Oscillated Insertion System with Target Stabilization for Atraumatic Implantation of Penetrating Neural Electrodes into Dorsal Root Ganglion and Peripheral Nerves

Information

  • Research Project
  • 9688656
  • ApplicationId
    9688656
  • Core Project Number
    R43DK120349
  • Full Project Number
    1R43DK120349-01
  • Serial Number
    120349
  • FOA Number
    PA-18-574
  • Sub Project Id
  • Project Start Date
    9/5/2018 - 5 years ago
  • Project End Date
    8/31/2019 - 4 years ago
  • Program Officer Name
    GOSSETT, DANIEL ROBERT
  • Budget Start Date
    9/5/2018 - 5 years ago
  • Budget End Date
    8/31/2019 - 4 years ago
  • Fiscal Year
    2018
  • Support Year
    01
  • Suffix
  • Award Notice Date
    9/4/2018 - 5 years ago
Organizations

Oscillated Insertion System with Target Stabilization for Atraumatic Implantation of Penetrating Neural Electrodes into Dorsal Root Ganglion and Peripheral Nerves

This Phase I SBIR will develop and test feasibility of a Peripheral Nerve Targeting (PNT) system for inserting penetrating neural electrode arrays into tough peripheral nerve targets, with an initial clinical focus on restoring bladder function. The approach will allow complete insertion of multichannel electrode implants into target nerves, with improved access to fascicles. The system will facilitate: a) improved mapping of the neural structures controlling urinary function, and ultimately b) development of clinical tools for electrode placement into peripheral structures for urinary function restoration. Problem to be solved: The ability to store and periodically eliminate urine is regulated by a dynamic neural circuit integrating information from the brain, spinal cord and peripheral autonomic ganglia. The current clinical standard treatment of bladder control defects is catheterization; however all forms of catheterization are associated with risk of infection. Neural Implants: Some of the most promising treatment alternatives currently under development incorporate electrical control of the bladder. The effectiveness of existing electrical stimulation devices is limited, however, by the inability to surgically access the target safely, difficulty in placing the electrodes, and limited specificity of stimulation. An interface enabling spatially specific activation of nerve fascicles, as provided by penetrating multichannel electrodes, would yield significantly better outcomes. However, implantation of penetrating electrodes into nerves remains a great challenge. Piercing the epineurium requires the electrode to withstand forces which may buckle or break the electrode. The insertion force is substantial enough to compress, stretch and/or roll the targeted nerve, which can prohibit electrode insertion, increase the risk of tissue trauma, and accentuate the chronic foreign body response that leads to cell death, tissue scaring and device failure. This project develops a novel Peripheral Nerve Targeting (PNT) system to improve the ability to insert penetrating electrodes into peripheral nerves. The PNT system employs a nerve stabilization feature combined with vibration of the penetrating electrode array to reduce insertion force, ultimately increasing insertion success while reducing strain and trauma to the nerve. Hypothesis: Vibration of penetrating neural electrode arrays through stabilized epineurium will reduce insertion force and mechanical strain on the nerve to significantly increase success rate (>80%) for complete insertion into peripheral nerve targets. Aim 1: Identification of insertion parameters (oscillation frequency, displacement amplitude, angle of approach, and insertion speed) for reliable, reduced-force insertion of single-shank penetrating electrodes through epineurium. Aim 2: Development and evaluation of handheld PNT system with automated vibration-aided insertion and integrated nerve/epineurium stabilization features. Aim 3: Confirm that the PNT system improves success rate of penetrating electrode insertions into peripheral nerves and dorsal root ganglion.

IC Name
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • Activity
    R43
  • Administering IC
    DK
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    224908
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    847
  • Ed Inst. Type
  • Funding ICs
    NIDDK:224908\
  • Funding Mechanism
    SBIR-STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    ACTUATED MEDICAL, INC.
  • Organization Department
  • Organization DUNS
    791379030
  • Organization City
    BELLEFONTE
  • Organization State
    PA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    168238445
  • Organization District
    UNITED STATES