Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors

Abstract

There is provided a series of substituted oxime-containing acyl guanidines of Formula (I)

Description

Claims

1. A compound of Formula (I); or a stereoisomer thereof

2. The compound of claim 1, wherein R2, R3, R4 and R5 are hydrogen.

3. The compound of claim 2, wherein R6 is methyl or ethyl.

4. The compound of claim 3, wherein R7 is p-methoxyphenyl or indol-3-yl.

5. The compound of claim 4, wherein R1 is 3,6-dichlophenyl, 4-amino-3,6-dichlorophenyl, 4-acetamido-3,5-dichlorophenyl or 4-acetamido-3-methyl-5-chlorophenyl.

6. The compound of claim 4 having the formula 1a,

7. The compound according to claim 1 selected from the group consisting of:

8. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 in association with a pharmaceutically acceptable adjuvant, carrier or diluent.

9. A method for the treatment of Alzheimer's Disease, cerebral amyloid angiopathy and Down's Syndrome which comprises administering to a mammal in need thereof a therapeutically effective amount of a compound of claim 1.