The present invention relates to oral care systems and related methods, and more particularly to a system and related method including a toothbrush and a detachable dispenser containing a dispensable fluidic oral care material.
Oral care materials or agents may be applied in variety of ways. For tooth whitening products, for example, a common technique used for applying tooth whitening products is to cast an impression of a person's teeth and provide a tray of the shape of this impression. A user then adds a whitening composition to the tray and applies the tray to his/her teeth. The tray is left in place for a period of time and then removed. Another technique is to use a whitening strip that has a whitening composition on one surface. This strip is applied to a person's teeth and left in place for a period of time. Yet another technique is to apply a whitening composition to teeth using a small brush. This brush is repeatedly dipped back into the container during the application of the tooth whitening composition to one's teeth. After a few treatments, the teeth gradually whiten using the foregoing techniques.
The foregoing approaches to oral care material storage, dispensing, and application may not be convenient and readily portable for travel. The oral care product is typically stored separately from the oral care tooth cleaning implements such as a toothbrush and treated as distinct parts of an oral care regimen which must be handled and packed separately.
A more portable, compact, and convenient way to store, dispense, and apply oral care materials to oral surfaces is desired.
According to an embodiment, an oral care material dispenser includes a housing defining a longitudinal axis, a pressurized product tube disposed in the housing and including a reservoir containing an oral care material, an outlet in fluid communication with the reservoir, and a valve fluidly coupled to the outlet. The valve is movable between an open dispensing position and a closed non-dispensing position. The valve is configured to dispense oral care material from the reservoir under pressure when in the dispensing position.
According to an embodiment, an oral care system includes a toothbrush including a head, and a handle coupled to the head and having an internal cavity, a dispenser detachably mounted in the internal cavity of the handle, and a dispenser. The dispenser includes a housing defining a longitudinal axis, a pressurized tube disposed in the housing and including a reservoir containing an oral care material, an outlet in fluid communication with the reservoir, and a valve fluidly coupled to the outlet. The valve is movable between an open dispensing position and a closed non-dispensing position. The valve is configured to dispense oral care material from the reservoir under pressure when in the dispensing position.
A method for dispensing an oral care material is provided. The method includes: providing a dispenser including a housing defining a longitudinal axis, a pressurized product tube disposed in the housing and including a reservoir containing an oral care material, and an outlet in fluid communication with the reservoir and defining a flow path for dispensing the oral care material; engaging opposite sides of the product tube with a compression device operably exerting an inward directed force on the reservoir; actuating a valve fluidly coupled to the outlet of the dispenser and including a flow orifice, the orifice movable into and out of the flow path; positioning the orifice into the flow path; and dispensing the oral care material from the dispenser.
Further areas of applicability of the present invention will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.
The present invention will become more fully understood from the detailed description and the accompanying drawings, wherein:
The following description of the preferred embodiment(s) is merely exemplary in nature and is in no way intended to limit the invention, its application, or uses.
As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. In addition, all references cited herein are hereby incorporated by referenced in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.
Referring to
In exemplary embodiments, the oral care material M may include without limitation the following types of flowable compositions in fluid form: tooth whitening, antibacterial, enamel protection, anti-sensitivity, anti-inflammatory, anti-attachment, fluoride, tartar control/protection, flavorant, sensate, colorant and others. However, other embodiments may be used to store and dispense any suitable type of flowable oral care material M. Accordingly, the invention is expressly not limited to any particular type of oral care material M.
With continuing reference to
In one embodiment with continuing reference to
The handle 210 transitions into the neck 220 at the distal end 213. While the neck 220 generally may have a smaller transverse cross-sectional area than the handle 220, the invention is not so limited. Broadly speaking, the neck 220 is merely the transition region between the handle 210 and the head 230 and can conceptually be considered as a portion of the handle 210 or a portion of the head 230. The head 230 and/or neck 220 may therefore be considered as connected to the distal end 213 of the handle 210.
The head 230 and handle 210 of toothbrush 200 may be formed as a single unitary structure using a molding, milling, machining or other suitable process known in the art. However, in other embodiments, handle 210 and head 230 may be formed as separate components which are operably connected at a later stage of the manufacturing process by any suitable technique known in the art, including without limitation thermal or ultrasonic welding, a tight-fit assembly, a coupling sleeve, threaded engagement, adhesion, or fasteners. Whether the head 230 and handle 210 are of a unitary or multi-piece construction (including connection techniques) is not limiting of the present invention, unless specifically claimed. In some embodiments of the invention, a replaceable type head 230 may be provided which is detachably mounted to the handle 210 (along with a portion of neck 220) using techniques known in the art, such as disclosed in PCT International Patent Application No. PCT/US2012/042973 filed Jun. 18, 2012, which is incorporated herein by reference in its entirety.
Head 230 generally includes a front surface 231, a rear surface 232 and a peripheral side surface 233 that extends between the front and rear surfaces 231, 232. The front surface 231 of the head 230 includes a plurality of oral cleaning elements such as tooth engaging elements 235 extending therefrom for cleaning and/or polishing contact with an oral surface and/or interdental spaces. While the tooth engaging elements 235 are suited for brushing teeth, the tooth engaging elements 235 can also be used to polish teeth instead of or in addition to cleaning teeth. As used herein, the term “tooth engaging elements” is used in a broad generic sense to refer to any structure that can be used to clean, polish or wipe the teeth and/or soft oral tissue (e.g. tongue, cheek, gums, etc.) through relative surface contact. Common examples of “tooth engaging elements” include, without limitation, bristle tufts, filament bristles, fiber bristles, nylon bristles, spiral bristles, rubber bristles, elastomeric protrusions, flexible polymer protrusions, combinations thereof and/or structures containing such materials or combinations. Suitable elastomeric materials include any biocompatible resilient material suitable for uses in an oral hygiene apparatus. To provide optimum comfort as well as cleaning benefits, the elastomeric material of the tooth or soft tissue engaging elements has a hardness property in the range of A8 to A25 Shore hardness. One suitable elastomeric material is styrene-ethylene/butylene-styrene block copolymer (SEBS) manufactured by GLS Corporation. Nevertheless, SEBS material from other manufacturers or other materials within and outside the noted hardness range could be used.
Tooth engaging elements 235 of the present invention can be connected to the head 230 in any manner known in the art. For example, staples/anchors, in-mold tufting (IMT) or anchor free tufting (AFT) could be used to mount the cleaning elements/tooth engaging elements. In AFT, a plate or membrane is secured to the brush head such as by ultrasonic welding. The bristles extend through the plate or membrane. The free ends of the bristles on one side of the plate or membrane perform the cleaning function. The ends of the bristles on the other side of the plate or membrane are melted together by heat to be anchored in place. Any suitable form of cleaning elements may be used in the broad practice of this invention. Alternatively, the bristles could be mounted to tuft blocks or sections by extending through suitable openings in the tuft blocks so that the base of the bristles is mounted within or below the tuft block.
Toothbrush 200 and the dispenser 300 are non-unitary separate structures that are specially designed and configured to be detachably coupled together when in an assembled state (referred to herein as a “storage state”) and completely isolated and separated from one another when in a disassembled state (referred to herein as an “application state”). The toothbrush 200 and the dispenser 300 are illustrated in the storage state in
Housing 301 may be a generally circular transverse cross-sectional profile in one embodiment. Of course, in other embodiments, the transverse cross-sectional profile of the housing 301 can take on various non-circular shapes. The housing 301 is constructed of a material and with a wall thickness that is sufficiently rigid to provide the necessary structural integrity and stiffness for handling and dispensing of an oral care material M from the dispenser 300 without substantial deformation. For example, the housing 301 can be formed of a moldable hard plastic. Suitable hard plastics include polymers and copolymers of ethylene, propylene, butadiene, vinyl compounds and polyesters such as polyethylene terephthalate. Others may be used and the invention is not limited to any particular material of construction.
While the housing 301 is exemplified as a single layer construction, in certain embodiments, the housing 301 may be a multilayer construction. In certain multi-layer embodiments, an inner layer can be formed from the hard plastic materials described immediately above while an outer layer can be formed of a soft resilient material, such as an elastomeric material. Suitable elastomeric materials include thermoplastic elastomers (TPE) or other similar materials used in oral care products. The elastomeric material of the outer layer may have a hardness durometer measurement ranging between A13 to A50 Shore hardness, although materials outside this range may be used. A suitable range of the hardness durometer rating is between A25 to A40 Shore hardness. While an over-molding construction is one suitable method of forming the outer layer, a suitable deformable thermoplastic material, such as TPE, may be formed in a thin layer and attached to inner layer with an appropriate adhesive, sonic welding, or by other means.
Housing 301 of dispenser 300 is an elongated hollow tubular structure extending along the longitudinal axis B-B from the proximal end 305 to the distal end 303. The housing 301 comprises an outer surface 314 and an inner surface 315 that forms an elongated internal chamber 316 for housing a pressurized product tube 317 containing an oral care material M. In one embodiment, proximal end 305 may be open before closure by end cap 306 attached thereto, thereby providing access to chamber 316 for insertion of the collapsible and squeezable product tube 317 with oral care material M. Proximal end 305 may further be closed by an end wall 406.
With continuing reference to
The sidewalls 403 define an internal reservoir 320 holding a volumetric amount of the oral care material M. In an undeformed state filled with oral care material M, sidewalls 403 of product tube 317 may be approximately circular in transverse cross-sectional shape at least in the middle and nozzled distal end 401 sections of the tube. The product tube 317 may assume a more flattened somewhat rectangular shape near the closed proximal end 400 (see, e.g.
Product tube 317 may be made of any suitable flexible material useable for forming squeeze tubes, such as without limitation extruded plastic squeeze tubes formed of HDPE (high density polyethylene) or LDPE (low density polyethylene). Other resilient polymers may be used.
Product tube 317 is filled with a desired flowable oral care material M, which can contain any active oral care agent and/or inactive ingredients. The oral care agent and/or its carrier may be in any form of a fluidic or flowable material including without limitation viscous pastes/gels or less viscous liquid compositions. Any suitable oral care material M can be stored in product tube 317 and used in the present invention. For example, the oral care material M may include any oral care agents such as without limitation oxidative or whitening agents with peroxide-containing chemical compositions which are well known in the art. Other contemplated fluidic oral care materials useable with the present invention include, without limitation: antibacterial agents; enamel strengthening or repair agents; tooth erosion preventing agents; anti-sensitivity ingredients; gum health actives; nutritional ingredients; tartar control or anti-stain ingredients; enzymes; sensate ingredients; flavors or flavor ingredients; breath freshening ingredients; oral malodor reducing agents; anti-attachment agents or sealants; diagnostic solutions; occluding agents; anti-inflammatory agents; dry mouth relief ingredients; catalysts to enhance the activity of any of these agents; colorants or aesthetic ingredients; dentifrice or toothpaste; and combinations thereof. In some embodiments, the oral care material M does not contain dentifrice or toothpaste and is instead contains active agents or ingredients that provide supplemental oral care benefits in addition to merely brushing one's teeth. Other suitable fluids could include lip balm or other similar materials that are typically available in a highly viscous semi-solid yet flowable state that may be extruded from collapsible bladder 317, as further described herein.
With continuing reference to
In certain alternative embodiments using a liquid and low viscosity oral care material M fluid, a porous applicator 302 may be provided which is constructed of a material that supports capillary fluid transport. Various porous polymeric foams or other suitable capillary materials may be used. In such embodiments, dispensing passageway 318 may be omitted as the entire porous applicator will conduct the fluidic oral care material M from the product tube nozzle 402 to the exposed surface on front wall 404 for application to the target oral tissue. Furthermore, in certain other embodiments, the dispensing passageway 318 can be located in other areas of the housing 301, such as on one of the longitudinal side walls of the dispenser 300 and/or applicator 302. In some embodiments, a plurality of dispensing passageways 318 can be provided. For example, the plurality of dispensing passageways 318 can be provided in a generally circular configuration that may be used to facilitate the fluid being dispensed through the applicator 302.
In one embodiment, applicator 302 may be formed of a soft resilient material, such as an elastomeric material. Suitable elastomeric materials include thermoplastic elastomers (TPE) or other similar materials used in oral care products. The elastomeric material of the outer layer may have a hardness durometer measurement ranging between A13 to A50 Shore hardness, although materials outside this range may be used. A suitable range of the hardness durometer rating is between A25 to A40 Shore hardness.
In alternative embodiments, the applicator 302 may be constructed of bristles, a porous or sponge material, or a fibrillated material. Suitable bristles include any common bristle material such as nylon or PBT. The sponge-like materials can be of any common foam material such as urethane foams. The fibrillated surfaces can be comprised of various thermoplastics. The invention, however, is not so limited and the applicator 302 can be any type of surface and/or configuration that can apply a viscous substance onto the hard surface of teeth, including merely an uncovered opening/passageway.
The applicator 302 may have a generally circular transverse cross section fitted at least partially into open distal end 303 of dispenser 300. Applicator 302 may be flushed mounted with the distal end 303 of dispenser 300 in some embodiments as shown in
Referring to
End wall 406 of dispenser housing 301 may optionally be configured to include a clamping member 410 disposed on an interior surface inside internal chamber 316 of the dispenser 300. Clamping member 410 may have a horizontally split structure with upper and lower halves configured to grip opposing sides of the proximal end 400 of product tube 317. This holds the tube in position during dispensing of the oral care material M from the tube via compression device 503. In some embodiments, clamping member 410 may be configured to also engage the proximal ends 509 of upper and lower pressure plates 500, 501 of the compression device 503 with the proximal end 400 of product tube 317 being sandwiched therebetween. In one embodiment, the proximal end 400 of product tube 317 and/or pressure plates 500, 501 may be releasably affixed to end wall 406 of dispenser housing 301. It will be appreciated that in other embodiments, clamping member 410 may be omitted.
The compression device 503 and the oral care material M dispensing mechanism will now be further described with reference to
Compression device 503 provides a compression mechanism configured to engage product tube 317 for automatically dispensing oral care material M from the 317. In one embodiment, compression device 503 includes an open front end 510, closed rear end 511, and an opposing pair of an upper pressure plate 500 and lower pressure plate 501 operably and resiliently coupled together. Each pressure plate 500, 501 is axially elongated and may be arcuately shaped in transverse cross section. In other embodiments, the plates may have straight cross sectional shape. The pressure plates 500, 501 are configured and operable to simultaneously engage opposing sidewalls 403 of product tube 317. This applies an inward directed compressive force Fc which places the contents of the product tube 317 (e.g. oral care material M) under a continuous positive pressure and ready for dispensing.
Each pressure plate 500, 501 includes a distal end 502, proximal end 504, and pair of axially extending longitudinal edges 505 defining an elongated longitudinally extending compartment 506 configured for insertion of product tube 317 between the plates. In one embodiment, the proximal ends 504 of the pressure plates 500, 501 are disposed proximate to each other and may be abutting. The distal ends 502 may be spaced apart to define the open front end 510 of the compression device 503 through which the product tube 317 may be axially inserted. Longitudinal edges 505 may have any suitable shape including straight. In one embodiment, the edges 505 may be ridged or scalloped.
The upper and lower compression pressure plates 500, 501 of compression device 503 may be formed of any suitable rigid material, including moldable hard plastic or metal. Injection molded hard plastics that may be used include polymers and copolymers of ethylene, propylene, butadiene, vinyl compounds and polyesters such as polyethylene terephthalate. Others materials may be used and the invention is not limited to any particular material of construction. Each pressure plate 500, 501 may be one piece having a unitary construction.
In one embodiment, the upper pressure plate 500 and lower pressure plate 501 may be resiliently coupled together by a pair of longitudinally extending elastomeric members 520. Each elastomeric member 520 is configured to engage mating opposing longitudinal edges 505 of upper and lower pressure plates 500, 501 along the lateral sides of the compression device 503. Elastomeric members 520 may each be continuous in structure and extend axially between the distal and proximal ends 502, 504 of the pressure plates 500, 501 without interruption for the entire length or nearly the entire length of the plates (see, e.g.
The elastomeric members 520 are deformable and stretchable by application of a force. Elastomeric members 520 have an elastic memory which returns the members to a non-deformed condition when the force is removed. Any suitable resilient material having an elastic memory may be used. In one non-limiting embodiment, the elastomeric members 520 may be made of thermoplastic elastomers (TPE). Preferably, the material selected for elastomeric members 520 has a tensile strength and tear properties suitable to allow the material to be stretched through a desired range of deformation in operation without breaking or experiencing excessive compression set (i.e. permanent deformation).
In one embodiment, each elastomeric member 520 may include a plurality of integrally formed elongated resilient anchors 521 permanently attached to the upper and lower pressure plates 500, 501 along opposite lateral sides of the plates. In one arrangement, the anchors 521 are attached along the longitudinal edges 505 of the pressure plates 500, 501. The anchors 521 may have a transversely elongated finger-like construction and configuration; however, other configurations of anchors 521 may be used. An upper and lower opposing row of anchors 521 may be provided for each elastomeric member 520 with the anchors in each row being are oriented transversely to the longitudinal axis B-B and extending in opposing transverse directions. Other suitable arrangements of anchors 521 may be used.
Anchors 521 form anchor points for attaching each elastomeric member 520 to an upper and lower pressure plate 500, 501 to resiliently couple the plates together along their longitudinal edges 505. Because the anchors 521 each have smaller axial width (measured along longitudinal axis B-B) than an entire elastomeric member 520, they are more resilient and stretchable in the transverse direction when the pressure plates 500, 501 are transversely pulled or pushed apart, as further described herein. In one embodiment, the anchors 521 may be spaced at intervals axially along a majority or substantially the entire length of the pressure plates 500, 501 as shown. Any suitable number of anchors 521 may be provided.
While an over-molding construction is one method that may be used for attaching the anchors 521 of the elastomeric members 520 to the upper and lower pressure plates 500, 501, other suitable methods may be used such as an appropriate adhesive, sonic welding, or others. It will also be appreciated that in other possible embodiments, the anchors 521 may be formed separately from the elastomeric members 520 and attached thereto by any suitable means, such as adhesives, sonic welding, or others.
In operation, the upper and lower pressure plates 500, 501 of compression device 503 are pivotably and resiliently movable apart and together in relation to each other about a pivot point P, as shown in
When a filled product tube 317 is positioned at least partially between the pressure plates 500, 501 (see, e.g.
To control and regulate dispensing of oral care material M from product tube 317, an actuator mechanism 600 is provided. In one embodiment shown in
The plug 604 includes a portion movably and slideably disposed in nozzle 402 to intercept the flow path of oral care material M between the distal end 401 of product tube 317 and terminal opening 319. In one non-limiting embodiment, the valve 602 may be a gate valve and plug 604 may be configured as a generally flat plate as shown. Other suitable types and configurations of valves and plugs may be provided. The plug 604 is slideably inserted through a pair of diametrically opposed transverse slots 614 formed through the top and bottom of the nozzle 402. The plug 604 may be configured to slide through both the top and bottom slots 614 such that the upper end of the plug may protrude upwards through the top slot and nozzle 402 (see, e.g.
Plug 604 further includes a flow orifice 612 which is transversely movable into and out of the nozzle 402 and its interior flow path for the oral care material M which is axially oriented along longitudinal axis B-B. In one embodiment, the orifice 612 may be disposed between the upper and lower ends of the plug 604 The actuator 600/valve 602 is movable between an open dispensing position wherein oral care material M is dispensed from product tube 317 when the orifice 612 is positioned inside the nozzle 402, and a closed non-dispensing position wherein oral care material M is blocked from being dispensed when the orifice is positioned outside at least the interior flow path through the nozzle. Because the contents of the product tube 317 are under pressure created by compression device 503 as described herein, oral care material M will be automatically dispensed when a user depresses operating button 608 (inwards against the force of spring 610 which is compressed) to activate the actuator 600. This moves the orifice 612 into concentric alignment with the nozzle 403 corresponding to the open dispensing position of actuator 600/valve 602, as shown in
In one embodiment, the components of valve 602 may be disposed inside distal end 303 of the dispenser housing 301 except for operating button 610 and adjoining portion of stem 606 which extends through the housing. The valve components may be made of any suitable materials, such as plastic (with possible exception of spring 610 which may be formed of spring steel). In one embodiment, the plug 604 and stem 606 may be of integral unitary construction.
In alternative or additional embodiments, the valve 602 may be located in dispenser 300 such that the plug 304 with flow orifice 614 is slideably insertable through the fluid passageway 318 in applicator 302 instead of the internal flow conduit 620 inside the product tube nozzle 402. In either construction, the plug 604 is operable to intercept and interrupt the flow of oral care product M from the tube 317 and dispenser 300 to prevent unintentional dispensing.
A method for dispensing oral care material M from dispenser 300 will now be summarized from the foregoing description. A dispenser 300 is first provided which is filled with oral care material M. The compression device 503 and pressure plates 500, 501 are in the open position shown in
To dispense oral care material M, a user depresses operating button 608 to active the actuator (see directional arrow). This in turn linearly translates the plug 604 of valve 602 in a first transverse direction, thereby further slideably inserting the plug through nozzle 402 to position and axially align flow orifice 612 inside the nozzle in the flow path of oral care material M, as shown in
When the actuator 600/valve 602 is in the open dispensing position, the compression device 503 squeezes and pushes the oral care material M inside product tube 317 forward and distally towards nozzle 402. The oral care material M now freely flows through valve flow orifice 612 and nozzle 402 into dispensing passageway 318, and then outwards from the applicator 302 for delivery to the target oral surfaces or an oral care implement such as toothbrush 100. With each dispensing action, the pressure plates 500, 501 move farther and farther towards the closed position shown in
During the foregoing dispensing action, it should be noted that the user may hold the operating button 608 inwards to continue to dispense a desired quantity of oral care material M. Releasing the operating button causes the valve 602 to automatically close under the biasing action of spring 610 and stop dispensing oral care material. This linearly translates the plug 604 of valve 602 in a second opposite transverse direction, thereby slideably removing the flow orifice 612 from inside the nozzle 402 and the flow path of oral care material M, as shown in
It will be appreciated that other forms of compression devices 503 beside the non-limiting exemplary embodiment disclosed herein may be used to pressurize the contents of product tube 317. For example, the internal chamber 316 of dispenser housing 301 may be hermetically sealed and pressurized with an inert gas at a suitable positive pressure to exert the inward compressive force Fc on the product tube 317. Other forms of elastomeric members 520 may be used or alternatively variously configured mechanical spring elements may be provided that are configured and arranged to maintain the product tube contents in a relatively continuous pressurized state. Accordingly, the compression device is not limited by the form or configuration of the device disclosed herein. The term “continuous” as used herein with respect to the pressure maintained in the product tube is intended to connote the tube contents are maintained under pressure, recognizing that the pressure may gradually decrease as the oral care material is dispensed over time.
The process of detaching and reattaching the dispenser from the toothbrush 200 will now be described. Referring initially to
In certain embodiments, the handle 210 of the toothbrush 200 will have a feature that enables the operating button 608 to fit within the cavity 280. Specifically, the inner surface 240 of the toothbrush 200 may include a slot or channel that receives the operating button 608 when the dispenser 300 is slidably inserted into the cavity 280 so that the operating button 608 is not depressed when the dispenser 300 is in the storage state. Such a slot or channel may extend from the proximal end 212 of the handle 200 a distance into the cavity 280 sufficient to enable the operating button 608 to slide within the slot or channel through the entire distance that the operating button 608 extends into the cavity 280.
In the exemplified embodiment, the entirety of the housing 301 of the dispenser 300, including the applicator 302, are located within the cavity 280 of the toothbrush 200 when the dispenser 300 is in the storage state. The end cap 306 of the dispenser 300, however, protrudes axially from the proximal end 212 of the handle 210 of the toothbrush 200. This allows a user to readily grasp, axially withdraw, and deploy the dispenser. In one embodiment, the end cap 306 may be dome shaped continues the natural curved contour of the handle 210. This conceals the dispenser 300 and provides a rounded proximal end to the oral care system 100, thereby providing a look that aesthetically resembles a traditional manual toothbrush. It will be appreciated that other suitable end cap 306 shapes may be provided.
To remove the dispenser 300 in the application state shown in
While the invention has been described with respect to specific examples including presently preferred modes of carrying out the invention, those skilled in the art will appreciate that there are numerous variations and permutations of the above described systems and techniques. It is to be understood that other embodiments may be utilized and structural and functional modifications may be made without departing from the scope of the present invention. Thus, the spirit and scope of the invention should be construed broadly as set forth in the appended claims.
Filing Document | Filing Date | Country | Kind |
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PCT/US2014/051128 | 8/14/2014 | WO | 00 |
Publishing Document | Publishing Date | Country | Kind |
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WO2016/024984 | 2/18/2016 | WO | A |
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Number | Date | Country | |
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20170245630 A1 | Aug 2017 | US |