Organotin compounds and pesticides containing them

Abstract

A compound of the formula: ##STR1## in which R.sup.1 represents alkyl, cycloalkyl or aralkyl, R* represents fluorophenyl or trifluoromethylphenyl when R.sup.1 is alkyl; R* represents dichlorophenyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR2## wherein R.sup.2 represents halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is cycloalkyl; or R* represents 2-thienyl, 3-thienyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR3## wherein R.sup.3, R.sup.4 and R.sup.5 independently represent halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is aralkyl, m represents 1 or 2, and X represents halogen, imidazolyl, triazolyl, phenylthio or a radical selected from the group consisting of: ##STR4## wherein R.sup.6 represents alkyl, R.sup.7 and R.sup.8 independently represent lower alkyl and R.sup.9 and R.sup.10 independently represent hydrogen or lower alkyl when m is 1; or they independently represent oxygen, sulfur or a radical selected from: ##STR5## A process for preparing the compound (I) and a pesticidal composition containing the compound (I) are also provided.

Description

This invention relates to novel asymmetric triorganotin compounds, to their preparation and to pesticidal compositions containing the novel compounds.

There exist a wide variety of pests which are parasitic on plants. Among them, mites (Acarina) do considerable damage to a wide range of crops and garden plants, which causes a serious problem in agricultural management. Since such phytophagous mites rapidly acquire a tolerance to pesticides, novel and efficient pesticides have continuously been sought.

Organic compounds which are known to be useful for controlling such mites include, for example, cyhexatin (Plictran.RTM., U.S. Pat. No. 3,264,177) and fenbutatin oxide (Osadan.RTM., U.S. Pat. No. 3,657,451). However, such known compounds have drawbacks that their pesticidal activities varies depending on species of pests, and that they do not inhibit a certain species of spider mites because of the acquired tolerance.

In view of the above, the present inventors have made extensive study on organotin compounds in order to find effective compounds exhibiting pesticidal activity, in particular, those effective to the spider mites which have already acquired a tolerance against the existing pesticides. As a result of the study, it has been found that the asymmetric triorganotin compounds of the formula (I) below exhibit an excellent pesticidal activity, in particular, to the spider mites exhibiting tolerance against the known organotin compounds.

Thus, the present invention provides assymmetric triorganotin compounds having pesticidal activity of the formula (I): ##STR6## in which R.sup.1 represents alkyl, cycloalkyl or aralkyl, R* represents fluorophenyl or trifluoromethylphenyl when R.sup.1 is alkyl; R* represents dichlorophenyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR7## wherein R.sup.2 represents halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is cycloalkyl; or R* represents 2-thienyl, 3-thienyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR8## wherein R.sup.3, R.sup.4 and R.sup.5 independently represent hydrogen,halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is aralkyl, m represents 1 or 2, and X represents halogen, imidazolyl, triazolyl, phenylthio or a radical selected from the group consisting of: ##STR9## wherein R.sup.6 represents alkyl, R.sup.7 and R.sup.8 independently represent lower alkyl and R.sup.9 and R.sup.10 independently represent hydrogen or lower alkyl when m is 1; or they independently represent oxygen, sulfur or a radical selected from: ##STR10##

For purposes of the present invention, as disclosed and claimed herein, the following terms are as defined below.

The term "alkyl" refers to a straight or branched saturated hydrocarbon radical having one to twelve carbon atoms, including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, tert-pentyl, neopentyl, 1-methylbutyl, 1,2-dimethylbutyl, hexyl, heptyl, octyl, nonyl, decyl, and the like.

The term "lower alkyl" refers to an alkyl radical having less than six carbons, of the above defined alkyl.

The term "aralkyl" refers to an alkyl substituted by an aryl radical and includes benzyl, phenylethyl, phenylpropyl, methylbenzyl, neophyl, and the like.

The term "cycloalkyl" refers to a saturated hydrocarbon ring having three to ten carbon atoms, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, and the like.

The term "halogen" means chloro, bromo, iodo and fluoro.

The term "pests" herein used should be considered to mean both insects and mites harmful to plants, especially phytophagous ones, and, the term "pesticides" or "pesticidal composition" to include insecticides and acaricides.

The process for the preparation of the compounds of the formula (I) will be detailed below.

The compounds (I) wherein X is halogen, which will hereinafter be referred to as compound (Ia), can be prepared according to the following Reaction Scheme I, whereas the other compounds (I) wherein X is other than halogen can be prepared from the compounds (Ia) according to the Reaction Schemes II to IV hereinafter described. ##STR11## In the above scheme, R* and R.sup.1 are as previously defined, Hal, Y.sup.1 and Y.sup.2 are each chlorine, bromine or iodine, and n is 1 or 2, with the proviso that when n is 1, R* is a silicon-containing group and when n is 2, R* is an aryl or neopentyl group. The reactions are detailed below.

1st step

A compound (II) is reacted with an organotin halide (III) at a temperature from about 5.degree. C. to 100.degree. C. in a suitable solvent to yield an asymmetric tetraorganotin compound of the general formula (IV). Preferred solvents are ethers such as diethyl ether, dibutyl ether, tetrahydrofuran and the like.

The starting compound (II) may be conventionally prepared under the conditions usually employed for the preparation of a Grignard reagent.

The starting organotin halide of the general formula (III) wherein n is 2 can be represented by the formula:

(R.sup.1).sub.2 Sn(Y.sup.2).sub.2 and may be prepared by redistribution reaction between a corresponding symmetric tetraorganotin compound of the formula: (R.sup.1).sub.4 Sn wherein R.sup.1 is as defined above, and a stannic halide according to known procedures. The asymmetric phenyldiorganotin halide, which corresponds to the starting compound of the formula (III) wherein n equals to 1 and has the formula: (R.sup.1).sub.2 Sn(Phe)Y.sup.2 is itself an objective compound of the present invention and, therefore, may be prepared from the aforementioned starting compound (III) wherein n is 2, in accordance with the Reaction Scheme I.

2nd step

Halogenation of the asymmetric tetraorganotin compound of the formula (IV) is convertionally carried out by direct addition of a gaseous halogen, or by addition of halogen dissolved in a suitable solvent, to a solution of the asymmetric tetraorganotin compound dissolved in the same solvent, while maintaining the reaction temperature at -50.degree. C. to 30.degree. C. Suitable solvents employed in the reaction include chloroform, carbon tetrachloride, benzene, toluene, heptane, hexane, and the like. Chloroform and carbon tetrachloride are especially preferred.

A preferred molar ratio of the asymmetric tetraorganotin compound (IV) and halogen is about 1:1. The reaction temperature is preferably maintained in the range of -10.degree. C. to 10.degree. C.

The reaction terminates when the addition of halogen or a halogen solution is complete. The reaction mixture is concentrated, and the desired compound is separated and purified by recrystallization, vacuum distillation or column chromatography, if necessary. The asymmetric triorganotin halides (Ia) thus prepared are liquid or solid at room temperature.

These halides (Ia) are easily converted to other objective compounds (I) of the invention, such as hydroxides, bis(asymmetric triorganotin)oxides and other various derivatives as shown in the following Reaction Schemes, by known procedures. ##STR12##

In the above schemes, R*, R.sup.1, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10 and Hal are as defined previously, Az is 1,3-imidazol-1-yl or 1,2,4-triazol-1-yl. Desirable conditions for the reactions shown in the above schemes are known in the art, and disclosed, for example, by R. Inhan, Chemical Reviews, 459-539, 1960(October).

The compounds of formula (I) of the present invention exhibit an excellent pesticidal activity against phytophagous pests of various orders, such as Acarina, Lepidoptera, Hemiptera, Coleoptera, Orthoptera and Diptera. In particular, the compounds (I) exhibit an excellent inhibiting activity against a wide variety of acarina such as citrus red mite (Panonychus citri), European red mite (Panonychus ulmi), hawthorn spider mite (Tetranychus viennensis), Kanzawa spider mite (Tetranychus kanzawai), citrus flat mite (Brevipalpus lewisi), privet mite (Brevipalpus obovatus) and pink citrus rust mite (Aculops pelekassi). Moreover, the compounds (I) exert no harm, or only minor harm which is easily repaired, on crops and garden plants.

A certain class of spider mites, for example the kanzawa spider mite, shows resistance to known acaricides, cyhezatin (Plictran.RTM., Dow Chemical Co., see U.S. Pat. No. 3,264,177), and fenbutatin oxide (Osadan.RTM., Shell Oil Co., see U.S. Pat. No. 3,657,451). The compounds (I) of the invention, as stated before, show an excellent inhibiting activity even to the mites having resistance against such known acaricides.

Therefore, the present invention also provides a pesticidal composition which comprises as an active ingredient a compound of formula (I) together with a suitable carrier and/or adjuvant.

The pesticidal composition of the invention can be in any desirable form, such as wettable powders, emulsifiable concentrates, dusts or flowables, and prepared by mixing a compound (I) with one or more of non-phytotoxic carriers or adjuvants in accordance with conventional methods in the art. Such carriers and adjuvants include various liquid substances such as organic solvents and water, surfactants, granular or fine solid substances, and the like.

Wettable powders may be obtained by mixing a compound (I) with a solid carrier, such as clay, talc, white carbon, diatomaceous earth or bentonite, an ionic or nonionic emulsifier or dispersing agent, such as higher alkoxysulfonate, polyoxyehtylenesorbitan, alkylphenoxypolyethoxyethanol or lignosulfonate, and if required, wetting agents, protective colloid and the like. Emulsifiable concentrates may be obtained by dissolving a compound (I) in a suitable organic solvent and then adding thereto an appropriate surfactant. The emulsifiable concentrates can exist as water-in-oil concentrates or as oil-in-water concentrates having a high concentration comparable to a condensed mayonnaise.

The pesticidal compositions of the invention may be employed alone or after mixing with other acaricidal, insecticidal, or fungicidal compositions, plant growth regulator, fertilizer or the like.

The content of the compound (I) in the pesticidal composition in the form of wettable powder or emulsifiable concentrate is generally from 7 to 70 percent by weight, preferably from 20 to 50 percent by weight. The amount of the composition to be applied to loci of pests will vary depending on a number of factors, such as a method, season or locus of application, species of pests and crops, and the like. However, the composition is usually applied at the application rate of 200 to 600 liter per 10 are, after diluted to 500 to 10,000 fold, preferably 1,000 to 5,000 fold.

Dust compositions usually contain from 0.5 to 10 percent, preferably from 2 to 5 percent by weight of the compound (I), and are applied at application rate of from 3 to 5 kg per 10 are. Fine dust compositions contain the compounds (I) in the range of from 0.5 to 10 percent, preferably 1 to 5 percent by weight, and are applied at the rate in the range of from 1.5 to 5 kg per 10 are.

The following detailed Examples, Formulations and Experiments are presented by way of illustration of certain specific embodiments of the invention.

EXAMPLE 1

Dineophyl-metatrifluoromethylphenyltin fluoride (compound 1)

(1) Dineophyl-di(metatrifluoromethylphenyl)tin

A 1,000 ml four-necked flask equipped with a stirrer, a thermometer, a dropping funnel and a condenser was charged with magnesium (12.5 g, 0.51 mol) and flushed with nitrogen. Each 3 ml of a mixture of metatrifluoromethylphenyl bromide (113.4 g, 0.504 mol) and tetrahydrofuran (220 g) was portionwise added from the dropping funnel. The reaction occurred with fuming when the mixture was heated to 60.degree.-70.degree. C. While the temperature of the solution was maintained at 60.degree. C., the solution of metatrifluoromethylphenyl bromide dissolved in tetrahydrofuran was added dropwise over about 2 hours.

After completion of the addition, the mixture was refluxed for 5 hours and then cooled to room temperature. Next, a solution of dineophyltin dichloride (85.6 g, 0.188 mol) dissolved in tetrahydrofuran (200 g) was dropwise added from a dropping funnel over 30 minutes, while maintaining the temperature at 10.degree. to 20.degree. C. After the addition, the mixture was kept at the reflux temperature for 7 hours. The mixture was then cooled to room temperature and hydrolyzed by the addition of a saturated aqueous ammonium chloride solution. The organic layer was separated, washed with water, filtered and concentrated under reduced pressure to yield a brown viscous liquid. To this substance was added n-hexane (300 g) and activated clay (50 g) for decolorization. The mixture was filtered and concentrated under reduced pressure to obtain 118 g of dineophyl-di(metatrifluoromethylphenyl)tin as a colorless, clear and viscous liquid. Analysis by gas chromatography of the viscous liquid showed 95% purity. Tin content was 17.2% (theoretical: 17.6%).

(2) Dineophyl-metatrifluoromethylphenyltin fluoride

A 500 ml four-necked flask with a stirrer, a thermometer, a dropping funnel and a condenser was charged with dineophyl-dl(metatrifluoromethylphenyl)tin (80 g, 0.118 mol) obtained in Example 1-(1) and chloroform (200 g). A mixture of bromine (19 g, 0.216 gram atom) and chloroform (100 ml) was dropwise added from the dropping funnel over about 2.5 hours with stirring, while maintaining the temperature of the reaction mixture at -5.degree. to 0.degree. C. After completion of the addition, the mixture was allowed to warm to room temperature, filtered and concentrated under reduced pressure to give 72.2 g of dineophyl-metatrifluoromethylphenyltin bromide as a viscous liquid. The purity of the liquid was 93% based on a gas chromatography analysis. Crude dineophyl-metatrifluoromethylphenyltin bromide (72.2 g) thus prepared, benzen (120 g), potassium fluoride (14 g) and water (56 g) were charged into a 500 ml three-necked flask, and the mixture was refluxed for 2 hours. After completion of the reaction, the aqueous layer was separated off and the organic layer was washed with water, filtered and concentrated under reduced pressure. The resulting residue was crystallizred from n-hexane at the temperature of -20.degree. C. to obtain 33.8 g of dineophyl-metatrifluoromethylphenyltin bromide. This substance was a liquid at room temperature and has a refractive index of n.sup.30 =1.5555. Tin content was 21.1% (theoretical: 21.6%).

EXAMPLE 2

Bis(dineophyl-metatrifluoromethylphenyltin)oxide (Compound 3)

Dineophyl-metatrifluoromethylphenyltin fluoride (13 g, 23.7 mmol) obtained in Example 1 was dissolved in benzene (60 g). To the resultant solution was added a 20% aqueous sodium hydroxide solution (7.2 g), and the mixture was allowed to react for one hour at a temperature between 75.degree. C. and 80.degree. C. After completion of the reaction, the aqueous layer was removed and the organic layer was washed with water and filtered. The benzene was distilled of from the organic layer under reduced pressure to yield 11.8 g of bis(dineophyl-metatrifluoromethylphenyltin)oxide as a pale-yellow viscous liquid. Refractive index: n.sup.30 =1.5651; Tin content: 21.9% (theoretical: 22.1%).

EXAMPLE 3

Dineophyl-metatrifluoromethylphenyltin acetate (compound 5)

Bis(dineophyl-metatrifluoromethylphenyltin)oxide (6 g, 5.57 mmol) prepared in Example 2 was dissolved in n-hexane (30 g). To this solution was added glacial acetic acid (0.67 g, 11.16 mmol), and the mixture was heated at temperature of 70.degree. to 75.degree. C. for one hour to effect an azeotropic dehydration. After completion of the reaction, the mixture was filtered, and n-hexane was distilled off from the filtrate to obtain 6.4 g of dineophyl-metatrifluoromethylphenyltin acetate as a pale-yellow viscous liquid. Refractive indes: n.sup.30 =1.5465. Tin content: 20.1% (theoretical: 20.1%).

EXAMPLE 4

Dineophyl-metatrifluoromethylphenyltindimethyldithiocarbamate (compound 6)

Dineophyl-metatrifluoromethylphenyltin fluoride (10 g, 18.2 mmol) prepared in Example 1 was dissolved in benzene (50 g), and the resulting solution was added with a solution of sodium dimethyldithiocarbamate dihydrate (3.9 g, 21.8 mmol) dissolved in water (15.6 g). The mixture was heated at a temperature of from 75.degree. to 80.degree. C. for one hour. The aqueous layer was removed and the organic layer was washed with water and filtered. The filtrate was distilled to remove the benzene under reduced pressure and the resultant residue was recrystallized from petroleum ether to give 11.4 g of dineophyl-metatrifluoromethylphenyltindimethyldithiocarbamate as a white solid.

Mp: 96.degree.-97.degree. C. Tin content: 18.1% (theoretical: 18.2%).

EXAMPLE 5

Dineophyl-orthotrifluoromethylphenyltin chloride (compound 25)

Dineophyl-diorthotrifluoromethylphenyltin (113 g), a pale-yellow viscous liquid, was prepared in accordance with the teaching of Example 1 except that orthotrifluoromethylphenyl bromide (113.4 g, 0.502 mol), rather than metatrifluoromethylphenyl bromide, was used. Analysis of the resulting liquid by gas chromatography showed 96.3% purity. Tin content was 17.3%(theoretical: 17.6%).

Dineophyl-diorthotrifluoromethylphenyltin (80 g, 0.108 mol) obtained above was dissolved in chloroform (200 g). Chlorine gas (7.6 g, 0.216 gram atom) was then introduced into the resultant solution while keeping the temperature of the solution at between 0.degree. C. and 5.degree. C. The reaction mixture was then concentrated under reduced pressure and the resulting residue was recrystallized from methanol to yield 61.1 g of dineophyl-orthotrifluoromethylphenyltin chloride as a white solid. Analysis by gas chromatography of the solid indicated 97.3% purity.

Mp: 49.degree.-50.degree. C. Tin content: 21.0%(theoretical: 21.0%).

EXAMPLE 6

Bis(dineophyl-orthotrifluoromethylphenyltin)oxide (compound 16)

Dineophyl-orthotrifluoromethylphenyltin chloride (13.4 g, 23.7 mmol) obtained in Example 5 was hydrolyzed in accordance with the procedure described in Example 2 and the resultant product was recrystallized from n-hexane to give 12.1 g of bis(dineophyl-orthotrifluoromethylphenyltin)oxide.

Mp: 42.degree.-44.degree. C. Tin content: 21.8%(theoretical: 22.1%).

EXAMPLE 7

Dineophyl(orthotrifluoromethylphenyl) (1,2,4-triazole-1-yl)tin (compound 7)

Bis(dineophyl-orthotrifluoromethylphenyltin)oxide (6 g, 5.57 mmol) prepared in Example 6 and 1,2,4-triazole (0.77 g, 11.1 mmol) were dissolved in toluene (30 g), and the mixture was heated at 110.degree.-112.degree. C. for one hour to perform an azeotropic dehydration. The reaction mixture was filtered and distilled to remove the benzene, which gave 6.5 g of (dineophyl) (orthotrifluoromethylphenyl) (1,2,4-triazol-1-yl)tin as a pale-yellow viscous liquid.

Refractive index: n.sup.30 =1.5690. Tin content: 20.7% (theoretical: 19.8%).

EXAMPLE 8

Bis(dineophyl-orthotrifluoromethylphenyltin)sulfate (compound 55)

Bis(dineophyl-orthotrifluoromethylphenyltin)oxide (2.7 g, 2.51 mmol) prepared in Example 6 was dissolved in benzene (30 ml). To the resultant solution was added a 50% aqueous sulfuric acid solution (5 ml) and the mixture was stirred at room temperature for 15 minutes. The aqueous layer was separated and removed, and the organic layer washed with water, filtered and concentrated under reduced pressure to give 2.8 g of bis(dineophyl-orthotrifluoromethylphenyltin)sulfate as a pale-yellow viscous liquid.

Refractive index: n.sup.30 =1.5700. Tin content: 21.0% (theoretical: 20.5%).

EXAMPLE 9

Dineophyl-p-fluorophenyltin fluoride (compound 9)

Dineophyl-diparafluorophenyltin (100.9 g) was obtained as a colorless viscous liquid, in accordance with the teaching of Example 1-(1) except that parafluorophenyl bromide (89.3 g, 0.51 mol), rather than metatrifluoromethylphenyl bromide, was employed.

Gas chromatography analysis of this liquid showed 96.9% purity of the desired compound. Tin content was 20.6% (theoretical: 20.6%).

Dineophyl-di(parafluorophenyl)tin (62.1 g, 0.108 mol) prepared above was dissolved in chloroform (200 g). While the resulting solution was maintained at -15.degree. to -20.degree. C., chlorine gas (7.6 g, 0.216 gram atom) was introduced. The mixture was then concentrated under reduced pressure to give 56 g of dineophyl-parafluorophenyltin chloride as a pale-yellow liquid. Gas chromatography analysis indicated 87.5% purity of the desired product.

A mixture consisting of the crude dineophyl-parafluorophenyltin chloride (50 g) and potassium fluoride (5.8 g, 0.1 mol) was heated for 2 hours in the presence of benzene (120 g) and water (23 g). The aqueous layer of the reaction mixture was removed, and the organic layer was washed with water, filtered and concentrated under reduced pressure. The residue thus obtained was crystallized from petroleum ether to give 38.5 g of dineophyl-parafluorophenyltin fluoride as a white solid.

Mp: 59.degree.-62.degree. C. Tin content: 23.2% (theoretical: 23.8%).

EXAMPLE 10

Bis(dineophyl-parafluorophenyltin)sulfide (compound 58)

Dineophyl-parafluorophenyltin fluoride (6 g, 12 mmol) obtained above was dissolved in benzene (30 ml). To this solution was added potassium sulfide (1 g, 17.7 mmol) dissolved in water (4 g) and the mixture was refluxed for 2 hours.

After the aqueous layer was separated and removed from the mixture, the organic layer washed with water and filtered. Evaporation of the benzene under reduced pressure yielded 6.4 g of bis(dineophyl-parafluorophenyltin)sulfide as a pale-yellow viscous liquid.

Refractive index: n.sup.30 =1.6155. Tin content: 23.1% (theoretical: 23.9%).

EXAMPLE 11

Bis(dineophyl-parafluorophenyltin)oxide (compound 17)

Using dineophyl-parafluorophenyltin fluoride (15 g, 30 mmol) prepared in Example 9 and a 20% aqueous sodium hydroxide solution (9 g), bis(dineophyl-parafluorophenyltin)oxide was prepared in accordance with the procedure as described in Example 2, as a white solid.

Mp: 84.degree.-86.degree. C. Tin content: 24.5% (theoretical: 24.3%).

EXAMPLE 12

Dineophyl(parafluorophenyl) (1,3-imidazol-1-yl)tin (compound 54)

Bis(dineophyl-parafluorophenyltin)oxide (6 g, 6.14 mmol) prepared in Example 11 and 1,3-imidazole (0.83 g, 12.3 mmol) were dissolved in toluene (30 g) and the mixture was heated at 110.degree.-112.degree. C. for one hour to effect an azeotropic dehydration. Filtration of the reaction mixture and evaporation of the benzene gave a solid residue, which was crystallized from n-hexane to yield 5.1 g of dineophyl(parafluorophenyl) (1,3-imidazol-1-yl)tin.

Mp: 123.degree.-127.degree. C. Tin content: 21.2% (theoretical: 21.7%).

EXAMPLE 13

Dicyclohexyl-parafluorophenyltin fluoride (compound 14)

Dicyclohexyl-diparafluorophenyltin (85.2g) was prepared in accordance with the procedure as described in Example 1(1) except that parafluorophenyl bromide (89.3 g, 0.51 mol) and dicyclohexyltin dichloride (76.9 g, 0.216 mol), rather than metatrifluoromethylphenyl bromide and dineophyltin dichloride, were employed. Gas chromatography of the recrystallized product from isopropanol showed 98.6% purity.

Mp: 88.degree.-90.degree. C. Tin content: 25.1% (theoretical: 25.0%).

In accordance with the procedure as described in Example 1(2), the above product (20 g, 0.042 mol) was first reacted with bromine to produce crude dicyclohexyl-parafluorophenyltin bromide, which was then treated with sodium fluoride to yield 11.7 g of dicyclohexyl-parafluorophenyltin fluoride as a white solid.

Mp: 234.degree.-240.degree. C. (dec.). Tin content: 29.9% (theoretical: 29.7%).

EXAMPLE 14

Dineophyl-orthotrifluoromethylphenyltin isocyanate (compound 60)

Dineophyl-orthotrifluoromethylphenyltin chloride (6 g, 10.6 mmol) prepared in Example 5, sodium cyanate (1.1 g, 15.9 mmol) and acetone (40 g) were charged into a flask and the mixture was refluxed for 3 hours. The mixture was then added with benzene (50 g) and water (30 g). The aqueous layer was removed, and the organic layer was washed with water and filtered.

Evaporation of the benzene under reduced pressure gave 5.6 g of dineophyl-orthotrifluoromethylphenyltin isocyanate as a colorless viscous liquid.

Refractive index: n.sup.30 =1.5609. Tin content: 21.0% (theoretical: 20.7%).

EXAMPLE 15

Dineophyl-orthotrifluoromethylphenyltin isothiocyanate (compound 59)

Dineophyl-orthotrifluoromethylphenyltin chloride (6 g, 10.6 mmol) prepared in Example 5, potassium thiocyanate (1.5 g, 15.9 mmol), benzene (40 g) and water (10 g) were charged into a flask and the mixture was refluxed for 2 hours. The aqueous layer was removed and the organic layer was washed with water and filtered. Evaporation of the benzene under reduced pressure gave 6.0 g of dineophyl-orthotrifluoromethylphenyltin isothiocyanate as a colorless viscous liquid.

Refractive index: n.sup.30 =1.5787. Tin content: 20.5% (theoretical: 20.2%).

EXAMPLE 16

Dineophyl-orthotrifluoromethylphenyltin methylsulfide (compound 67)

Dineophyl-orthotrifluoromethylphenyltin chloride (6 g, 10.6 mmol) prepared in Example 5, a 15% aqueous sodium methylsulfide solution (7.4 g, 15.9 mmol) and benzene (40 g) were charged into a flask and the mixture was refluxed for 2 hours. The aqueous layer was removed and the organic layer was washed with water and filtered. Evaporation of the benzene under reduced pressure yielded 4.6 g of dineophyl-orthotrifluoromethylphenyltin methylsulfide as a colorless viscous liquid.

Refractive index: n.sup.30 =1.5804. Tin content: 20.9% (theoretical: 20.6%).

EXAMPLE 17

Dineophyl-orthotrifluoromethylphenyltin phenoxide (compound 68)

Bis(dineophyl-orthotrifluoromethylphenyltin)oxide (6 g, 5.6 mmol) prepared in Example 6, phenol (1.0 g, 11.2 mmol) and toluene (40 g) were charged into a flask and the mixture was allowed to react substantially in accordance with the procedure described in Example 7. Evaporation of the toluene followed by recrystallization of the resulting residue from petroleum ether yielded 4.4 g of dineophyl-orthotrifluoromethylphenyltin phenoxide as a white solid.

Mp: 69.degree.-71.degree. C. Tin content: 19.1% (theoretical: 19.0%).

EXAMPLE 18

Dineophyl-orthotrifluoromethylphenyltin phenylsulfide (compound 69)

A mixture of bis(dineophyl-orthotrifluoromethylphenyltin)oxide (6.0 g, 5.6 mmol) prepared in Example 6, thiophenol (1.2 g, 11.2 mmol) and toluene (40 g) was treated with the procedure described in Example 7. The product was recrystallized from n-hexane to obtain 5.2 g of dineophyl-orthotrifluoromethylphenyltin phenylsulfide as a white solid.

Mp: 81.degree.-82.degree. C. Tin content: 18.7% (theoretical: 18.6%).

EXAMPLE 19

S-Dineophyl-orthotrifluoromethylphenyltin) O,O-diethyldithiophosphate (compound 71)

In substantial accordance with the procedure described in Example 7, a mixture of bis(dineophyl-orthotrifluoromethylphenyltin)oxide (6.8 g, 6.4 mmol) prepared in Example 6, O,O-diethyldithiophosphate (2.2 g, 12.8 mmol) and toluene (40 g) was reacted to provide 8.0 g of S-(dineophyl-orthotrifluoromethylphenyltin) O,O-diethyldithiophosphate as a colorless viscous liquid.

Refractive index: n.sup.30 =1.5759.

EXAMPLE 20

Dineophyl (4-chloro-3-trifluoromethylphenyl)tin bromide (compound 74)

Dineophyl-di(4-chloro-3-trifluoromethylphenyl)tin (125.8), a pale-yellow viscous liquid, was prepared in substantial accordance with the procedure described in Example 1-(1) except that 4-chloro-3-trifluoromethylphenyl bromide (131.0 g, 0.504 mol), rather than metatrifluoromethylphenyl bromide, was employed. Gas chromatography analysis of this liquid showed 98.5% purity. Tin content was 15.6% (theoretical: 15.9%).

Following the procedure described in Example 1-(2), dineophyl-di(4-chloro-3-trifluoromethylphenyl)tin (87.8 g, 0.118 mol) obtained above was then reacted with bromine to obtain a pale yellow solid (79.2 g). This solid was recrystallized from methanol (200 g) to give 65.7 g of dineophyl-4-chloro-3-trifluoromethylphenyltin bromide as a white solid. Gas chromatography analysis of this solid showed 99.0% purity. Mp: 72.degree.-74.degree. C. Tin content: 18.3% (theoretical: 18.4%).

EXAMPLE 21

Dineophyl-2,4-difluorophenyltin fluoride (compound 79)

Dineophyl-di(2,4-difluorophenyl)tin (107.9 g), a colorless viscous liquid, was prepared according to the procedure described in Example 1-(1) except that 2,4-difluorophenyl bromide (98.4 g, 0.51 mol), rather than metatrifluoromethylphenyl bromide, was used. Gas chromatography analysis of this liquid showed 95.5% purity. Tin content was 19.0% (theoretical: 19.4%).

Next, following the procedure described in Example 1(2), the above product (72.1 g, 0.118 mol) was reacted with bromine to obtain crude dineophyl-2,4-difluorophenyltin bromide, which was then treated with sodium fluoride. Recrystallization of the resultant product from n-hexane gave 30.6 g of dineophyl-2,4-difluorophenyltin fluoride as a white solid.

Mp: 60.degree.-65.degree. C. Tin content: 22.6% (theoretical: 22.9%).

EXAMPLE 22

Dineophyl-2,4,5-trifluorophenyltin chloride (compound 92)

Dineophyl-di(2,4,5-trifluorophenyl)tin (113.1 g), a pale-yellow viscous liquid, was prepared in substantial accordance with the procedure described in Example 1(1) except that 2,4,5-trifluorophenyl bromide (105.9 g, 0.502 mol), rather than metatrifluoromethylphenyl bromide, was employed. Gas chromatography analysis of this liquid showed 96.0% purity. Tin content was 17.8% (theoretical: 18.3%).

The above product (76.4 g, 0.118 mol) was then reacted with chlorine and the reaction mixture was worked up in substantial accordance with the procedure described in Example 5. Recrystallization of the product from n-hexane gave 39.3 g of dineophyl-2,4,5-trifluorophenyltin chloride as a white solid. Gas chromatography analysis of this solid showed 99.9% purity.

Mp: 65.degree.-67.degree. C. Tin content: 21.7% (theoretical: 21.5%).

EXAMPLE 23

Dineophyl-parachlorophenyltin fluoride (compound 108)

Dineophyl-di(parachlorophenyl)tin (107.5 g), a colorless viscous liquid, was prepared in substantial accordance with the procedure described in Example 1 except that metachlorophenyl bromide (97.4 g, 0.51 mol), rather than metatrifluoromethylphenyl bromide, was employed. Gas chromatography analysis of this liquid indicated 97.5% purity. Tin content was 19.1% (theoretical: 19.5%).

In substantial accordance with the procedure described in Example 1(2), the above product (71.8 g, 0.118 mol) was reacted with bromine to obtain crude dineophyl-metachlorophenyltin bromide, which was then reacted with sodium fluoride. The resulting product was recrystallized from n-hexane to provide 32.7 g of dineophyl-metachlorophenyltin fluoride as a white solid.

Mp: 104.degree.-105.degree. C. Tin content: 23.0% (theoretical: 23.0%).

EXAMPLE 24

Dineophyl-phenyltin fluoride (compound 144)

Dineophyl-diphenyltin (108.9 g), a colorless viscous liquid, was prepared in substantial accordance with the procedure described in Example 1-(1) except that phenyl bromide (78.8 g, 0.502 mol), rather than metatrifluoromethylphenyl bromide, was employed. Gas chromatography analysis of this liquid showed 97.8% purity. Tin content was 21.7% (theoretical: 22.0%).

Dineophyl-phenyltin fluoride (39.6 g), a white solid, was prepared using the above product (80 g, 0.128 mol) as described in Example 1(2).

Mp: 37.degree.-40.degree. C. Tin content: 24.9% (theoretical: 24.7%).

EXAMPLE 25

Dineophyl-orthomethoxyphenyltin chloride (compound 133)

Dineophyl-di(orthomethoxyphenyl)tin (105.9 g), a colorless viscous liquid, was prepared in substantial accordance with the procedure described in Example 1(1) except that orthoanisyl bromide (93.8 g, 0.502 mol), rather than metatrifluoromethylphenyl bromide, was employed. Gas chromatography analysis of this liquid showed 96.5% purity. Tin content was 19.5% (theoretical: 19%).

Dineophyl-orthomethoxyphenyltin chloride (30.1 g), a white solid, was prepared using the above product (70.7 g, 0.118 mol) and chlorine in the manner as described in Example 5. Gas chromatography analysis of this solid showed 99.5% purity.

Mp: 69.degree.-72.degree. C. Tin content: 22.7% (theoretical: 22.5%).

EXAMPLE 26

Dineophyl-3-thienyltin fluoride (compound 215)

(1) Dineophyl-di(3-thienyl)tin

A 1,000 ml four necked flask equipped with a stirrer, a thermometer, a dropping funnel and a condenser was charged with 3-thienyl bromide (75 g, 0.0461 mol) and absolute ether (200 g). n-Butyl lithium (185.3 g) (15% solution in n-hexane) was added in dropwise fashion from the dropping funnel while maintaining the temperature of the reaction mixture at below -50.degree. C. After completion of the addition, the reaction mixture was stirred for about 10 minutes at below -50.degree. C. and then added with a solution of dineophyltin dichloride (73.5 g, 0.161 mol) dissolved in tetrahydrofuran (140 g) through the dropping funnel at -50.degree. to -60.degree. C. over about 30 minutes. After completion of the addition, the mixture was stirred for about 2 hours at that temperature, allowed to warm to room temperature and stirred for about additional one hour. The reaction mixture was then hydrolyzed by the addition of water (120 ml). The organic layer was separated, added with hexane (200 g), washed with water, filtered and concentrated under reduced pressure to yield a brown viscous liquid. To this liquid were added n-hexane (300 g) and activated clay (50 g) for dicolorization. The mixture was filtered and concentrated under reduced pressure to obtain 81.7 g of dineophyl-di(3-thienyl)tin as a colorless, transparent and viscous liquid. Gas chromatography analysis of this liquid showed 95.0% purity. Tin content was 21.0% (theoretical: 21.6%).

(2) Dineophyl-3-thienyltin fluoride

In substantial accordance with the procedure described in Example 1(2), dineophyl-di(3-thienyl)tin (80 g, 0.145 mol) obtained above was reacted with bromine to give crude dineophyl-3-thienyltin bromide, which was then reacted with sodium fluoride. The resulting product was recrystallized from n-hexane to provide 21.5 g of dineophyl-3-thienyltin fluoride as a white solid.

Mp: 85.degree.-90.degree. C. Tin content: 24.7% (theoretical: 24.4%).

EXAMPLE 27

Dicyclohexyl-paratrifluoromethylphenyltin chloride (compound 164)

Crude dicyclohexyl-di(paratrifluoromethylphenyl)tin (101.7 g), a white solid, was prepared in accordance with the procedure described in Example 1(1) except that paratrifluoromethylphenyl bromide (113.4 g, 0.504 mol) and dicyclohexyltin dichloride (66.9 g, 0.188 mol), rather than metatrifluoromethylphenyl bromide and dineophyltin dichloride, were employed. Gas chromatography analysis of this solid indicated 93.3% purity.

In substantial accordance with the procedure described in Example 5, the above product (60 g, 0.105 mol) was then reacted with chlorine and the resulting mixture was worked up to yield 31.5 g of dicyclohexyl-paratrifluoromethylphenyltin chloride as a white solid. gas chromatography analysis of this solid indicated 99.0% purity.

Mp: 74.degree.-75.degree. C. Tin content: 25.8% (theoretical: 25.5%).

EXAMPLE 28

Bis(dicyclohexyl-paratrifluoromethylphenyltin)oxide (compound 165)

Dicyclohexyl-paratrifluoromethylphenyltin chloride (15.0 g, 32.2 mmol) prepared in Example 27 was treated in the manner as described in Example 6 to provide 11.3 g of bis(dicyclohexyl-paratrifluoromethylphenyltin)oxide as a white solid.

Mp: 86.degree.-89.degree. C. Tin content: 26.8% (theoretical: 27.1%).

Dicyclohexyl-paratrifluoromethylphenyltin-n-butylthioglycolate (compound 167)

Bis-(dicyclohexyl-paratrifluoromethylphenyltin)oxide (6 g, 16.8 mmol) prepared in Example 28 and n-butyl thioglycolate (2.0 g, 13.6 mmol) were dissolved in toluene (30 g) and the mixture was heated at 110.degree.-112.degree. C. for one hour to effect an azeotropic dehydration. Evaporation of the toluene under reduced pressure gave 7.8 g of pale-yellow liquid.

Refractive index: n.sup.30 =1.5337. Tin content: 20.4% (theoretical: 20.6%).

EXAMPLE 30

Dicyclohexyl-3,4-dichlorophenyltin fluoride (compound 190)

Dicyclohexyl-di(3,4-dichlorophenyl)tin (191.9 g), a colorless viscous liquid, was prepared in substantial accordance with the procedure described in Example 1(1) except that 3,4-dichlorophenyl bromide (113.8 g, 0.504 mol) and dicyclohexyltin dichloride (66.9 g, 0.188 mol), rather than metatrifluoromethylphenyl bromide and dineophyltin dichloride, were employed. Gas chromatography analysis of this liquid showed 95.9% purity. Tin content was 20.2% (theoretical: 20.6%).

Dicyclohexyl-di(3,4-dichlorophenyl)tin (86.5 g, 0.150 mol) prepared above was allowed to react and the resulting mixture was worked up, as described in Example 1-(2), to obtain 35.5 g of dicyclohexyl-3,4-dichlorophenyltin fluoride as a white solid.

Mp: 193.degree. C. Tin content: 26.0% (theoretical: 26.4%).

EXAMPLE 31

Dicyclohexyl-paratolyltin chloride (compound 197)

Dicyclohexyl-di(paratolyl)tin (82.5 g), a pale-yellow viscous liquid, was prepared in substantial accordance with the procedure described in Example 1(1) except that paratolyl bromide (86.2 g, 0.504 mol) and dicyclohexyltin dichloride (66.9 g, 0.188 mol), rather than metatrifluoromethylphenyl bromide and dineophyltin dichloride, were employed. gas chromatography analysis of this liquid showed 94.5% purity. Tin content was 24.7% (theoretical: 25.4%).

The above product (70 g, 0.150 mol) was then allowed to react with chlorine and the resulting mixture was worked up, as described in Example 5, to obtain 34.5 g of dicyclohexyl-paratolyltin chloride as a colorless viscous liquid. Gas chromatography analysis of this liquid showed 98.4% purity.

Refractive index: n.sup.+ =1.5705. Tin content: 28.6% (theoretical: 28.8%).

EXAMPLE 32

Dicyclohexyl-trimethylsilylmethyltin chloride (compound 232)

(1) Dicyclohexyl-phenyltin chloride

Dicyclohexyl-di(phenyl)tin (155.2 g), a white solid, was prepared in substantial accordance with the procedure described in Example 1(1) except that phenyl bromide (156.2 g, 1.008 mol) and dicyclohexyltin dichloride (133.8 g, 0.376 mol), rather than metatrifluoromethylphenyl bromide and dineophyltin dichloride, were employed. Gas chromatography analysis of this solid showed 94.95 purity.

The above product (150.8 g, 0.343 mol) was then allowed to react with chlorine and the resultant mixture was worked up as described in Example 5. Recrystallization of the product from n-hexane gave 86.0 g of dicyclohexyl-phenyltin chloride as a white solid. Gas chromatography analysis of this solid showed 98.8% purity.

MP: 50.degree.-52.degree. C. Tin content: 30.2% (theoretical: 29.9%)

(2) Dicyclohexyl-trimethylsilylmethyltin chloride

Dicyclohexyl-phenyl-trimethylsilylmethyltin (79.4 g), a colorless viscous liquid, as prepared as described in Example 1(1). Using dicyclohexyl-phenyltin chloride (74.7 g, 0.188 mol) obtained above and trimethylsilylmethyl cloride (30.8 g, 0.251 mol) instead of dineophyltin dichloride and metatrifluoromethylphenyl bromide respectively. In this example, 6.1 g (0.251 mol) of magnesium and 110 g of tetrahydrofuran were employed. Gas chromatography analysis of this liquid showed 97.5% purity.

In the manner as taught in Example 5, the above product (48.5 g, 0.108 mol) was reacted with chlorine, and the resultant mixture was concentrated. The residue was recrystallized from n-hexane to yield 35.2 g of dineophyl-trimethylsilylmethyltin chloride as a white solid. Gas chromatography analysis of this solid showed 99.0% purity.

Mp: 74.degree. C.

EXAMPLE 33

Bis(dicyclohexyl-trimethylsilylmethyltin)oxide (compound 233)

Dicyclohexyl-trimethylsilylmethyltin chloride (25.3 g, 0.062 mol) prepared in Example 32 was allowed to react and the resultant mixture was worked up, as described in Example 2, to provide 21.2 g of bis(dicyclohexyl-trimethylsilylmethyltin)oxide as a white solid. Mp: 151.degree.-153.degree. C.

EXAMPLE 34

o-(Dicyclohexyl-trimethylsilylmethyltin) o,o-dibutylphosphate (compound 237)

Bis(dicyclohexyl-trimethylsilylmethyltin)oxide (6.8 g, 8.9 mmol), o,o-dibutylphosphate (3.7 g, 17.8 mmol) and toluene (40 g) were allowed to react as described in Example 7. Evaporation of the toluene from the mixture and recrystallization of the residue from methanol/acetonitrile gave 8.3 g of o-(dicyclohexyl-trimethylsilylmethyltin) o,o-dibutylphosphate as a white solid. Mp: 130.degree.-132.degree. C.

In substantial accordance with the procedures as taught in the above examples, a variety of organotin compounds (I) of the invention were prepared. Physicochemical properties of the compounds are listed in Table 1.

In Table 1, the following abbreviations were employed:

Me: methyl Et: ethyl Bu: butyl Oct: octyl Phe: phenyl Ac: acetyl Tin content in parenthesis represents theoretical amount. TABLE 1-1__________________________________________________________________________ ##STR13## Physical propertyCom- GLCpound purityNo. R.sup.2 R.sup.1 m X Appearance m.p. or b.p. n.sup.30 Tin (%)tent__________________________________________________________________________ (%)1 m-CF.sub.3 Neophyl 1 F Viscous liquid 1.5555 21.1 (21.6)2 p-F n-Butyl 1 F White solid 205-210.degree. C. 34.2 (34.4)3 m-CF.sub.3 Neophyl 2 O Viscous liquid 1.5651 21.9 (22.1)4 m-CF.sub.3 Neophyl 1 Cl Colorless liquid 1.5591 21.2 99.3 (21.0)5 m-CF.sub.3 Neophyl 1 OCOMe Viscous liquid 1.5465 20.1 (20.1)6 m-CF.sub.3 Neophyl 1 SSCN(Me).sub.2 White solid 96-97.degree. C. 18.1 (18.2)7 o-CF.sub.3 Neophyl 1 Triazolyl Viscous liquid 1.5690 20.7 (19.8)8 o-CF.sub.3 Neophyl 1 F White solid 38-40.degree. C. 21.0 (21.6)9 p-F Neophyl 1 F White solid 59-62.degree. C. 23.2 (23.8)10 m-F Neophyl 1 F White solid 35-38.degree. C. 23.3 (23.8) (mg)11 o-CF.sub.3 n-Butyl 1 F White solid 105-111.degree. C. 29.2 (decomp.) (29.9)12 m-CF.sub.3 n-Butyl 1 F White solid 142.degree. C. 29.2 (decomp.) (29.9)13 p-F n-Octyl 1 F White solid 57-60.degree. C. 26.0 (25.8)14 p-F Cyclohexyl 1 F While solid 235-240.degree. C. 29.9 (decomp.) (29.7)15 m-CF.sub.3 Cyclohexyl 1 F While solid 280.degree. C. 26.8 (decomp.) (26.4)16 o-CF.sub.3 Neophyl 2 O White solid 42-44.degree. C. 21.8 (22.1)17 p-F Neophyl 2 O White solid 84-86.degree. C. 24.5 (24.3)18 m-F Neophyl 2 O White solid 37-39.degree. C. 24.6 (24.3)19 o-CF.sub.3 n-Butyl 2 O Colorless liquid 1.5031 31.3 (32.2)20 m-CF.sub.3 n-Butyl 2 O Colorless liquid 1.4939 30.8 (30.7)21 p-F n-Butyl 2 O Colorless liquid 1.5285 35.3 (35.3)22 p-F n-Octyl 2 O Colorless liquid 1.5084 26.5 (26.5)23 p-F Cyclohexyl 2 O White solid 69-72.degree. 30.4 (30.6)24 m-CF.sub.3 n-Butyl 1 Br Colorless liquid 170-172.degree. C./ 1.5109 25.5 96.3 7 mmHg (25.9)25 o-CF.sub.3 Neophyl 1 Cl White solid 49-50.degree. C. 21.0 97.3 (21.0)26 p-F Neophyl 1 Cl Colorless liquid 1.5824 23.0 99.3 (23.0)27 m-F Neophyl 1 Cl Colorless liquid 1.5829 23.1 97.1 (23.0)28 o-CF.sub.3 n-Butyl 1 Cl Colorless liquid 1.5005 28.1 95.0 (28.7)29 p-F n-Butyl 1 Cl Colorless liquid 160-165.degree. C./ 1.5249 32.2 96.2 4-6 mmHg (32.7)30 p-F n-Octyl 1 Cl Colorless liquid 1.5041 25.1 96.2 (25.0)31 p-F Cyclohexyl 1 Cl White solid 52-55.degree. C. 28.6 98.7 (28.6)32 m-CF.sub.3 Cyclohexyl 1 Cl Pale yellow liquid 1.5352 24.5 98.4 (25.5)33 o-CF.sub.3 Neophyl 1 OCOMe Viscous liquid 1.5535 20.0 (25.1)34 p-F Neophyl 1 OCOMe Viscous liquid 1.5669 22.5 (22.0)35 m-F Neophyl 1 OCOMe Viscous liquid 1.5675 22.4 (22.0)36 o-CF.sub.3 n-Butyl 1 OCOMe Viscous liquid 1.4851 26.5 (27.2)37 m-CF.sub.3 n-Butyl 1 OCOMe Colorless solid 75-78.degree. C. 27.3 (27.2)38 p-F n-Butyl 1 OCOMe Colorless solid 83-85.degree. C. 31.1 (30.7)39 p-F n-Octyl 1 OCOMe Colorless solid 27-30.degree. C. 24.0 (23.8)40 p-F Cyclohexyl 1 OCOMe Colorless solid 48-50.degree. C. 27.5 (27.0)41 o-CF.sub.3 Neophyl 1 SSCN(Me).sub.2 Colorless solid 102- 105.degree. C. 18.5 (18.3)42 p-F Neophyl 1 SSCN(Me).sub.2 Colorless solid 74-76.degree. C. 19.6 (20.2)43 m-F Neophyl 1 SSCN(Me).sub.2 Solid 20.3 (20.2)44 o-CF.sub.3 n-Butyl 1 SSCN(Me).sub.2 Colorless solid 28-30.degree. C. 23.9 (23.8)45 m-CF.sub.3 n-Butyl 1 SSCN(Me).sub.2 Yellow liquid 1.5611 23.8 (23.8)46 p-F n-Butyl 1 SSCN(Me).sub.2 Pale yellow liquid 1.5880 26.5 (26.5)47 p-F n-Octyl 1 SSCN(Me).sub.2 Pale yellow liquid 1.5510 21.2 (21.2)44 p-F Cyclohexyl 1 SSCN(Me).sub.2 Colorless solid 101-105.degree. C. 24.2 (23.7)49 p-F Neophyl 1 1,2,4-Triazol-1-yl Colorless solid 134-137.degree. C. 21.0 (21.6)50 m-F Neophyl 1 1,2,4-Triazol-1-yl Colorless solid 154-157.degree. C. 21.6 (21.6)51 p-F n-Butyl 1 1,2,4-Triazol-1-yl Colorless solid 68-72.degree. C. 28.7 (30.0)52 m-CF.sub.3 n-Butyl 1 1,2,4-Triazol-1-yl Viscous liquid 1.5205 26.0 (26.6)53 p-F n-Octyl 1 1,2,4-Triazol-1-yl Viscous liquid 1.5220 22.8 (23.4)54 p-F Neophyl 1 1,3-Imidazol-1-yl Colorless solid 123-127.degree. C. 21.2 (21.7)55 o-CF.sub.3 Neophyl 2 OSO.sub.2 O Viscous liquid 1.5700 21.0 (20.5)56 p-F Neophyl 2 OSO.sub.2 O Viscous liquid 1.5961 23.0 (22.5)57 o-CF.sub.3 Neophyl 2 S Viscous liquid 1.6029 20.9 (21.7)58 p-F Neophyl 2 S Viscous liquid 1.6155 23.1 (23.9)59 o-CF.sub.3 Neophyl 1 NCS Liquid 1.5787 20.5 (20.2)60 o-CF.sub.3 Neophyl 1 NCO Liquid 1.5609 21.0 (20.7)61 o-CF.sub.3 Neophyl 1 ##STR14## Liquid 1.5279 16.5 (16.3)62 o-CF.sub.3 Neophyl 1 ##STR15## Liquid 1.5414 18.6 (18.8)63 o-CF.sub.3 Neophyl 2 ##STR16## Solid 128-131.degree. C. 17.5 (17.6)64 o-CF.sub.3 Neophyl 1 SCH.sub.2 COO-n-Bu Liquid 1.563265 o-CF.sub.3 Neophyl 1 SCH.sub.2 COO-n-Oct Liquid 1.549966 o-CF.sub.3 Neophyl 1 1,3-Imidazol-1-yl Viscous liquid 1.5686 19.7 (19.9)67 o-CF.sub.3 Neophyl 1 SMe Viscous liquid 1.5804 20.9 (20.6)68 o-CF.sub.3 Neophyl 1 Phenoxy Solid 69-71.degree. C. 19.1 (19.0)69 o-CF.sub.3 Neophyl 1 Phenylthio Solid 81-82.degree. C. 18.7 (18.6)70 o-CF.sub.3 Neophyl 1 ##STR17## Solid 63-69.degree. C.71 o-CF.sub.3 Neophyl 1 ##STR18## Viscous liquid 1.575972 3-CF.sub.3 Neophyl 1 F Solid 50-56.degree. C. 20.6 4-Cl (20.3)73 3-CF.sub.3 Neophyl 1 Cl Solid 69-71.degree. C. 20.9 99.0 4-Cl (19.8)74 3-CF.sub.3 Neophyl 1 Br Solid 72-74.degree. C. 18.3 99.0 4-Cl (18.4)75 3-CF.sub.3 Neophyl 2 O Solid 58-61.degree. C. 20.4 4-Cl (20.7)76 3-CF.sub.3 Neophyl 1 OAc Solid 60-62.degree. C. 19.2 4-Cl (19.0)77 3-CF.sub.3 Neophyl 1 SSCN(Me).sub.2 Solid 86-88.degree. C. 17.6 4-Cl (17.3)78 3-CF.sub.3 Neophyl 1 1,2,4-Triazol-1-yl Solid 159-161.degree. C. 18.7 4-Cl (18.8)79 2.4-Difluoro Neophyl 1 F Solid 60-63.degree. C. 22.6 (22.9)80 2,4-Difluoro Neophyl 1 Cl Liquid 1.5730 21.9 98.1 (22.2)81 2,4-Difluoro Neophyl 2 O Viscous liquid 1.5821 23.1 (23.4)82 2,4-Difluoro Neophyl 1 OAc Viscous liquid 1.5598 21.3 (21.3)83 2,4-Difluoro Neophyl 1 SSCN(Me).sub.2 Viscous liquid 1.6156 19.1 (19.2)84 2,4-Difluoro Neophyl 1 1,2,4-Triazol-1-yl Solid 131-134.degree. C. 20.9 (21.0)85 3,4-Difluoro Neophyl 1 F Liquid 1.5793 23.2 (22.9)86 3,4-Difluoro Neophyl 1 Cl Liquid 1.5745 22.1 96.9 (22.2)87 3,4-Difluoro Neophyl 2 O Viscous liquid 1.5820 23.3 (23.4)88 3,4-Difluoro Neophyl 1 OAc Solid 33-35.degree. C. 21.3 (21.3)89 3,4-Difluoro Neophyl 1 SSCN(Me).sub.2 Solid 92-94.degree. C. 19.5 (19.2)90 3,4-Difluoro Neophyl 1 1,2,4-Triazol-1-yl Solid 50-53.degree. C. 20.8 (21.0)91 2,4,5-Trifluoro Neophyl 1 F Liquid 1.5644 22.0 (22.2)92 2,4,5-Trifluoro Neophyl 1 Cl Solid 65-67.degree. C. 21.7 99.9 (21.5)93 2,4,5-Trifluoro Neophyl 2 O Viscous liquid 1.5729 22.4 (22.6)94 2,4,5-Trifluoro Neophyl 1 OAc Solid 59-61.degree. C. 20.8 (20.6)95 2,4,5-Trifluoro Neophyl 1 SSCN(Me).sub.2 Solid 81-83.degree. C. 18.7 (18.7)96 2,4,5-Trifluoro Neophyl 1 1,2,4-Triazol-1-yl Solid 125-130.degree. C. 20.2 (20.3)97 o-Cl Neophyl 1 F Solid 72-74.degree. C. 23.2 (23.0)98 o-Cl Neophyl 1 Cl Viscous liquid 1.5981 22.2 (22.3)99 o-Cl Neophyl 2 O Viscous liquid 1.6070 23.4 (23.5)100 o-Cl Neophyl 1 OAc Viscous liquid 1.5800 21.2 (21.4)101 o-Cl Neophyl 1 SSCN(Me).sub.2 Solid 100-103.degree. C. 19.1 (18.7)102 m-Cl Neophyl 1 F Solid 58-62.degree. C. 23.1 (23.0)103 m-Cl Neophyl 1 Cl Solid 41-43.degree. C. 22.3 96.3 (22.3)104 m-Cl Neophyl 2 O Viscous liquid 1.6048 23.6 (23.5)105 m-Cl Neophyl 1 OAc Viscous liquid 1.5801 21.5 (21.4)106 m-Cl Neophyl 1 SSCN(Me).sub.2 Viscous liquid 1.6326 19.0 (19.2)107 m-Cl Neophyl 1 1,2,4-Triazol-1-yl Solid 165-169.degree. C. 21.1 (21.0)108 p-Cl Neophyl 1 F Solid 104-105.degree. C. 23.0 (23.0)109 p-Cl Neophyl 1 Cl Solid 70-72.degree. C. 22.6 99.0 (22.3)110 p-Cl Neophyl 2 O Viscous liquid 1.6045 23.4 (23.5)111 p-Cl Neophyl 1 OAc Viscous liquid 1.5808 21.5 (21.4)112 p-Cl Neophyl 1 SSCN(Me).sub.2 Solid 89-92.degree. C. 19.3 (19.2)113 p-Cl Neophyl 1 1,2,4-Triazol-1-yl Solid 70-73.degree. C. 20.8 (21.0)114 p-Me Neophyl 1 F Viscous liquid 1.5925 24.2 (24.0)115 p-Me Neophyl 1 Cl Solid 34.5-35.5.degree. C. 23.5 96.7 (23.2)116 p-Me Neophyl 2 O Viscous liquid 1.6013 24.4 (24.5)117 p-Me Neophyl 1 OAc Viscous liquid 1.5780 22.4 (22.2)118 p-Me Neophyl 1 SSCN(Me).sub.2 Solid 126-128.degree. C. 20.1 (19.9)119 p-Me Neophyl 1 1,2,4-Triazol-1-yl Solid 103-108.degree. C. 21.5 (21.8)120 m-Me Neophyl 1 F Solid 58-59.degree. C. 24.0 (24.0)121 m-Me Neophyl 1 Cl Viscous liquid 1.5893 23.5 98.2 (23.2)122 m-Me Neophyl 2 O Viscous liquid 1.5969 24.8 (24.5)123 m-Me Neophyl 1 OAc Viscous liquid 1.5748 22.5 (22.2)124 m-Me Neophyl 1 SSCN(Me).sub.2 Solid 51-54.degree. C. 20.1 (19.9)125 m-Me Neophyl 1 1,2,4-Triazol-1-yl Solid 130-135.degree. C. 21.5 (21.8)126 p-Me Neophyl 1 F Solid 95-98.degree. C. 24.1 (24.0)127 p-Me Neophyl 1 Cl Solid 51-53.degree. C. 23.3 99.3 (23.2)128 p-Me Neophyl 2 O Viscous liquid 1.5982 24.7 (24.5)129 p-Me Neophyl 1 OAc Viscous liquid 1.5755 22.4 (22.2)130 p-Me Neophyl 1 SSCN(Me).sub.2 Solid 92-94.degree. C. 20.2 (19.9)131 p-Me Neophyl 1 1,2,4-Triazol-1-yl Solid 146-148.degree. C. 21.5 (21.8)132 o-OMe Neophyl 1 F Viscous liquid 1.5885 23.0 (23.2)133 o-OMe Neophyl 1 Cl Solid 69-72.degree. C. 22.7 99.5 (22.5)134 o-OMe Neophyl 2 O Viscous liquid 1.6013 24.1 (23.7)135 o-OMe Neophyl 1 OAc Viscous liquid 93-96.degree. C. 1.5756 21.8 (21.5)136 o-OMe Neophyl 1 SSCN(Me).sub.2 Solid 93-96.degree. C. 19.6 (19.4)137 o-OMe Neophyl 1 1,2,4-Triazol-1-yl Solid 107-113.degree. C. 21.3 (21.2)138 p-OMe Neophyl 1 F Viscous liquid 1.5943 23.4 (23.2)139 p-OMe Neophyl 1 Cl Viscous liquid 1.5918 22.7 96.2 (22.5)140 p-OMe Neophyl 2 O Viscous liquid 1.6004 23.5 (23.7)141 p-OMe Neophyl 1 OAc Viscous liquid 1.5777 21.9 (21.5)142 p-OMe Neophyl 1 SSCN(Me).sub.2 Viscous liquid 1.6281 19.0 (19.4)143 p-OMe Neophyl 1 1,2,4-Triazol-1-yl Solid 134-140.degree. C. 21.4 (21.2)144 H Neophyl 1 F Solid 37-40.degree. C. 24.9 (24.7)145 H Neophyl 1 Cl Viscous liquid 1.5937 24.3 97.1 (23.9)146 H Neophyl 2 O Viscous liquid 1.6021 24.8 (25.2)147 H Neophyl 1 OAc Viscous liquid 1.5769 23.1 (22.8)148 H Neophyl 1 SSCN(Me).sub.2 Viscous liquid 1.6343 20.6 (20.4)149 H Neophyl 1 1,2,4-Triazol-1-yl Solid 130-135.degree. C. 22.5 (22.4)150 o-CF.sub.3 Cyclohexyl 1 F Solid 98-102.degree. C. 25.9 (26.4)151 o-CF.sub.3 Cyclohexyl 1 Cl Solid 51-52.degree. C. 25.4 98.6 (25.5)152 o-CF.sub.3 Cyclohexyl 2 O Solid 125-128.degree. C. 26.2 (27.1)153 o-CF.sub.3 Cyclohexyl 1 OAc Liquid 1.5250 23.8 (24.3)154 o-CF.sub.3 Cyclohexyl 1 ##STR19## Liquid 1.5111 21.8 (22.3)155 o-CF.sub.3 Cyclohexyl 1 SCH.sub.2 COO-n-Bu Liquid 1.5400156 o-CF.sub.3 Cyclohexyl 1 SCH.sub.2 COO-n-Oct Liquid 1.5312157 o-CF.sub.3 Cyclohexyl 1 SSCN(Me).sub.2 Solid 154-156.degree. C. 21.7 (21.7)158 o-CF.sub.3 Cyclohexyl 1 1,2,4-Triazol-1-yl Solid 176-180.degree. C. 23.5 (23.8)159 m-CF.sub.3 Cyclohexyl 2 O Solid 84-86.degree. C. 26.9 (27.1)160 m-CF.sub.3 Cyclohexyl 1 OAc Solid 59-61.degree. C. 25.0 (24.3)161 m-CF.sub.3 Cyclohexyl 1 SSCN(Me).sub.2 Solid 124-126.degree. C. 21.6 (21.6)162 m-CF.sub.3 Cyclohexyl 1 1,2,4-Triazol-1-yl Solid 191-184.degree. C. 22.9 (23.8)163 p-CF.sub.3 Cyclohexyl 1 F Solid 240.degree. C. 26.4 (decomp.) (26.4)164 p-CF.sub.3 Cyclohexyl 1 Cl Solid 74-75.degree. C. 25.8 99.0 (25.5)165 p-CF.sub.3 Cyclohexyl 2 O Solid 86-89.degree. C. 26.8 (27.1)166 p-CF.sub.3 Cyclohexyl 1 OAc Solid 68-71.degree. C. 23.9 (24.3)167 p-CF.sub.3 Cyclohexyl 1 SCH.sub.2 COO-n-Bu Liquid 1.5337 20.4 (20.6)168 p-CF.sub.3 Cyclohexyl 1 SSCN(Me).sub.2 Solid 85-87.degree. C. 21.7 (21.6)169 p-CF.sub.3 Cyclohexyl 1 1,2,4-Triazol-1-yl Solid 215-225.degree. C. 23.4 (23.8)170 m-F Cyclohexyl 1 F Solid 225.degree. C. 29.6 (decomp.) (29.7)171 m-F Cyclohexyl 1 Cl Solid 52-53.degree. C. 28.7 (28.6)172 m-F Cyclohexyl 2 O Solid 44-46.degree. C. 31.0 (30.6)173 m-F Cyclohexyl 1 OAc Solid 52-54.degree. C. 27.1 (27.0)174 m-F Cyclohexyl 1 SCH.sub.2 COO-n-Bu Liquid 1.5555 22.9 (22.5)175 m-F Cyclohexyl 1 SSCN(Me).sub.2 Solid 110-112.degree. C. 24.0 (23.7)176 m-F Cyclohexyl 1 1,2,4-Triazol-1-yl Solid 208.degree. C. 26.7 (decomp.) (26.5)177 o-CF.sub.3 Neophyl 1 SSCN(Et).sub.2 Liquid 1.5931 17.2 (17.5)178 o-CF.sub.3 Neophyl 1 o-t-Butylphenoxy Solid 75-76.degree. C. 17.5 (17.5)179 o-CF.sub.3 Neophyl 1 2,6-Diisopropylphenoxy Liquid 1.5619 16.7 (16.8)180 o-CF.sub.3 Cyclohexyl 1 SSCN(Et).sub.2 Solid 105-107.degree. C. 20.6 (20.5)181 o-CF.sub.3 Cyclohexyl 1 o-t-Butylphenoxy Liquid 1.5519 19.9 (20.5)182 o-CF.sub.3 Cyclohexyl 1 2,6-Diisopropylphenoxy Solid 53-57.degree. C. 19.3 (19.5)183 p-Cl Cyclohexyl 1 F Solid 256-258.degree. C. 28.2 (28.6)184 p-Cl Cyclohexyl 1 Cl Solid 49-50.degree. C. 27.1 (27.5)185 p-Cl Cyclohexyl 2 O Solid 111-113.degree. C. 29.4 (29.3)186 p-Cl Cyclohexyl 1 OAc Solid 97-99.degree. C. 26.4 (26.1)187 p-Cl Cyclohexyl 1 SCH.sub.2 COO-n-Bu Liquid 1.5645 21.9 (21.8)188 p-Cl Cyclohexyl 1 SSCN(Me).sub.2 Solid 70-73.degree. C. 22.5 (23.0)189 p-Cl Cyclohexyl 1 1,2,4-Triazol-1-yl Solid 217-223.degree. C. 25.5 (25.5)190 3,4-Dichloro Cyclohexyl 1 F Solid 193.degree. C. 26.0 (decomp.) (26.4)191 3,4-Dichloro Cyclohexyl 1 Cl Liquid 1.5903 25.1 97.2 (25.4)192 3,4-Dichloro Cyclohexyl 2 O Solid 129-130.degree. C. 27.4 (27.0)193 3,4-Dichloro Cyclohexyl 1 OAc Solid 99-101.degree. C. 24.4 (24.2)194 3,4-Dichloro Cyclohexyl 1 SSCN(Me).sub.2 Solid 138-140.degree. C. 21.5 (21.5)195 3,4-Dichloro Cyclohexyl 1 1,2,4-Triazol-1-yl Solid 207-213.degree. C. 24.0 (23.8)196 p-Me Cyclohexyl 1 F Solid 245-247.degree. C. 29.7 (30.0)197 p-Me Cyclohexyl 1 Cl Liquid 1.5705 28.6 (28.8)198 p-Me Cyclohexyl 2 O Solid 71-73.degree. C. 31.0 (30.9)199 p-Me Cyclohexyl 1 OAc Solid 83-85.degree. C. 27.6 (27.3)200 p-Me Cyclohexyl 1 SCH.sub.2 COO-n-Bu Liquid 1.5605 22.9 (22.7)201 p-Me Cyclohexyl 1 SSCN(Me).sub.2 Solid 92-94.degree. C. 23.8 (23.9)202 p-Me Cyclohexyl 1 1,2,4-Triazol-1-yl Solid 205-210.degree. C. 26.5 (26.7)203 p-Methoxy Cyclohexyl 1 F Solid 234-236.degree. C. 29.4 (28.9)204 p-Methoxy Cyclohexyl 1 Cl Liquid 1.5749 27.6 96.9 (27.8)205 p-Methoxy Cyclohexyl 2 O Solid 65-69.degree. C. 29.6 (29.7)206 p-Methoxy Cyclohexyl 1 OAc Solid 82-84.degree. C. 26.7 (26.3)207 p-Methoxy Cyclohexyl 1 SCH.sub.2 COO-n-Bu Liquid 1.5630 22.5 (22.0)208 p-Methoxy Cyclohexyl 1 SSCN(Me).sub.2 Solid 78-80.degree. C. 23.1 (23.2)209 p-Methoxy Cyclohexyl 1 1,2,4-Triazol-1-yl Solid 202-207.degree. C. 25.4 (25.8)__________________________________________________________________________ TABLE 1-2__________________________________________________________________________ ##STR20## Physical propertyCompound Tin content GLCNo. R* R.sup.1 m X Appearance m.p. or b.p. n.sup.30 (%) purity__________________________________________________________________________ (%)210 2-Thienyl Neophyl 1 Cl Viscous liquid 1.5987 23.5 (23.6)211 2-Thienyl Neophyl 2 O Solid 90-99.degree. C. 24.7 (24.9)212 2-Thienyl Neophyl 1OAC Viscous liquid 1.5798 22.5 (22.6)213 2-Thienyl Neophyl 1 SSCN(Me).sub.2 Solid 77-79.degree. C. 20.4 (20.2)214 2-Thienyl Neophyl 1 1,2,4-Triazol-l-yl Solid 147-157.degree. C. 21.8 (22.1)215 3-Thienyl Neophyl 1 F Solid 85-90.degree. C. 24.7 (24.4)216 3-Thienyl Neophyl 1 Cl Viscous liquid 1.5988 23.9 97.8 (23.6)217 3-Thienyl Neophyl 2 O Solid 78-81.degree. C. 25.0 (24.9)218 3-Thienyl Neophyl 1 OAc Solid 46-48.degree. C. 22.7 (22.5)219 3-Thienyl Neophyl 1 SSCN(Me).sub.2 Solid 87-89.degree. C. 20.6 (20.2)220 3-Thienyl Neophyl 1 1,2,4-Triazol-l-yl Solid 140-144.degree. C. 21.9 (22.1)221 Trimethyl- Neophyl 1 F Liquid 1.5412 silylmethyl222 Trimethyl- Neophyl 1 Cl Solid 42.5-43.5.degree. C. 99.0 silylmethyl223 Trimethyl- Neophyl 2 O Solid 90.5-91.0.degree. C. silylmethyl224 Trimethyl- Neophyl 1 OAc Liquid 1.5372 silylmethyl225 Trimethyl- Neophyl 1 SSCN(Me).sub.2 Solid 62-63.degree. C. silylmethyl226 Trimethyl- Neophyl 1 1,2,4-Triazol-l-yl Solid 78-85.degree. C. silylmethyl227 Dimethyl- Neophyl 1 Cl Solid 30.degree. C. 99.0 phenylsilyl- methyl228 Dimethyl- Neophyl 2 O Solid 87-89.degree. C. phenylsilyl- methyl229 Dimethyl- Neophyl 1 OAc Liquid 1.5617 phenylsilyl- methyl230 Dimethyl- Neophyl 1 SSCN(Me).sub.2 Liquid 1.6141 phenylsilyl- methyl231 Trimethyl- Cyclo- 1 F Solid 167-170.degree. C. silylmethyl hexyl232 Trimethyl- Cyclo- 1 Cl Solid 74.degree. C. 99.0 silylmethyl hexyl233 Trimethyl- Cyclo- 2 O Solid 151-153.degree. C. silylmethyl hexyl234 Trimethyl- Cyclo- 1 OAc Solid 52-53.degree. C. silylmethyl hexyl235 Trimethyl- Cyclo- 1 SSCN(Me).sub.2 Solid 101-102.degree. C. silylmethyl hexyl236 Trimethyl- Cyclo- 1 1,2,4-Triazol-l-yl Solid 197-201.degree. C. silylmethyl hexyl (decomp.)237 Trimethyl- silylmethyl Cyclo- hexyl 1 ##STR21## Solid 130-132.degree. C.238 Neopentyl Neophyl 1 Cl Solid 65-66.degree. C. 23.6 99.9 (24.1)239 Neopentyl Neophyl 2 O Solid 100-101.degree. C. 25.7 (25.6)240 Neopentyl Cyclo- 1 Cl Solid 106-107.degree. C. 29.5 hexyl (30.3)241 Neopentyl Cyclo- 2 O Solid 202-203.degree. C. 32.5 hexyl (32.6)242 Dimethyl- Neophyl 1 F Solid 47-48.degree. C. phenylsilyl- methyl243 Dimethyl- Neophyl 1 1,2,4-Triazol-1-yl Solid 66-71.degree. C. phenylsilyl- methyl244 Dimethyl- phenylsilyl- methyl Neophyl 1 ##STR22## Liquid 1.5484245 Dimethyl- Cyclo- 1 F Solid 107-110.degree. C. phenylsilyl- hexyl methyl246 Dimethyl- Cyclo- 1 Cl Liquid 1.5593 phenylsilyl- hexyl methyl247 Dimethyl- Cyclo- 2 O Solid 48-51.degree. C. phenylsilyl- hexyl methyl248 Dimethyl- Cyclo- 1 OAc Liquid 1.5421 phenylsilyl- hexyl methyl249 Dimethyl- Cyclo- 1 SSCN(Me).sub.2 Liquid 1.6054 phenylsilyl- hexyl methyl250 Dimethyl- Cyclo- 1 1,2,4-Triazol-l-yl Solid 118- 124.degree. C. phenylsilyl- hexyl methyl251 Dimethyl- phenylsilyl- methyl Cyclo- hexyl 1 ##STR23## Solid 125-126.degree. C.__________________________________________________________________________

Various compounds to be employed in accordance with the present invention were formulated as wettable powders, emulsifiable concentrates, fine dusts, etc., as shown below.

______________________________________ Ingredient Part by weight______________________________________Formulation 1 Wettable powderCompound No. 28 50.0Clay 40.5White carbon 5.0Polyoxyalkylenealkyl- 3.0allylethersulfateAlkylbenzensulfonate 1.5Formulation 2 Emulsifiable concentrateCompound No. 25 25.0Alkylallylsulfonate 3.0Polyoxyalkylenealkylallyl 10.0etherXylene 42.0Dimethylformamide 20.0______________________________________

Compound No. 25, alkylalkylsulfonate and polyoxyalkylenealkylallyl ether are uniformly dissolved in xylene and dimethylformamide to obtain emulsifiable concentrate. The preparation is diluted with water when use.

______________________________________Formulation 3 Fine dust______________________________________Compound No. 33 15.0White carbon 20.0Isopropylazidophosphate 0.3Fine clay 64.7______________________________________

The above ingredients are mixed and ground. The mixture is finely ground by Jetmizer grinder to obtain fine dust. The preparation is used as it is.

______________________________________Formulation 4 Dust______________________________________ Compound No. 49 5.0 Clay 91.7 White carbon 3.0 Tall oil 0.3______________________________________

The above ingredients are mixed and ground to obtain dust preparation. The dust is used as it is.

Experiment 1

Sample

Compounds of the invention to be tested are dissolved in a minimum of DMF. Distilled water containing Tween 20 at the concentration of 100 ppm is thereto added to prepare a series of samples of the desired concentrations.

Test Procedure

A. Suppression of Spodoptera litura (common cutworm) larvae

Cabbage leaves (5.times.5 cm) were immersed in the sample solution as prepared above and air dried. Two leaves were placed in a petri dish (9 cm diameter) and 10 third-instar larvae of Spodoptera litura were placed in the dish. The dish was held at 25.degree. C. and the mortality of the larvae was measured after 48 hours.

C. Suppression of Plutella xylostella (diamond backmoth) larvae

Cabbage leaf (7.times.7 cm) was immersed in the sample solution and air dried. The leaf was placed in a petri dish (9 cm diameter) and 10 third-instar larvae of Plutella xylostella were placed in the dish. The dish was held at 25.degree. C. and the mortality of the larvae was measured after 48 hours.

D. Suppression of Adoxophyes sp. larvae

Whole tea leaves were immersed in the sample solution and air dried. Three leaves were placed in a polyethylene petri dish (6 cm diameter, 4 cm depth) and 10 forth-instar larvae of Adoxophyes sp. were placed in the dish. The dish was held at 25.degree. C. and the mortality of the larvae was measured after 48 hours.

E. Suppression of Nephotettix cincticeps (green rice leaf hopper) (sensitive)

Six or seven rice seedlings of 1.5 to 2 plant age in leaf number were bundled and the roots were wrapped in sponge. The seedlings were placed in a polyethylene cup (diameter 6 cm, depth 4 cm) and the cup is placed in a rotary application tower, whereby the leaves and sheaths of the seedlings were sprayed with 2 ml of the sample solution and air dried. The treated seedlings were covered with a transparent plastic cylinder and ten female larvae were placed in the cylinder. The atmosphere in the cylinder was kept at 25.degree. C., and the mortality after 48 hours was measured.

I. and J. Suppression of Myzus persicae (green peach aphid) larvae (I: sensitive, J: resistant)

A polyethylene cup (diameter 6 cm, depth 4 cm) was filled with 0.3% agar gel and a piece of Chinese cabbage leaf (3.times.3 cm) was placed on the gel. An apterous adult of Myzus persicae was placed on the cabbage and allowed to egg-deposit while keeping the surrounding atmosphere at 25.degree. C. for 24 hours. After removing the adult, 2 ml of the sample was sprayed on the leaf under a rotary application tower. The test system was kept at 25.degree. C. for 48 hours and the mortality of born larvae was measured.

M. Suppression of Tetranychus cinnabrinus (carmine spider mite)

A polyethylene cup (diameter 6 cm, depth 4 cm) was filled with 0.3% agar gel and a piece of bush bean leaf (diameter 2 cm) was placed on the gel. About twelve adults of Tetranychus cinnabrinus were placed on the leaf. After 24 hours at 25.degree. C., dead and feeble adults were removed and 2 ml of the sample solution was sprayed on the leaf and audlts under a rotary application tower. Following such treatment the test system was kept at 25.degree. C. and the mortality was measured after 48 hours.

O. Suppression of Tetranychus urticae (Two-spotted spider mite)

The same test procedure as above was repeated on Tetranychus urticae.

X. Suppression of Tetranychus cinnabrinus larvae

A polyethylene cup (diameter 6 cm, depth 4 cm) was filled with 0.3% agar gel and a piece of bush bean leaf (diameter 2 cm) was placed on the gel. Seven adults of Tetranychus cinnabrinus were placed on the leaf and allowed to egg-deposit while keeping the surrounding atmosphere at 25.degree. C. for 24 hours. After removing the adult, 2 ml of the sample was sprayed on the leaf under a rotary application tower. The test system was kept at 25.degree. C. for 7 days and the mortality of born larvae was measured.

Y. Suppression of Tetranychus urticae larvae

The same test procedure as above was repeated on Tetranychus urticae larvae.

N. Suppression of Tetranychus cinnabrinus eggs P. Suppression of Tetranychus urticae eggs

The test procedure as described in X and Y were repeated on Tetranychus cinnabrinus and urticae eggs. The test system was kept at 25.degree. C. for 7 days and the mortality of eggs was measured by counting the number of eggs which did not hatch.

T. Suppression of Henosepilachna vigintioctopunctata (twenty-eight-spotted beetle) adults

Japanese eggplant leaf (6.times.6 cm) was immersed in the sample solution and air dired. The leaf was placed in a petri dish (9 cm diameter) and 5 adults of Henosepilachna vigintioctopunctata were placed in the dish. The dish was held at 25.degree. C. and the mortality was measured after 48 hours.

R. Suppression of Periplaneta americana (American cockroach) larvae

A filter paper soaked with the sample solution was placed in a petri dish (diameter 9 cm). Five Periplaneta americana larvae with 7 days after hatching were placed in the dish hold at 25.degree. C. and the mortality after 48 hours was measured.

W. Suppression of Callosobruchus chinensis (adzuki bean weevil)

Ten Callosobruchus chinensis adults within 24 hours after hatching were placed in a screw cylinder (diameter 1.8 cm, height 5 cm) with stainless nets at the up-and-down openings. The cylinder was submerged in the sample solution, and the adults exposed to the solution were air dried. The mortality was measured after 48 hours at 25.degree. C.

K. Suppression of Panonychus citri (citrus red mite)

The same test procedure as M and O was repeated on Panonychus citri except that lemon leaf, rather than bush bean leaf, was employed.

Q. Suppression of Tetranychus kanzawai (kanzawa spider mite) (resistant adults)

The same test procedure as M and O was repeated on resistant adults of Teranychus kanzawai.

Test Results

Table 2 below shows the mortality (%) of various pests exposed to the indicated compounds (I) at several concentrations, wherein the following codes are employed for pests.

A: Spodoptera litura (larvae) C: Plutella xylostella (larvae) D: Adoxophyes sp. (larvae) E: Nephotettix cincticeps (sensitive adults) I: Myzus persicae (sensitive larvae) J: Myzus persicae (resistant larvae) K: Panonychus citri (adults) L: Panonychus citri (eggs) M: Tetranychus cinnabrinus (adults) N: Tetranychus cinnabrinus (eggs) O: Tetranychus urticae (adults) P: Tetranychus urticae (eggs) Q: Tetranychus kanzawai (resistant adults) R: Periplaneta americana (larvae) T: Henosepilachna vigintioctopunctata (adults) W: Callosobruchus chinensis (adults) X: Tetranychus cinnabrinus (eggs-larvae) Y: Tetranychus urticae (eggs-larvae)

Table 2 also lits the test results on commercially available Osadan.RTM. and Plictran.RTM. employed as a control.

Resistance adults of Tetranychus kanzawai used in Test Q were those which acquired resistance against Osadan.RTM. and Plictran.RTM. and were gathered at Yaguchihara and Okadahara, Shizuoka, Japan. Test results on the adults from Yaguchihara and Okadahara are shown on the left and right, respectively, of column "Q" in Table 2.

TABLE 2 Concen- Compound tration No. (ppm) A C D E G H I J K L M N O P Q R T W X Y Osadan 1000 100 93 47 52 100 250 100 95 37 36 100 100 63 90 27 16 80 Plictran 1000 100 100 51 69 100 250 100 100 100 23 36 100 100 63 100 100 93 10 24 40 50 15 88 1 3 1 1000 100 70 97 100 250 100 90 90 63 97 100 16 77 2 1000 100 100 250 100 100 100 63 70 100 97 3 1000 100 100 250 100 100 63 87 100 70 16 79 4 1000 100 100 70 100 250 100 97 70 100 63 91 100 80 16 76 5 1000 100 100 250 100 71 76 100 63 97 100 80 16 89 80 6 1000 100 100 250 100 100 63 90 100 80 16 86 72 7 1000 100 100 81 96 100 250 92 100 100 80 89 90 63 95 100 74 16 78 8 1000 100 100 95 100 100 250 95 100 100 83 79 93 100 63 94 100 9 1000 100 100 100 250 100 70 100 79 85 96 100 100 63 97 100 100 84 95 90 16 74 88 10 1000 100 96 100 250 100 95 96 100 63 84 100 70 16 93 11 1000 100 72 100 100 90 80 100 100 100 250 100 95 100 92 100 75 100 100 100 63 70 87 81 100 95 12 1000 100 93 100 100 250 90 90 95 80 63 16 1000 100 100 87 100 100 250 86 100 100 88 76 93 100 63 100 100 79 16 74 92 17 1000 100 97 100 250 100 80 100 86 81 89 100 100 63 97 100 100 100 98 16 73 75 85 18 1000 100 100 250 100 87 78 92 100 63 94 100 70 70 100 16 91 80 19 1000 100 100 100 100 95 80 100 100 100 250 80 80 84 100 100 92 100 100 100 63 81 86 100 98 16 91 20 1000 70 100 100 100 100 250 97 97 70 80 63 80 23 1000 100 94 98 250 90 100 63 25 1000 100 100 85 100 100 100 250 94 100 100 86 89 100 63 97 97 80 21 1000 100 100 100 83 80 100 250 80 100 100 93 100 100 63 100 100 16 24 1000 75 100 100 100 80 100 250 90 100 100 100 70 100 63 73 92 97 26 1000 100 100 100 250 1 00 100 78 83 93 100 100 63 97 91 97 100 95 16 85 70 27 1000 100 100 100 250 100 88 97 100 63 100 95 16 82 70 28 1000 100 100 96 100 100 100 100 250 100 100 100 100 71 100 100 63 95 100 100 29 1000 100 100 100 85 100 100 250 75 100 100 100 63 77 97 100 30 1000 100 250 63 31 1000 100 93 95 250 95 85 63 16 32 1000 100 100 100 100 80 250 80 80 83 100 94 33 1000 100 100 100 100 250 93 100 100 70 86 92 100 63 92 100 16 72 77 34 1000 100 100 100 250 100 84 100 83 96 100 100 63 97 100 100 79 80 98 16 78 79 80 35 1000 100 100 250 100 74 100 63 94 100 90 16 93 36 1000 100 84 100 100 98 100 100 100 100 250 70 75 100 100 85 100 100 100 63 74 100 100 37 1000 85 100 100 100 250 100 100 100 74 100 75 100 100 63 93 88 38 1000 100 100 100 95 250 95 75 100 100 100 100 100 63 100 100 100 39 1000 84 92 100 250 100 40 1000 100 100 100 91 100 100 250 87 100 90 41 1000 100 100 73 85 100 250 100 73 90 63 97 92 42 1000 100 72 100 100 250 100 84 100 96 100 100 63 97 100 100 71 70 98 16 91 84 70 43 1000 100 100 250 100 92 89 100 63 90 97 71 80 16 84 44 1000 100 100 100 100 250 70 100 90 100 92 100 100 100 63 80 94 45 1000 100 100 100 100 250 80 84 100 100 85 100 63 93 70 46 1000 100 100 100 82 100 100 250 100 100 100 100 80 100 63 100 69 97 100 47 1000 85 100 90 250 100 93 48 1000 100 100 100 250 85 88 100 100 63 90 71 95 49 1000 100 100 250 100 84 100 100 100 63 91 94 100 70 70 50 1000 100 250 100 82 95 63 82 97 16 82 51 1000 100 100 100 75 100 100 250 85 75 100 100 100 100 63 70 100 97 52 1000 100 100 100 100 250 80 80 75 100 100 100 100 63 94 89 54 1000 100 250 100 100 63 97 92 59 1000 250 100 100 63 100 60 1000 250 75 100 100 63 100 61 1000 250 100 100 63 97 62 1000 250 89 100 63 63 1000 250 97 100 63 100 64 1000 250 63 100 90 16 92 80 65 1000 250 63 100 70 66 1000 250 72 100 90 63 100 67 1000 250 83 90 68 1000 250 90 100 100 63 100 16 71 69 1000 250 100 100 63 94 70 1000 250 100 100 63 81 71 1000 250 100 100 63 97 72 1000 250 100 100 63 84 73 1000 250 100 100 63 82 74 1000 250 100 100 63 88 75 1000 250 100 100 63 93 76 1000 250 100 100 63 94 77 1000 250 100 100 78 1000 250 100 100 63 79 79 1000 250 100 100 100 98 63 79 97 95 80 1000 250 100 100 100 98 63 83 70 89 70 81 1000 250 100 100 100 100 63 87 80 100 82 1000 250 100 100 100 100 63 90 92 80 83 1000 250 96 100 100 100 63 93 80 84 1000 250 100 100 95 100 63 96 85 1000 250 90 100 63 100 16 90 86 1000 250 100 100 100 100 63 84 70 84 70 87 1000 250 97 94 95 100 63 73 76 70 88 1000 250 100 100 100 100 63 90 90 89 1000 250 100 93 100 100 63 77 95 16 80 90 1000 250 94 100 100 100 63 80 80 91 1000 250 97 98 63 74 92 1000 250 83 100 82 97 80 63 84 93 16 74 93 1000 250 100 100 63 97 94 1000 250 100 100 63 95 95 1000 250 100 100 63 91 96 1000 250 100 100 63 100 97 1000 250 74 100 100 63 100 16 72 98 1000 250 94 100 78 100 63 97 99 1000 250 100 100 63 100 100 1000 250 100 100 63 95 101 1000 250 100 70 63 94 102 1000 250 100 100 63 94 103 1000 250 100 100 63 93 104 1000 250 100 100 63 100 105 1000 250 100 100 63 97 106 1000 250 72 100 63 89 107 1000 86 250 63 93 90 108 1000 250 100 100 63 96 109 1000 250 100 100 63 100 110 1000 250 100 100 63 100 111 1000 250 100 63 92 112 1000 250 100 100 63 91 113 1000 250 100 100 63 90 114 1000 250 63 94 90 16 80 115 1000 250 63 98 80 16 79 116 1000 250 98 63 92 117 1000 250 90 63 118 1000 250 63 93 75 16 75 119 1000 250 63 100 85 16 88 120 1000 250 100 63 100 16 91 121 1000 250 63 98 100 16 78 90 122 1000 250 100 63 100 16 95 123 1000 250 100 63 96 124 1000 250 63 91 70 125 1000 250 63 97 90 126 1000 250 63 100 80 16 70 127 1000 76 250 63 96 98 16 80 128 1000 250 63 100 90 16 80 129 1000 250 63 95 16 80 130 1000 250 63 92 95 131 1000 250 63 98 90 132 1000 250 100 63 97 16 81 133 1000 250 63 88 80 134 1000 250 100 63 97 135 1000 250 100 63 97 136 1000 250 63 89 80 137 1000 250 92 63 92 138 1000 250 100 63 82 139 1000 250 100 63 81 140 1000 250 100 63 81 141 1000 250 100 142 1000 250 100 143 1000 250 100 63 81 144 1000 250 100 63 93 16 76 145 1000 250 100 63 100 146 1000 250 100 63 96 147 1000 250 100 63 98 148 1000 250 100 63 97 149 1000 250 73 100 63 91 150 1000 100 100 100 100 250 75 90 100 100 100 100 63 100 100 16 97 94 151 1000 100 100 100 100 250 70 100 100 100 100 63 91 93 100 100 16 97 97 152 1000 250 80 100 100 82 100 63 74 153 1000 250 90 100 100 100 63 94 100 97 16 76 154 1000 250 100 94 100 63 100 16 90 155 1000 250 63 100 99 16 96 156 1000 250 63 100 100 16 93 157 1000 250 100 100 100 100 63 100 100 97 95 158 1000 250 45 100 100 91 100 159 1000 100 100 100 250 100 100 63 97 100 16 81 96 160 1000 100 100 250 90 100 94 63 97 161 1000 100 100 100 250 70 100 100 63 97 100 16 83 86 162 1000 100 100 100 250 70 100 100 63 100 100 16 73 81 163 1000 250 80 164 1000 250 100 63 100 16 83 165 1000 250 100 63 100 16 71 166 1000 250 100 63 100 167 1000 250 100 63 96 16 87 168 1000 250 86 100 63 100 16 82 169 1000 250 100 63 100 16 90 170 1000 250 100 63 90 171 1000 95 81 250 100 63 97 16 72 172 1000 250 90 97 63 96 173 1000 250 80 100 63 100 16 94 174 1000 250 100 100 63 100 16 72 175 1000 250 100 100 63 91 176 1000 250 90 100 63 97 16 76 210 1000 250 100 63 85 211 1000 250 95 63 78 212 1000 250 70 213 1000 250 95 214 1000 250 70 63 77 216 1000 250 100 63 95 16 70 217 1000 250 100 63 95 218 1000 250 100 63 93 219 1000 250 100 63 84 220 1000 250 100 63 95 221 1000 250 85 76 100 63 100 16 97 222 1000 250 100 80 63 100 16 93 223 1000 250 92 88 100 63 100 16 97 224 1000 250 100 100 63 100 16 84 225 1000 250 83 100 63 100 16 93 226 1000 250 86 79 100 63 100 16 97 227 1000 250 100 100 63 100 16 76 228 1000 250 100 100 63 92 229 1000 250 100 100 63 93 230 1000 250 100 63 100 231 1000 250 100 100 100 63 100 16 93 232 1000 250 100 100 100 63 100 16 96 233 1000 250 100 98 100 63 100 16 96 234 1000 250 100 100 63 100 16 96 235 1000 250 100 92 100 63 100 16 96 236 1000 250 90 100 100 63 100 91 16 86 237 1000 250 90 100 100 63 100 16 90

Claims

1. A compound of the formula: ##STR24## in which R.sup.1 represents alkyl, cyclohexyl or neophyl, R* represents fluorophenyl or trifluoromethylphenyl when R.sup.1 is alkyl; R* represents neopentyl, trimethylsilylmethyl or dimethylphenylsilylmethyl when R.sup.1 is cyclohexyl; or R* represents 2-thienyl, 3-thienyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR25## wherein R.sup.3, R.sup.4 and R.sup.5 independently represent hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is neophyl, m represents 1 or 2, and X represents, when m is 1, halogen, imidazolyl, triazolyl, phenylthio or a radical selected from the group consisting of: ##STR26## wherein R.sup.6 represents alkyl, R.sup.7 and R.sup.8 independently represent lower alkyl and R.sup.9 and R.sup.10 independently represent hydrogen or lower alkyl; or X represents oxygen, sulfur or a radical selected from: ##STR27##

2. A pesticidal composition which comprises as an essential component the compound of the formula (I) as defined in claim 1 together with a suitable carrier or adjuvant.