Claims
- 1. A compound of formula (I)
- 2. A compound according to claim 1 of formula (II)
- 3. A compound according to claim 1 wherein A is phenyl.
- 4. A compound according to claim 3 wherein B is
- 5. A compound according to claim 4 selected from the group consisting of
N-(((5S)-3-(3-fluoro-4-((E)-(2-oxo-1,2-dihydro-3H-pyrrolo(2,3-b)pyridin-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((Z)-(4,5-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-2-oxo-3-(4-((E)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((Z)-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo- 1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(3-fluoro-4-((E)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(3-fluoro-4-((Z)-(1-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(3-fluoro-4-((E)-(1-methyl-5-nitro-2-oxo-1,2-dihydro-3H-indol-3 -ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(6-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(5-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((Z)-(5-chloro-2-oxo-1,2-dihydro-3 H-indol-3-ylidene)methyl)-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(1-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-[((5S)-3-{4-[(E)-(6-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide, N-[((5S)-3-{4-[(E)-(5,6-dimethoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-fluorophenyl}-2-oxo- 1,3-oxazolidin-5-yl)methyl]acetamide, N-[((5S)-3-{4-[(Z)-(5-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide, N-[((5S)-3-{4-[(E)-(1-acetyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide, N-[((5S)-3-{4-[(Z)-(4,7-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide, N-{[(5S)-3-(3-fluoro-4-{(E)-[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]methyl}phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide, and N-{[(5S)-3-(3-fluoro-4-{(Z)-[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]methyl}phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide.
- 6. A compound according to claim 3 wherein B is
- 7. A compound according to claim 6 which is
N-(((5S)-3-(4-((E)-(3-methyl-2,5-dioxo-4-imidazolidinylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide.
- 8. A compound according to claim 3 wherein B is
- 9. A compound according to claim 8 selected from the group consisting of
N-(((5S)-3-(4-((Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, and N-(((5S)-3-(4-((Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl)-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide.
- 10. A compound according to claim 3 wherein B is
- 11. A compound according to claim 10 which is
N-[((5S)-2-oxo-3-{4-[(Z)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl}-1,3-oxazolidin-5-yl)methyl]acetamide.
- 12. A compound according to claim 3 wherein B is
- 13. A compound according to claim 12 selected from the group consisting of
N-(((5S)-3-(4-((Z)-(3-tert-butyl-1-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, and N-(((5S)-3-(4-((Z)-(3-tert-butyl-5-oxo-1-phenyl- 1,5-dihydro-4H-pyrazol-4-5ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide.
- 14. A pharmaceutical composition comprising a compound of claim 1 or a therapeutically acceptable salt thereof, in combination with a therapeutically acceptable carrier.
- 15. A method for treating bacterial infections in a patient in recognized need of such treatment comprising administering to the patient a therapeutically acceptable amount of a compound of claim 1, or a therapeutically acceptable salt thereof.
- 16. A method for treating psoriasis in a patient comprising administering to the patient a therapeutically acceptable amount of a compound of claim 1, or a therapeutically acceptable salt thereof.
- 17. A method for treating arthritis in a patient comprising administering to the patient a therapeutically acceptable amount of a compound of claim 1, or a therapeutically acceptable salt thereof.
- 18. A method for treating toxicity due to chemotherapy in a patient comprising administering to the patient a therapeutically acceptable amount of a compound of claim 1, or a therapeutically acceptable salt thereof.
- 19. A composition comprising a compound of claim 2, or a therapeutically acceptable salt thereof, and a therapeutically acceptable carrier.
- 20. A method for treating bacterial infections in a patient in recognized need of such treatment comprising administering to the patient a therapeutically acceptable amount of a compound of claim 2, or a therapeutically acceptable salt thereof.
- 21. A method for treating psoriasis in a patient comprising administering to the patient a therapeutically acceptable amount of a compound of claim 2, or a therapeutically acceptable salt thereof.
- 22. A method for treating arthritis in a patient comprising administering to the patient a therapeutically acceptable amount of a compound of claim 2, or a therapeutically acceptable salt thereof.
- 23. A method for treating toxicity due to chemotherapy in a patient comprising administering to the patient a therapeutically acceptable amount of a compound of claim 2, or a therapeutically acceptable salt thereof.
- 24. A compound selected from the group consisting of
N-(((5S)-3-(3-fluoro-4-((E)-(2-oxo-1,2-dihydro-3H-pyrrolo(2,3-b)pyridin-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((Z)-(4,5-dimethyl-2-oxo-1 ,2-dihydro-3H-indol-3-5 ylidene)methyl)phenyl)-2-oxo- 1 ,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-2-oxo-3-(4-((E)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((Z)-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo- 1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(3-fluoro-4-((E)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(3-methyl-2,5-dioxo-4-imidazolidinylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((Z)-(3-tert-butyl-1-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((Z)-(3-tert-butyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl)-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(3-fluoro-4-((Z)-(1-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(3-fluoro-4-((E)-(1-methyl-5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(6-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-3-fluorophenyl)-2-oxo- 1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(5-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetarnide, N-(((5S)-3-(4-((Z)-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl)methyl)acetamide, N-(((5S)-3-(4-((E)-(1-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)phenyl)-2-oxo-1 ,3-oxazolidin-5-yl)methyl)acetamide, N-[((5S)-3-{4-[(E)-(6-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide, N-[((5S)-3-{4-[(E)-(5,6-dimethoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-fluorophenyl}-2-oxo- 1,3-oxazolidin-5-yl)methyl]acetamide, N-[((5S)-2-oxo-3-{4-[(Z)-(4-oxo-2-thioxo- 1,3-thiazolidin-5-ylidene)methyl]phenyl}-1,3-oxazolidin-5-yl)methyl]acetamide, N-[((5S)-3-{4-[(Z)-(5-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide, N-[((5S)-3-{4-[(E)-(1-acetyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide, N-[((5S)-3-{4-[(Z)-(4,7-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide, N-{[(5S)-3-(3-fluoro-4-{(E)-[2-oxo-5-(trifluoromethoxy)- 1,2-dihydro-3H-indol-3-ylidene]methyl}phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide, and N-{[(5S)-3-(3-fluoro-4-{(Z)-[2-oxo-5-(trifluoromethoxy)- 1,2-dihydro-3H-indol-3-ylidene]methyl}phenyl)-2-oxo- 1,3-oxazolidin-5-yl]methyl}acetamide.
Parent Case Info
[0001] This application claims priority to co-pending, U.S. Provisional Application Serial No. 60/231,125, filed Sep. 8, 2000.
Provisional Applications (1)
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Number |
Date |
Country |
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60231125 |
Sep 2000 |
US |