ORGAN CROPRESERVATION USING MOLECULAR ICE CONTROL

Information

  • Research Project
  • 6643294
  • ApplicationId
    6643294
  • Core Project Number
    R43DK064488
  • Full Project Number
    1R43DK064488-01
  • Serial Number
    64488
  • FOA Number
  • Sub Project Id
  • Project Start Date
    8/1/2003 - 21 years ago
  • Project End Date
    1/31/2005 - 19 years ago
  • Program Officer Name
    HEART, LUNG, AND BLOOD INST., NATIONAL
  • Budget Start Date
    8/1/2003 - 21 years ago
  • Budget End Date
    1/31/2005 - 19 years ago
  • Fiscal Year
    2003
  • Support Year
    1
  • Suffix
  • Award Notice Date
    7/25/2003 - 21 years ago

ORGAN CROPRESERVATION USING MOLECULAR ICE CONTROL

[unreadable] DESCRIPTION (provided by applicant): [unreadable] Donated organs are used to extend life for thousands of people each year. Unfortunately, the availability of donor organs is greatly outweighed by current demand causing enormous shortages. The problem is compounded by the time critical nature of transplantation as the organ health begins to deteriorate rapidly during transport from donor to recipient. A mechanism that provided open-ended storage periods for donated organs would eliminate the detrimental effects of prolonged cold ischemia and improve organ transplant success by lifting time limits for improved tissue-typing and extended immunological preconditioning. The objective of this study is to determine if a new cryopreservation method using molecular ice control technology in a vitrification process can successfully block ice formation during preservation and permit long-term storage in a rat kidney model. We will evaluate vitrification solutions formulated with natural and synthetic molecular ice blocking compounds that are capable of limiting ice nucleation and growth. In this proposal, both in vitro and in vivo studies will be conducted to assess the viability and function of rat kidneys following vitrification with molecular ice control formulations and a standard vitrification solution. It is anticipated that solutions containing molecular ice control compounds will experience less ice formation than a standard vitrification solution and result in better renal function following transplantation. [unreadable] [unreadable]

IC Name
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • Activity
    R43
  • Administering IC
    DK
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    130342
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    847
  • Ed Inst. Type
  • Funding ICs
    NIDDK:130342\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    ORGAN RECOVERY SYSTEMS, INC.
  • Organization Department
  • Organization DUNS
  • Organization City
    CHARLESTON
  • Organization State
    SC
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    294035000
  • Organization District
    UNITED STATES