Claims
- 1. An oral formulation comprising a biguanide and an organic acid, wherein the organic acid is a member selected from the group consisting of malic acid, citric acid, tartaric acid, succinic acid, fumaric acid, maleic acid, gluconic acid, glucuronic acid and mixtures thereof.
- 2. An oral formulation according to claim 1, wherein the organic acid is a member selected from the group consisting of malic acid, citric acid, tartaric acid and mixtures thereof.
- 3. An oral formulation according to claim 1, further comprising a sweetening agent.
- 4. An oral formulation according to claim 1, further comprising L-aspartyl-L-phenylalanine methyl ester, saccharine, saccharine sodium,'stevioside or a mixture thereof.
- 5. An oral formulation according to claim 3, wherein the ratio (w/w) of the biguanide to the sweetening agent is 1:0.001 to 1:10.
- 6. An oral formulation according to claim 1, wherein the biguanide is a member selected from the group consisting of metformin, buformin, phenformin and pharmaceutically acceptable salts thereof.
- 7. An oral formulation according to claim 1, wherein the biguanide is metformin or a pharmaceutically acceptable salt thereof.
- 8. An oral formulation according to claim 1, wherein the ratio (w/w) of the biguanide to the organic acid is 1:0.01 to 1:50.
- 9. An oral formulation according to any one of claims 1 to 8, wherein the formulation is a member selected from the group consisting of a solution, jelly, gum drops, dry syrup, powders, fine granules or granules.
- 10. An oral formulation according to claim 9, which is in the form of a solution wherein the pH of the solution is 3.5 to 6.
- 11. An oral formulation according to claim 9, which is not in the form of a solution and the pH of the solution or dispersion which is formed by dispersing 1 part of the formulation in 10 parts by weight of water is 3.5 to 6.
- 12. A method of masking an unpleasant taste of a biguanide, comprising adding an organic acid to an oral formulation containing the biguanide.
Priority Claims (1)
Number |
Date |
Country |
Kind |
10-136126 |
Apr 1998 |
JP |
|
Parent Case Info
This application is the national phase under 35 U.S.C. §371 of PCT International Application No. PCT/JP99/02192 which has an International filing date of Apr. 26, 1999, which designated the United States of America.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/JP99/02192 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO99/55320 |
11/4/1999 |
WO |
A |
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