Claims
- 1. An amide selected from the group consisting of a compound of the formula
- 2. The amide of claim 1 wherein said compound is
- 3. The amide of claim 2 wherein R1 is cyclopentyl.
- 4. The amide of claim 4 wherein R2 is a substituted or unsubstituted five-membered heteroaromatic ring.
- 5. The amide of claim 4 wherein R is aryl substituted with a nitro group.
- 6. The amide of claim 5 wherein said compound is N-{4-[2-cyclopentyl-1-(thiazol-2-ylcarbamoyl)-ethyl]-phenyl}-4-nitro-benzamide.
- 7. The amide of claim 4 wherein R is unsubstituted aryl.
- 8. The amide of claim 7 wherein said compound is N-{4-[2-cyclopentyl-1-(thiazol-2-ylcarbamoyl)-ethyl]-phenyl }-benzamide.
- 9. The amide of claim 4 wherein R is said heteroaromatic ring.
- 10. The amide of claim 9 wherein said compound is 3-cyclopentyl-N-thiazol-2-yl-2-[4-(2-thiophen-2-yl-acetylamino)-phenyl]-propionamide.
- 11. The amide of claim 9 wherein said compound is N-{4-[2-cyclopentyl-1-(thiazol-2-ylcarbamoyl)-ethyl]-phenyl}-isonicotinamide.
- 12. The amide of claim 9 wherein said compound is 2-(3-cyclopentyl-2-{4-[(pyridine-3-carbonyl)-amino]-phenyl}-propionylamino)-thiazole-4-carboxylic acid ethyl ester.
- 13. The amide of claim 9 wherein said compound is N-{4-[2-cyclopentyl-1-(thiazol-2-ylcarbamoyl)-ethyl]-phenyl}-nicotinamide.
- 14. The amide of claim 9 wherein said compound is [2-(3-cyclopentyl-2-{4-[(pyridine-3-carbonyl)-amino]-phenyl}-propionylamino)-thiazol-4-yl]-acetic acid ethyl ester.
- 15. The amide of claim 3 wherein R2 is a substituted or unsubstituted 6-membered heteroaromatic ring.
- 16. The amide of claim 15 wherein R is unsubstituted aryl or heteroaromatic ring.
- 17. The amide of claim 16 wherein said compound is N-{4-[2-cyclopentyl-1-(pyridin-2-ylcarbamoyl)-ethyl]-phenyl}-nicotinamide.
- 18. The amide of claim 16 wherein said compound is 6-(3-cyclopentyl-2-{4-[(pyridine-3-carbonyl)-amino]-phenyl}-propionylamino)-nicotinic acid methyl ester.
- 19. The amide of claim 16 wherein said compound is 6-(3-cyclopentyl-2-{4-[(pyridine-3-carbonyl)-amino]-phenyl}-propionylamino)-nicotinic acid.
- 20. The amide of claim 4 wherein R is lower alkoxy carbonyl.
- 21. The amide of claim 20 wherein said compound is N-{4-[2-cyclopentyl-1-(thiazol-2-ylcarbamoyl)-ethyl]-phenyl}-oxalamic acid methyl ester.
- 22. The amide of claim 20 wherein said compound is acetic acid {4-[2-cyclopentyl-1-(thiazol-2-ylcarbamoyl)-ethyl]-phenylcarbamoyl}-methyl ester.
- 23. The amide of claim 1 wherein said compound is
- 24. The compound of claim 23 wherein R1 is cyclopentyl.
- 25. The amide of claim 24 wherein R2 is a 5-membered heterocyclic ring.
- 26. The amide of claim 25 wherein R2 is thiazolyl.
- 27. The amide of claim 26 wherein R is lower alkyl or perfluorolower alkyl.
- 28. The amide of claim 27 wherein said compound is 3-cyclopentyl-2-(4-methanesulfonylamino-phenyl)-N-thiazol-2-yl-propionamide.
- 29. The amide of claim 27 wherein said compound is 3-cyclopentyl-N-thiazol-2-yl-2-(4-trifluoromethanesulfonylamino-phenyl)-propionamide.
- 30. The amide of claim 27 wherein said amide is 3-cyclopentyl-N-thiazol-2-yl-2-[4-(2,2,2-trifluoro-ethanesulfonylamino)-phenyl]-propionamide.
- 31. The amide of claim 26 wherein R is
- 32. The amide of claim 31 wherein said compound is N-{4-[2-cyclopentyl-1-(thiazol-2-ylcarbamoyl)-ethyl]-phenyl}-dimethylsulfamide.
- 33. The amide of claim 26 wherein R is aryl or nitro substituted aryl.
- 34. The amide of claim 33 wherein said compound is 3-cyclopentyl-2-[4-(4-nitro-benzenesulfonylamino)-phenyl]-N-thiazol-2-yl-propionamide.
PRIORITY TO PROVISIONAL APPLICATION(S) UNDER 35 U.S.C. §119(e)
[0001] This application claims priority under 35 U.S.C. §119(e) of provisional application Serial No. 60/202,389, filed on May 8, 2000
Provisional Applications (1)
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Number |
Date |
Country |
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60202389 |
May 2000 |
US |