Patent Application
20140107070
This disclosure features combinations that include a paraffinic oil. The combinations can further include (but are not limited to) one or more of the following: one or more emulsifiers, one or more pigments, one or more silicone surfactants, one or more anti-settling agents, one or more conventional chemical fungicides (e.g., a DMI or a QoI), and water. In some implementations, the combinations can be in the form of a single composition (e.g., which is contained within a storage pack or a vessel (e.g., a tank) suitable for applying the composition to a plant, e.g., crop plant). Typically, the composition is applied to a plant after dilution with water. In other implementations, the combinations can include two or more separately contained (e.g., packaged) compositions, each containing one or more of the above-mentioned components. Said compositions can be combined and applied to a plant typically after dilution with water; or each composition can be applied separately to the same plant either simultaneously or sequentially, and typically after dilution with water. This disclosure also features methods of using the combinations for controlling infection of a crop plant by a fungal pathogen as well as methods of formulating combinations that include both oil and water as oil-in-water (O/W) emulsions.
Rusts are plant diseases caused by fungal pathogens of the order Pucciniales. Rusts can affect a variety of plants, including monocotyledons and dicotyledons, as well as various plant organs, including leaves, stems, fruits and seeds. Rust is typically observed as colored powdery pustules composed off tiny spores that form on the lower plant organ surfaces. Common rust-causing fungal species include Gymnosporangium juniperi-virginianae (Cedar-apple rust) which attacks apple and pear and hawthorn; Cronartium ribicola (White pine blister rust); which attacks white pines and currants; Hemileia vastatrix (Coffee rust) which attacks coffee plant; Puccinia graminis (wheat stem rust) which attacks Kentucky bluegrass, barley, and wheat; Puccinia coronata (Crown Rust of Oats and Ryegrass) which attacks oats; Phakopsora meibomiae and P. pachyrhizi (soybean rust) which attacks soybean and various legumes; Uromyces phaseoli (Bean rust) which attacks bean; Puccinia hemerocallidis (Daylily rust) which attacks Daylily; Puccinia persistens subsp. triticina causes (wheat rust in grains, also known as ‘brown or red rust’); P. sriiformis (yellow or stripe rust); Uromyces appendeculatus which attacks bean.
Wheat stem rust is caused by the fungus Puccinia graminis and is a significant disease affecting cereal crops, particularly wheat (Triticum spp.) An epidemic of stem rust on wheat caused by race Ug99 is currently spreading across Africa, the Middle East, and Asia, and threatening large numbers of people who are dependent on wheat for sustenance. The rust fungus attacks the parts of the plant which are above ground. Spores that land on green wheat plants form a pustule that invades the outer layers of the stalk. Where infection has occurred on the stem or leaf, elliptical blisters or pustules called uredia develop. Infected plants produce fewer tillers and set fewer seed.
Soybean rust is a disease that primarily affects soybeans and other legumes. It is caused by two species of fungi, Phakopsora pachyrhizi and Phakopsora meibomiae. Soybean rust has been reported in Asia, Australia, Africa, South America and North America. Soybean rust is spread by wind-borne spores, which are released in cycles of seven days to two weeks. Yield losses can be severe with this disease and losses of 10-80% have been reported.
Multi-pronged approaches are desirable to address the spread of fungal infection. A variety of preventative methods may be employed. For example, rust diseases are correlated to relatively high moisture. Accordingly, avoidance of overhead watering at night, using drip irrigation, reducing crop density, and the use of fans to circulate air flow may serve to lower the relative moisture and decrease the severity of rust infection.
Other strategies may include reducing the area of the plant that the pathogen destroys, or slowing down the spread of the fungus. Fungus-resistant plants may be used to interrupt the disease cycle because many rusts are host-specific. This approach has proven very successful in the past for control of wheat stem rust; however, Ug99 is currently virulent against most wheat varieties. Currently, there are no commercial soybean varieties with resistance to soybean rust. Accordingly, soybean rust is managed with fungicides.
In large agricultural operations, conventional synthetic fungicides can be used to control fungal pathogens. De-methylation inibitors (DMI) such tebuconazole (Folicur™ Bayer) and propioconazole (Tilt™) may be effective for the control of wheat stem rust, while tetraconazole (Domark™, Valent) be effective for the control of soybean rust. Quinone Outside Inhibitors (QoI), such as pyraclostrobin (Headline™, BASF), may be effective for the control of soybean rust, while azoxystrobin (Quadris™) may be effective for the control of wheat stem rust.
Conventional fungicides are generally applied by air to the foliage as contact between the pathogen with the fungicide is required for efficacy. This process can expensive and fungicide application is often reserved for seasons when foliar diseases are severe. Second, conventional fungicides typically target specific sites of important pathogen proteins. Accordingly, strains may develop resistance to the fungicide after repeat applications. Third, the efficacy of conventional chemical fungicides is not always satisfactory for some of the diseases, such as Fusarium Head Blight (Scab). Finally, conventional fungicides are generally not acceptable for use in organic farming.
As an alternative approach to conventional chemical fungicides, oil-in-water emulsions comprising paraffinic oils (paraffinic oil-in-water emulsions) and paraffinic spray oils have been used in turfgrass management practices for controlling turfgrass pests (see, for example, Canadian Patent Application 2,472,806 and Canadian Patent Application 2,507,482). In addition, oil-in-water formulations comprising paraffinic oils and a pigment for controlling turfgrass pests have been reported (see, for example, WO 2009/155693). For example, Petro-Canada produces CIVITAS™, is a paraffinic oil-in-water emulsion that functions as a broad spectrum fungicide and insecticide for use on golf course turf and landscape ornamentals, used for example to control powdery mildew, adelgids and webworms on landscape ornamentals (US EPA REG. NO. 69526-13). Product labeling indicates that CIVITAS™ may be applied as part of an alternating spray program or in tank mixes with other turf and ornamental protection products; and that CIVITAS™ may be used as a preventative treatment with curative properties for the control of many important diseases on turf, including fairways and roughs.
This disclosure features combinations that include a paraffinic oil. The combinations can further include (but are not limited to) one or more of the following: one or more emulsifiers, one or more pigments, one or more silicone surfactants, one or more anti-settling agents, one or more conventional chemical fungicides (e.g., a DMI or a QoI), and water. In some implementations, the combinations can be in the form of a single composition (e.g., which is contained within a storage pack or a vessel (e.g., a tank) suitable for applying the composition to a plant, e.g., crop plant). Typically, the composition is applied to a plant after dilution with water. In other implementations, the combinations can include two or more separately contained (e.g., packaged) compositions, each containing one or more of the above-mentioned components. Said compositions can be combined and applied to a plant typically after dilution with water; or each composition can be applied separately to the same plant either simultaneously or sequentially, and typically after dilution with water. This disclosure also features methods of using the combinations for controlling infection of a crop plant by a fungal pathogen as well as methods of formulating combinations that include both oil and water as oil-in-water (O/W) emulsions.
It has been found that the combinations described herein (e.g., combinations that include one or more conventional chemical fungicides, such as a DeMethylation Inhibitor (DMI) or a Quinone outside Inhibitor (QoI) fungicide, and the components present in CIVITAS™/CIVITAS HARMONIZER™) are surprisingly effective in controlling fungal diseases, including, e.g., wheat stem rust, soybean rust, leaf rust, stripe rust, fusarium head blight, spot blotch, and Septoria complex in vascular crop plants. In some implementations, the combined effect of two (or more) components of the combination (e.g., the paraffinic oil and one or more conventional chemical fungicides, such as a DeMethylation Inhibitor (DMI) or a Quinone outside Inhibitor (QoI) fungicide and/or the pigment) on controlling fungal disease is greater than the expected sum of each component's individual effect on controlling a fungal disease (e.g., wheat stem rust, soybean rust, leaf rust, stripe rust, fusarium head blight, spot blotch, and Septoria complex in vascular crop plants). In certain implementations, the combined effect of the two (or more) components present in the combinations described herein is a synergistic effect. The Examples illustrate that combined use of paraffinic oil with a pigment, a DMI fungicide, and or a QoI fungicide provides an unexpected synergistic response in the control of wheat stem rust, soybean rust, leaf rust, fusarium head blight, and spot blotch, in crop plants. In certain implementations, the dosage of such conventional chemical fungicides can be reduced significantly, such as to 50% the recommended label rates, as well provide significant reduction in the dosage of the combinations described herein.
In one aspect, combinations (e.g., fungicidal compositions) are featured that include various combinations of a paraffinic oil-in-water emulsion with a pigment and/or a conventional chemical fungicide, such as a DMI or a QoI, for controlling infection of a crop plant (e.g., vascular crop) plant by a fungal pathogen. In some implementations, two (or more) components of the combination (e.g., the paraffinic oil and one or more conventional chemical fungicides, such as a DeMethylation Inhibitor (DMI) or a Quinone outside Inhibitor (QoI) fungicide and/or the pigment) are present in amounts in which the combined effect of two (or more) components is greater than the expected sum of each component's individual effect on controlling a fungal disease (e.g., wheat stem rust, soybean rust, leaf rust, stripe rust, fusarium head blight, spot blotch, and Septoria complex in vascular crop plants). In certain implementations, the paraffinic oil and conventional chemical fungicide are present in amounts that are synergistically effective when applied to a plant for controlling a fungal pathogen of the plant.
In another aspect, uses are provided for combinations (e.g., fungicidal compositions) that include a paraffinic oil-in-water emulsion in controlling infection of a vascular plant by a fungal pathogen. The paraffinic oil-in-water emulsion includes paraffinic oil and an emulsifier and can further include any one or more of the components listed above.
The plant can be a crop plant.
The plant may be monocotyledonous. The monocotyledonous plant may be of the order Poaceae. The plant may be of the genus Triticum, Secale, Hordeum, Oryza, Zea, or Elymus. The fungal pathogen may be of the order Pucciniales. The fungal pathogen may be of the genus Puccinia. The fungal pathogen may be of the species Puccinia graminis, Puccinia triticina, or Puccinia sriiformis. The fungal pathogen can also be Bipolaris sorokiniana or Fusarium graminearum.
The plant can be dicotyledonous. The plant can be of the order Fabaceae. The plant can be of the species Glycine max. The fungal pathogen can be of the genus Phakopsora. The fungal pathogen can be Phakopsora pachyrhizi and Phakopsora meibomiae. The plant can be of the genus Gossypium. The fungal pathogen can be Phakopsora gossypii.
The paraffinic oil can include a paraffin having a number of carbon atoms of from 12 to 50. The paraffin can have a number of carbon atoms of from about 16 to 35. The paraffin can have an average number of carbon atoms of 23.
The paraffinic oil may have a paraffin content of at least 80%. The paraffinic oil may have a paraffin content of at least 90%. The paraffinic oil may have a paraffin content of at least 99%.
The paraffinic oil can be used in a range from 13 to 3200 oz/acre (i.e. 0.3 to 75 oz/1000 square feet). The paraffinic oil can be used in a range from 40 to about 640 oz/acre. The oil-in-water emulsion can be used in a range from 2 to 50 gallons per acre for foliar application. The oil-in-water emulsion can be used in a range from 200 to 400 gallons per acre for soil drench application or water-in application with irrigation.
The combinations (e.g., fungicidal compositions) can further include a demethylation inhibitor (DMI). The DMI may be tetraconazole, tebuconazole, propioconazole, azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, prothioconazole, simeconazole, triadimefon, triadimenol, triticonazole, imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, nuarimol, triforine, or pyrifenox. The DMI can be tebuconazole, and may be used in a range from about 0.02 to about 0.5 lb. ai./acre. The DMI may be propioconazole, and can be used in a range from about 0.01 to about 0.6 lb. ai./acre. The DMI can be tetraconazole, and may be used in a range from 0.015 to 0.15 lb. ai./acre. The DMI can be prothioconazole, and may be used in a range from 0.02 to 0.4 lb. ai./acre.
The combinations (e.g., fungicidal compositions) can further include a Quinone outside Inhibitor (QoI). The QoI may be azoxystrobin, enestrobin, picoxystrobin, pyraclostrobin, trifloxystrobin, dimoxystrobin, metominostrobin, orysastrobin, famoxadonem, fluoxastrobin, fenamidone, or pyribencarb. The QoI can be azoxystrobin, and may be used in a range from 0.01 to 0.50 lb. ai./acre. The QoI can be pyraclostrobin, and may be used in a range from 0.02 to 0.40 lb. ai./acre.
The combinations (e.g., fungicidal compositions) can further include an emulsifier (e.g., a natural or synthetic alcohol ethoxylate, an alcohol alkoxylate, an alkyl polysaccharide, a glycerol oleate, a polyoxyethylene-polyoxypropylene block copolymer, an alkyl phenol ethoxylate, a polymeric surfactant, a polyethylene glycol, a sorbitan fatty acid ester ethoxylate, or a combination thereof).
The combinations (e.g., fungicidal compositions) can further include a pigment (e.g., a polychlorinated (Cu II) phthalocyanine).
The combinations (e.g., fungicidal compositions) can further include a silicone surfactant.
The combinations (e.g., fungicidal compositions) can further include a pigment and a silicone surfactant.
The combinations (e.g., fungicidal compositions) can further include a pigment, a silicone surfactant, and an emulsifier.
In certain implementations, the combinations (e.g., fungicidal compositions) can further include an emulsifier and a combination of a pigment and a silicone surfactant, and the combined effect of the emulsifier, the paraffinic oil, the pigment and the silicone surfactant is greater than the expected sum of each component's individual effect on controlling infection by the fungal pathogen (e.g., the aforementioned components can be present in amounts that, when applied to the plant, are synergistically effective at controlling infection by the fungal pathogen). The pigment can be a polychlorinated (Cu II) phthalocyanine. The pigment can be dispersed in water. The emulsifier can include a natural or synthetic alcohol ethoxylate, an alcohol alkoxylate, an alkyl polysaccharide, a glycerol oleate, a polyoxyethylene-polyoxypropylene block copolymer, an alkyl phenol ethoxylate, a polymeric surfactant, a polyethylene glycol, a sorbitan fatty acid ester ethoxylate, or a combination thereof. The pigment can be be dispersed in oil, and the emulsifier may include a natural or synthetic alcohol ethoxylate, a polymeric surfactant, a sorbitan fatty acid ester, or a combination thereof, and the combination may further comprises a polyethylene glycol according to formula IV:
R1—O—(CH2CH2O)f—R2
The ratio of the paraffinic oil-in-water emulsion to the combination of the pigment and the silicone surfactant can be from 32:1 to 4:1.
The ratio of the paraffinic oil to the pigment can be from about 5:1 to 100:1, such as 30:1).
The weight ratio of the paraffinic oil to the emulsifier can be from 10:1 to 100:1.
The weight ratio of the pigment to the silicone surfactant can be from 2:1 to 50:1.
The weight ratio of the paraffinic oil to the conventional chemical fungicide can be from 2:1 to 10,000:1
The fungicidal composition can be applied to the root tissue of the plant. The application to the root tissue can be by soil drench.
The compositions further include one or more anti-settling agents.
This disclosure also features combinations that include a paraffinic oil and a QoI fungicide. The combinations can further include (but are not limited to) one or more of the following: one or more emulsifiers, one or more pigments, one or more silicone surfactants, one or more anti-settling agents, and water.
As used herein, the term “oil-in-water emulsion” refers to a mixture in which one of the paraffinic oil and water (e.g., the paraffinic oil) is dispersed as droplets in the other (e.g., the water). In some implementations, an oil-in-water emulsion is prepared by a process that includes combining the paraffinic oil, water, and any other components and the paraffinic oil and applying shear until the emulsion is obtained (typically a white milky color is indicative of the formation of an emulsion in the absence of any pigment; a green color is observed in the presence of a pigment). In other implementations, an oil-in-water emulsion is prepared by a process that includes combining the paraffinic oil, water, and any other components in the mixing tank and sprayed through the nozzle of a spray gun.
As used herein, the term “control a fungal pathogen of a plant” or “control a disease caused by a fungal pathogen” (and the like) means to diminish, ameliorate, or stabilize the disease and/or any other existing unwanted condition or side effect that is caused by the association of a fungal pathogen with the plant.
As used herein, the term “crop plant” refers to a non-woody plant, which is grown, tended to, and harvested in a cycle of one year or less as source of foodstuffs and/or energy. Examples of crop plants include, without limitation, sugar cane, wheat, rice, corn (maize), potatoes, sugar beets, barley, sweet potatoes, cassava, soybeans, tomatoes, legumes (beans and peas).
In certain implementations, the combinations, e.g., fungicidal compositions, exhibit a synergistic response, for example in controlling a fungal pathogen in a crop plant. In certain implementations, the combinations, e.g., fungicidal compositions may be synergistic fungicidal compositions for treating a fungal pathogen in crop plants. In selected implementations, the fungicidal compositions may exhibit a synergistic response, for example in controlling stem rusts in crop plants. As for example is suggested by Burpee and Latin (Plant Disease Vol. 92 No. 4, April 2008, 601-606), the term “synergy”, “synergistic”, or the like, may refer to the interaction of two or more agents so that their combined effect is greater than the sum of their individual effects, this may include, in the context of the invention, the action of two or more fungicidal agents in which the total response of a fungus to the fungicidal agent combination is greater than the sum of the individual components. Applying the approach to identifying synergy a set out in S. R. Colby, “Calculating synergistic and antagonistic responses of herbicide combinations”, Weeds 15, 20-22 (1967), expected efficacy, E, may be expressed as: E=X+Y(100−X)/100, where X is the efficacy, expressed in % of the untreated control, of a first composition, and Y is the efficacy, expressed in % of the untreated control, of the second composition.
The details of one or more implementations of the combinations and methods described herein are set forth in the accompanying description below. Other features and advantages of the combinations and methods described herein will be apparent from the description and drawings, and from the claims.
This disclosure features combinations that include a paraffinic oil. The combinations can further include (but are not limited to) one or more of the following: one or more emulsifiers, one or more pigments, one or more silicone surfactants, one or more anti-settling agents, one or more conventional chemical fungicides (e.g., a DMI or a QoI), and water. In some implementations, the combinations can be in the form of a single composition (e.g., which is contained within a storage pack or a vessel (e.g., a tank) suitable for applying the composition to a plant, e.g., crop plant). Typically, the composition is applied to a plant after dilution with water. In other implementations, the combinations can include two or more separately contained (e.g., packaged) compositions, each containing one or more of the above-mentioned components. Said compositions can be combined and applied to a plant typically after dilution with water; or each composition can be applied separately to the same plant either simultaneously or sequentially, and typically after dilution with water. This disclosure also features methods of using the combinations for controlling infection of a vascular crop plant by a fungal pathogen as well as methods of formulating combinations that include both oil and water as oil-in-water (O/W) emulsions.
I. Components
[A] Conventional Chemical Fungicides
The combinations include isomers such as geometrical isomers, optical isomers based on asymmetric carbon, stereoisomers and tautomers of the compounds described herein and are not limited by the description of the compounds for the sake of convenience.
[1]
In some implementations, the conventional fungicide is a DMI fungicide.
In certain implementations, the DMI fungicide is at least one fungicide selected from the group consisting of tetraconazole, tebuconazole, propioconazole, azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, prothioconazole, simeconazole, triadimefon, triadimenol, triticonazole, imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, nuarimol, triforine, and pyrifenox.
In certain implementations, the DMI fungicide is at least one fungicide selected from the group consisting of tetraconazole, tebuconazole, and propioconazole. Tetraconazole can be obtained commercially, for example, as a product identified as Domark™ (available from Valent). Tebuconazole can be obtained commercially, for example, as a product identified as Folicur™ (available from Bayer Crop Science). Propioconazole can be obtained commercially, for example, in the product identified as Quilt™ (available from Syngenta).
In other implementations, the DMI fungicides described herein can be synthesized using conventional techniques known in the art of synthetic organic chemistry.
[2]
In some implementations, the conventional fungicide is a QoI fungicide.
In certain implementations, the QoI fungicide is at least one fungicide selected from the group consisting of pyraclostrobin, azoxystrobin, fluoxastrobin, trifloxystrobin, coumoxystrobin, dimoxystrobin, enoxastrobin, famoxadone, fenamidone, fenaminostrobin, flufenoxystrobin, kresoxim-methyl, metominostrobin, orysastrobin, pyraoxystrobin picoxystrobin, pyrametastrobin, pyribencarb, and triclopyricarb.
In certain implementations, the QoI fungicide is at least one fungicide selected from the group consisting of pyraclostrobin, azoxystrobin, fluoxastrobin, and trifloxystrobin.
In certain implementations, the QoI fungicide is at least one fungicide selected from the group consisting of pyraclostrobin and azoxystrobin.
In certain implementations, the QoI fungicide is methyl (2E)-2-{2-[(3-butyl-4-methyl-2-oxo-2H-chromen-7-yl)oxymethyl]phenyl}-3-methoxyacrylate (coumoxystrobin): CAS No. 850881-70-8.
In certain implementations, the QoI fungicide is (E)-2-(methoxyimino)-N-methyl-2-[α-(2,5-xylyloxy)-o-tolyl]acetamide (dimoxystrobin): CAS No. 149961-52-4.
In certain implementations, the QoI fungicide is enoxastrobin. In alternative implementations, the QoI fungicide may be, for example, (RS)-3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione (famoxadone): CAS No. 131807-57-3.
In certain implementations, the QoI fungicide is (S)-1-anilino-4-methyl-2-methylthio-4-phenylimidazolin-5-one (fenamidone): CAS No. 161326-34-7.
In certain implementations, the QoI fungicide is fenaminostrobin.
In certain implementations, the QoI fungicide is flufenoxystrobin.
In certain implementations, the QoI fungicide is methyl (E)-methoxyimino[α-(o-tolyloxy)-o-tolyl]acetate (kresoxim-methyl): CAS No. 143390-89-0.
In certain implementations, the QoI fungicide is (E)-2-(methoxyimino)-N-methyl-2-(2-phenoxyphenyl)acetamide (metominostrobin): CAS No. 133408-50-1.
In certain implementations, the QoI fungicide may be, for example, (2E)-2-(methoxyimino)-2-{2-[ (3E,5E,6E)-5-(methoxyimino)-4,6-dimethyl-2,8-dioxa-3,7-diazanona-3,6-dien-1-yl]phenyl}-N-methylacetamide (orysastrobin): CAS No. 248593-16-0.
In certain implementations, the QoI fungicide is methyl (2E)-2-(2-{[3-(4-chlorophenyl)-1-methylpyrazol-5-yl]oxymethyl}phenyl)-3-methoxyacrylate (pyraoxystrobin): CAS No. 862588-11-2.
In certain implementations, the QoI fungicide is methyl (2E)-3-methoxy-2-{2-[6-(trifluoromethyl)-2-pyridyloxymethyl]phenyl}acrylate (picoxystrobin): CAS No. 117428-22-5.
In certain implementations, the QoI fungicide is pyrametastrobin.
In certain implementations, the QoI fungicide is methyl {2-chloro-5-[(1E)-1-(6-methyl-2-pyridylmethoxyimino)ethyl]benzyl}carbamate (pyribencarb): CAS No. 799247-52-2.
In certain implementations, the QoI fungicide is triclopyricarb.
In certain implementations, the QoI fungicide is carbamic acid, [2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]-phenyl]methoxy-,methyl ester (pyraclostrobin). Pyraclostrobin may be commercially available, for example, as a product identified as Insignia™ (available from BASF Corporation, 26 Davis Drive, Research Triangle Park, N.C. 27709).
In certain implementations, the QoI fungicide is methyl (E)-2-{2-[6-(2-cyano-phenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxy-acrylate (azoxystrobin). Azoxystrobin may be commercially available, for example, as a product identified as Heritage™ (available from Syngenta Crop Protection, Inc., Greensboro, N.C. 27409).
In certain implementations, the QoI fungicide is [(1E)-[2-[[6-(2-chlorophenoxy)-5-fluoro-4-pyrimidinyl]oxy]phenyl]5,6-dihydro-1,4,2-dioxazin-3-yl]methanone-O-methyloxime] (fluoxastrobin). Fluoxastrobin may be commercially available, for example, as a product identified as Disarm™ (available from Arysta LifeScience North America, LLC, 15401 Weston Parkway, Suite 150, Cary, N.C. 27513).
In certain implementations, the QoI fungicide is benzeneacetic acid, (E,E)-alpha-(methoxyimino)-2 ((((1-(3-trifluoromethyl)phenyl)ethylidene)-amino)oxy)methyl)-,methyl ester (trifloxystrobin). Trifloxystrobin may be commercially available, for example, as a product identified as Compass™ (available from Bayer Environmental Science, 2T. W. Alexander Drive, Research Triangle Park, N.C. 27709).
In other implementations, the QoI fungicides described herein can be synthesized using conventional techniques known in the art of synthetic organic chemistry.
[B] Paraffinic Oil
The paraffinic oil confers properties (e.g., fungicidal properties) that are useful for promoting the health of a plant (e.g., crop plant). While not wishing to be bound by theory, it is believed that the paraffinic oil is able to provoke an induced systemic resistance (ISR) response, a systemic acquired resistance (SAR), or other defense response in a plant.
[1]
In some implementations, the paraffinic oil includes an oil enriched in paraffin.
In certain implementations, the paraffinic oil includes a paraffin having from 12 carbon atoms to 50 carbon atoms (e.g., 12 carbon atoms to 40 carbon atoms, 16 carbon atoms to 35 carbon atoms, 12 carbon atoms to 21 carbon atoms; e.g., 16 carbon atoms to 35 carbon atoms).
In certain implementations, the paraffinic oil includes a paraffin having an average number of carbon atoms that is less than or equal to about 20 (e.g., 16).
In certain implementations, the paraffinic oil includes a paraffin having an average number of carbon atoms of from 16 to 30 e.g., 23 or 27).
In certain implementations, the paraffinic oil includes a paraffin having from 16 carbon atoms to 35 carbon atoms and an average number of carbon atoms of 23.
In certain implementations, the paraffin is an isoparaffin (e.g., a synthetic isoparaffin manufactured from two-stage Severe Hydrocracking/Hydroisomerization process).
In some implementations, a paraffin is present in the paraffinic oil in an amount, that is at least 80% (e.g., at least 90%, at least 99%).
[2]
In some implementations, the paraffinic oil has been refined to remove compounds that are associated with plant injury, for example, aromatic compounds or compounds containing sulfur, nitrogen, or oxygen. In certain implementations, the paraffinic oil includes relatively low levels of aromatic compounds and/or compounds containing sulfur, nitrogen, or oxygen, e.g., less than 10 weight percent (less than 5 weight percent, less than 2 weight percent, less than 0.5 weight percent) of aromatic compounds and/or compounds containing sulfur, nitrogen, or oxygen.
[3]
Non-limiting examples of suitable paraffinic oils include, HT60, HT100, High Flash Jet, LSRD, and N65DW (available from Petro-Canada, Calgary, AB, Canada).
[C] Emulsifier
In some implementations, the combinations include both paraffinic oil, emulsifier, and water. It can be advantageous to store and/or apply such combinations as oil-in-water (O/W) emulsions.
Emulsions tend to be thermodynamically unstable due to excess free energy associated with the surface of the dispersed droplets such that the particles tend to flocculate (clumping together of dispersed droplets or particles) and subsequently coalesce (fusing together of agglomerates into a larger drop or droplets) to decrease the surface energy. If these droplets fuse, the emulsion will “break” (i.e., the phases will separate) destroying the emulsion, which in some cases can be detrimental to the storage shelf-life of the combinations. While not wishing to be bound by theory, it is believed that the addition of one (or more) emulsifying agents or emulsifiers can prevent or slow the “breaking” of an emulsion. As the skilled artisan will appreciate, the type and concentration of a particular emulsifying agent will depend, inter alfa, on the emulsion phase components and the desired result.
[1]
In some implementations, the emulsifier is a “fast break” or “quick break” emulsifier. While not wishing to be bound by theory, it is believed that a “fast break” or “quick break” emulsifier allows the paraffinic oil to be quickly released from the O/W emulsion upon application to the turfgrass for contact, e.g., with a fungal pathogen. When a “fast break” or “quick break” emulsifier is present in a suitable amount (for example a selected proportion or ratio with respect to the paraffinic oil), the resulting “fast break” or “quick break” O/W emulsion quickly releases the oil phase upon application to the turfgrass. As such, there is less runoff of the O/W emulsion from the grass blades (as compared to more stable O/W emulsions) resulting in more oil adhering to the turfgrass for a longer period of time to more effectively contact and control, e.g., associated fungal pathogen. In certain implementations, the oil phase resides on the turfgrass for a period of not less than one hour. In certain implementations, the oil phase resides on the turfgrass for a period of from not less than 1 hour but not more than 30 days. In certain implementations, the “fast break” or “quick break” emulsion may be, for example, an emulsion having an oil phase that, after mixing with water, is reconstituted in 0.5 to 15 minutes according to the following test:
1. Fill 100 mL graduated cylinder with tap water.
2. Add 1 mL of emulsified oil.
3. Invert graduated cylinder 5 times.
4. Using a stop watch and human observation, measure how long it takes for the oil phase to reconstitute after inversion (step 3).
In some implementations, the oil phase is reconstituted in from 2 minutes to 5 minutes according to the test described above. In some instances, the “fast break” or “quick break” property of the O/W emulsion is balanced with the need to provide an O/W emulsion with a suitable shelf life under suitable storing conditions, and for a suitable timeframe.
[2]
In some implementations, the emulsifier is (or includes) one (or more of the following) a natural or synthetic alcohol ethoxylate, an alcohol alkoxylate, an alkyl polysaccharide, a glycerol oleate, a polyoxyethylene-polyoxypropylene block copolymer, an alkyl phenol ethoxylate, a polymeric surfactant, a polyethylene glycol, a sorbitan fatty acid ester ethoxylate, or any combination thereof.
In certain implementations, the emulsifier is (or includes) a natural or synthetic alcohol ethoxylate, a polymeric surfactant, a sorbitan fatty acid ester, or any combination thereof.
In certain implementations, the natural or synthetic alcohol ethoxylate is a polyoxyethylene (4 to 12) lauryl ether (C12), polyoxyethylene (10) cetyl ether (C16), polyoxyethylene (10) stearyl ether (C18), polyoxyethylene (10) oleyl ether (C18 mono-unsaturated), a polyoxyethylene (2 to 11) C12-C15 alcohol, a polyoxyethylene (3 to 9) C11-C14 alcohol, a polyoxyethylene (9) C12-C14 alcohol, a polyoxyethylene (11) C16-C18 alcohol, a polyoxyethylene (20) C12-C15 alcohol, or any combination thereof. For example, the natural or synthetic alcohol ethoxylate can be a polyoxyethylene (4 to 7) lauryl ether (C12), polyoxyethylene (10) cetyl ether (C16), a polyoxyethylene (2 to 11) C12-C15 alcohol, a polyoxyethylene (3 to 9) C11-C14 alcohol, a polyoxyethylene (9) C12-C14 alcohol, or any combination thereof. As another example, the alcohol alkoxylate can be a butyl ether polyoxyethylene/polyoxypropylene block copolymer.
In certain implementations, the emulsifier is (or includes) an alkyl polysaccharide, e.g., a C8-C11 alkylpolysaccharide or any combination thereof.
In certain implementations, the emulsifier is (or includes) a glycerol oleate, e.g., a glycerol mono-, di-, tri-oleate, or any combination thereof.
In certain implementations, the emulsifier is (or includes) a polyoxyethylene-polyoxypropylene block copolymer, e.g., a polyoxyethylene-polyoxypropylene block copolymer having a molecular weight (or relative molar mass) of from 1100 to about 11400 and 10 to 80% (ethylene oxide) EO.
In certain implementations, the emulsifier is (or includes) an alkyl phenol ethoxylate, e.g., a nonyl phenol ethoxylate, a dodecyl phenol ethoxylate, or any combination thereof. For example, the nonyl phenol ethoxylate can be a polyoxyethylene (2 to 8) nonylphenol.
In certain implementations, the emulsifier is (or includes) a polymeric surfactant, e.g., a graft copolymer, a random copolymer, or any combination thereof. For example, the graft copolymer can be a polymethacrylic acid and acrylate with polyoxyethylene chains. For example, the random copolymer can be a random copolymer having ester and ether groups.
In certain implementations, the emulsifier is (or includes) a polyethylene glycol, e.g., a polyethylene glycol having a molecular weight (“MW”) (or relative molar mass) of from 200 to 8000, e.g., MW 400 PEG dioleate; or MW600 PEG dioleate.
In certain implementations, the emulsifier is (or includes) a sorbitan fatty acid ester ethoxylate, e.g., polyoxyethylene (20) sorbitan tristearate, polyoxyethylene (20) sorbitan monooleate, polyoxyethylene (5) sorbitan monooleate, polyoxyethylene (20) sorbitan trioleate, or any combination thereof. For example, the sorbitan fatty acid ester can be a sorbitan tristearate, a sorbitan triolate, or any combination thereof.
In certain implementations, the emulsifier is (or includes) an alkyl phenol ethoxylate, a mixture of an ethoxylated alcohol and a glycerol oleate, or any combination thereof.
In certain implementations, the emulsifier is (or includes) a mixture of an ethoxylated alcohol and a glycerol oleate, e.g.: a C10 to C16 alcohol ethoxylate and a glycerol oleate combination; or polyoxyethylene lauryl ether, C10 to C16 alcohol ethoxylates, and glycerol oleate; or ethoxylated alcohols having primary C5-C20 carbon chains with an average of about 2 to about 7 ethoxylation groups, and a glycerol oleate; or a polyoxyethylene (11) C16-18 alcohol.
In certain implementations, the emulsifier is (or includes) a sorbitan tristearate.
Non-limiting examples of suitable emulsifiers include AL3149 (available from Uniqema), AL3313 (available from Uniqema), PC Emuls Green (available from Petro-Canada, Calgary, AB, Canada), Lutensol™ AT11 (available from BASF), SPAN65 (available from Uniqema), and S-MAZ™65 K (available from BASF).
[3]
In some implementations, the weight ratio of the paraffinic oil to the emulsifier is from 10:1 to 500:1 (e.g., from 98:2 to 99.9:0.1, from 98:2 to 99.5:0.5). By way of example, the weight ratio of the paraffinic oil to the emulsifier can be 95:5, 98:2, 98.5:1.5, 99:1, 99.5:0.5.
[D] Pigment
In some implementations, the combinations can include one (or more) pigments. The pigments can provide color to the plant being treated (e.g., turf grass) and/or in some implementations, the pigment(s) and the paraffinic oil can exhibit a greater than additive effect in promoting the health of a plant (e.g., controlling a fungal pathogen of a plant; see, for example, WO 2009/155693).
In some implementations, the pigment is a water-based pigment dispersion.
In some implementations, the pigment is an oil-based pigment dispersion.
In some implementations, the pigment is a phthalocyanine compound.
In certain implementations, the pigment is a metal-free phthalocyanine compound. In certain implementations, the pigment is a halogenated, metal-free phthalocyanine, e.g., a polychlorinated metal-free phthalocyanine.
In certain implementations, the pigment is a metal phthalocyanine compound.
In certain implementations, the pigment is a copper phthalocyanine.
In certain implementations, the copper phthalocyanine is a non-halogenated copper phthalocyanine, e.g., a nonchlorinated copper phthalocyanine. As an example, the pigment can be Phthalocyanine Blue BN (CAS 147-14-8).
In certain implementations, the copper phthalocyanine is a halogenated copper phthalocyanine. As an example, the pigment can be Phthalocyanine Green 6G (CAS 14302-13-7). As another example, the pigment can be polychlorinated (Cu II) phthalocyanine, such as Phthalocyanine Green G (CAS 1328-45-6 and 1328-53-6).
Non-limiting examples of suitable pigments include Sunsperse™ Green 7 (Pigment Green 7 dispersed in water, available from Sun Chemical Corp. Performance Pigments Cincinnati, Ohio, USA), Sunsperse™ EXP 006-102 and 006-95B (Pigment Green 7 dispersed in oil, available from Sun Chemical Corp. Performance Pigments, Cincinnati, Ohio, USA), and Pigment Green 7 powder (available from Hercules Exports, Mumbai, India).
[E] Silicone Surfactant
In some implementations, it can be advantageous to further include one (or more) silicone surfactants in combinations that further include one or more pigments.
[1]
In some implementations, the silicone surfactant is (or includes) a silicone polyether.
In certain implementations, the silicone surfactant is (or includes) a silicone polyether having a suitable alkoxy group with hydrogen end groups (H-capped), methyl end groups (CH3-capped), or acetyl end groups (COCH3-capped). In certain implementations, the silicone surfactant is (or includes) a trisiloxane having a suitable alkoxy group with hydrogen end groups (H-capped), methyl end groups (CH3-capped), or acetyl end groups (COCH3-capped).
In certain implementations, the silicone surfactant is (or includes) a silicone polyether of the formula I:
in which R is H, CH3 or COCH3; x is 1 to 24; and n is 0 or ≧1.
In certain implementations, the silicone surfactant is (or includes) a silicone polyether of the formula I wherein R═H; x=1 to 24; and n=0; e.g., a silicone polyether of the formula I wherein n=0; x=1-24; the average x=8-10; and R═H.
In certain implementations, the silicone surfactant is (or includes) a silicone polyether of the formula I wherein R═H; x=1 to 24; and n≧1.
In certain implementations, the silicone surfactant is (or includes) a silicone polyether of the formula I wherein R═CH3; x=1 to 24; and n=0.
In certain implementations, the silicone surfactant is (or includes) a silicone polyether of the formula I wherein R═CH3; x=1 to 24; and n≧1.
In certain implementations, the silicone surfactant is (or includes) a silicone polyether of the formula I wherein R═COCH3; x=1 to 24; and n=0; e.g., a silicone polyether of the formula I wherein n=0; x=1-24, the average x=8-10; and R═COCH3.
In certain implementations, the silicone surfactant is (or includes) a silicone polyether of the formula I wherein R═COCH3; x=1 to 24; and n≧1.
In certain implementations, the silicone surfactant is (or includes) an H-capped dimethyl methyl (polyethylene oxide) silicone polymer; e.g., having a molecular weight (or relative molar mass) from 200 to 6000.
In certain implementations, the silicone surfactant is (or includes) a silicone polyether of the formula II:
wherein c=2-16; and b=2-70. In certain implementations, the average b=44. In certain implementations, the average c=10. In certain implementations, the average b=44, and the average c=10.
In certain implementations, the silicone surfactant is (or includes) an H-capped trisiloxane, such as a silicone polyether of the formula III:
wherein d=1-24. In certain implementations, d=1-20. In certain implementations, the average d=8-10 (e.g., 8).
In certain implementations, the silicone surfactant is (or includes) a silicone copolyol, containing a hydrogen end group and one pendant polyethylene oxide group and has an average molecular weight between about 600 to about 1000 Daltons. In certain implementations, the silicone surfactant is (or includes) a trisiloxane with an ethoxylated alkyl group having a hydrogen end group (H-End); e.g., having a number of ethoxylation groups in the range of 1-20. In certain implementations, the silicone surfactant the silicone surfactant is (or includes) a methyl (propylhydroxide, ethoxylated)bis(trimethylsiloxy) silane; e.g., a dimethyl, methyl (polyethylene oxide) silicone polymer.
[2]
In some implementations, commercial preparations of the silicone surfactants may or may not contain small amounts of polyethylene glycols (PEG) or other low molecular weight polydimethyl siloxanes (PDMS).
In some implementations, the silicone surfactant further includes a polyethylene glycol.
In certain implementations, the polyethylene glycol is (or includes) a polyethylene glycol of the formula IV:
R1—O—(CH2CH2O)f—R2
wherein R1═H or CH2═CH—CH2 or COCH3; R2═H or CH2═CH—CH2 or COCH3; and f≧1.
In certain implementations, the polyethylene glycol has a relatively low molecular weight, e.g. from 300 Daltons to 1500 Daltons. In certain implementations, the polyethylene glycol is a low molecular weight polyethylene glycol allyl ether, such as a low molecular weight polyethylene glycol mono-allyl ether having an average molecular of from about 300 to about 600 Daltons and having from 1 to 20 moles of ethylene glycol with an average ethylene oxide unit (EO) of 8 to 10.
In certain implementations, the polyethylene glycol is (or includes) a polyethylene glycol of the formula IV wherein R1═CH2═CH—CH2, R2═H, and f=1-20 with an average f=8, a polyethylene glycol of the formula IV wherein R1═CH2═CH—CH2 or COCH3, and R2═COCH3, a polyethylene glycol of the formula IV wherein R1═CH2═CH—CH2, and R2═H, or any combination thereof.
In certain implementations, the polyethylene glycol is (or includes) a polyethylene glycol of the formula IV wherein R1═CH2═CH—CH2 or COCH3, and R2═COCH3, a polyethylene glycol of the formula IV wherein R1═CH2═CH—CH2, and R2═H, or any combination thereof.
In certain implementations, the polyethylene glycol is (or includes) a polyethylene glycol of the formula IV wherein R1═CH2═CH—CH2, R2═H, and f=1-20 with an average f=8.
In certain implementations, the polyethylene glycol is (or includes) a polyethylene glycol of the formula IV wherein R1═CH2═CH—CH2 or COCH3, and R2═COCH3.
In certain implementations, the polyethylene glycol is (or includes) a polyethylene glycol of the formula IV wherein R1═CH2═CH—CH2, and R2═H.
Non-limiting examples of suitable polyethylene glycols may include Polyglykol A500 (available from Clariant).
In certain implementations, the silicone surfactant includes from 10 to 30 weight percent of a polyethylene glycol as described anywhere herein.
[3]
Non-limiting examples of suitable silicone surfactants may include Sylgard™ 309 (available from Dow Corning, Midland, Mich., USA), Silfsurf™ A008-UP (available from Siltech Corp. Toronto, ON, Canada), Lambent MFF 199 SW (available from Lambent Technologies Corp., Gurnee, Ill., USA), and Lambent MFF 159-100 (available from Lambent Technologies Corp., Gurnee, Ill., USA).
[F] Anti-Settling Agent
In some implementations, the combination can include one (or more) “anti-settling agents,” which reduce the likelihood of having solids suspended in a dispersion from settling out under the influence of gravity.
In some implementations, the anti-setting agent is (or includes) a metal oxide and/or an organically modified clay.
In some implementations, the anti-setting agent is (or includes) a metal oxide.
In certain implementations, the anti-setting agent is (or includes) a fumed metal oxide and/or a precipitated metal oxide.
In certain implementations, the anti-setting agent is (or includes) one or more of the following forms of silica: precipitated silica (e.g., an untreated, precipitated silica) or fumed silica (e.g., an untreated, fumed silica). As used herein, the term “untreated fumed silica”, or the like, is used to refer to a hydrophilic fumed silica. As used herein, the term “treated fumed silica”, or the like, is used to refer to a hydrophobic fumed silica.
In some implementations, the anti-settling agent is (or includes) an organically modified clay. In certain implementations, the anti-setting agent is (or includes) one or more of the following organically modified clays: an organically modified smectite clay, an organically modified hectorite clay, an organically modified bentonite clay, an organically modified montmorillonite clay and an organically modified attapulgite clay.
In certain implementations, the organically modified clay is activated by a chemical activator.
In certain implementations, the chemical activator includes a low-molecular-weight polar organic compound, e.g., a least one compound selected from the group consisting of a low-molecular weight ketone, a low-molecular weight alcohol and propylene carbonate.
In certain implementations, the chemical activator includes water and at least one compound selected from the group consisting of a low-molecular weight ketone, a low-molecular weight alcohol and propylene carbonate.
In certain implementations, the chemical activator includes a low-molecular weight ketone; or a low-molecular weight ketone and water (such as a low molecular weight ketone and water in a weight ratio of 95/5). An example of a low-molecular weight ketone is acetone.
In certain implementations, the chemical activator includes a low-molecular weight alcohol; or a low-molecular weight alcohol and water (such as a low-molecular weight alcohol and water in a weight ratio of 95/5). Examples of low-molecular weight alcohols include methanol or ethanol.
In certain implementations, the chemical activator includes propylene carbonate; or propylene carbonate and water (such as, propylene carbonate and water in a weight ratio of 95/5).
[G] Water
In some implementations, the combinations can further include water.
In some implementations, the pigment is dispersed in water before it is added to the remaining components of the combination (typically water is 1:1 weight percent with with pigment), resulting in, e.g., the presence of 3 parts per weight of water in the combination.
In some implementations, the combinations can further include water, e.g., as a diluent, e.g., as a diluent added prior to application of the combinations to a plant (e.g., a turfgrass).
In some implementations, the combinations can further include both sources of water described above.
In some implementations the water is distilled water and/or other waters having a low mineral electrolyte content.
[H] Other Components
In some implementations, the combinations further include one or more other components that are customary additives or adjuvants for the preparation of compositions in the field of crop protection and/or components that are inert (e.g., may not materially affect the activity and/or overall performance of the combinations) and/or one or more other active components. As an example, the combinations can further include customary additives or adjuvants that may be present in a commercially available conventional chemical fungicide.
In some implementations, the combinations include only combinations of the components set forth is sections [A] through [G] above.
In certain implementations, the combinations do not include one or more other components that are customary additives or adjuvants for the preparation of compositions in the field of crop protection and/or components that are inert (e.g., may not materially affect the activity and/or overall performance of the combinations) and/or one or more other active components that are other than conventional chemical fungicides.
In certain implementations, the combinations are free of one or more other components that are customary additives or adjuvants for the preparation of compositions in the field of crop protection and/or components that are inert (e.g., may not materially affect the activity and/or overall performance of the combinations) and/or one or more other active components that are other than conventional chemical fungicides; (e.g., the combinations contain less than 5%, less than 4%, less than 3%, less than 2%, less than 1% (w/w or w/v) of one or more other components that are customary additives or adjuvants for the preparation of compositions in the field of turf or field crop protection and/or components that are inert (e.g., may not materially affect the activity and/or overall performance of the combinations) and/or one or more other active components that are other than conventional chemical fungicides.
In some implementations, the combinations are substantially free of one or more other components that are customary additives or adjuvants for the preparation of compositions in the field of crop protection and/or components that are inert (e.g., may not materially affect the activity and/or overall performance of the combinations) and/or one or more other active components that are other than conventional chemical fungicides (e.g., the combinations contain less than 0.5%, less than 0.2, less than 0.1, less than 0.05% (w/w or w/v), do not include a detectable amount of one or more other components that are customary additives or adjuvants for the preparation of compositions in the field of turf or field crop protection and/or components that are inert (e.g., may not materially affect the activity and/or overall performance of the combinations) and/or one or more other that are other than conventional chemical fungicides.
II. Non-Limiting Combinations of Components
[A] Combinations that Include a Single Composition
[1]
In some implementations, the combinations can be in the form of a single composition (e.g., contained within a storage pack or a vessel suitable for applying the composition to a plant, e.g., turf grass). These compositions are sometimes referred to herein (without limitation, e.g., as to quantity or application mode) as a 1-pack formulations or concentrates in the absence of water for dilution.
In some implementations, the composition includes one (or more) paraffinic oils, which can include any one or more of the features described in any one or more of sections [I][B][1], [I][B][2], and [I][B][3] above.
In some implementations, the combination further includes (but is not limited to) one or more of the following:
(ii) one (or more) conventional chemical fungicides, which can include any one or more of the features described in any one or more of sections [I][A][1] and/or [I] [A] [2] (e.g., one or more DMI fungicides and/or one or more QoI fungicides);
(iii) one (or more) emulsifiers, which can include any one or more of the features described in any one or more of sections [I][C][1], [I][C][2], and [I][C][3] above;
(iv) one (or more) pigments which can include any one or more of the features described in section [I] [D] above;
(v) one (or more) silicone surfactants, which can include any one or more of the features described in any one or more of sections [I][E][1], [I][E][2], and [I] [E] [3] above;
(vi) one (or more) anti-settling agents, which can include any one or more of the features described in section [I] [D] above; and
(vii) one (or more) components described in section [I][H].
In some implementations, the composition includes (i) and (iii).
In some implementations, the composition includes (i), (iii), and (vi).
In some implementations, the composition includes (i), (iii), (iv), and (v).
In some implementations, the composition includes (i), (iii), (iv), (v), and (vi).
In some implementations, the composition includes (i), (ii), and (iii).
In some implementations, the composition includes (i), (ii), (iii), and (vi).
In some implementations, the composition includes (i), (ii), (iii), (iv), and (v).
In some implementations, the composition includes (i), (ii), (iii), (iv), (v), and (vi).
[2] Concentrates
In some of the implementations described in section [II][A] [1], one or more of the following applies:
(2-a) the weight ratio of paraffinic oil to the emulsifier is from 10:1 to 500:1 (e.g., from 45:1 to 55:1, e.g., 49:1, 50:1);
(2-b) the weight ratio of paraffinic oil to the pigment is from 5:1 to 100:1 (e.g., from 25:1 to 35:1, e.g., 28:1, 30:1);
(2-c) the weight ratio of pigment to the silicone surfactant is from 2:1 to 50:1 (e.g., from 3:1 to 6:1, e.g., 4.5:1);
(2-d) the weight ratio of paraffinic oil to the conventional chemical fungicide (e.g., one or more DMI fungicides and/or one or more QoI fungicides) is from 2:1 to 10000:1 (e.g., from 100:1 to 160:1; from 90:1 to 120:1, e.g., 111:1, 110:1; from 130:1 to 150:1, e.g., 139:1, 140:1).
In certain implementations, (2-a) applies; or (2-a), (2-b) and (2-c) apply; or (2-b), and (2-c) apply. In certain implementations, (2-d) further applies to any one of the above-listed combinations of (2-a), (2-b) and (2-c).
In some of the implementations described in section [II][A] [1], one or more of the following applies:
(2-aa) the concentrate includes from 50 to 300 parts per weight (e.g., 200-300, e.g., 260; e.g., 50-150, e.g., 100) parts per weight of the paraffinic oil;
(2-bb) the concentrate includes from 1 to 10 parts per weight (e.g., 3-7, e.g., 5; e.g., 1-5, e.g., 1.9, e.g., 2) parts per weight of the emulsifier;
(2-cc) the concentrate includes from 1 to 15 parts per weight (e.g., 7-11, e.g., 9; e.g., 2-5, e.g., 3.5) parts per weight of the pigment;
(2-dd) the concentrate includes from 0.1 to 10 parts per weight (e.g., 0.5-1, e.g., 0.8, e.g., e.g., 2-5, e.g., 3.1) parts per weight of the silicone surfactant;
(2-ee) the concentrate includes from 0.5 to 20 parts per weight (e.g., 6-10, e.g., 8; e.g., 2-5, e.g., 3.1) parts per weight of the anti-settling agent; or
(2-ff) the concentrate includes from 0.01 to 10 parts per weight (e.g., 0.5-1, e.g., 0.8, e.g., e.g., 1-3, e.g., 2) parts per weight of the conventional chemical fungicide.
In certain implementations, (2-aa) and (2-bb) apply; or (2-cc) and (2-dd) apply; or (2-aa), (2-bb), and (2-ff) apply; or (2-cc), (2-dd), and (2-ff) apply; or (2-aa), (2-bb), (2-cc), and (2-dd) apply, or (2-aa), (2-bb), (2-cc), (2-dd), and (2-ff) apply. In certain implementations, (2-ee) further applies to each of the above-listed implementations.
In some implementations, any one or more of the features described in one or more of (2-a) and (2-d) can be combined with any one or more of the features described in one or more of (2-aa) and (2-ff).
In some implementations, the pigment is dispersed in compatible oil, e.g., a paraffinic oil, e.g., the same paraffinic oil as is used to provide the fungicidal properties as described herein, for addition to the other components of the combinations described herein. In certain implementations, a silicone surfactant and/or emulsifier and/or anti-settling agent can be included, e.g., to stabilize the pigment in the oil-based combination.
For example, polychlorinated Cu (II) phthalocyanine can be dispersed in a paraffinic oil, such as N65DW (available from Petro-Canada) to provide about 18% polychlorinated CU (II) phthalocyanine (SUNSPERSE® EXP 006-102, available from Sun Chemical Corp. Performance Pigments, Cincinnati, Ohio USA) prior to mixing with the remaining components. In certain implementations, a silicone surfactant and/or emulsifier and/or anti-settling agent can be included. While not wishing to be bound by theory, it is believed that the addition of these components can provide an intermolecular hydrophilic and lipophilic balance within the fungicidal formulation so as to substantially prevent the polychlorinated Cu (II) phthalocyanine from separating out of suspension during application, e.g., to a turf grass.
In some of the implementations described in section [II][A] [1], the composition includes the components present in Civitas™ 1-pack and those present in commercially available conventional chemical fungicides described anywhere herein.
[3]
In some of the implementations described in sections [II] A[1] and [II][A][2], the composition further includes water. In certain implementations, weight percent ratio of the undiluted composition to water is from 1:1 to 1:100 (e.g., from 1-50, 1-30, 1-20, 1-15). In certain implementations, the weight percent of the paraffinic oil in the diluted compositions is from 2-50 weight percent (e.g., 15%). In certain implementations, the composition is in the form of an oil in water emulsion as described anywhere herein.
In some implementations, the pigment is dispersed in water for addition to the other components of the combinations described herein. In certain implementations, a silicone surfactant and/or emulsifier and/or anti-settling agent can be included, e.g., to stabilize the pigment in the oil/water-based combination.
For example, polychlorinated Cu (II) phthalocyanine can be dispersed in a water to provide about 40% polychlorinated CU (II) phthalocyanine (SUNSPERSE® GREEN 7, available from Sun Chemical Corp. Performance Pigments, Cincinnati, Ohio USA) prior to mixing with the remaining components. In certain implementations, a silicone surfactant and/or emulsifier and/or anti-settling agent can be included. While not wishing to be bound by theory, it is believed that the addition of these components can provide an intermolecular network so as to substantially prevent the polychlorinated Cu (II) phthalocyanine from separating out of suspension during application, e.g., to a turf grass.
[B] Combinations that Include Two or More Compositions
[1]
In some implementations, the combinations include two or more separately contained (e.g., packaged) compositions, each containing one or more of the components described in sections [I] [A]-[I] [F] and [I] [H]. These implementations are sometimes referred to (as appropriate and without limitation, e.g., as to quantity or application mode) as 2-pack and 3-pack formulations, compositions, or concentrates in the absence of water for dilution.
In some implementations, the combinations include a first and separately contained composition and a second and separately contained composition, in which:
(1) the first and separately contained composition includes:
(2) the second and separately contained composition includes:
In some implementations, the combinations include a first and separately contained composition and a second and separately contained composition, in which:
(1) the first and separately contained composition includes:
(2) the second and separately contained composition includes:
In some implementations, the combinations include a first and separately contained composition and a second and separately contained composition, in which:
(1) the first and separately contained composition includes:
(2) the second and separately contained composition includes:
[I] [A] [1] and/or [I] [A][2] (e.g., one or more DMI fungicides and/or one or more QoI fungicides);
In some implementations, the combinations include a first and separately contained composition and a second and separately contained composition, in which:
(1) the first and separately contained composition includes:
(2) the second and separately contained composition includes:
In some implementations, the combinations include a first and separately contained composition, a second and separately contained composition, and a third and separately contained composition, wherein:
(1) the first and separately contained composition includes:
(2) the second and separately contained composition includes:
(3) the third and separately contained composition includes:
[2] Component Amounts in Combinations Having Two or More Composition (Concentrates)
In some of the implementations described in section [II][B] [1], one or more of the following applies:
(2-aaa) the weight ratio of paraffinic oil to the emulsifier is from 10:1 to 500:1 (e.g., from 45:1 to 55:1, e.g., 49:1, 50:1);
(2-bbb) the weight ratio of paraffinic oil in a composition to the pigment (in the same or a different composition) is from 5:1 to 100:1 (e.g., from 25:1 to 35:1, e.g., 28:1, 30:1);
(2-ccc) the weight ratio of pigment to the silicone surfactant is from 2:1 to 50:1 (e.g., from 3:1 to 6:1, e.g., 4.5:1);
(2-ddd) the weight ratio of paraffinic oil in a composition to the weight ratio of paraffinic oil to the conventional chemical fungicide (e.g., one or more DMI fungicides and/or one or more QoI fungicides) in the same or a different composition is from 2:1 to 10,000:1 (e.g., from 100:1 to 160:1; from 90:1 to 120:1, e.g., 111:1, 110:1; from 130:1 to 150:1, e.g., 139:1, 140:1).
In certain implementations, (2-aaa) applies; or (2-aaa), (2-bbb) and (2-ccc) apply; or (2-bbb), and (2-ccc) apply. In certain implementations, (2-ddd) further applies to any one of the above-listed combinations of (2-aaa), (2-bbb) and (2-ccc).
In some of the implementations described in section [II][B] [1], one or more of the following applies:
(2-aaaa) the composition (concentrate) includes from 50 to 300 parts per weight (e.g., 100) parts per weight of the paraffinic oil;
(2-bbbb) the composition (concentrate) includes from 1 to 10 parts per weight (e.g., 1.9, e.g., 2) parts per weight of the emulsifier;
(2-cccc) the composition (concentrate) includes from 1 to 10 parts per weight (e.g., 3.5) parts per weight of the pigment;
(2-dddd) the composition (concentrate) includes from 0.1 to 10 parts per weight (e.g., 0.8) parts per weight of the silicone surfactant;
(2-eeee) the composition (concentrate) includes from 0.5 to 20 parts per weight (e.g., 3.1) parts per weight of the anti-settling agent; or
(2-ffff) the composition (concentrate) includes from 0.01 to 10 parts per weight (e.g., 0.8) parts per weight of the conventional chemical fungicide (e.g., one or more DMI fungicides and/or one or more QoI fungicides).
In certain implementations, (2-aaaa) and (2-bbbb) apply; or (2-aaaa) through (2-eeee) apply; or (2-ffff) applies; or (2-cccc), (2-dddd), and (2-ffff) apply; or (2-cccc) and (2-dddd) apply.
In certain implementations, (2-aaaa) through (2-eeee) apply in a composition (concentrate), and (2-ffff) applies in another composition (concentrate).
In certain implementations, (2-aaaa) and (2-bbbb) apply in a composition (concentrate), and (2-cccc), (2-dddd), and (2-ffff) apply in another composition (concentrate).
In certain implementations, (2-aaaa) and (2-bbbb) apply in a composition (concentrate), and (2-cccc) and (2-dddd) apply in another composition (concentrate).
In certain implementations, (2-aaaa) through (2-eeee) apply in a composition (concentrate), (2-cccc) and (2-dddd) apply in a second composition (concentrate), and (2-ffff) applies in a third composition (concentrate).
In some implementations, any one or more of the features described in one or more of (2-aaa) and (2-ddd) can be combined with any one or more of the features described in one or more of (2-aaaa) and (2-ffff).
In some of the implementations described in section [II][B][1], the second composition can further include water (e.g., resulting in a dispersion of the pigment in the water).
In some of the implementations described in section [II][B][1], the first and second composition include the components present in Civitas™ 2-pack (Civitas™/Harmonizer™ 16:1) and those present in commercially available conventional chemical fungicides described anywhere herein.
In some of the implementations described in section [II][B][1], the first and second composition include the components present in Civitas™ 2-pack (Civitas™/Harmonizer™ 16:1), and the third composition includes the components present in commercially available conventional chemical fungicides described anywhere herein.
[3]
In some of the implementations described in sections [II][B] [1] and [II][B] [2], each of the compositions, independently, further includes water. In certain implementations, the combination of compositions (concentrates) described above are combined and diluted with water ((e.g., spray volume of the diluted end product is 5 to 50 gal/acre, e.g., 10 to 20 gal/acre). In certain implementations, oil in the end product is from 80 to 640 oz/acre (other components can be calculated based on ratio with oil).
[C] As the skilled artisan will appreciate, the weight percent of a given component(s) can vary, e.g., due to dilution with water or whether the combination is in the form of a single composition or two or more separately contained compositions. In some implementations, the weight ratio of any two or more components is essentially the same regardless of whether the combination is in the form of a single composition (diluted with water or undiluted) or in the form two or more separately contained compositions (diluted with water or undiluted). In the latter case, this can be achieved by adjusting the component amounts in each of the separately contained compositions to match, for example, a weight percent ratio employed in single composition combination.
III. Application of Combinations
In general, the combinations can be applied to the plant by conventional methods known in the art, e.g., spraying, misting, sprinkling, pouring, or any other suitable method. The compositions may be reapplied as required.
In some implementations, the combinations include both paraffinic oil and water. It is advantageous to apply such combinations as oil-in-water (O/W) emulsions. In some implementations, an oil-in-water emulsion is prepared by a process that includes combining the paraffinic oil, water, and any other components and the paraffinic oil and applying shear until the emulsion is obtained. In other implementations, an oil-in-water emulsion is prepared by a process that includes combining the paraffinic oil, water, and any other components at the nozzle of a spray gun.
In other implementations, the combinations can include two or more separately contained (e.g., packaged) compositions, each containing one or more of the above-mentioned components. Said compositions can be combined and applied to a plant (e.g., crop plant) with or without prior dilution with water; or each composition can be applied separately to the same plant (e.g., crop plant) either simultaneously or sequentially, and each independently applied with or without prior dilution with water.
In the above-described implementations, application of any one (or more) compositions can be repeated one or more times.
In some implementations, any one or more of the following can apply:
In certain implementations, the interval rates for the paraffinic oil and the conventional chemical fungicide (e.g., one or more DMI fungicides and/or one or more QoI fungicides) overlap (e.g., when tank-mixed and applied at the same time). In other implementations, the interval rates for the paraffinic oil and the conventional chemical fungicide (e.g., one or more DMI fungicides and/or one or more QoI fungicides) do not overlap (e.g., when applied separately and/or sequentially).
In some implementations, the combinations described herein can be prepared using the methods described in, for example, WO 2009/155693.
The features described in section III above can be combined with any one or more of the features described in sections I and II above.
In some implementations, the fungal pathogen may be, for example, Gymnosporangium juniperi-virginianae, Cronartium ribicola, Hemileia vastatrix Puccinia graminis, Puccinia coronata, Puccinia hemerocallidis, Puccinia persistens subsp. Triticina, Puccinia sriiformis, Puccinia triticina, Phakopsora meibomiae, Phakopsora pachyrhizi, Uromyces phaseoli, Uromyces appendeculatus, Fusarium graminearum, Bipolaris sorokiniana, or a combination thereof. In alternative implementations, the fungal disease may be, for example: cedar-apple rust, which attacks, for example, apple and pear and hawthorn); white pine blister rust, which attacks, for example, white pines and currants; coffee rust, which attacks, for example, the coffee plant; wheat stem rust, which attacks, for example, Kentucky bluegrass, barley, and wheat; crown rust, which attacks, for example, oats and ryegrass; soybean rust, which attacks, for example, soybean and various legumes; leaf rust, which attacks, for example, wheat; bean rust which attacks, for example, bean; Daylily rust, which attacks, for example, Daylily; wheat rust in grains, also known as “brown” or “red rust”); “yellow” or “stripe rust”, which attacks, for example, wheat; spot blotch, which attacks, for example, wheat; and Fusarium head blight, which attacks, for example, wheat.
In alternative implementations, the fungal pathogen may be, for example, a fungus that blights leaf tissue in a crop plant. In selected implementations, the crop plant pathogen is the fungal pathogen Gymnosporangium juniperi-virginianae, and the disease may be, for example, cedar-apple rust. In alternative implementations, the crop plant pathogen is the fungal pathogen Cronartium ribicola, and the disease may be, for example, white pine blister rust. In selected implementations, the crop plant pathogen is the fungal pathogen, and the disease may be, for example, coffee rust. In alternative implementations, the crop plant pathogen is the fungal pathogen Puccinia graminis, and the disease may be, for example, wheat stem rust. In selected implementations, the crop plant pathogen is the fungal pathogen Puccinia coronata, and the disease may be, for example, crown rust. In alternative implementations, the crop plant pathogen is the fungal pathogen Phakopsora meibomiae or Phakospora pachyrhizi, and the disease may be, for example, soybean rust. In alternative implementations, the crop plant pathogen is the fungal pathogen Uromyces phaseoli, and the disease may be, for example, bean rust. In selected implementations, the crop plant pathogen is the fungal pathogen Puccinia hemerocallidis, and the disease may be, for example, Daylily rust. In alternative implementations, the crop plant pathogen is the fungal pathogen Puccinia persistens subsp. triticina, and the disease may be, for example, brown rust or red rust. In selected implementations, the crop plant pathogen is the fungal pathogen Puccinia sriiformis, and the disease may be, for example, yellow rust or strip rust. In alternative implementations, the crop plant pathogen is the fungal pathogen Uromyces appendeculatus, and the disease may be, for example, bean rust. In selected implementations, the crop plant pathogen is the fungal pathogen Puccinia triticina, and the disease may be, for example, leaf rust. In alternative implementations, the crop plant fungal pathogen is Fusarium graminearum and the disease may be, for example, Fusarium head blight. In selected implementations, the crop plant pathogen is the fungal pathogen Bipolaris sorokiniana, and the disease may be, for example, spot blotch.
In various additional implementations wherein the crop plant is wheat, the fungal pathogen may be any one of the fungal pathogens listed in the right hand column of Table 1, and the disease may be the corresponding disease of wheat listed in the left column of Table 1.
Alternaria leaf blight
Alternaria triticina
Colletotrichum graminicola
Glomerella graminicola [teleomorph]
Ascochyta leaf spot
Ascochyta tritici
Aureobasidium
Microdochium bolleyi =
Aureobasidium bolleyi
Alternaria spp.
Cladosporium spp.
Epicoccum spp.
Sporobolomyces spp.
Stemphylium spp. and other genera
Cephalosporium
Hymenula cerealis =
Cephalosporium gramineum
Tilletia tritici =
Tilletia caries
Tilletia laevis =
Tilletia foetida
Cochliobolus sativus [teleomorph]
Bipolaris sorokiniana [anamorph] =
Helminthosporium sativum
Coprinus psychromorbidus
Fusarium spp.
Fusarium pseudograminearum
Gibberella zeae
Fusarium graminearum Group II [anamorph]
Gibberella avenacea
Fusarium avenaceum [anamorph]
Fusarium culmorum
Dilophospora leaf
Dilophospora alopecuri
Sclerophthora macrospora
Tilletia controversa
Claviceps purpurea
Sphacelia segetum [anamorph]
Tapesia yallundae
Ramulispora herpotrichoides [anamorph] =
Pseudocercosporella herpotrichoides
Tapesia acuformis
Ramulispora acuformis [anamorph] =
Pseudocercosporella herpotrichoides
Gibellina cerealis
Urocystis agropyri
Fusarium spp.
Pseudoseptoria donacis =
Selenophoma donacis
Tilletia indica =
Neovossia indica
Puccinia triticina =
Puccinia recondita f.sp. tritici
Puccinia tritici-duri
Leptosphaeria
Phaeosphaeria herpotrichoides =
Leptosphaeria herpotrichoides
Stagonospora sp. [anamorph]
Ustilago tritici =
Ustilago segetum var. tritici
Ustilago segetum var. nuda
Ustilago segetum var. avenae
Microscopica
Phaeosphaeria microscopica =
Leptosphaeria microscopica
Phoma spot
Phoma spp.
Phoma glomerata
Phoma sorghina =
Phoma insidiosa
Microdochium nivale =
Fusarium nivale
Monographella nivalis [teleomorph]
Platyspora
Clathrospora pentamera =
Platyspora pentamera
Erysiphe graminis f. sp. tritici
Blumeria graminis =
Erysiphe graminis
Oidium monilioides [anamorph]
Pythium root
Pythium aphanidermatum
Pythium arrhenomanes
Pythium graminicola
Pythium myriotylum
Pythium volutum
Rhizoctonia
Rhizoctonia solani
Thanatephorus cucumeris [teleomorph]
Pyrenophora seminiperda =
Drechslera campanulata
Drechslera wirreganensis
Fusarium spp.
Gibberella zeae
Fusarium graminearum Group II [anamorph]
Gibberella avenacea
Fusarium avenaceum [anamorph]
Fusarium culmorum
Microdochium nivale =
Fusarium nivale
Monographella nivalis [teleomorph]
Sclerotinia
Myriosclerotinia borealis =
Sclerotinia borealis
Sclerotium
Sclerotium rolfsii
Athelia rolfsii [teleomorph]
Septoria
Septoria tritici
Mycosphaerella graminicola [teleomorph]
Rhizoctonia cerealis
Ceratobasidium cereale [teleomorph]
Pythium spp.
Pythium aristosporum
Pythium iwayamae
Pythium okanoganense
Sclerotium rolfsii
Athelia rolfsii [teleomorph]
Typhula idahoensis
Typhula incarnata
Typhula ishikariensis
Typhula blight
Typhula ishikariensis var. canadensis
Cochliobolus sativus [teleomorph]
Bipolaris sorokiniana [anamorph] =
Helminthosporium sativum
Stagonospora
Phaeosphaeria avenaria f. sp. triticae
Stagonospora avenae f. sp. triticae [anamorph] =
Septoria avenae f. sp. triticea
Phaeosphaeria nodorum
Stagonospora nodorum [anamorph] =
Septoria nodorum
Puccinia graminis =
Puccinia graminis f. sp. tritici (Ug99)
Aspergillus spp.
Penicillium spp.
Puccinia striiformis
Uredo glumarum [anamorph]
Gaeumannomyces graminis var. tritici
Gaeumannomyces graminis var. avenae
Pyrenophora tritici-repentis
Drechslera tritici-repentis [anamorph]
Phyllachora graminis
Linochora graminis [anamorph]
Magnaporthe grisea
Lagena radicicola
Ligniera pilorum
Olpidium brassicae
Rhizophydium graminis
In various additional embodiments wherein the crop plant is of the genus Zea, the fungal pathogen may be any one of the fungal pathogens listed in the right hand column of Table 2, and the disease may be the corresponding disease of wheat listed in the left column of Table 2.
Colletotrichum graminicola
Glomerella graminicola [teleomorph]
Glomerella tucumanensis
Glomerella falcatum [anamorph]
Aspergillus ear and
Aspergillus flavus
Rhizoctonia solani = Rhizoctonia microsclerotia
Thanatephorus cucumeris [teleomorph]
Acremonium strictum = Cephalosporium acremonium
Lasiodiplodia theobromae = Botryodiplodia theobromae
Marasmiellus sp.
Physoderma maydis
Cephalosporium kernel
Acremonium strictum = Cephalosporium acremonium
Macrophomina phaseolina
Corticium ear rot
Thanatephorus cucumeris = Corticium sasakii
Curvularia leaf spot
Curvularia clavata
Curvularia eragrostidis = Curvularia maculans
Cochliobolus eragrostidis [teleomorph]
Curvularia inaequalis
Curvularia intermedia
Cochliobolus intermedius [teleomorph]
Curvularia lunata
Cochliobolus lunatus [teleomorph]
Curvularia pallescens
Cochliobolus pallescens [teleomorph]
Curvularia senegalensis
Curvularia tuberculata
Cochliobolus tuberculatus [teleomorph]
Didymella leaf spot
Didymella exitalis
Diplodia ear rot and
Diplodia frumenti
Botryosphaeria festucae [teleomorph]
Diplodia ear rot
Diplodia maydis
Diplodia leaf spot or
Stenocarpella macrospora = Diplodia macrospora
Sclerophthora rayssiae
Sclerophthora macrospora = Sclerospora macrospora
Sclerospora graminicola
Graminicola downy mildew
Peronosclerospora maydis = Sclerospora maydis
Peronosclerospora philippinensis =
Sclerospora philippinensis
Peronosclerospora sorghi = Sclerospora sorghi
Spontaneum downy
Peronosclerospora spontanea = Sclerospora spontanea
Peronosclerospora sacchari = Sclerospora sacchari
Nigrospora oryzae
Khuskia oryzae [teleomorph]
Alternaria alternata = Alternaria tenuis
Aspergillus glaucus
Aspergillus niger
Aspergillus spp.
Botrytis cinerea
Botryotinia fuckeliana [teleomorph]
Cunninghamella sp.
Curvularia pallescens
Doratomyces stemonitis = Cephalotrichum stemonitis
Fusarium culmorum
Gonatobotrys simplex
Pithomyces maydicus
Rhizopus microsporus
Rhizopus stolonifer = Rhizopus nigricans
Scopulariopsis brumptii
Claviceps gigantea
Sphacelia sp. [anamorph]
Aureobasidium zeae = Kabatiella zeae
Fusarium ear and stalk
Fusarium subglutinans = Fusarium moniliforme
Fusarium kernel, root
Fusarium moniliforme
Gibberella fujikuroi [teleomorph]
Fusarium stalk rot
Fusarium avenaceum
Gibberella avenacea [teleomorph]
Gibberella ear and
Gibberella zeae
Fusarium graminearum [anamorph]
Botryosphaeria zeae = Physalospora zeae
Macrophoma zeae [anamorph]
Cercospora sorghi = Cercospora sorghi
Cercospora leaf spot
Cercospora zeae-maydis
Helminthosporium root
Exserohilum pedicellatum =
Helminthosporium pedicellatum
Setosphaeria pedicellata [teleomorph]
Hormodendrum ear rot
Cladosporium cladosporioides =
Cladosporium rot
Hormodendrum cladosporioides
Cladosporium herbarum
Mycosphaerella tassiana [teleomorph]
Hyalothyridium leaf
Hyalothyridium maydis
Cephalosporium maydis
Alternaria alternata
Ascochyta maydis
Ascochyta tritici
Ascochyta zeicola
Bipolaris victoriae = Helminthosporium victoriae
Cochliobolus victoriae [teleomorph]
Cochliobolus sativus
Bipolaris sorokiniana [anamorph] =
Helminthosporium sorokinianum = H. sativum
Epicoccum nigrum
Exserohilum prolatum = Drechslera prolata
Setosphaeria prolata [teleomorph]
Graphium penicillioides
Leptosphaeria maydis
Leptothyrium zeae
Ophiosphaerella herpotricha
Scolecosporiella sp. [anamorph]
Paraphaeosphaeria michotii
Phoma sp.
Septoria zeae
Septoria zeicola
Septoria zeina
Setosphaeria turcica
Exserohilum turcicum [anamorph] =
Helminthosporium turcicum
Cochliobolus carbonum
Helminthosporium ear rot
Bipolaris zeicola [anamorph] =
Helminthosporium carbonum
Penicillium ear rot
Penicillium spp.
Penicillium chrysogenum
Penicillium expansum
Penicillium oxalicum
Phaeocytostroma stalk
Phaeocytostroma ambiguum = Phaeocytosporella zeae
Phaeosphaeria leaf
Phaeosphaeria maydis = Sphaerulina maydis
Physalospora ear rot
Botryosphaeria festucae = Physalospora zeicola
Botryosphaeria ear rot
Diplodia frumenti [anamorph]
Pyrenochaeta stalk rot
Phoma terrestris = Pyrenochaeta terrestris
Pythium root rot
Pythium spp.
Pythium arrhenomanes
Pythium graminicola
Pythium stalk rot
Pythium aphanidermatum = Pythium butleri
Epicoccum nigrum
Rhizoctonia ear rot
Rhizoctonia zeae
Waitea circinata [teleomorph]
Rhizoctonia root rot
Rhizoctonia solani
Rhizoctonia zeae
Alternaria alternata
Cercospora sorghi
Dictochaeta fertilis
Fusarium acuminatum
Gibberella acuminata [teleomorph]
Fusarium equiseti
Gibberella intricans [teleomorph]
Fusarium oxysporum
Fusarium pallidoroseum
Fusarium poae
Fusarium roseum
Gibberella cyanogena
Fusarium sulphureum [anamorph]
Microdochium bolleyi
Mucor sp.
Periconia circinata
Phytophthora cactorum
Phytophthora drechsleri
Phytophthora nicotianae
Rhizopus arrhizus
Rostratum leaf spot
Setosphaeria rostrata = Helminthosporium rostratum
Helminthosporium leaf disease,
Puccinia sorghi
Puccinia polysora
Physopella pallescens
Physopella zeae = Angiopsora zeae
Sclerotium ear rot
Sclerotium rolfsii
Athelia rolfsii [teleomorph]
Bipolaris sorokiniana
Bipolaris zeicola = Helminthosporium carbonum
Diplodia maydis
Exserohilum pedicillatum
Exserohilum turcicum = Helminthosporium turcicum
Fusarium avenaceum
Fusarium culmorum
Fusarium moniliforme
Gibberella zeae
Fusarium graminearum [anamorph]
Macrophomina phaseolina
Penicillium spp.
Phomopsis spp.
Pythium spp.
Rhizoctonia solani
Rhizoctonia zeae
Sclerotium rolfsii
Spicaria spp.
Selenophoma leaf spot
Selenophoma sp.
Gaeumannomyces graminis
Myrothecium gramineum
Monascus purpureus
Monascus ruber
Ustilago zeae = Ustilago maydis
Ustilaginoidea virens
Sphacelotheca reiliana = Sporisorium holci-sorghi
Cochliobolus heterostrophus
Bipolaris maydis [anamorph] = Helminthosporium maydis
Stenocarpella macrospora = Diplodia macrospora
Cercospora sorghi
Fusarium episphaeria
Fusarium merismoides
Fusarium oxysporum
Fusarium poae
Fusarium roseum
Fusarium solani
Nectria haematococca
Fusarium tricinctum
Mariannaea elegans
Mucor spp.
Rhopographus zeae
Spicaria spp.
Aspergillus spp.
Penicillium spp. and other fungi
Phyllachora maydis
Trichoderma ear rot
Trichoderma viride = Trichoderma lignorum
Hypocrea sp. [teleomorph]
Stenocarpella maydis = Diplodia zeae
Ascochyta ischaemi
Phyllosticta maydis
Mycosphaerella zeae-maydis [teleomorph]
Gloeocercospora sorghi
In various additional embodiments wherein the crop plant is barley, the fungal pathogen may be any one of the fungal pathogens listed in the right hand column of Table 3, and the disease may be the corresponding disease of wheat listed in the left column of Table 3.
Colletotrichum cereale Manns
Pyrenophora graminea =
Drechslera graminea
Cephalosporium stripe
Hymenula cerealis =
Cephalosporium gramineum
Cochliobolus sativus =
Bipolaris sorokiniana
Fusarium culmorum
Fusarium graminearum
Gibberella zeae [teleomorph]
Sclerophthora rayssiae
Tilletia controversa
Claviceps purpurea
Sphacelia segetum [anamorph]
Pseudocercosoporella herpotrichoides
Tapesia yallundae [teleomorph]
Pseudoseptoria donacis =
Selenophoma donacis
Alternaria spp.
Arthrinium arundinis
[2]
Apiospora montagnei [teleomorph]
Cochlioboluus sativus
Fusarium spp.
Ascochyta leaf spot[1][3]
Ascochyta hordei
Ascochyta graminea
Ascochyta sorghi
Ascochyta tritici
Drechslera teres
Pyrenophora teres [teleomorph]
Drechslera feres f. maculata
Erysiphe graminis f. sp. hordei =
Blumeria graminis
Oidium monilioides [anamorph]
Pythium root rot
Pythium spp.
Pythium arrhenomanes
Pythium graminicola
Pythium tardicrescens
Rhizoctonia root rot
Rhizoctonia solani
Thanatephorus cucumeris [teleomorph]
Puccinia coronata var. hordei
Puccinia hordei
Puccinia graminis f. sp. secalis
Puccinia graminis f. sp. tritici
Puccinia striiformis f. sp. hordei
Fusarium spp.
Fusarium graminearum
Rhynchosporium secalis
Septoria speckled leaf blotch
Septoria passerinii
Stagonospora avenae f. sp. triticae
Rhizoctonia cerealis
Ceratobasidium cereale [teleomorph]
Ustilago hordei
Ustilago nigra =
Ustilago avenae
Ustilago nuda =
Ustilago tritici
Typhula incarnata
Typhula ishikariensis
Microdochium nivale =
Fusarium nivale
Monographella nivalis [teleomorph]
Typhula idahoensis
Pythium iwayamae
Pythium okanoganense
Pythium paddicum
Myriosclerotinia borealis =
Sclerotinia borealis
Sclerotium rolfsii
Athelia rolfsii [teleomorph]
Cochliobolus sativus
Drechslera feres [anamorph]
Stagonospora blotch
Stagonospora avenae f. sp. triticae
Phaeosphaeria avenaria f. sp. triticae
Stagonospora nodorum =
Septoria nodorum
Phaeosphaeria nodorum [teleomorph]
Gaeumannomyces graminis var tritici
Pyrenophora tritici-repentis =
Pyrenophora trichostoma
Drechslera tritici-repentis [anamorph] =
Helminthosporium tritici-repentis
Verticillium wilt[4][5]
Verticillium dahliae
Drechslera wirreganensis
In various additional embodiments wherein the crop plant is rice, the fungal pathogen may be any one of the fungal pathogens listed in the right hand column of Table 4, and the disease may be the corresponding disease of wheat listed in the left column of Table 4.
Ceratobasidium oryzae-sativae
Rhizoctonia oryzae-sativae
Curvularia lunata
Cochliobolus lunatus [teleomorph]
Pyricularia grisea =
Pyricularia oryzae
Magnaporthe grisea [teleomorph]
Cochliobolus miyabeanus
Bipolaris oryzae [anamorph]
Gaeumannomyces graminis
Sclerophthora macrospora
Drechslera gigantea
Ustilaginoidea virens
Tilletia barclayana =
Neovossia horrida
Entyloma oryzae
Microdochium oryzae =
Rhynchosporium oryzae
Cercospora janseana =
Cercospora oryzae
Sphaerulina oryzina [teleomorph]
Cochliobolus miyabeanus
Curvularia spp.
Fusarium spp.
Microdochium oryzae
Sarocladium oryzae
Fusarium spp.
Pythium spp.
Pythium dissotocum
Pythium spinosum
Cochliobolus miyabeanus
Curvularia spp.
Fusarium spp.
Rhizoctonia solani
Sclerotium rolfsii
Athelia rolfsii [teleomorph]
Thanatephorus cucumeris
Rhizoctonia solani [anamorph]
Sarocladium oryzae =
Acrocylindrium oryzae
Rhizoctonia oryzae
Alternaria padwickii
Magnaporthe salvinii
Sclerotium oryzae [synanamorph]
Achlya conspicua
Achlya klebsiana
Fusarium spp.
Pythium spp.
Pythium dissotocum
Pythium spinosum
In various additional embodiments wherein the crop plant is soybean, the fungal pathogen may be any one of the fungal pathogens listed in the right hand column of Table 5, and the disease may be the corresponding disease of wheat listed in the left column of Table 5.
Alternaria leaf spot
Alternaria spp.
Colletotrichum truncatum
Colletotrichum dematium f. truncatum
Glomerella glycines
Colletotrichum destructivum
Arkoola nigra
Thielaviopsis basicola
Chalara elegans [synanamorph]
Septoria glycines
Mycosphaerella usoenskajae
Phialophora gregata =
Cephalosporium gregatum
Macrophomina phaseolina
Choanephora leaf blight
Choanephora infundibulifera
Choanephora trispora
Rhizoctonia solani
Thanatephorus cucumeris
Pythium aphanidermatum
Pythium debaryanum
Pythium irregulare
Pythium myriotylum
Pythium ultimum
Peronospora manshurica
Drechslera blight
Drechslera glycines
Cercospora sojina
Fusarium root rot
Fusarium spp.
Leptosphaerulina leaf spot
Leptosphaerulina trifolii
Mycoleptodiscus root rot
Mycoleptodiscus terrestris
Neocosmospora stem rot
Neocosmospora vasinfecta
Acremonium spp. [anamorph]
Phomopsis seed decay
Phomopsis spp.
Phytophthora root and stem rot
Phytophthora sojae
Phyllosticta leaf spot
Phyllosticta sojaecola
Phymatotrichum root rot =
Phymatotrichopsis omnivora =
Phymatotrichum omnivorum
Diaporthe phaseolorum
Phomopsis sojae [anamorph]
Microsphaera diffusa
Cercospora kikuchii
Pyrenochaeta leaf spot
Pyrenochaeta glycines
Pythium rot
Pythium aphanidermatum
Pythium debaryanum
Pythium irregulare
Pythium myriotylum
Pythium ultimum
Cylindrocladium crotalariae
Calonectria crotalariae
Dactuliochaeta glycines =
Dactuliophora leaf spot
Pyrenochaeta glycines
Dactuliophora glycines
Rhizoctonia aerial blight
Rhizoctonia solani
Thanatephorus cucumeris
Rhizoctonia root and stem rot
Rhizoctonia solani
Phakopsora pachyrhizi
Spaceloma glycines
Sclerotinia stem rot
Sclerotinia sclerotiorum
Sclerotium rolfsii
Athelia rolfsii [teleomorph]
Diaporthe phaseolorum
Diaporthe phaseolorum
Phomopsis phaseoli [anamorph]
Stemphylium leaf blight
Stemphylium botryosum
Pleospora tarda [teleomorph]
Fusarium solani f. sp. glycines
Corynespora cassiicola
Nematospora coryli
In various additional embodiments wherein the crop plant is potato, the fungal pathogen may be any one of the fungal pathogens listed in the right hand column of Table 6, and the disease may be the corresponding disease of wheat listed in the left column of Table 6.
Colletotrichum coccodes =
Colletotrichum atramentarium
Alternaria alternata =
Alternaria tenuis
Cercospora leaf blotch
Mycovellosiella concors =
Cercospora concors
Cercospora solani
Cercospora solani-tuberosi
Macrophomina phaseolina =
Sclerotium bataticola
Choanephora blight
Choanephora cucurbitarum
Puccinia pittieriana
Aecidium cantensis
Alternaria solani
Fusarium dry rot
Fusarium spp.
Gibberella pulicaris =
Fusarium solani
Fusarium avenaceum
Fusarium oxysporum
Fusarium culmorum
Fusarium acuminatum
Fusarium equiseti
Fusarium crookwellense
Fusarium wilt
Fusarium spp.
Fusarium avenaceum
Fusarium oxysporum
Fusarium solani f. sp. eumartii
Phoma solanicola f. foveata
Phoma foveata =
Phoma exigua var. foveata =
Phoma exigua f. sp. foveata
Phoma exigua var. exigua
Botrytis cinerea
Botryotinia fuckeliana [teleomorph]
Phytophthora infestans
Pythium spp.
Pythium ultimum var. ultimum =
Pythium debaryanum
Pythium aphanidermatum
Pythium deliense
Phoma leaf spot
Phoma andigena var. andina
Phytophthora spp.
Phytophthora cryptogea
Phytophthora drechsleri
Phytophthora erythroseptica
Phytophthora megasperma
Phytophthora nicotianae var. parasitica
Erysiphe cichoracearum
Spongospora subterranea f. sp. subterranea
Rhizoctonia canker and
Rhizoctonia solani
Thanatephorus cucumeris [teleomorph]
Rosellinia black rot
Rosellinia sp.
Dematophora sp. [anamorph]
Septoria leaf spot
Septoria lycopersici var. malagutii
Helminthosporium solani
Polyscytalum pustulans
Sclerotium rolfsii
Athelia rolfsii [teleomorph]
Thecaphora smut
Angiosorus solani =
Thecaphora solani
Ulocladium blight
Ulocladium atrum
Verticillium wilt
Verticillium albo-atrum
Verticillium dahliae
Synchytrium endobioticum
Sclerotinia sclerotiorum
Various alternative embodiments and examples of the invention are described herein. These embodiments and examples are illustrative, and not limiting.
Various implementations and examples of the combinations are described herein. These implementations and examples are illustrative, and not limiting.
The efficacy of Civitas™ alone or in combination with Harmonizer™ in controlling infection of wheat (Triticum aestivum ‘Norin43’) by Puccinia graminis f. sp. tritici (“Pgt”) was tested under greenhouse conditions. Briefly, each treatment consisted of four pots containing four plants. Plants were planted on March 2nd. Civitas™, Harmonizer™, and combinations thereof were applied to test plants, by foliar application, on March 10th, seven days before inoculation (DBI) on March 17th as indicated in Table 7. The average severity of infection, in terms of % leaf area infected, was evaluated 12
The efficacy of Civitas™ alone or in combination with Harmonizer™, Folicur™, or Quilt™ in controlling infection of wheat (Triticum aestivum ‘Norin43’) by Pgt was tested between May and July. A field was treated with Roundup™ on May 9th and cultivated twice before planting. Plots were planted on May 28 using a seeding rate of 1.25 bu/A, and were 15 ft long by 5 ft wide with 7 rows. Due to flooding in the field shortly after planting, plots lengths were reduced to 7 ft long prior to cutting of the alleys. Plots consisting of a highly susceptible rust spreader mixture were alternated with the experimental units.
The experimental design was a randomized complete block with five replicates. Puma™ (0.4 pt/A) and Bronate Advanced™ (0.8 pt/A) were applied on June 10th to control weeds. On July 14th, urediniospores of Pgt were collected from nearby trap plots and applied to the spreader rows in a 0.1% water agar suspension using a hand-powered backpack sprayer. On July 20th, fungicide treatments were applied with a CO2-powered backpack sprayer in a carrier volume of 20 gal/A using XR8002 flat fan nozzles and an application pressure of 40 PSI. The plants in each plot were at Feekes 10.51 (early anthesis). At 48 hr after fungicide application, the experimental plots were inoculated as previously described with Pgt and misted at night for 7 days (3 min on per each 30 min) to facilitate infection and disease development. One treatment received a second application 7 days later (Treatment 5, see Table 8 below). Plots were rated for stem rust severity at 14 d after inoculation by visually estimating the percentage of stem area covered with pustules for 50 plants per plot (5 randomly chosen locations of 10 plants each). Plots were harvested with a small plot combine and yield was determined. Data were analyzed using an ANOVA and pair-wise comparisons were performed using Tukey's HSD (P=0.05).
The efficacy of Civitas™/Harmonizer™, alone or in combination with Folicur™ in controlling infection of wheat (Triticum aestivum Taut′) by Bipolaris sorokiniana was tested under greenhouse conditions. Briefly, each treatment consisted of three pots (4″ by 4″) containing three plants each. Plants were planted on March 1st. Civitas™/Harmonizer™, Folicur™, and combinations thereof were applied to test plants, by foliar application on March 8 (seven DBI), by soil drench on March 8th (7 DBI), or by foliar application on March 14th (1 DBI), as indicated in Table 9 (rates of Civitas, Harmonizer, and Folicur are expressed in oz/acre). For foliar application, the treatments were applied in 0.2 mL per pot, which is the equivalent of 20 gal/A. For soil drench, treatments were applied in 3.8 mL, which is the equivalent of 400 gal/A. Plants were innoculated on March 15th. The average severity of infection, in terms of % leaf area infected, was evaluated 14 days after inoculation on March 29th.
Images of the untreated, inoculated control are presented in
The efficacy of Civitas™/Harmonizer™, alone or in combination with Folicur™ in controlling infection of wheat (Triticum aestivum ‘Bawl’) by Puccinia triticina was tested under greenhouse conditions. Briefly, each treatment consisted of three pots (4″ by 4″) containing three plants each. Plants were planted on March 1st. Civitas™/Harmonizer™, Folicur™, and combinations thereof were applied to test plants, by foliar application on March 8 (seven DBI), by soil drench on March 8th (7 DBI), or by foliar application on March 14th (1 DBI), as indicated in Table 10 (rates of Civitas, Harmonizer, and Folicur are expressed in oz/acre). For foliar application, the treatments were applied in 0.2 mL per pot, which is the equivalent of 20 gal/A. For soil drench, treatments were applied in 3.8 mL, which is the equivalent of 400 gal/A. Plants were innoculated on March 15th. The average severity of infection, in terms of % leaf area infected, was evaluated 14 days after inoculation on March 29th.
Images of the untreated, inoculated control are presented in
The efficacy of Civitas™, Harmonizer™, and Folicur™ alone or in combination, in controlling infection of wheat (Triticum aestivum ‘Sonalika’) by Fusarium graminearum was tested under greenhouse conditions. Briefly, each treatment consisted of four pots (4″ by 4″) containing nine plants each. Plants were planted on March 2nd. Civitas™, Harmonizer™, Folicur™, and combinations thereof were applied to test plants, by foliar application or by soil drench on March 10 (39 DBI), or 35 DBI by foliar application on March 16th, as indicated in Table 11 (rates of Civitas, Harmonizer, and Folicur are expressed in oz/acre). For foliar application, the treatments were applied in 0.2 mL per pot, which is the equivalent of 20 gal/A. For soil drench, treatments were applied in 3.8 mL, which is the equivalent of 400 gal/A. Plants were innoculated on April 18th. The average severity of infection was evaluated 14 days after inoculation on May 2nd.
The efficacy of Civitas™, Harmonizer™, and Headline™ (Pyraclostrobin, BASF), and Domark®230 ME (Tetraconazole, Valent), alone or in combination, in controlling infection of soybean (Glycine max) by Phakospora pachyrhizi was tested in the field in Georgia. Civitas was tested at 640 oz/a (5 gal/a) and 320 oz/a (2.5 gal/a), with and without Harmonizer. Two conventional chemical fungicides that are labelled for soybean rust, Headline® and Domark®230 ME were used alone, as well as tank mix partners with Civitas. The total spray volume is 15 gal/a, significantly lower than the spray volume for turf applications (50-100 gal/a). Accordingly, the concentrations of the Civitas solution were much higher than in turf application (16% to 33% in this study). The treatments are listed in Table 12. The results of this study are provided in Table 13. Civitas showed significant control of Phakospora pachyrhizi on soybean. The incidence and severity were equal to or exceeded control by the conventional fungicides. The combination of the conventional fungicides with Civitas alone or Civitas/Harmonzier provided better efficacy than the conventional fungicides used alone.
Leaf rust field trial was carried out on spring wheat cultivars. Spores from the spreader plots were served as innoculum source for the natural infection of experimental plots. Treatments were applied at heading (Feekes 10.1/10.2) using a CO2-powered backpack sprayer operating at the pressure of ca. 276 kPa, fitted with flat-fan spray tip (TeeJet SS8003; Spraying Systems Co., Wheaton, Ill.), at the rate of 20 gal per acre. Prosaro (Bayer Crop Science) was used as the standard chemical control.
Disease rating was done 19 days after chemical spray. Leaf rust severity was rated as percent leaf area infected on 12 randomly selected flag leaves per plot. Data were analyzed using ‘R’ statistical package. Data on leaf rust severity was transformed using square root and arcsin function for analysis of variance. Means presented for rust severity in the graph and tables are back transformed mean value.
The treatments of Civitas/Harmonizer (160:10 oz/acre) and Civitas/Harmonizer (320:20 oz/acre) resulted in significantly low rust infection compared to control plots. The efficacy of Civitas treatments are at par with the chemical standard Prosaro (6.5 oz/acre).
Gray Leaf Spot (Cercospora zeae-maydis) field trial was conducted on hybrid corns (NK 67 3000GT) with natural infection. Civitas treatments were applied at R1 and R3 growth stage with the spray rate of 20 gal per acre. Headline (BASF) and Stratego (Bayer Crop Science) were applied at R1 as the standard chemical control.
Disease rating was done about 16 days and 40 days after R1 application. Gray leaf spot severity was rated as percent leaf area infected in the plots.
All of the chemical treatments resulted in lower disease severity than control plots.
Although various embodiments of the invention are disclosed herein, many adaptations and modifications may be made within the scope of the invention in accordance with the common general knowledge of those skilled in this art. Such modifications include the substitution of known equivalents for any aspect of the invention in order to achieve the same result in substantially the same way.
Citation of references herein is not an admission that such references are prior art to the present invention. Any priority document(s) and all publications, including but not limited to patents and patent applications, cited in this specification are incorporated herein by reference as if each individual publication were specifically and individually indicated to be incorporated by reference herein and as though fully set forth herein.
The invention includes all embodiments and variations substantially as hereinbefore described and with reference to the examples. Other implementations are within the scope of the following claims.
This application claims the benefit of U.S. Provisional Application No. U.S. 61/493,118, filed Jun. 3, 2011, and U.S. Provisional Application No. 61/496,500, filed Jun. 13, 2011, each of which is incorporated by reference in its entirety.
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/CA2012/050376 | 6/4/2012 | WO | 00 | 12/3/2013 |
| Number | Date | Country | |
|---|---|---|---|
| 61493118 | Jun 2011 | US | |
| 61496500 | Jun 2011 | US |
