Claims
- 1. A process for preparing a compound of the formula
- 2. A process according to claim 1, wherein the borane is borane, diborane, or (C1-C12)alkylborane.
- 3. A process according to claim 1, wherein R1, R2, R3 and R4 are each independently selected from hydrogen, deuterium, (C3-C10)cycloalkyl, (C3-C10)cycloalkoxy, (C1-C6)alkylsulfonyl, (C6-C10)arylsulfonyl, (C1-C6)acyl, (C3-C10)cycloalkyl, (C5-C9)heteroaryl, (C2-C9)heterocycloalkyl, (C6-C10)aryl, wherein heteroaryl, heterocycloalkyl, aryl groups are optionally substituted by one to three halo, (C1-C6)alkyl or (C1-C6)alkoxy.
- 4. A process according to claim 1, wherein R1 and R2, or R3 and R4, R1 and R3, or R2 and R4 are taken together with the carbon to which they are attached to form a (C3-C10)cycloalkyl or (C2-C9)heterocycloalkyl group optionally substituted by one to five groups consisting of carboxy, cyano, amino, deuterium, hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy, halo, (C1-C6)acyl, (C1-C6)alkylamino, amino(C1-C6)alkyl, (C1-C6)alkoxy-CO—NH, (C1-C6)alkylamino-CO—, (C2-C6)alkenyl, (C2-C6) alkynyl, (C1-C6)alkylamino, amino(C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)acyloxy(C1-C6)alkyl, nitro, cyano(C1-C6)alkyl, halo(C1-C6)alkyl, nitro(C1-C6)alkyl, trifluoromethyl, trifluoromethyl(C1-C6)alkyl, (C1-C6)acylamino, (C1-C6)acylamino(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)acylamino, amino(C1-C6)acyl, amino(C1-C6)acyl(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)acyl, ((C1-C6)alkyl)2amino(C1-C6)acyl, R15R16N—CO—O—, R15R16N—CO-(C1-C6)alkyl, (C1-C6)alkyl-S(O)m, R15R16NS(O)m, R15R16NS(O)m(C1-C6)alkyl, R15S(O)mR16N, R15S(O)mR16N(C1-C6)alkyl wherein m is 1 or 2 and R15 and R16 are each independently selected from hydrogen or (C1-C6)alkyl; and a group of the formula
- 5. A process according to claim 1, wherein a is 0; b is 1; X is carbonyl; c is 0; d is 0; e is 0; f is 0; and g is 0.
- 6. A process according to claim 1, wherein a is 0; b is 1; X is carbonyl; c is 0; d is 1; e is 0; f is 0, and g is 0.
- 7. A process according to claim 1, wherein a is 0; b is 1; X is carbonyl; c is 1; d is 1; e is 0; f is 0; and g is 0.
- 8. A process according to claim 1, wherein a is 0; b is 1; X is —C(═N=cyano)-; c is 1; d is 0; e is 0; f is 0; and g is 0.
- 9. A process according to claim 1, wherein a is 0; b is 0; c is 0; d is 0; e is 0; f is 0; g is 1; and Z is —C(O)—O—.
- 10. A process according to claim 1, wherein a is 0; b is 1; X is S(O)n; n is 2; c is 0; d is 0; e is 0; f is 0; and g is 0.
- 11. A process according to claim 1, wherein a is 0; b is 1; X is S(O)n; n is 2; c is 0; d is 2; e is 0; f is 1; g is 1; and Z is carbonyl.
- 12. A process according to claim 1, wherein a is 0; b is 1; X is S(O)n; n is 2; c is 0; d is 2; e is 0; f is 1; and g is 0.
- 13. A process according to claim 1, wherein a is 0; b is 1; X is carbonyl; c is 1; d is 0; e is 1; Y is S(O)n; n is 2; f is 0; and g is 0.
- 14. A process according to claim 1, wherein a is 0; b is 1; X is S(O)n; n is 2; c is 1; d is 0; e is 0; f is 0; and g is 0.
- 15. A process according to claim 1, wherein a is 1; b is 1; X is carbonyl; c is 1; d is 0; e is 0;f is 0; and g is 0.
- 16. A process according to claim 1, wherein a is 0; b is 1; X is S(O)n; c is 0; d is 1; e is 1; Y is S(O)n; n is 2; f is 0; and g is 0.
- 17. A process according to claim 1, wherein a is 0; b is 1; X is S(O)n; c is 0; d is 2, 3 or 4; e is 1; Y is S(O)n; n is 2; f is 1; and g is 0.
- 18. A process according to claim 1, wherein a is 0; b is 1; X is oxygen; c is 0; d is 2, 3 or 4; e is 1; Y is S(O)n; n is 2; f is 1; and g is 0.
- 19. A process according to claim 1, wherein a is 0; b is 1; X is oxygen; c is 0; d is 2,3 or 4;e is 1;Y is S(O)n; n is 2;f is 0; and g is 0.
- 20. A process according to claim 1, wherein a is 0; b is 1; X is carbonyl; c is 1; d is 2, 3 or4; e is 1; Y is S(O)n; f is 0; and g is 0.
- 21. A process according to claim 1, wherein a is 0; b is 1; X is carbonyl; c is 1; d is 2, 3 or 4; e is 1; Y is S(O)n; n is 2; f is 1; and g is 0.
- 22. A process according to claim 1, wherein R is cyano, deuterium, hydroxy, trifluoromethyl, (C1-C6)alkyl, triflouromethyl(C1-C6)alkyl, (C1-C6)alkoxy, halo, (C1-C6)acyl, (C6-C10)aryl, (C2-C9)heteroaryl, (C3-C10)cycloalkyl, or (C2-C9)heterocycloalkyl.
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This non-provisional patent application is based upon and claims priority from U.S. provisional application No. 60/214,109, filed Jun. 26, 2000.
Provisional Applications (1)
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Number |
Date |
Country |
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60214109 |
Jun 2000 |
US |