Patent Application
20150196720
The present invention relates to an outer cylinder for a prefilled syringe, a piercing tool for the prefilled syringe, the prefilled syringe, and a packaging body for packaging the outer cylinder for the prefilled syringe.
The prefilled syringe is provided with a medical liquid such as a liquid medicine and a medical agent solution filled therein. The front end of a certain type of a prefilled syringe is sealed with a cap on which a double-ended needle can be mounted. A piercing member having the double-ended needle is mounted on the cap when the prefilled syringe is used. An example of the piercing member having the double-ended needle and an example of a form of mounting the piercing member having the double-ended needle on the cap are disclosed in a patent document 1 (Japanese Unexamined Patent Application Publication No. 2010-540122, WO-2009/043000).
In the prefilled syringe of the patent document 1, because the piercing member is mounted on the prefilled syringe by means of only the thread engagement between the piercing member and the outer cylinder, there is a possibility that when the prefilled syringe is used to administer a medical agent to a patient, the thread engagement loosens and the medical agent leaks.
It is an object of the present invention to provide an outer cylinder for a prefilled syringe, a piercing tool for the prefilled syringe, and the prefilled syringe in which it is easy to perform an operation of mounting a piercing member having a double-ended needle on a closure member of the syringe which seals a front end of the piercing member and prevent a medical agent from leaking because the closure member mounted on the outer cylinder for the syringe is so constructed that the closure member does not loosen in performing an operation of mounting the piercing member on the closure member, and a packaging body.
It is an object of the present invention to provide an outer cylinder for a prefilled syringe which comprises an outer cylinder body which has a distal part having an opening, an outer cylinder closure member is mounted on said distal part of said outer cylinder body, wherein said outer cylinder can be mounted a piercing member which includes a piercing member body and a hollow needle mounted to said piercing member body, wherein said outer cylinder closure member accommodates a sealing member which seals said opening of said distal part of said outer cylinder body and is penetrable by said hollow needle of said piercing member, wherein said outer cylinder closure member has a piercing member mounting portion is mountable to said piercing member, wherein said outer cylinder has a regulation portion which regulates separation and rotation of said outer cylinder closure member mounted on said outer cylinder body; and wherein said piercing member mounting portion of said outer cylinder closure member engages said piercing member when said outer cylinder is pressed into said piercing member from a side of said outer cylinder closure member, and said piercing member mounting portion of said outer cylinder closure member has a cylinder closure member side engaging portion which engages to said piercing member and regulates separation of said piercing member from said outer cylinder closure member after said outer cylinder closure member side engaging portion engages said piercing member.
Using embodiments shown in the drawings, description is made on embodiments of an outer cylinder for a prefilled syringe of the present invention, a piercing tool for the prefilled syringe, the prefilled syringe, and a packaging body for packaging outer cylinders for the prefilled syringe.
It is possible to mount a piercing member 6 including a hollow needle 61 having a needle portion 61a at one end thereof and a needle portion 61b at other end thereof and a piercing member body 60 on which the hollow needle 61 is mounted and which has a piercing member side engaging portion 62 on an outer cylinder 2 of the present invention for the prefilled syringe. The outer cylinder 2 for the prefilled syringe has an outer cylinder body 4 which has a distal part 41 having an opening 48 and an outer cylinder closure member 5 which seals the opening 48 of the distal part 41, accommodates a sealing member 10 through which the needle portion 61b of the hollow needle 61 is penetrable, and is mounted on the distal part 41 of the outer cylinder body 4.
The outer cylinder closure member 5 has a piercing member mounting portion 50 on which the piercing member 6 is mountable. The outer cylinder 1 has a regulation portion (in other words, regulation mechanism) regulates the separation and rotation of the outer cylinder closure member 5 mounted on the outer cylinder body 4. The outer cylinder closure member 5 further includes an outer cylinder closure member side engaging portion 53 which engages the piercing member side engaging portion 62 when the outer cylinder 2 is pressed into the piercing member 6 from the side of the outer cylinder closure member 5 and which regulates the separation of the piercing member 6 from the outer cylinder closure member 5, after the outer cylinder closure member side engaging portion engages the piercing member side engaging portion 62.
The prefilled syringe 1 of the present invention is composed of the outer cylinder 2 for the prefilled syringe, a gasket 8 accommodated inside the outer cylinder 2 and being liquid-tightly slidable inside the outer cylinder, and a medical agent 11 accommodated inside a space formed of the outer cylinder 2 and the gasket 8.
As shown in
As shown in
The distal part 41 projects in a distal direction from a shoulder portion of the body part 40. The distal part 41 has the opening 48 for discharging a liquid medicine accommodated inside the outer cylinder and cannot be connected to a medical appliance, having a connection portion to be connected to a nozzle, which conforms to the ISO Standard. That is, the distal part 41 does not have a luer taper configuration unlike an ordinary syringe having the distal portion.
In the outer cylinder body 4 of this embodiment, the distal part 41 has a large-diameter portion 44 formed at a boundary between the distal part 41 and the body part 40, a concave portion 47 (specifically, two opposed concave portions) formed at the large-diameter portion 44, and a projected portion 43 (specifically, opposed two projected portions) formed in the neighborhood of a distal end (in other words, in the neighborhood of a central portion of the distal part 41 in its axial direction) of an intermediate portion 42 (portion having a smaller diameter than the large-diameter portion 44 and a larger diameter than the end of the distal portion) of the distal part 41. The distal part 41 has a small-diameter portion at its distal end. The opening 48 is formed at the distal end of the small-diameter portion.
In the outer cylinder body 4 of this embodiment, the projected portion 43 circumferentially extends a predetermined length. The two concave portions 47 axially extend a predetermined length. The two projected portions 43 and the two concave portions 47 are so formed as not to axially overlap each other.
In the outer cylinder, the concave portions 47 and the projected portions 43 are so disposed that one concave portion and the adjacent projected portion form 90 degrees with respect to the central axis of the distal part 41. In the outer cylinder, 90 degrees is formed between the line connecting the central axis of the distal part 41 and the projected portion 43 to each other and the line connecting the central axis thereof and the concave portion 47 adjacent to the projected portion 43 to each other.
The projected portion 43 of the distal part 41 of the outer cylinder body 4 constructs an engaging portion for regulating the separation of the outer cylinder closure member at the outer cylinder side. The concave portion 47 of the distal part 41 constructs an engaging portion for regulating the rotation of the outer cylinder closure member at the outer cylinder side.
The flange 46 is formed as a disk portion, having the shape of an elliptic donut, which is formed by projecting it from the entire circumference of the rear end of the outer cylinder body 4 in a direction vertical to the outer cylinder body. As shown in
The outer cylinder body 4 is a tubular body formed of a transparent or semitransparent material which may have oxygen permeability and a low degree of water vapor permeability as necessary.
Examples of a material for the outer cylinder body 4 include resins such as polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly-(4-methylpentene-1), acrylic resin, acrylonitrile-butadiene-styrene copolymer, and polyester including polyethylene terephthalate; and cyclic polyolefin. Of these resins, the polypropylene and the cyclic polyolefin are preferable because these resins can be easily molded and have excellent heat resistance.
The distal part 41 of the outer cylinder body 4 is sealed with the outer cylinder closure member 5 which will be described in detail later.
As shown in
The body part 51 having the piercing member mounting portion 50 is a tubular body and has a small-diameter open portion 57 formed at a distal end of the body part 51, a flange portion 55 formed at a proximal end thereof, a window portion 53 (specifically, opposed two window portions) formed at a side thereof, an outer cylinder closure member side engaging portion (annular rib) 52 formed on an outer surface thereof disposed at a side distal from the window portion 53, a rib 59 (a plurality of ribs circumferentially formed) formed at a side distal from the flange portion 55 and proximal from the window portion 53, and a projected portion 58 (specifically, opposed two projected portions) formed on an inner surface of the proximal portion of the body part 51 and axially extending.
In the outer cylinder closure member 5 of this embodiment, the window portion 53 accommodates and engages the projected portion 43 of the outer cylinder body 4 and circumferentially extends a predetermined length. The projected portion 43 of the outer cylinder body 4 enters and engages the window portion 53 of the outer cylinder closure member 5. Thereby the outer cylinder closure member is prevented from separating from the outer cylinder body 4 and from rotating. Thus in the prefilled syringe 1 of this embodiment, the outer cylinder closure member 5 is inseparably mounted on the outer cylinder body 4.
In a state where the outer cylinder closure member 5 is mounted on the outer cylinder body 4, the projected portion 58 formed on the inner surface of the proximal portion of the outer cylinder closure member 5 enters and engages the concave portion 47 of the outer cylinder body 4. Thereby the outer cylinder closure member 5 is unrotatable with respect to the outer cylinder body 4. Thus following the rotation of the outer cylinder body 4, the outer cylinder closure member 5 rotates.
Thus the window portion 53 of the outer cylinder closure member 5 constructs the engaging portion for regulating the separation of the outer cylinder closure member at the tubular body side. The projected portion 58 constructs the engaging portion for regulating the rotation of the outer cylinder closure member at the tubular body side.
An outer cylinder closure member side engaging portion 52 is formed on a distal side outer surface of the body part 51 having the piercing member mounting portion 50. In this embodiment, the outer cylinder closure member side engaging portion 52 is formed of an annular rib. A distal portion of the annular rib 52 is formed as an annular inclined surface 52a whose diameter decreases toward its distal end. A rear end surface of the annular rib 52 is formed as an erect surface orthogonal to the central axis of the piercing member. As shown in
The outer cylinder closure member 5 of this embodiment has two opposed flat portions 54 on sides disposed at its proximal side to easily grip the outer cylinder closure member 5.
As materials for the outer cylinder closure member, resins such as polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly-(4-methylpentene-1), acrylic resin, acrylonitrile-butadiene-styrene copolymer, and polyester including polyethylene terephthalate; and cyclic polyolefin are listed. Of these resins, the polypropylene and the cyclic polyolefin are preferable because these resins can easily molded and have excellent heat resistance.
The sealing member 10 is accommodated inside the distal portion of the body part 51 having the piercing member mounting portion 50 and seals the open portion 57 and liquid-tightly seals the opening 48 formed at the distal part 41 of the outer cylinder body 4 in a state in which the outer cylinder closure member 5 is mounted on the distal part 41 of the outer cylinder body 4, as shown in
As materials for the sealing member, it is preferable to use natural rubber; synthetic rubber such as isoprene rubber, butadiene rubber, fluororubber, and silicone rubber; and thermoplastic elastomers such as olefin elastomers and styrene elastomers.
As shown in
As shown in
As materials for the gasket 8, it is preferable to use elastic rubber (for example, butyl rubber, latex rubber, silicone rubber, styrene-butadiene rubber, and isoprene rubber); and thermoplastic elastomers (for example, styrene elastomer such as SBS elastomer, SEBS elastomer, and SEPS elastomer; and olefin elastomer such as ethylene-α-olefin copolymer elastomer).
The gasket 8 has a concave portion extending into the inside thereof from the rear end thereof. The concave portion serves as a plunger mounting portion 84. More specifically, the plunger mounting portion 84 is female screw-like and thus engageable with a male screw portion 93 formed on an outer surface of a gasket-mounting portion 92 formed at a distal portion of the plunger 9. The plunger 9 is mounted on the gasket 8 by the engagement between the female screw portion and the male screw portion.
As shown in
Although the medical agent 11 to be filled inside the outer cylinder body 4 is not limited to a specific one, examples of medical agents include protein preparations such as vitamin preparation (multivitamin preparation), amino acids, antithrombotic agents such as heparin, insulin, antibiotic, antitumor agent, painkillers, cardiotonic drug, intravenous anesthetic, antiperkinsonian agent, anti-ulcer agent, corticosteroid, an antiarrhythmic agent, a hormone drug, an interferon preparation, human immunoglobulin preparation; a blood coagulation factor preparation, and vaccine preparation.
The piercing tool 3 of the present invention for the prefilled syringe is described below with reference to
The piercing tool 3 of the present invention for the prefilled syringe is used by mounting the piercing tool 3 on the outer cylinder 2 for the prefilled syringe or on the outer cylinder closure member 5 of the prefilled syringe 1. The piercing tool 3 has the hollow needle 61 having the needle portion (specifically, a piercing needle portion 61a at one end thereof, and a sealing member piercing needle portion 61b at the other end thereof) at both ends thereof; the piercing member 6 on which the hollow needle 61 is mounted and which is mountable on the outer cylinder closure member 5 and has the piercing member body 60 having the piercing member side engaging portion 62; and an accommodation member 7 separably accommodating the piercing member 6. The accommodation member 7 is pulled in a distal direction after the piercing member 6 is mounted on the outer cylinder closure member 5, and the piercing member side engaging portion 62 and the outer cylinder closure member side engaging portion 52 engage each other. Thereby the accommodation member 7 is separated from the piercing member 6.
In this embodiment, the outer cylinder closure member side engaging portion is composed of the annular rib 52 formed on the outer surface of the outer cylinder closure member 5. The piercing member side engaging portion is composed of the projecting portion 62, formed on the inner surface of the piercing member body 60, which is capable of riding across the annular rib 52 when the outer cylinder closure member 5 is pressed into the piercing member 6.
The piercing tool 3 is composed of the accommodation member 7 and the piercing member 6 accommodated inside the accommodation member 7.
As shown in
As shown in
The piercing member body 60 is a tubular body which has a hollow needle fixing part having a small diameter at its distal end portion and an outer cylinder closure member accommodation part at its proximal portion. The outer cylinder closure member accommodation part has an outer cylinder closure member mounting portion on which the outer cylinder closure member 5 of the outer cylinder 2 is mountable.
More specifically, the outer cylinder closure member mounting portion has the piercing member side engaging portion 62 which engages the outer cylinder closure member side engaging portion 52 formed on the outer surface of the outer cylinder closure member 5.
In this embodiment, the piercing member 6 has an open portion 64 (specifically, opposed two open portions). The piercing member side engaging portion is formed of the projecting portion 62 projecting into the piercing member 6 from a bottom portion of the open portion 64. The projecting portion 62 extends a predetermined length in the circumferential direction of the piercing member body. The form of the piercing member side engaging portion is not limited to a short rib as described above, but may be an annular rib or composed of a plurality of annularly disposed ribs. A lower surface of the projecting portion 62 is formed as an inclined surface 62a extended toward the inner surface of the piercing member body. When the piercing member 6 is mounted on the outer cylinder closure member 5, the inclined surface 62a contacts the annular inclined surface 52a of the annular rib 52 of the outer cylinder closure member 5. Because both are formed as the inclined surface, the projecting portion 62 is guided in riding across the annular rib 52. After the projecting portion 62 rides across the annular rib 52, a rear end surface of the annular rib 52 which is erect and a front end surface of the projecting portion 62 which is also erect contact each other. Thereby the piercing member 6 is prevented from separating from the outer cylinder closure member 5.
The piercing member 6 of this embodiment has an annular concave portion 87 formed on an inner surface of the piercing member body in the neighborhood of the proximal portion thereof. When the piercing member 6 is mounted on the outer cylinder closure member 5, the rib 59 (a plurality of ribs circumferentially formed) of the outer cylinder closure member 5 enters the annular concave portion 87, thus engaging the annular concave portion 87. Thereby the piercing member 6 is prevented from separating from the outer cylinder body 4.
Thus the outer cylinder closure member 5 of this embodiment has the first outer cylinder closure member side engaging portion 52 and the second outer cylinder closure member side engaging portion 59 (arc-shaped rib) positioned nearer to the proximal side of the outer cylinder closure member 5 than the first outer cylinder closure member side engaging portion 52. The piercing member 6 has the first piercing member side engaging portion 62 which engages the first outer cylinder closure member side engaging portion 52 and the second piercing member side engaging portion (annular concave portion) 87 positioned at the proximal side of the piercing member 6 and engaging the second outer cylinder closure member side engaging portion 59. The piercing member 6 has a concave portion 67 (specifically, two opposed concave portions) on the outer surface of the piercing member body 60 at an axial central portion thereof.
The window portion 53 locates between the first outer cylinder closure member side engaging portion 52 and the second outer cylinder closure member side engaging portion 59.
The hollow needle 61 is fixed to a hollow needle fixing part 63 of the piercing member body 60 with a fixing agent 68 and has the needle portion at both ends thereof. More specifically, one end side of the hollow needle 61 projects to a side distal from the fixing part 63 and has the piercing needle portion 61a to be pierced into a living body at its distal end. The other end side of the hollow needle 61 projects from the fixing portion 63 into the inside of the piercing member 6 and has the sealing member piercing needle portion 61b which can be pierced through the sealing member of the outer cylinder closure member 5 at the end of the other side of the hollow needle 61. The hollow needle 61 extends almost parallel with the central axis of the piercing member body 60.
In the prefilled syringe of this embodiment and an injector for the prefilled syringe, the piercing member 6 mounted on the outer cylinder closure member 5 of the outer cylinder 2 is substantially inseparable from the outer cylinder closure member 5.
In the outer cylinder 2 for the prefilled syringe of this embodiment and the piercing tool 3 therefor, the outer cylinder closure member side engaging portion 52 and the piercing member side engaging portion 62 are so disposed that after the sealing member piercing needle portion 61b of the hollow needle 61 pierces through the sealing member 10, the outer cylinder closure member side engaging portion 52 and the piercing member side engaging portion 62 engage each other.
It is preferable that the outer cylinder 2 of the present invention for the prefilled syringe is subjected to autoclave sterilization. The outer cylinder 2 for the prefilled syringe may be subjected to the autoclave sterilization before it is used. Similarly the prefilled syringe 1 may be subjected to the autoclave sterilization before it is used.
The action of the prefilled syringe 1 of the present invention is described below with reference to
As shown in
As shown in
As shown in
After an administering operation finishes, the accommodation member 7 is mounted on the syringe body and the syringe is discarded.
An embodiment of a packaging body of the present invention accommodating a plurality of the outer cylinders for the prefilled syringe is described below with reference to
A packaging body 100 of the present invention accommodating a plurality of the outer cylinders for the prefilled syringe can be or is subjected to autoclave sterilization before it is used.
The packaging body 100 has a container 102 whose upper surface is open and which has shape retainability, an outer cylinder holding member 104 capable of holding a plurality of the outer cylinders 2 for the prefilled syringe, a plurality of the outer cylinders 2 for the prefilled syringe held by the outer cylinder holding member 104, and a sheet-shaped lid member 103 which airtightly seals an open upper surface of the container 102 and is peelable from the container 102. The packaging body 100 further includes an air-permeable part, having bacteria impermeability and water vapor permeability, which is provided in the container 102 or the lid member 103.
As shown in
As shown in
As shown in
The outer cylinder holding member holding part 126 is formed at a position located below the flange 124 by spacing it at a predetermined interval from the flange 124. In the container 102 of this embodiment, the outer cylinder holding member holding part 126 is formed as an annular stepped portion so that the peripheral portion of the outer cylinder holding member 104 holding the outer cylinders for the prefilled syringe can be placed thereon. The outer cylinder holding member holding part may be annularly uncontinuously formed instead of being annularly continuously formed.
One air-permeable sealing member forming the lid member is used for the container 102 of this embodiment. To do so is preferable because it is easy to perform an operation of fixing the lid member to the container 102.
It is preferable that the container 102 has shape retainablity and rigidity to some extent. To respond to autoclave sterilization, it is desirable to use a thermoplastic material having heat resistance (not less than 120 degrees C.) for the container. As materials shape-retainable and rigid to some extent, heat-resistant, and thermoplastic, polyolefin such as polypropylene and polyethylene; vinyl chloride resin, polystyrene/polypropylene resin, polyethylene/ionomer (for example, ethylene-based, styrene-based, fluorine-based)/polyethylene, polyester resin (for example, polyethylene terephthalate, polybutylene terephthalate, and amorphous polyethylene terephthalate), and PP/EVOH/PP (laminate) are listed. In this case, the thickness of the container 102 is favorably 0.05 to 4.00 mm and especially favorably 1.00 to 2.00 mm.
As shown in
As the outer cylinder 2 for the prefilled syringe, the above-described outer cylinder is used.
The sheet-shaped lid member 103 covers and seals the open upper surface of the container 102 and is peelable from the container 102. In the packaging body 100, the sheet-shaped lid member 103 is peelably fixed to the periphery of the open upper surface of the container 102 through an annular heat-sealing portion 131. The sheet-shaped lid member 103 does not substantially permeate bacteria and water vapor therethrough and can be peelably sealed to the container 102.
It is preferable to form the sheet-shaped lid member 103 of a material which does not allow fine particles such as bacteria and virus to permeate therethrough and has water vapor permeability. It is preferable that the sheet-shaped lid member 103 can be heat-sealed to the container 102. For example, it is possible to suitably use nonwoven cloth made of synthetic resin, for example, nonwoven cloth, known as Tyvek (registered trademark), which is made of a synthetic resin material such as polyolefin and a porous film made of synthetic resin.
The peripheral portion of the sheet-shaped lid member 103 is peelably heat-sealed to the heat-sealing convex part 125 formed on the annular flange 124 of the container 102. In this embodiment, the outer edge of the sheet-shaped lid member is not heat-sealed to the annular flange 124 of the container 102 to easily peel the sheet-shaped lid member from the container. The projected portion 125a formed at each corner of the heat-sealing convex part 125 functions as a peeling starting portion. The thickness of the sheet-shaped lid member 103 is favorably 0.05 to 1.00 mm and more favorably 0.10 to 0.50 mm.
In the above-described embodiment, the lid member has the air-permeable part. But the lid member does not necessarily have the air-permeable part, but the container 102 may have the air-permeable part.
A medical instrument of this invention comprises the outer cylinder 1 for a prefilled syringe and the piercing member 6 which is mountable to the outer cylinder 1. The outer cylinder 1 is as described above. The piercing member 6 is as described above. The piercing member 6 may has the accommodation member 7. As a piercing member, can be used piercing tool 3.
The outer cylinder for the prefilled syringe of the present invention is constructed as described below.
The outer cylinder for a prefilled syringe comprises an outer cylinder body which has a distal part having an opening, an outer cylinder closure member is mounted on the distal part of the outer cylinder body, wherein the outer cylinder can be mounted a piercing member which includes a piercing member body and a hollow needle mounted to the piercing member body, wherein the outer cylinder closure member accommodates a sealing member which seals the opening of the distal part of the outer cylinder body and is penetrable by the hollow needle of the piercing member, wherein the outer cylinder closure member has a piercing member mounting portion is mountable to the piercing member, wherein the outer cylinder has a regulation portion which regulates separation and rotation of the outer cylinder closure member mounted on the outer cylinder body; and wherein the piercing member mounting portion of the outer cylinder closure member engages the piercing member when the outer cylinder is pressed into the piercing member from a side of the outer cylinder closure member, and the piercing member mounting portion of the outer cylinder closure member has a cylinder closure member side engaging portion which engages to the piercing member and regulates separation of the piercing member from the outer cylinder closure member after the outer cylinder closure member side engaging portion engages the piercing member.
In the outer cylinder for the prefilled syringe, it is easy to perform the operation of mounting the piercing member having the double-ended needle on the outer cylinder closure member of the outer cylinder for the syringe. In addition, in performing the operation of mounting the piercing member on the outer cylinder closure member, the outer cylinder closure member mounted on the outer cylinder for the prefilled syringe does not loosen. Thereby there does not occur loosening-caused leak of the medical liquid. Because the piercing member can be mounted on the syringe in a simple way, the present invention provides the appliance easy to use irrespective of the degree of skill of a user.
Because the piercing member does not separate from the syringe in normal use of the prefilled syringe, the present invention provides an effect of preventing reuse of the piercing member. Thereby the effect of preventing infection to patients and medical care workers through the piercing member is expected.
Further in the case where the piercing needle portion whose distal end is narrow is selected, it is difficult to refill a liquid medicine in a state where the piercing member and the plunger are mounted on the outer cylinder and on the gasket respectively. Thus the outer cylinder for the prefilled syringe is discarded by one-time use. To thin the front end of the piercing needle portion has the effect of not only decreasing patient's pain, but also preventing the piercing member from being continuously used.
The embodiments of the present invention may be carried out as described below.
The outer cylinder for the prefilled syringe according to the above outer cylinder is subjected to autoclave sterilization.
The outer cylinder for the prefilled syringe subjected to autoclave sterilization can be used as it is in producing an aseptic filling machine.
The piercing tool of the present invention is constructed as described below.
The piercing tool for a prefilled syringe can be mounted on an outer cylinder for the prefilled syringe on the outer cylinder closure member of the prefilled syringe, wherein the piercing tool has the piercing member and an accommodation member separably accommodating the piercing member; and the accommodation member is separated from the piercing member by pulling the accommodation member in a distal direction after the piercing member is mounted on the outer cylinder closure member.
It is easy to perform the operation of mounting the piercing tool on the outer cylinder closure member of the outer cylinder for the syringe. In addition, in performing the operation of mounting the piercing member on the outer cylinder closure member, the outer cylinder closure member mounted on the outer cylinder for the prefilled syringe does not loosen. Thereby there does not occur loosening-caused leak of the medical liquid.
The packaging body for packaging the outer cylinders for the prefilled syringe of the present invention is constructed as described below.
The packaging body for packaging outer cylinders for a prefilled syringe accommodates a plurality of outer cylinders for a prefilled syringe according to claim 1 and can be subjected to or is subjected to autoclave sterilization, the packaging body comprising a container whose upper surface is open and which has shape retainability; an outer cylinder holding member capable of holding a plurality of the outer cylinders for the prefilled syringe; a plurality of the outer cylinders for the prefilled syringe held by the outer cylinder holding member; a sheet-shaped lid member which airtightly seals the open upper surface of the container and is peelable from the container; and an air-permeable part, having bacteria impermeability and water vapor permeability, which is provided in the container or the lid member.
The packaging body for packaging the outer cylinders for the prefilled syringe is capable of providing the outer cylinder for the prefilled syringe having the above-described high effect in a favorable state.
This application claims priority as a continuation application under 35 U.S.C. §120 to PCT/JP2012/074909, which was filed as an International Application on Sep. 27, 2012 designating the U.S. The entire contents of these applications are hereby incorporated by reference in their entireties.
| Number | Date | Country | |
|---|---|---|---|
| Parent | PCT/JP2012/074909 | Sep 2012 | US |
| Child | 14671256 | US |
