Claims
- 1. A method for treating a bone defect, comprising:
identifying a bone site suitable for receiving an implant; and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site.
- 2. A method for treating a bone defect, comprising:
identifying a bone site suitable for receiving an implant; and introducing a hydrated precursor to a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby the hydrated precursor is converted in vivo to a poorly crystalline apatitic calcium phosphate and whereby bone is formed at the implant site.
- 3. The method of claim 1, wherein the poorly crystalline apatitic calcium phosphate is introduced in the form selected from the group consisting of paste, putty and preshaped object.
- 4. The method of claim 2, wherein the hydrated precursor is introduced in the form selected from the group consisting of paste and putty.
- 5. The method of claim 3 or 4, characterized in that, said paste is injectable for a time greater than about 10 minutes at about 25° C., hardens within about 10 to 60 minutes at about 37° C.
- 6. The method of claim 1, wherein said poorly crystalline apatitic calcium phosphate has x-ray diffraction substantially as shown in FIG. 3a.
- 7. The method of claim 1, wherein the strongly bioresorbable, poorly crystalline apatitic calcium phosphate has an X-ray diffraction pattern comprising broad peaks at 2θ values of 26°, 28.5°, 32° and 33°.
- 8. The method of claim 1, wherein the strongly bioresorbable, poorly crystalline apatitic calcium phosphate is characterized in that, when placed in a rat intramuscular site, resorption of at least 1 g of the material is at least 80% resorbed within one year.
- 9. The method of claim 1, wherein the strongly bioresorbable, poorly crystalline apatitic calcium phosphate is characterized in that, when placed in a rat intramuscular site, resorption of at least 1 g of the material is at least 80% resorbed within one month.
- 10. The method of claim 1 or 2, wherein the implant site comprises a tooth socket.
- 11. The method of claim 1 or 2, wherein the implant site comprises a non-union bone.
- 12. The method of claim 1 or 2, wherein the implant site comprises a bone prosthesis.
- 13. The method of claim 1 or 2, wherein the implant site comprises an osteoporotic bone.
- 14. The method of claim 1 or 2, wherein the implant site comprises an intervertebral space.
- 15. The method of claim 1 or 2, wherein the implant site comprises a alveolar ridge.
- 16. The method of claim 1 or 2, wherein the implant site comprises a bone fracture.
- 17. A method of preparing a ceramic implant, comprising:
mixing in any order,
(a) a reactive amorphous calcium phosphate, (b) a second calcium phosphate, the second calcium phosphate and the reactive amorphous calcium phosphate in a proportion to form an apatitic calcium phosphate, and (c) a physiological liquid, said liquid in the amount to provide a paste or putty; and introducing the paste or putty into an implant site.
- 18. The method of claim 17, wherein the reaction is carried out at no greater than about 37° C.
- 19. The method of claim 17, wherein the fluid selected from the group consisting of water, a physiologically acceptable pH-buffered solution, saline solution, serum and tissue culture medium.
- 20. The method of claim 17, wherein the paste or putty is injected into the implant site.
Parent Case Info
[0001] This application is a continuation-in-part application of co-pending application U.S. Ser. No. 08/650,764 filed May 20, 1996 entitled “Novel Bone Substitution Material and a Method of Its Manufacture”, which is a continuation-in-part application of co-pending application U.S. Ser. No. 08/446,182 filed May 19, 1995 entitled “Synthesis of Reactive Amorphous Calcium Phosphates”, both of which are herein incorporated in its entirety by reference. This application also is related to several co-pending applications filed on even day herewith, entitled, “Bioresorbable Ceramic Composites”, “Delivery Vehicle”, “Cell Seeding of Ceramic Compositions” and “Method and Products Related to the Physical Conversion of Reactive Amorphous Calcium Phosphate”, each of which is incorporated by reference.
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
08650764 |
May 1996 |
US |
Child |
08729343 |
Oct 1996 |
US |
Parent |
08446182 |
May 1995 |
US |
Child |
08650764 |
May 1996 |
US |