Claims
- 1. A method for delivering a medicament to an individual comprising the steps of:
providing a chewing gum that includes a tableted gum center and a coating that substantially surrounds the tableted gum center, the coating comprising at least 50% by weight of the chewing gum, the coating including a medicament; chewing the chewing gum to cause the medicament to be released from the chewing gum composition into the buccal cavity of the individual; and continuing to chew the chewing gum thereby creating a fluid pressure causing the medicament to enter the systemic system of the individual through an oral mucosa of the individual.
- 2. The method of claim 1 wherein the coating includes a high-intensity sweetener.
- 3. The method of claim 1 wherein the high-intensity sweetener is chosen from the group consisting of aspartame, sucralose, saccharin, and acesulfame-k.
- 4. The method of claim 1 wherein the coating is produced by alternating layers of a powder and a syrup onto the tableted gum center.
- 5. The method of claim 1 wherein the tableted gum center includes at least 50% by weight water-insoluble gum base.
- 6. The method of claim 1 wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; and cardiovascular agents.
- 7. The method of claim 1 wherein the coating has a matte finish.
- 8. The method of claim 1 wherein the coating does not include a shellac layer.
- 9. A chewing gum comprising:
a tableted gum center including a water soluble portion and a water insoluble portion; and a coating including a medicament that surrounds the tableted gum center, the coating comprising at least 50% by weight of the chewing gum product.
- 10. The chewing gum of claim 9 wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; stimulants; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; and cardiovascular agents.
- 11. The chewing gum of claim 9 wherein the coating includes a sufficient amount of taste masking agent to provide acceptable organoleptic properties.
- 12. The chewing gum of claim 1 wherein the taste masking agent is chosen from the group consisting of: zinc gluconate, ethyl maltol, glycine, acesulfame-k, aspartame; saccharin; fructose; xylitol; isomalt; maltitol; spray dried licorice root; glycerrhizine; sodium gluconate; glucono delta-lactone; ethyl vanillin; dextrose; sucralose; vanillin; and ethyl maltol.
- 13. The chewing gum of claim 11 wherein the taste masking agent comprises approximately 30% to about 99% by weight of the coating.
- 14. The chewing gum of claim 9 wherein the coating includes approximately 0.5% to about 5% by weight of a high-intensity sweetener chosen from the group consisting of aspartame, sucralose, saccharine, and acesulfame-k.
- 15. The chewing gum of claim 9 wherein the tableted gum center includes at least 50% by weight water-insoluble gum base.
- 16. The chewing gum of claim 9 wherein the coating does not have a shellac layer.
- 17. The chewing gum of claim 9 wherein the tableted gum center and coating are sugar-free.
- 18. A product including a medicament comprising:
a tableted gum center including a water soluble portion and a water insoluble portion, the water insoluble portion comprising at least 30% by weight of the tableted gum center; and a coating that at least substantially surrounds the tableted gum center and includes a medicament and a high-intensity sweetener, the coating comprising at least 50% by weight of the product.
- 19. The product of claim 18 wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; stimulants; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; and cardiovascular agents.
- 20. The product of claim 18 wherein the coating includes a sufficient amount of taste masking agent to provide acceptable organoleptic properties.
- 21. The product of claim 18 wherein the taste masking agent is chosen from the group consisting of: zinc gluconate, ethyl maltol, glycine, acesulfame-k, aspartame; saccharin; fructose; xylitol; isomalt; maltitol; spray dried licorice root; glycerrhizine; sodium gluconate; glucono delta-lactone; ethyl vanillin; dextrose; sucralose; vanillin; and ethyl maltol.
- 22. The product of claim 18 wherein the taste masking agent comprises approximately 30% to about 99% by weight of the coating.
- 23. The product of claim 18 wherein the coating includes approximately 0.5% to about 5% by weight of a high-intensity sweetener chosen from the group consisting of aspartame, sucralose, saccharine, and acesulfame-k.
- 24. The product of claim 18 wherein the coating comprises at least 70% by weight powder when it is applied to the tableted gum center.
- 25. The product of claim 18 wherein the product is sugar-free.
- 26. The chewing gum of claim 18 wherein the coating does not have a shellac layer.
- 27. A method of delivering a medicament comprising the steps of:
providing a chewing gum having a tableted gum center and a coating that substantially surrounds the center, the coating comprising at least 50% by weight of the chewing gum, the coating including a medicament and not including a shellac layer; and chewing the chewing gum for at least 2 minutes in a buccal cavity of an individual chewing the chewing gum.
- 28. The method of claim 27 wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; and cardiovascular agents.
- 29. The method of claim 27 wherein the tableted gum center comprises approximately 30% to about 90% by weight insoluble gum base.
- 30. A method for delivering a medicament to an individual comprising the steps of:
providing a chewing gum product that includes a tableted gum center that is substantially coated by a formulation that includes a medicament and a sufficient amount of a masking agent to provide acceptable organoleptic properties, the formulation comprising at least 50% by weight of the chewing gum product; and chewing the chewing gum product to cause the medicament to be released from the formulation into a buccal cavity of the individual.
- 31. The method of claim 30 wherein the formulation includes a high-intensity sweetener.
- 32. The method of claim 30 wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; stimulants; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; and cardiovascular agents.
- 33. The method of claim 30 wherein the taste masking agent is chosen from the group consisting of: zinc gluconate, ethyl maltol, glycine, acesulfame-k, aspartame; saccharin; fructose; xylitol; isomalt; maltitol; spray dried licorice root; glycerrhizine; sodium gluconate; glucono delta-lactone; vanillin; dextrose; sucralose; and ethyl maltol.
- 34. The method of claim 30 wherein the masking agent comprises approximately 30% to about 99% by weight of the coating.
- 35. A method of manufacturing a product containing an agent comprising the steps of:
preparing a gum center having water soluble portion and a water insoluble by tableting the water-soluble portion and water-insoluble portion to produce a tableted gum center; and coating the center by placing alternating layers of a powder and a syrup on the center to create a coated product, at least one of the powder or syrup layers including at least one agent.
- 36. The method of claim 35 wherein the coated product comprises at least 50% by weight syrup and powder coating.
- 37. The method of claim 35 wherein the tableted gum center includes at least 50% by weight water-insoluble gum base.
- 38. The method of claim 35 wherein the coating includes a high-intensity sweetener.
- 39. The method of claim 35 wherein the agent is a medicament.
- 40. The method of claim 38 wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; and cardiovascular agents.
- 41. The method of claim 35 wherein at least two alternating layers are coated on to the center.
- 42. The method of claim 35 wherein the powder comprises at least 70% by weight of the coating.
- 43. The method of claim 35 wherein the coating does not include a shellac layer.
- 44. A method of providing chewing gum that includes a medicament comprising the steps of:
preparing a gum center having a water-soluble portion and a water-insoluble portion by tableting the water-soluble and water-insoluble portions into a predefined shape; and coating the predefined shape with at least one layer including a medicament.
- 45. The method of claim 44 wherein the coated product comprises at least 50% by weight syrup and powder coating.
- 46. The method of claim 44 wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics; antivirals; antihistamines; decongestants; anti-inflammatories; antacids; psychotherapeutic agents; insulin; vitamins; minerals; and cardiovascular agents.
- 47. The method of claim 44 wherein the coating includes a high-intensity sweetener.
Parent Case Info
[0001] This is a divisional of U.S. patent application Ser. No. 09/618,808, filed on Jul. 18, 2000, which is a continuation-in-part of U.S. patent application Ser. No. 09/510,878, filed on Feb. 23, 2000, which is a continuation-in-part of U.S. patent application Ser. No. 09/286,818, filed on Apr. 6, 1999 and PCT Patent Application No. PCT/US99/29742 filed on Dec. 14, 1999.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09618808 |
Jul 2000 |
US |
Child |
09759838 |
Jan 2001 |
US |