Claims
- 1. A method for preparation of a medicament with immunomodulating activity which comprises adding to a pharmaceutical composition for parenteral, peroral, topical administration, or inhalation as an active ingredient a salt of an organic base and N,N'-diacetyl cystine having the formula: ##STR2## or a hydrate or a solvate thereof, wherein the organic base, R.sup.+ or R.sup.2, is selected from the group consisting of lysinium, ethylenediaminium, N,N'-dibenzylethylenediaminium, N-benzyl-2-phenylethylaminium, piperazinium and 1-adamantanaminium.
- 2. The method for the preparation of a medicament according to claim 1, wherein the active ingredient is useful for the treatment of malignant diseases.
- 3. The method for the preparation of a medicament according to claim 1, wherein the active ingredient is useful for the treatment of chronic bronchitis, rheumatoid arthritis, hepatitis, asthma, rhinitis, atherosclerosis, HIV infection or AIDS.
- 4. The method of preparation of a medicament according to claim 1, wherein the active compound is added in dry micronized crystal form to the pharmaceutical composition for inhalation.
- 5. The method of preparation of a medicament according to claim 4, wherein the crystalline compound has a dosage of 0.1-1.0 mg.
Priority Claims (1)
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9103572 |
Nov 1991 |
SEX |
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Parent Case Info
This application is a divisional of application Ser. No. 08/335,941, filed on Nov. 8, 1994, which is a continuation of application Ser. No. 07/981,373, filed Nov. 25, 1992, issued as U.S. Pat. No. 5,385,904 on Jan. 31, 1995.
US Referenced Citations (11)
Foreign Referenced Citations (6)
Number |
Date |
Country |
0300100 |
Jan 1989 |
EPX |
2503151 |
Apr 1981 |
FRX |
155298 |
Dec 1981 |
JPX |
62-195356 |
Aug 1987 |
JPX |
9118594 |
Dec 1991 |
WOX |
9221362 |
Dec 1992 |
WOX |
Non-Patent Literature Citations (2)
Entry |
Marshall, et al. "Preparation and Properties of the Isomeric Forms of Cystine and S-Benzylpenicillamine," J. Amer. Chem. Soc. 79: 4538-4544, 1957. |
Greenstein, et al. "Ammonia Formation from Cystine Peptides and Dehydropeptides in Rat Liver Digests," Arch. of Biochem. 18: 377-82, 1948. |
Divisions (1)
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Number |
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335941 |
Nov 1994 |
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Continuations (1)
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Parent |
981373 |
Nov 1992 |
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