Claims
- 1. A compound of the formula ##STR9## wherein (a) W is a group of the formula CH.sub.2 ;
- (b) Z is a group of the formula CO;
- (c) Y is a group of the formula CO;
- (d) R.sub.7 is hydrogen, a group of the formula R.sub.8 CO wherein R.sub.8 is hydrogen, loweralkyl of 1 to 6 carbon atoms, CH.sub.3 CHOH, HOCH.sub.2 CHOH, ##STR10## or a group of the formula R.sub.10 O(CH.sub.2).sub.n wherein R.sub.10 is hydrogen or loweralkyl of 1 to 6 carbon atoms and n is 2, 3, or 4;
- (e) R.sub.9 is hydrogen; the optical and geometric isomers thereof, or a pharmaceutically acceptable acid addition salt thereof.
- 2. The compound according to claim 1 wherein W is a group of the formula CH.sub.2 ; Z is a group of the formula CO; Y is a group of the formula CO; and R.sub.9 is hydrogen.
- 3. The compound according to claim 2 which is 7.beta.-acetoxy-8,13-epoxylabd-14-en-1,6,11-trione.
- 4. A method or reducing intraocular pressure in mammals comprising administering topically to a mammal requiring intraocular pressure reduction an intraocular pressure reducing effective amount of a compound of claim 1.
- 5. An intraocular pressure reducing composition comprising an inert adjuvant and as the active ingredient, an amount effective in reducing intraocular pressure of a compound of claim 1.
Parent Case Info
This is a continuation, of application Ser. No. 493,610 filed Mar. 15, 1990, now abandoned which is a divisional of application Ser. No. 381,885 filed Jul. 19, 1989, now U.S. Pat. No. 4,933,476 which is a divisional of application Ser. No. 153,631 filed Feb. 8, 1988, now U.S. Pat. No. 4,883,885 which is a divisional of application Ser. No. 901,337 filed Aug. 28, 1986 now U.S. Pat. No. 4,740,522.
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Divisions (3)
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Number |
Date |
Country |
Parent |
381885 |
Jul 1989 |
|
Parent |
153631 |
Feb 1988 |
|
Parent |
901337 |
Aug 1986 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
493610 |
Mar 1990 |
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