Organization and Function of Visual Cortical Feedback Systems

Information

  • Research Project
  • 10220039
  • ApplicationId
    10220039
  • Core Project Number
    R01EY022577
  • Full Project Number
    5R01EY022577-10
  • Serial Number
    022577
  • FOA Number
    PA-16-160
  • Sub Project Id
  • Project Start Date
    5/1/2012 - 12 years ago
  • Project End Date
    8/31/2022 - 2 years ago
  • Program Officer Name
    FLANDERS, MARTHA C
  • Budget Start Date
    9/1/2021 - 3 years ago
  • Budget End Date
    8/31/2022 - 2 years ago
  • Fiscal Year
    2021
  • Support Year
    10
  • Suffix
  • Award Notice Date
    9/1/2021 - 3 years ago

Organization and Function of Visual Cortical Feedback Systems

Project Summary Visual perception is mediated by complex interactions amongst neurons in the retina, visual cortex, and subcortical brain structures. The importance of vision to humans and other primates is reflected in the enormous percentage of cerebral cortex devoted to processing visual information. Thus, deficits in visual processing are particularly debilitating and arise from abnormalities not only in the eye, but also in cortical circuitry. For example, strabismus or amblyopia during childhood can have long-lasting effects on the cortical circuits that process visual information. There is also evidence that some forms of dyslexia result from central visual system abnormalities. The function of the nervous system is dependent on complex interactions between networks of neurons composed of multiple neuron types across multiple cortical areas. The proposed studies are aimed at revealing the organization and functional impact of local and long-distance feedback connections within and between mouse visual cortical areas. These studies are conducted in mice to take advantage of the range of molecular, genetic, and viral tools that can be used to elucidate brain circuits and link them to function using optogenetic and imaging methods. The 2 aims will reveal: the fine-scale organization of V1 microcircuits linking cortical layers 2/3 and 5, and the functional impact of feedback from layer 5 to layer 2/3; and the organizational principles and functional impact of cortico-cortical feedback.

IC Name
NATIONAL EYE INSTITUTE
  • Activity
    R01
  • Administering IC
    EY
  • Application Type
    5
  • Direct Cost Amount
    269425
  • Indirect Cost Amount
    253260
  • Total Cost
    522685
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    867
  • Ed Inst. Type
  • Funding ICs
    NEI:522685\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    SPC
  • Study Section Name
    Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section
  • Organization Name
    SALK INSTITUTE FOR BIOLOGICAL STUDIES
  • Organization Department
  • Organization DUNS
    078731668
  • Organization City
    La Jolla
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    920371002
  • Organization District
    UNITED STATES