Claims
- 1. Process for preventing or inhibiting the adherent deposition of cariogenic or other oral bacteria and plaque formed therefrom on teeth, which process comprises applying to the teeth an oral hygiene composition comprising an effective among of at least one polymer has a molecular weight of at least about 5000 and units of general structure A ##STR32## and one or more repeating units of general structure B ##STR33## wherein X, which in the repeating units of structure A may be the same or different, and Y, which is the repeating units of structure B may be the same or different, are unsubstituted hydrocarbyl residues or residues substituted with groups such as hydroxy, alkoxy and halogen provided that the desired properties of the polymer are not adversely effected by such substituents, said residues providing a backbone for the polymer;
- R.sup.1, which in the same repeating unit of structure B (when n or q is 2 or more) or in different repeating units of structure B may be the same or different, is hydrogen or methyl;
- R.sup.2, which in the same repeating unit of structure B (when n or q is 2 or more) or in different repeating units of structure B may be the same or different, is hydrogen or methyl;
- except that R.sup.1 and R.sup.2 in a single unit (CHR.sup.1 CHR.sup.2 O) cannot both be methyl;
- R.sup.3, which in the same repeating unit of structure B (when q is 2 or more) or in different repeating units of structure B may be the same or different, is hydrogen, or a lower alkyl group containing up to 5 carbon atoms, or an acyl groups derived from an alkanoic acid having up to 5 carbon atoms;
- n is a number of from 1 to 60;
- p is a number of from 1 to 4, and q is a number of from 1 to 4; and wherein each (CH.sub.2 H) group is joined via an intermediary or intermediaries L to the hydrocarbon residue X, and in cases where
- p is 2 to 4 may be joined by 1 to the same or different carbon atoms of x;
- and wherein L represents one or more intermediaries, and wherein L may be the same or different in the repeating units of structure A and is selected from one or more direct links and one or more groups of atoms each group providing a chain of one or more atoms for linking a (Co.sub.2 H) group with X, except that more than two (CO.sub.2 H) groups cannot be directly linked to the same carbon atom in X;
- and wherein each (CHR.sup.1 CHR.sup.2 O).sub.n group is joined via an intermediary or intermediaries M to the hydrocarbyl residue Y, and in cases where q is 2 to 4 may be joined to the same or different carbon atoms of Y;
- and wherein M represents one or more intermediaries, and wherein M may be the same ox different in the repeating units of structure B and is selected from one or more direct links and one or more groups of atoms each group providing a chain of one or more atoms for lining a (CHR.sup.1 CHR.sup.2 O).sub.n group with Y, except that more than two (CHR.sup.1 CHR.sup.2 O) groups cannot be directly linked to the same carbon atom in Y;
- and wherein the ratio of the member of --CO.sub.2 H groups to the number of --CHR.sup.1 CHR.sup.2 O-- groups is within the range of from 1:20 to 20:1; and said composition also comprising a pharmaceutically acceptable vehicle for said polymer.
- 2. A process according to claim 1 wherein said process is present therein at a concentration of 0.05 to 30 weight % of the composition.
- 3. A process according to claim 1 in the form of a mouthwash, rinse, irrigating solution, abrasive or nonabrasive gel dentifrice, denture cleaner, coated dental floss, toothbrush bristle coating or impregnant, interdental stimulator coating, chewing gum, lozenge, breath freshener, foam or spray.
- 4. A process according to claim 1 wherein L is selected from one or more direct links and one or more groups of atoms each providing a chain of one or more carbon and/or hetero atoms.
- 5. A process according to claim 1 wherein m is selected from one or more groups of atoms each group providing a chain of one or more carbon and/or hetero atoms.
- 6. A process according to claim 5 wherein M is selected from one or more --COO-- and --CONH-- groups.
- 7. A process according to claim 1 wherein p in structure A is 1 or 2.
- 8. A process according to claim 1 wherein q in structure B is 1 or 2.
- 9. A process according to claim 1 wherein structure A is the repeat unit derived from the polymerization of a polymerizable olefinically unsaturated carboxylic acid.
- 10. A process according to claim 9 wherein said acid is acrylic acid, methacrylic acid, maleic or fumaric acid, N-methacryloyl alanine, or U-acryloyl hydroxy glycine, whereby the corresponding structures A are respectively: ##STR34##
- 11. A process according to claim 1 wherein structure B is the repeating unit derived from the polymerization of a polymerizable olefinically unsaturated ester or amide formed from an olefinically unsaturated carboxylic acid (or an esterifiable or amidifiable derivative thereof) and a hydroxy compound of formula HO--CHR.sup.1 CHR.sup.2 O).sub.n R.sup.3 (to form the ester) or an amine of formula H.sub.2 N--(CHR.sup.1 CHR.sup.2 O).sub.n R.sup.3 (to form the amide).
- 12. A process according to claim 11 wherein the acid used for the ester or amide formation is methacrylic acid, and the corresponding structure B are respectively: ##STR35##
- 13. A process according to claim 1 wherein both structures A and B are the repeat units resulting from the partial esterification or amidification of an already-polymerized olefinically unsaturated carboxylic acid (or an esterifiable or amidifiable derivative thereof) using an alcohol of formula HO--(CHR.sup.1 CHR.sup.2 O).sub.n R.sup.3 or an amide of formula H.sub.2 N--(CHR.sup.1 CHR.sub.2 O).sub.n R.sup.3.
- 14. A process according to claim 13 wherein already-polymerised acid or acid derivative is the polymerized acid anhydride of maleic acid, or repeat unit ##STR36## and the resulting repeating units A and B after esterification or amidification comprising respectively ##STR37##
- 15. A process according to claim 1 wherein substantially all the R.sup.1 and R.sup.2 groups are hydrogen so that (CHR.sup.1 CHR.sup.1 O).sub.n is (CH.sub.2 CH.sub.2 O).sub.n.
- 16. A process according to claim 1 wherein one or more of, or all of, the R.sup.1 groups or one or more of, or all of, the R.sup.2 groups in one more of the (CHR.sup.1 CHR.sup.2 O).sub.n chains are methyl.
- 17. Process for preventing or inhibiting the adherent deposition of cariogenic or other oral bacterial and plaque formed therefrom on teeth, which process comprises applying to the teeth an effective amount of a composition comprising at least one polymer and a pharmaceutically acceptable vehicle for said polymer, which polymer has a molecular weight of at least about 5000 and comprises repeating units of structure A and repeating units of structure B, wherein said polymer comprises one of the following pairs of structures for A and B:
- __________________________________________________________________________A B__________________________________________________________________________ ##STR38## ##STR39## ##STR40## ##STR41## ##STR42## ##STR43## ##STR44## ##STR45## ##STR46## ##STR47## ##STR48## ##STR49## ##STR50## ##STR51## ##STR52## ##STR53##__________________________________________________________________________ wherein the ratio of --CO.sub.2 H groups to --CHR.sup.1 CH.sub.2 O-- groups (where R.sup.1 is H or methyl as depicted above) is from 1:20 to 20:1.
- 18. A process according to either of claims 1 and 17 wherein said polymer has a weight average molecular weight within the range of from 5000 to 500,000.
- 19. A process according to either of claims 1 and 17 wherein the backbone of said polymer is derived from said repeating units A and said remaining units B and 0 to 50% w/w of at least one other repeating unit structure which does not adversely affect the properties of the oral hygiene composition.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8428523 |
Nov 1984 |
GBX |
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Parent Case Info
This is a division of application Ser. No. 07/016,257, filed Feb. 19, 1987 now abandoned, which, in turn, is a division of Ser No. 06/793,763, filed 11/1/85, now abandoned.
US Referenced Citations (7)
Divisions (2)
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Number |
Date |
Country |
Parent |
16257 |
Feb 1987 |
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Parent |
793763 |
Nov 1985 |
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