Claims
- 1. The method of inducing sleep in an animal comprising administering to an animal in which said treatment is desired a sleep-inducing effective amount of a compound of the formula: ##STR17## wherein R is halo of atomic weight of from 18 to 36,
- R' is hydrogen or halo of atomic weight of from 18 to 36, and
- R.degree. is hydrogen or alkyl of 1 to 4 carbon atoms.
- 2. The method of claim 1 in which the compound is 5-fluoro-oxindole.
- 3. The method of claim 1 in which the compound is 5-chloro-oxindole.
- 4. The method of claim 1 in which the compound is administered in a dose of from 80 to 2000 milligrams.
- 5. The method of claim 1 in which the compound is a compound in which R is 5-fluoro and R' is hydrogen.
- 6. The method of claim 5 in which the compound is a compound in which R.degree. is hydrogen or methyl.
- 7. The method of claim 6 in which the compound is 5-fluoro-1-methyloxindole.
- 8. The method of claim 1 in which the compound is 7-chloro-oxindole.
- 9. The method of claim 1 in which the compound is a compound in which each of R and R' is fluoro.
- 10. The method of claim 9 in which the compound is a compound in which R is 5-fluoro and R' is 6-fluoro.
- 11. The method of claim 10 in which the compound is 5,6-difluoro-oxindole.
- 12. The method of claim 9 in which the compound is a compound in which R.degree. is hydrogen.
- 13. The method of claim 9 in which the compound is a compound in which R.degree. is alkyl of 1 to 4 carbon atoms.
- 14. The method of claim 13 in which the compound is a compound in which R.degree. is methyl.
- 15. The method of claim 10 in which the compound is a compound in which R.degree. is alkyl of 1 to 4 carbon atoms.
- 16. The method of claim 14 in which the compound is 5,6-difluoro-1-methyloxindole.
- 17. A pharmaceutical composition comprising from 80 to 2000 milligrams of a compound of the formula: ##STR18## wherein R is fluoro or chloro, in association with a pharmaceutical carrier.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 417,815, filed Nov. 21, 1973, now abandoned which is a continuation-in-part of application Ser. No. 338,997, filed Mar. 7, 1973, now abandoned.
Non-Patent Literature Citations (2)
Entry |
muller et al., Med. Exp. 11 (3), pp. 149-156, (1964). |
Orcutt et al., Arch. Int. Paracodyn 152, pp. 121-131, (1964). |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
417815 |
Nov 1973 |
|
Parent |
338997 |
Mar 1973 |
|