Claims
- 1. A method of treating tumors which respond to photodynamic chemotherapy consisting essentially of administering an amount effective to therapeutically treat a tumor of a pharmaceutical liposome composition to an animal in need thereof, said composition comprising:
- a) the zinc-phthalocyanine complex in an amount of 0.1 to 5% by weight based on the total amount of the phospholipid (b) dissolved in N-methyl-2-pyrrolidone;
- b) at least one synthetic, substantially pure phospholipid dissolved in tert-butanol, said phospholipid selected from the group consisting of
- i) a phospholipid of formula I ##STR3## wherein R.sub.1 is C.sub.10 -C.sub.20 alkanoyl having an even number of carbon atoms, R.sub.2 is C.sub.10 -C.sub.20 alkenoyl having an even number of carbon atoms, R.sub.a, R.sub.b and R.sub.c are hydrogen or C.sub.1 -C.sub.4 alkyl and n is an integer from two to four, and
- ii) a phospholipid of formula II ##STR4## wherein R.sub.3 and R.sub.4 are each independently of the other C.sub.10 -C.sub.2 alkenoyl having an even number of carbon atoms, n is an integer from one to three and Y.sup..sym. is the cation of a pharmaceutically acceptable base; and
- c) a pharmaceutically acceptable carrier liquid.
- 2. The method of claim 1, wherein the pharmaceutical composition further comprises at least one water-soluble excipient suitable for a parenteral dosage form.
Priority Claims (1)
Number |
Date |
Country |
Kind |
01104/90 |
Apr 1990 |
CHX |
|
Parent Case Info
This is a continuation of Ser. No. 124,111, filed Sep. 20, 1993, now abandoned, which is a divisional of Ser. No. 988,399, filed Dec. 9, 1992, now U.S. Pat. No. 5,270,053, which is a continuation of Ser. No. 759,406, filed Nov. 20, 1991, now abandoned, which is a continuation in part of Ser. No. 674,644, filed Mar. 25, 1991, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4774085 |
Fidler |
Sep 1988 |
|
4971802 |
Tarcsay |
Nov 1990 |
|
Non-Patent Literature Citations (6)
Entry |
Ginerva et al. Cancer Letters 49, 59, 1990. |
Vacha, Acta. Uni. Olomucensis 52, 145, 1969. |
Vaduga et al. J. Inorg. Biochem 29, 59 (1987). |
Florsheimer et al Thin Solid Films 159, 115 (1988). |
Reddy et al. Br. J. Cancer 61, 407 (1990). |
Jones et al Thrombosis Res. 39, 711 (1985). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
988399 |
Dec 1992 |
|
Continuations (2)
|
Number |
Date |
Country |
Parent |
124111 |
Sep 1993 |
|
Parent |
795406 |
Nov 1991 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
674644 |
Mar 1991 |
|