Claims
- 1. A solid-support for use in simultaneously assaying for a blood serum-derived test substance and a blood serum-derived marker substance in oral fluid wherein the marker is always present in oral fluid comprising:
- a first region to which is attached a first binding agent effective to bind specifically to a blood serum-derived test substance in oral fluid;
- a second region to which is attached a second binding agent effective to bind specifically to a blood serum-derived marker substance in such oral fluid;
- means for visualizing test substance bound to said first region; and
- means for visualizing marker substance bound to said second region;
- whereby oral fluid containing the marker substance and not the test substance gives rise to a pattern on the solid-support surface that is distinguishable from a pattern that appears for oral fluid containing both the marker substance and the test substance.
- 2. The solid-support of claim 1, wherein
- said first and second regions are bar-shaped and overlap to form a "+" symbol.
- 3. A solid support of claim 1 wherein the serum-derived marker substance is albumin.
- 4. A solid support of claim 1 wherein the serum-derived marker substance is ceruloplasmin.
- 5. A solid support of claim 1 wherein the serum-derived marker substance is transferrin.
- 6. A solid support of claim 1 wherein at least one of the binding agents is an antibody.
Parent Case Info
This is a continuation of application Ser. No. 08/099,926, filed Aug. 3, 1993, now U.S. Pat. No. 5,479,937, which is a continuation-in-part of Ser. No. 07/935,845, filed Aug. 25, 1992, now U.S. Pat. No. 5,339,829, which is a continuation-in-part of Ser. No. 07/865,054, filed Apr. 8, 1992, now abandoned, which is a continuation-in-part of Ser. No. 07/641,739, filed Jan. 15, 1991, now U.S. Pat. No. 5,103,836, which is a continuation-in-part of Ser. No. 07/486,415, filed Feb. 28, 1990, now abandoned, which is a continuation-in-part of Ser. No. 07/410,401, filed Sep. 21, 1989, now U.S. Pat. No. 5,022,409.
US Referenced Citations (6)
Non-Patent Literature Citations (3)
Entry |
Parry, J.V., et al., "Sensitive Assays for Viral Antibodies in Saliva: An Alternative to Tests on Serum." The Lancet, pp. 72-75 (Jul. 11, 1987). |
Thieme, T., et al., "Clinical Evaluation of Oral Fluid Samples for Diagnosis of Viral Hepatitis." J. Clin. Microbiol. vol. 30, No. 5, pp. 1076-1079 (May 1992). |
Thieme, T. et al., "Oral Fluid Sampling for Determination of HIV-I Antibody Serostatus." Abstract from VIII Int'l. Conf. on AIDS, p. C328 (Jul. 1992). |
Continuations (1)
|
Number |
Date |
Country |
Parent |
99926 |
Aug 1993 |
|
Continuation in Parts (5)
|
Number |
Date |
Country |
Parent |
935845 |
Aug 1992 |
|
Parent |
865054 |
Apr 1992 |
|
Parent |
641739 |
Jan 1991 |
|
Parent |
486415 |
Feb 1990 |
|
Parent |
410401 |
Sep 1989 |
|