic agents, fluoride ion sources, erosion prevention agents and/or combinations thereof.
In further embodiments, the disclosure is a method to whiten a surface of a tooth with an oral care composition, wherein the oral care composition comprises a whitening agent and wherein the whitening agent is an ascorbic acid derivative, and wherein the composition further comprises one or more of a: fluoride ion source, a zinc ion source, a stannous ion source and/or a combination thereof.
In further embodiments, the disclosure provides a method to whiten a surface of a tooth with an oral care composition, wherein the oral care composition comprises a whitening agent, and wherein the whitening agent is an ascorbic acid derivative selected from ascorbyl 6-palmitate, sodium ascorbyl phosphate and combinations thereof.
In yet another embodiment, the methods described herein may comprise direct application of the oral care composition including rinsing, painting, and brushing. In some embodiments, application of the oral care composition comprises the use of an application device which aids in maintaining contact of the ascorbic acid derivative whitening agent to the tooth surface for sufficient time so as to allow whitening. Suitable application devices include dental trays, mouthpieces, dental floss, fibers, chips, dental strips and tapes. Dental strips comprise polymers, natural and synthetic woven materials, non-woven material, foil, paper, rubber and/or combinations thereof. In one embodiment, the oral care composition of the disclosure is applied using a “paint on” technique. A small application device, such as a brush or spatula is coated with an oral care composition of the disclosure which is placed on a tooth surface.
In one embodiment, the oral care composition of the disclosure is in the form selected from: dentifrice (e.g., toothpaste), mouthwash, mouth rinse, topical oral gel, denture cleanser, dental strips, beads, varnish, dental floss, tablets, ribbon strips, ribbon toothpaste, chewing gum, lozenges and toothpowder.
In one embodiment, the oral care composition of the disclosure comprises one or more ascorbic acid derivatives, and further comprises a fluoride ion source.
In one embodiment, the oral care composition of the disclosure comprises one or more ascorbic acid derivatives, further comprise a zinc ion source.
In one embodiment, the oral care composition of the disclosure comprises one or more ascorbic acid derivatives, further comprise a stannous ion source.
In one embodiment, the oral care compositions of the disclosure may comprise at least one abrasive agent in addition to an ascorbic acid derivative (e.g., ascorbyl 6-palmitate, sodium ascorbyl phosphate). The role of an abrasive is to act as a polishing agent within the oral care composition. In some embodiments, the abrasive agents include without limitation silica (in the form of silica gel, hydrated silica, perlite, high cleaning silica, core shell silica or precipitated silica), alumina, insoluble phosphates, calcium carbonate, resinous abrasives such as urea-formaldehyde condensation products, dicalcium phosphate, calcium pyrophosphate, calcium carbonate, sodium bicarbonate, alumina, dicalcium orthophosphate dihydrate, n-calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, insoluble sodium polymetaphosphate, precipitate calcium carbonate. The average particle size of the abrasive is generally about 0.1 to about 30 μm for example about 1 to about 20 μm or about 5 to about 15 μm. In some embodiments, one or more abrasives are present in an amount of about 0.1% by weight to about 60% by weight of the total weight of the oral care composition. In some embodiments, the abrasive is calcium pyrophosphate. In some embodiments, the calcium pyrophosphate is present in an amount from about 5% to about 50% by weight of the total weight of the oral care composition. In some embodiments the abrasive is perlite, sold under the name of Perlite ImerCare® 25P. In some embodiments the abrasive is core shell silica. In some embodiments the abrasive is precipitated calcium carbonate. In some embodiments the oral care composition of the disclosure comprises an abrasive comprising cellulose, such as non-colloidal microcrystalline cellulose, colloidal microcrystalline cellulose and/or combinations thereof.
In one embodiment, the oral care compositions of the disclosure may comprise at least one stain prevention agent in addition to an ascorbic acid derivative (e.g., ascorbyl 6-palmitate, sodium ascorbyl phosphate). In some embodiments the stain prevention agents include tetrasodium pyrophosphate (TSPP), disodium pyrophosphate (SAPP), sodium tripyrophosphate (STPP), sodium hexametaphosphate (SHMP), or zinc citrate.
In some embodiments, one or more stain prevention agents are present in an amount of about 0.1% to about 60% by weight of the total weight of the oral care composition.
In one embodiment, the oral care compositions of the disclosure may comprise at least one surfactant agent in addition to an ascorbic acid derivative (e.g., ascorbyl 6-palmitate, sodium ascorbyl phosphate). The role of the surfactant is to enhance the stability of the oral care composition and create foam during stirring which ensures cleaning the oral cavity. In some embodiments the surfactant agents comprise anionic, nonionic or amphoteric surfactants.
Suitable anionic surfactants include without limitation water-soluble salts of C8-20 alkyl sulfates, sulfonated monoglycerides of C8-20 fatty acids, sarcosinates, taurates and the like. Illustrative examples of these and other classes include sodium cocoyl monoglyceride sulfonate, sodium stearate, sodium lauryl sarcosinate (sold under the name of Maprosyl®30-B), lauryl glucoside, sodium lauryl isoethionate (sold under the name of Tauranol®WHSP), sodium laureth carboxylate, sodium lauryl sulfate (same as sodium dodecyl sulfate or SLS or SDS) and sodium dodecyl benzenesulfonate.
Suitable nonionic surfactants include without limitation poloxamers, polyoxyethylene sorbitan esters, fatty alcohol ethoxylates, alkylphenol ethoxylates, tertiary amine oxides, tertiary phosphine oxides, dialkyl sulfoxides and the like. Suitable amphoteric surfactants include without limitation derivatives of C8-20 aliphatic secondary and tertiary amines having an anionic group such as carboxylate, sulfate, sulfonate, phosphate, phosphonate or cocoamidopropyl betaine, alkyl betaines and alkyl amido betaines.
In some embodiments the surfactant is a mixture of sodium cocoamphoacetate and glycerin and lauryl glucoside and sodium cocoyl glutamate, sold under the name of Plantapon®, and sodium lauryl glucose carboxylate. In some embodiments the surfactant is sodium carboxymethyl cellulose, sodium stearate, lauryl glucoside, polyanionic cellulose, sodium lauryl isoethionate, sodium lauryl sarcosinate, sodium cocoyl glutamate, cocamidopropyl betaine, and/or combinations thereof. In some embodiments, one or more surfactants may be present in a total amount of from about 0.01% by weight to about 20.00% by weight of the total weight of the oral care composition. In some embodiments, one or more surfactants may be present in a total amount of from about 1.8% by weight to about 2% by weight of the total weight of the oral care composition. In some embodiments, one or more surfactants may be present in a total amount of from about 1.9% to about 2% by weight of the total weight of the oral care composition. In some embodiments, one or more surfactants may be present in a total amount of about 2% by weight of the total weight of the oral care composition.
In one embodiment, the oral care compositions of the disclosure may comprise at least one thickening agent in addition to an ascorbic acid derivative (e.g., ascorbyl 6-palmitate, sodium ascorbyl phosphate). In some embodiments the thickening agents include without limitation: carbomers, also known as carboxyvinyl polymers, carrageenans, also known as Irish moss and more particularly carrageenan (iota-carrageenan), high molecular weight polyethylene glycols (such as CARBOWAX®, available from The Dow Chemical Company), cellulosic polymers such as hydroxyethylcellulose, carboxymethyl cellulose (CMC) and salts thereof, CMC sodium, polyanionic cellulose, natural gums such as karaya, xanthan gum, thickening silica, gum arabic and tragacanth, microcrystalline cellulose, colloidal magnesium aluminum silicate, and colloidal silica, fumed silica and/or combinations of the same.
In some embodiments the thickening agent is thickening silica or xanthan gum and/or a combination thereof. In some embodiments, the thickening agent is present in a total amount of about 0.1% by weight to about 90% by weight of the total weight of the oral care composition. In some embodiments, the one or more optional thickening agents are present in a total amount of about 1% by weight to about 50% by weight of the total weight of the oral care composition. In some embodiments, the one or more optional thickening agents are present in a total amount of about 5% by weight to about 35% by weight of the total weight of the oral care composition.
In one embodiment, the oral care compositions of the disclosure may comprise at least one humectant agent in addition to an ascorbic acid derivative (e.g., ascorbyl 6-palmitate, sodium ascorbyl phosphate). In some embodiments the humectant agents include polyhydric alcohols such as vegetable refined glycerin, non-crystal sorbitol, xylitol or low molecular weight polyethylene glycols (PEGs) or polyoxyethylenes. In some embodiments, the humectant agent is non crystal sorbitol, vegetable glycerin or polyoxyethylene glycol and/or a combination thereof. High molecular weight PEGs are suitable, including those having an average molecular weight of about 200,000 to about 7,000,000, for example about 500,000 to about 5,000,000 or about 1,000,000 to about 2,500,000. One or more PEGs are optionally present in a total amount of about 0.1% to about 10%, for example about 0.2% by weight to about 5% by weight or about 0.25% by weight to about 2% by weight of the total weight of the oral care composition.
The oral care composition of the disclosure may comprise at least one adhesion agent. The role of the adhesion agent is to ensure the retention of the oral care composition on the oral cavity surface. In some embodiments, the adhesion agents include adhesives, film forming materials, viscosity enhancers, hydrophilic organic polymers, hydrophobic organic polymers, silicone gums, silicone adhesives, silicas, and/or combinations thereof. Adhesion agents are preferably present at a level of from about 0.01% by weight to about 75% by weight, optionally from about 1% by weight to about 40% by weight of the total weight of the oral care composition.
In one embodiment, the oral care compositions of the disclosure may comprise at least one hydrophobic polymer carrier in addition to an ascorbic acid derivative (e.g., ascorbyl 6-palmitate, sodium ascorbyl phosphate), and wherein the oral care composition is free of water. The term hydrophobic or water-insoluble as applied to polymers and as employed herein refers to polymers which are substantially non-aqueous having a water solubility of less than one gram per 100 grams of water at 25° C. In certain embodiments, compositions of the disclosure comprise at least one hydrophobic polymer carrier, wherein the hydrophobic polymer carrier is a silicone pressure sensitive adhesive, and at least one whitening agent, wherein the whitening agent is an ascorbic acid derivative. For example, the ascorbic acid derivative may be present in the oral care composition in an amount ranging from about 0.5% by weight to about 5.0% by weight relative to the total weight of the oral care composition.
In various embodiments, a hydrophobic polymer is compatible with the at least one whitening agent described herein (e.g., ascorbyl 6-palmitate, sodium ascorbyl phosphate). In certain embodiments, a hydrophobic polymer is selected for the carrier to produce a tooth whitening oral care composition having a viscosity ranging from about 1,000 cPs to about 900,000 cPs, such as from about 10,000 cPs to about 900,000 cPs or from about 10,000 cPs to about 100,000 cPs. One class of hydrophobic polymers that may be used according to certain exemplary embodiments, comprise siloxane polymers, which are also generally known in the art as “silicone” polymers, such as silicone pressure sensitive adhesives (PSA). In certain embodiments disclosed herein, the hydrophobic polymers in the carrier are those in which a whitening agent can be dispersed and are well known in the art. For example, silicone polymers may be commercially available. In various embodiments, a silicone-based hydrophobic polymer is a polyorganosiloxane, such as polydimethylsiloxane. In one embodiment, the oral care compositions disclosed herein may further comprise crospovidone (poly[N-vinyl-2-pyrrolidone]) as an adhesion enhancing agent. Crospovidone may be present in the oral care composition in an amount ranging from about 10% by weight to about 30%, by weight relative to the total weight of the tooth whitening oral care composition, such as ranging from about 15% by weight to about 25% by weight, or ranging from about 18% by weight to about 25% by weight of the total weight of the oral care composition. In another embodiment the oral care compositions disclosed herein may further comprise N-vinyl heterocyclic polymers. The N-vinyl heterocyclic polymers are derived from N-heterocyclic vinyl monomers, or specific monomers such as N-vinyl imides or N-vinyl lactams. One preferred polymer is polyN-vinyl-poly-2-pyrrolidone (PVP).
In another embodiment, the oral care composition of the disclosure may comprise at least one antioxidant agent. In some embodiments, the antioxidant agent(s) maybe be selected from the group consisting of: butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, quercetin, rutin, catechin, trolox, vitamin E, flavonoids, polyphenols, ascorbic acid, 2,4-dihydroxybenzoic acid, m-methoxybenzoic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, stannous compounds, potassium or sodium meta-bisulfite, butylated hydroxytoluene (BHT), ammonium sulfate, herbal antioxidants, chlorophyll, melatonin, and/or combinations thereof.
In another embodiment, the oral care composition of the disclosure may comprise at least one erosion prevention agent selected from the group consisting of: sodium fluoride, arginine, arginine phosphate, arginine hydrochloride, arginine bicarbonate, sodium monofluorophosphate, potassium citrate, titanium phosphate, zinc oxide, zinc citrate, zinc citrate trihydrate, zinc lysine chloride complexes, zinc arginine chloride complexes are erosion prevention agents. The erosion prevention agent or combinations thereof may be present in the oral care composition in an amount ranging from about 0.2% by weight to about 10.0% by weight relative to the total weight of the oral care composition.
In another embodiment, the oral care composition of the disclosure may comprise at least one preservative agent selected from the group consisting of: benzyl alcohol, chlorhexidine, benzoic acid, benzoic acid salts, quaternary ammonium compounds (such as benzalkonium chloride) are preservative agents.
In another embodiment, the oral care composition of the disclosure may comprise at least one antimicrobial agent selected from the group consisting of: triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol); 8-hydroxyquinoline and salts thereof; zinc and stannous ion sources such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate; copper (II) compounds such as copper (II) chloride, fluoride, sulfate and hydroxide; phthalic acid and salts thereof such as magnesium monopotassium phthalate; sanguinarine; quaternary ammonium compounds, such as alkylpyridinium chlorides, cetylpyridinium chloride (CPC), combinations of CPC with zinc and/or enzymes, tetradecylpyridinium chloride, and N-tetradecyl-4-ethylpyridinium chloride; bisguanides, such as chlorhexidine digluconate, hexetidine, octenidine, and alexidine; halogenated bisphenolic compounds, such as 2,2′ methylenebis-(4-chloro-6-bromophenol); benzalkonium chloride; salicylanilide, domiphen bromide; iodine; sulfonamides; bisbiguanides; phenolics; piperidine derivatives such as delmopinol and octapinol; magnolia extract; grapeseed extract; thymol; eugenol; menthol; geraniol; carvacrol; citral; eucalyptol; catechol; 4-allylcatechol; hexyl resorcinol; methyl salicylate; antibiotics such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanamycin and clindamycin; and/or combinations thereof.
In another embodiment, the oral care composition of the disclosure may comprise at least one antitartar (anticalculus) agent selected from the group consisting of: phosphates and polyphosphates (for example pyrophosphates), polyaminopropanesulfonic acid (AMPS), polyolefin sulfonates, polyolefin phosphates, diphosphonates such as azacycloalkane-2,2-diphosphonates (e.g., azacycloheptane-2,2-diphosphonic acid), N-methyl azacyclopentane-2,3-diphosphonic acid, ethane-1-hydroxy-1,1-diphosphonic acid (EHDP) and ethane-1-amino-1,1-diphosphonate, phosphonoalkane carboxylic acids and salts of any of these agents, for example their alkali metal and ammonium salts. Useful inorganic phosphate and polyphosphate salts include monobasic, dibasic and tribasic sodium phosphates, sodium tripolyphosphate, tetrapolyphosphate, mono-, di-, tri- and tetrasodium pyrophosphates, sodium trimetaphosphate, sodium hexametaphosphate and/or combinations thereof, wherein sodium may optionally be replaced by potassium or ammonium. Anticalculus agents include polycarboxylate polymers and polyvinyl methyl ether/maleic anhydride (PVME/MA) copolymers, such as those available under the Gantrez™ brand from ISP, Wayne, N.J. In another embodiment, the oral care compositions of the disclosure comprise one or more anticalculus agents present in an effective total amount, e.g., 0.01% by weight to 50% by weight, for example 0.05% by weight to 25% by weight, or 0.1% by weight to 15% by weight of the total weight of the oral care composition.
In another embodiment, the oral care composition of the disclosure may comprise at least one stannous ion source. Stannous ions may act as a periodontal active, antitartar agent, anticariogenic agent or tooth desensitizer. In some embodiments, the stannous ion source can be selected from the group consisting of: stannous fluoride, other stannous halides such as stannous chloride dihydrate, organic stannous carboxylate salts such as stannous formate, acetate, gluconate, lactate, tartrate, oxalate, malonate and citrate, stannous ethylene glyoxide, and/or combinations thereof.
In another embodiment, the oral care composition of the disclosure may comprise at least one fluoride ion source. Fluoride ions may act as an anticariogenic agent. In some embodiments, the fluoride ion source can be selected from the group consisting of: potassium, sodium and ammonium fluorides and monofluorophosphates, sodium monofluorophosphates, stannous fluoride, indium fluoride, and/or combinations thereof.
In another embodiment, the oral care composition of the disclosure may comprise at least one zinc ion source. Zinc ions may act as antimalodor agents. In some embodiments, the zinc ion source can be selected from the group consisting of: zinc oxide, zinc citrate, zinc chloride, zinc acetate, zinc lactate, zinc salicylate, zinc sulfate, zinc phosphate, zinc tartrate and zinc nitrate and/or combinations thereof.
In another embodiment, the oral care composition of the disclosure may comprise at least one colorant source. In some embodiments, the colorant source can be selected from the group consisting of: pigments, dyes, lakes and agents imparting a particular luster or reflectivity such as pearling agents. In various embodiments, colorants are operable to provide a white or light-colored coating on a dental surface, to act as an indicator of locations on a dental surface that have been effectively contacted by the oral care composition, and/or to modify appearance, in particular color and/or opacity, of the oral care composition to enhance attractiveness to the consumer.
In another embodiment, the oral care composition of the disclosure may comprise at least one flavoring agent. For example, the oral care compositions of the disclosure may comprise 0.1% by weight to 2.0% by weight of flavoring agent, of the total weight of the oral care composition. In some embodiments, the flavoring agent can be any material and/or combinations of materials operable to enhance the taste of the oral care composition, e.g., any orally acceptable natural or synthetic flavoring agent (e.g., flavoring oils, flavoring aldehydes, esters, alcohols, similar materials, and/or combinations thereof). Flavoring agents include vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, oil of wintergreen (methyl salicylate) peppermint oil, clove oil, bay oil, anise oil, eucalyptus oil, citrus oils, fruit oils and essences including those derived from lemon, orange, lime, grapefruit, apricot, banana, grape, apple, strawberry, cherry, pineapple, bean- and nut-derived flavors such as coffee, cocoa, cola, peanut, almond, adsorbed and encapsulated flavoring agents and/or combinations thereof. Also encompassed within flavoring agents herein are ingredients that provide other sensory effects in the mouth, including cooling or warming effects.
In another embodiment, the oral care compositions of the disclosure may comprise at least one sweetener. The oral care composition of the disclosure may comprise from 0.1% by weight to 2.0% by weight of sweetener of the total weight of the oral care composition. In some embodiments, the sweetener includes dextrose, sucrose, polydextrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose galactose, corn syrup, partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof, sucralose, dipeptide-based intense sweeteners, cyclamates, dihydrochalcones, stevia, glycosilated stevia glucosides and/or combinations thereof.
In another embodiment, the oral care compositions of the disclosure may comprise at least one mouth-feel agent. In some embodiments, the mouth-feel agents include materials imparting a desirable texture or other feeling during use of the oral care composition of the disclosure.
In another embodiment, the oral care compositions of the disclosure may comprise at least one pH modifying agent. The role of the pH modifying agent is to keep the oral care compositions at an orally acceptable pH range. In some embodiments, the pH modifying agents include acidifying agents to lower pH, basifying agents to raise pH, and buffering agents to control pH within a desired range. Orally acceptable pH modifying agents include carboxylic, phosphoric and sulfonic acids, acid salts, monosodium citrate, disodium citrate, monosodium malate, alkali metal hydroxides such as sodium hydroxide, carbonates such as sodium carbonate, bicarbonates, sesquicarbonates, borates, silicates, phosphates, monosodium phosphate, trisodium phosphate, pyrophosphate salts, imidazole, and/or combinations thereof. The oral care composition of the disclosure may comprise a viscosity modifier. The role of the viscosity modifier is to ensure the oral care composition is homogenous. In some embodiments, the viscosity modifiers include mineral oil, petrolatum, clays and organomodified clays, silica, and/or combinations thereof.
In another embodiment, the oral care compositions of the disclosure may comprise at least one foam modulator. The role of the foam modulator is to generate foam upon mixing which contributes to the dispersion of the oral care composition in the oral cavity. In some embodiments, the foam modulators include sodium lauroyl sarcosinate, sodium lauryl sulfate powder, polyethylene glycols (PEGs), also known as polyoxyethylenes. High molecular weight PEGs are suitable, including those having an average molecular weight of about 200,000 to about 7,000,000, for example about 500,000 to about 5,000,000 or about 1,000,000 to about 2,500,000. One or more PEGs are optionally present in a total amount of about 0.1% by weight to about 10% by weight, for example about 0.2% by weight to about 5% by weight or about 0.25% by weight to about 2% by weight of the total weight of the oral care composition.
In another embodiment, the oral care compositions of the disclosure may comprise at least one saliva stimulating agent. The role of the saliva stimulating agent is to keep the mouth from drying. In some embodiments, the saliva stimulating source includes food acids such as citric, lactic, rilalic, succinic, ascorbic, adipic, fumaric and tartaric acids, and/or combinations thereof.
In another embodiment, the oral care compositions of the disclosure may comprise at least one freshening agent. In some embodiments, the breath freshening agent includes zinc salts such as zinc gluconate, zinc citrate and zinc chlorite, a-ionone, and/or combinations thereof.
In another embodiment, the oral care compositions of the disclosure may comprise at least desensitizing agent. In some embodiments, the desensitizing agents include potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate, strontium salts, and/or combinations thereof.
In another embodiment, the oral care compositions of the disclosure may comprise at least one nutrient agent. In some embodiments, the nutrient includes vitamins, minerals, amino acids, and/or combinations thereof. Vitamins include vitamin D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids, and/or combinations thereof. Nutritional supplements include amino acids, arginine, L-tryptophane, L-lysine, methionine. threonine, levocarnitine and L-carnitine, lipotropics, choline, inositol, betaine, and linoleic acid, fish oil, including components thereof such as omega-3 (N-3) polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, coenzyme Q10, and/or combinations thereof. The oral care composition of the disclosure may comprise neutral amino acids, wherein the neutral amino acid is selected from the group consisting of alanine, aminobutyrate, asparagine, cysteine, cystine, glutamine, glycine, hydroxyproline, isoleucine, leucine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, valine, and/or combinations thereof; wherein preferably selected from glycine, asparagine, glutamine, and/or combinations thereof; and wherein the neutral amino acid is present in the amount of from 0.1% by weight to 5% by weight of the total weight of the oral care composition.
In another embodiment, the oral care compositions of the disclosure may comprise at least one anti-inflammatory agent. In some embodiments, the anti-inflammatory agents include steroidal agents such as fluocinolone and hydrocortisone, and nonsteroidal agents (NSAIDs) such as ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, diclofenac, etodolac, indomethacin, sulindac, tolmetin, ketoprofen, fenoprofen, piroxicam, nabumetone, aspmn, diflunisal, meclofenamate, mefenamic acid, oxyphenbutazone and phenylbutazone, and/or combinations thereof.
In some embodiments, the oral care compositions of the disclosure may comprise at least one ingredient selected from the following: a humectant, an abrasive, a surfactant, a thickening agent, a foam modulator, a stain prevention agent, a preservative, an erosion prevention agent, an antiplaque agent, a sweetener, water, and combinations thereof.
In some embodiments, the oral care compositions of the disclosure may comprise at least one humectant from 0.10% by weight to 70% by weight, at least one abrasive from about 0.10% by weight to about 60% by weight, at least one anionic surfactant from 0.01% by weight to 20% by weight, at least one a nonionic surfactant from 0.01% by weight to 20% by weight, at least one amphoteric surfactant from 0.01% by weight to 20% by weight, at least one thickening agent from 0.10% by weight to 90% by weight, at least one foam modulator from 0.10% by weight to 10% by weight, at least one stain prevention agent from 0.10% by weight to 60% by weight, at least one preservative from 0.20% by weight to 1% by weight, at least one erosion prevention agent 0.10% by weight to 10% by weight, at least one antiplaque agent from 0.01% to 5% by weight, at least one sweetener from 0.10% by weight to 2% by weight, and/or combinations thereof, wherein the weight is based on the total weight of the composition.
In some embodiments the oral care composition of the disclosure may comprise at least one humectant from 0.10% by weight to 70% by weight, or from 0.10% by weight to 1% by weight, or from 1% by weight to 5.5% by weight, or from 5.5% by weight to 20% by weight, or from 20% by weight to 40% by weight, or from 40% by weight to 46% by weight, or from 45% by weight to 53% by weight, or from 50% by weight to 60% by weight, or from 61.00% by weight to 68.00% by weight, relative to the total oral care composition.
In some embodiments the oral care composition of the disclosure may comprise at least one abrasive from 0.10% by weight to 60% by weight, or from about 0.10% by weight to 10% by weight, or from 5% by weight to 7.5% by weight, or from about 10.00% by weight to 15.00% by weight, or from 15.00% by weight to 21.00% by weight, or from 21.00% by weight to 35.00% by weight, or from 7.00% by weight to 17.00% by weight, or from 35.00% by weight to 51.00% by weight, or from 51.00% by weight to 60.00% by weight, relative to the total oral care composition.
In some embodiments the oral care composition of the disclosure may comprise at least one anionic surfactant from 0.01% by weight to 20% by weight, or from 0.01% by weight to 0.7% by weight, or from 0.45% by weight to 0.7% by weight, or from 0.7% by weight to 1% by weight, or from 1.00% by weight to 10% by weight, or from 10% by weight to 15.5% by weight, or from 4.2% by weight to 5% by weight, or from 15.5% by weight to 20% by weight, relative to the total oral care composition.
In some embodiments the oral care composition of the disclosure may comprise at least one nonionic surfactant from 0.01% by weight to 20% by weight, or from 0.01% by weight to 0.05% by weight, or from 0.04% by weight to 1% by weight, or from 1% by weight to 3% by weight, or from 3% by weight to 5% by weight, or from 5% by weight to 7% by weight, or from 7% by weight to 14% by weight, or from 14% by weight to 20% by weight, relative to the total oral care composition.
In some embodiments the oral care compositions of the disclosure may comprise at least one amphoteric surfactant from 0.01% by weight to 20% by weight, or from 0.01% by weight to 1.00% by weight, or from 1.00% by weight to 1.6% by weight, or from 1.5% by weight to 2% by weight, or from 2% by weight to 2.6% by weight, or from 2.5% by weight to 3% by weight, or from 3% by weight to 5% by weight, or from 5% by weight to 7% by weight, or from 7% by weight to 14% by weight, or from 14% by weight to 20% by weight, relative to the total oral care composition.
In some embodiments the oral care compositions of the disclosure may comprise at least one thickening agent from 0.1% by weight to 90% by weight, or from 0.1% by weight to 5.5% by weight, or from 5.5% by weight to 7.5% by weight, or from 7.5% by weight to 15.5% by weight, or from 1.5% by weight to 5.5% by weight, or from 0.2% by weight to 0.5% by weight, or from 0.4% by weight to 1.5% by weight, or from 1.5% by weight to 2.5% by weight, or from 2.5% by weight to 3.5% by weight, or from 3.5% by weight to 5% by weight, or from 5% by weight to 5.5% by weight, or from 5.5% by weight to 7% by weight, or from 7% by weight to 8% by weight, or from 7.2% by weight to 12.8% by weight, or from 15.5% by weight to 35.5% by weight, or from 35.5% by weight to 55.5% by weight, or from 55.5% by weight to 75.5% by weight, or from 75.5% by weight to 85.5% by weight, or from 85.5% by weight to 90% by weight, relative to the total oral care composition.
In some embodiments the oral care compositions of the disclosure may comprise at least one foam modulator from 0.10% by weight to 10% by weight, or from 1% by weight to 2% by weight, or from 2% by weight to 3.5% by weight, or from 3.5% by weight to 5% by weight, or from 5% by weight to 6% by weight, relative to the total oral care composition. The oral care composition of the disclosure may comprise at least one stain prevention agent from 0.1% by weight to 60% by weight, or from 0.1% by weight to 0.45% by weight, or from 0.45% by weight to 5.45% by weight, or from 5.45% by weight to 10.65% by weight, or from 10.65% by weight to 20.85% by weight, or from 20.85% by weight to 40% by weight, or from 40% by weight to 50% by weight, or from 50% by weight to 60% by weight, relative to the total oral care composition.
In some embodiments the oral care compositions of the disclosure may comprise at least one preservative from 0.20% by weight to 1% by weight, or from 0.2% by weight to 0.45% by weight, or from 0.45% by weight to 0.55% by weight, or from 0.55% by weight to 0.85% by weight, or from 0.85% by weight to 1% by weight, relative to the total oral care composition.
In some embodiments the oral care compositions of the disclosure may comprise at least one erosion prevention agent from 0.10% by weight to 10% by weight, or from 0.55% by weight to 0.85% by weight, or from 0.10% by weight to 0.2% by weight, or from 0.2% by weight to 0.5% by weight, or from 0.2% by weight to 0.35% by weight, or from 0.35% by weight to 0.65% by weight, or from 0.65% by weight to 0.85% by weight, or from 0.85% by weight to 1% by weight, relative to the total oral care composition.
In some embodiments the oral care composition of the disclosure may comprise at least one antiplaque agent from 0.01% by weight to 50% by weight, or from 0.01% by weight to 0.5% by weight, or from 0.5% by weight to 1% by weight, or from 1% by weight to 5% by weight, or from 5% by weight to 10% by weight, or from 10% by weight to 20% by weight, or from 20% by weight to 30.2% by weight, or from 30.2% by weight to 40% by weight, or from 40% by weight to 50% by weight, relative to the total oral care composition.
The oral care composition of the disclosure may comprise at least one sweetener from 0.10% by weight to 2% by weight, or from 0.1% by weight to 0.4% by weight, or from 0.4% by weight to 1% by weight, or from 1% by weight to 1.2% by weight, or from 1.2% by weight to 1.7% by weight, or from 1.7% by weight to 2% by weight, relative to the total oral care composition.
It is understood that while general attributes of each of the above categories of materials may differ, there may be some common attributes and any given material may serve multiple purposes within two or more of such categories of materials.
In certain embodiments, the oral care composition is anhydrous. Anhydrous, refers to less than 5% by weight of water, optionally less than 4%, less than 3%, less than 2% by weight, less than 1% by weight, less than 0.5% by weight, less than 0.1% by weight down to 0% by weight water.
In certain embodiments, the oral care compositions of the disclosure comprise water in an amount of 60% by weight to 90% by weight of the total weight of the oral care composition. In certain embodiments, the oral care composition comprises water in an amount of 65% by weight to 85% by weight of the total weight of the oral care composition.
In certain embodiments, the oral care composition comprises water in an amount of 70% by weight to 80% by weight of the total weight of the oral care composition. In certain embodiments, the oral care composition comprises water in an amount of 10% by weight to 22% by weight of the total weight of the oral care composition. In certain embodiments, the oral care composition comprises water in an amount of 5% by weight to 30% by weight of the total weight of the oral care composition.
The oral care compositions of the disclosure may comprise various agents which are active to protect and enhance the strength and integrity of the enamel and tooth structure and/or to reduce bacteria and associated tooth decay and/or gum disease. Effective concentration of the active ingredients used herein will depend on the particular agent and the delivery system used.
In one aspect, the present disclosure therefore provides an oral care composition (Composition 1.0) for whitening than 0.1 dental enamel, wherein the oral care composition comprises an effective amount of an ascorbic acid derivative,
For example, Composition 1.0 also includes the following:
wherein R1 is a saturated or unsaturated, straight or branched alkyl chain with 6 to 18 C atoms R2 is H or methyl, and M+ is H, sodium, or potassium (e.g., sodium methyl cocoyl taurate).
Any of Composition 1.0 et seq for use in a method as described herein.
The disclosure also provides a method (Method 1.0) for whitening a surface of a tooth (e.g., extrinsic whitening) of a patient in need thereof, wherein the method comprises contacting the surface of the tooth with an oral care composition (e.g., any of Composition 1.0 et seq.) comprising an ascorbic acid derivative, in a patient in need thereof, for a duration of time sufficient to whiten the surface of the tooth.
The disclosure also provides a method for increasing the color stability of an oral care composition comprising an ascorbic acid derivative (Method 2.0), wherein the method comprises adding sodium stearate to a composition of any of Composition 1.0 et seq, (e.g., wherein the composition comprises sodium ascorbyl phosphate or ascorbyl 6-palmitate) wherein the sodium stearate reduces the amount of yellowing in the oral care composition relative to a reference oral care composition comprising sodium ascorbyl phosphate or ascorbyl 6-palmitate but that does not contain sodium stearate.
In some embodiments, any of Composition 1.0 et seq, is administered as part of a method to treat or reduce staining of the enamel.
In a further aspect, any of Composition 1.0 et seq, can be used in a method to whiten the enamel surface in order to remove extrinsic staining.
In one aspect, the disclosure contemplates the use of any of the disclosed compositions, e.g., any of Composition 1.0 et seq., in any of the methods (e.g., Method 1.0 et seq or Method 2.0 et seq) described herein.
As used herein, “staining” refers to a discoloration of a dental surface caused by adsorption or absorption of a color agent on or into the surface, or caused by reaction of material of the dental surface (e.g., dental enamel) with a color or noncolor agent contacting the surface. In one aspect, that staining is consequent to exposure to tobacco smoke, chewing tobacco, tea and/or coffee.
The oral care compositions of the disclosure are made by any variety of methods including adding and mixing the ingredients of the oral care composition in a suitable vessel provided with a mixer. In one embodiment, the ascorbic acid derivative, humectant(s), surfactant(s) and carrier(s) are mixed to form a homogenous mixture. Additional ingredients such as flavoring agents, coloring or sweeteners are added at any point during the mixing process but in various embodiments such ingredients are preferably added last or close to last.
The following examples are for illustrative purposes only and are not intended, nor should they be construed as limiting the disclosure in any manner. Those skilled in the art will appreciate that variations and modifications of the following examples can be made without exceeding the spirit or scope of the disclosure.
As will be evident to those skilled in the art, individual isomeric forms can be obtained by separation of mixtures thereof in conventional manner. For example, in the case of diasteroisomeric isomers, chromatographic separation may be employed.
The following compounds are used in the examples:
Several basic toothpastes comprising a variety of backbones were formulated as described in the following tables. In order to evaluate the whitening efficacy of reducing agents, an array of reducing agents is added to the basic toothpastes in different percentages by weight. The pH of the toothpaste samples is adjusted as needed using 1M sodium hydroxide (NaOH) and 1 M hydrochloric acid (HCl) to maintain a pH between 5-11. The whitening efficacy of these toothpaste samples is determined in a standard brushing study, as described below in Example 1. In each study, the whitening efficacy was compared to the basic toothpaste and to whitening toothpastes comprising more traditional whitening agents such as peroxides and/or abrasives.
Bovine enamel teeth mounted individually in resin blocks are purchased and brushed with an abrasive paste until initial “L” values were 56-68. Trays are prepared for the brushing machine and each tray consists of six teeth mounted using 3D printed trays. Baseline optical measurements of the bovine teeth are taken using a spectrophotometer and the trays are loaded onto the brushing machine.
Toothbrushes are placed on the brushing machine by removing the head of a manual toothbrush from its handle. Slurry composed of 1:1 ratio by weight of test toothpaste to artificial saliva is prepared and added to each tray. The teeth are brushed for two minutes with 250 grams of pressure at 120 strokes per minute. After brushing is stopped, the slurry is removed and residual toothpaste is rinsed away with deionized water. The brushing treatment is repeated a total of 14 times and measurements are taken every 2 cycles. The teeth are then gently blotted with a paper towel to remove excess liquid and measurements are taken with the spectrophotometer. Six teeth are tested in each cell. The “L”, “a”, and “b” values are determined and are used to calculate the change in whiteness “ΔW” for each tooth after the treatment. The “L”, “a”, and “b” values, according to the International Committee of Illumination (CIE), provide a numerical representation of three-dimensional color space where “L” represents a lightness axis, “a” represents a red-green axis and “b” represents a yellow-blue axis. All “ΔW” values are averaged for teeth within the same treatment. A lower “ΔW” means the whiter the teeth.
W*=√{square root over (a2+(b*)+(L*−100)2)}
ΔW*=Wtreated*−Wbaseline*
Anova-Tukey statistical analysis is performed to check for statistical difference from buffer alone (p<0.05 declared as significant).
Basic Toothpaste A is prepared without a coloring agent according to Table 1.
Various reducing agents are added to Toothpaste A in an amount of 2.5% by weight, based on the total weight of the toothpaste sample and the pH is adjusted as necessary.
The whitening efficacy of Toothpaste A samples is determined in the standard brushing study, as described in Example 1. The ΔW values are tabulated in Table 3.
The ΔW data presented in Table 3 show that ascorbic acid salts: sodium ascorbyl phosphate and ascorbyl 6-palmitate provide whitening efficacy when added to Toothpaste A: sample 3 and sample 4, respectively. Based on the results, the whitening efficacy of ascorbyl 6-palmitate is further investigated in a different basic toothpaste formulation.
Basic Toothpaste B is prepared without flavor or coloring agent according to Table 4.
Ascorbyl 6-palmitate is added in different amounts to basic Toothpaste B and the pH of the samples is adjusted as necessary.
The whitening efficacy of Toothpaste B samples is determined in the standard brushing study, as described in Example 1. Besides basic Toothpaste B, two more toothpaste samples are used as controls: Toothpaste C and Toothpaste D. Toothpaste C, contains dicalcium phosphate dihydrate and Toothpaste D contains 0.1% hydrogen peroxide as whitening agent. The ΔW values are tabulated in Table 6.
The ΔW data in Table 6 demonstrate that all the toothpaste samples, containing ascorbyl 6-palmitate, had an impact on whitening efficacy. The formulas of Toothpaste “C” and Toothpaste “D” are as follows:
Based on the results obtained in Table 3, the whitening efficacy of sodium ascorbyl phosphate are further investigated. Toothpaste samples are prepared by adding different amounts of sodium ascorbyl phosphate to basic Toothpaste B of Table 4. The pH values of the samples were adjusted as necessary.
The whitening efficacy of Toothpaste B samples was determined in the standard brushing study, as described in Example 1. Besides basic Toothpaste B, two more toothpaste samples were used as controls: Toothpaste C and Toothpaste D. The ΔW values are tabulated in Table 8.
The ΔW data in Table 8 demonstrate that all the toothpaste samples containing sodium ascorbyl phosphate had an impact on whitening efficacy.
Basic Toothpaste B1 is prepared without a coloring agent according to Table 8A. 1.5% weight sodium ascorbyl phosphate is added to the Basic Toothpaste B1.
Based on the results obtained in Table 3 and Table 8, the whitening efficacy of sodium ascorbyl phosphate are further investigated. Basic Toothpaste E are prepared according to Table 9.
Toothpaste samples are prepared by adding different amounts of sodium ascorbyl phosphate to basic Toothpaste E. The pH values of the samples are adjusted as necessary.
The whitening efficacy of the toothpaste samples according to Table 10 is determined in the standard brushing study, as described in Example 1. The only change is the starting “L” 59-66. The brushing treatment was repeated a total of 14 times and measurements were taken every 5 cycles. Basic Toothpaste E was used as a control. The ΔW values are tabulated in Table 11.
aTP E is toothpaste E as defined in Table 9
bToothpaste E comprising 0.5% weight sodium ascorbyl phosphate
cToothpaste E comprising 2.75% weight sodium ascorbyl phosphate
dToothpaste E comprising 5.0% weight sodium ascorbyl phosphate
The ΔW data in Table 11 show that all the toothpaste samples, containing sodium ascorbyl phosphate had an impact on whitening efficacy.
To further study the effect of sodium ascorbyl phosphate on whitening, basic Toothpaste F is prepared according to Table 12.
Toothpaste samples are prepared by adding sodium ascorbyl phosphate to basic Toothpaste F in different amounts. The pH values of the samples were adjusted as necessary, and shown in Table 13.
The brushing study is performed as described previously in Example 1. The only change is the starting “L” 57.3-66.3, and there are twelve teeth per cell, and the measurements are on cycle 4, 8, and 14 to keep in line with standard brushing studies vs. the factorial study design.
The ΔW data in Table 14 show that the dose of sodium ascorbyl phosphate has a significant effect on whitening efficacy.
The addition of sodium ascorbyl phosphate to basic toothpaste formulas yields an observable yellow color in the toothpaste compositions. To overcome this color issue, surfactants are added to the basic toothpaste formulas in combination with sodium ascorbyl phosphate. Table 15 describes one basic toothpaste formula, to which sodium ascorbyl phosphate and surfactants are added. Three surfactants, sodium stearate, sodium cocoyl glutamate and sodium lauryl isoethionate, are screened, alone and in different combinations with/without sodium ascorbyl phosphate. The color of the final toothpaste formulas was determined, as tabulated in Table 16.
Table 16 describes the samples which were tested for color with a spectrophotometer.
Samples of basic toothpaste G with different amounts and combinations of surfactants with/without sodium ascorbyl phosphate are prepared and evaluated for color, as shown in Table 16. The L*, a*, b* values of these samples are tabulated in Table 16. A high “b*” value indicates a more yellow color while a lower value indicates a more blue color. A high “L*” value indicates a whiter sample compared to a low “L*” value which indicates a darker sample. As can be observed in Table 16 samples without sodium stearate that incorporate sodium ascorbyl phosphate tends to increase the “b*” value, indicating a more yellow color. Samples that incorporate sodium stearate with sodium ascorbyl phosphate tend to have a relative reduction in “b*” value, indicating less yellow color.
Filing Document | Filing Date | Country | Kind |
---|---|---|---|
PCT/US2021/062627 | 12/9/2021 | WO |
Number | Date | Country | |
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63123016 | Dec 2020 | US |