Patent Grant
9079026
The present invention relates to a particle beam therapy apparatus, more particularly to a particle beam scanning irradiation system for irradiating a diseased portion with a particle beam in accordance with its three-dimensional shape.
In a particle beam therapy, a diseased portion is irradiated with, for example, a proton beam or a carbon beam accelerated up to 70% of the light velocity. Such a high-energy particle beam has the following characteristics when irradiating into a tumor or the like in a body. Firstly, an irradiating particle beam stops almost at a penetration position proportional to the particle beam energy raised to the 1.7th power. Secondly, the energy density that is imparted to the path through which the irradiating particle beam penetrates until it stops in a body becomes maximum at the particle beam stop position. The energy density of the particle beam is referred to as a dose. A characteristic depth dose profile formed along the path through which a particle beam penetrates into a body is referred to as “Bragg curve”.
The position where the dose of the particle beam becomes a maximum value is referred to as “Bragg peak”. The particle beam scanning irradiation system scans a tumor so that the Bragg peak position is kept coincident with its three-dimensional shape. A peak dose at each scanning position is adjusted to form a three-dimensional dose distribution in a target (tumor portion) determined preliminarily by an imaging diagnosis.
A method of scanning irradiation positions with a particle beam includes a scanning method in the lateral directions (X- and Y-directions) substantially orthogonal to the irradiation direction of the particle beam and a scanning method in the depth direction (Z-direction) being the irradiation direction of the particle beam. In the lateral scanning, there are a method of moving a patient with respect to the particle beam and a method of shifting the position of the particle beam using an electromagnet or the like. The latter method using an electromagnet is generally employed.
Varying energy of the particle beam is only method for scanning in the depth direction. Two methods are conceivable for the energy variation: a method of varying the particle beam energy by an accelerator and a method of using an energy varying device called a range shifter installed in a beam delivery line or an irradiation line. Nowadays, the method using an energy varying device is widely employed. A range shifter may sometimes include a device called an energy selection system that performs energy analysis and momentum selection.
The method for lateral scanning of a particle beam is classified into two basic irradiation methods: a spot scanning irradiation method and a hybrid scanning irradiation method. In a spot scanning irradiation method, a particle beam is emitted and intensity of the particle beam is once weakened when an irradiation amount at a given irradiation position reaches a planned value (refer to Non-Patent Document 1). At this time, the particle beam intensity is generally set to zero. To irradiate a next irradiation position with the particle beam, a current value for the scanning electromagnet is changed and the particle beam intensity is increased again, and then the particle beam is emitted. Instead of increasing the particle beam intensity, re-extraction of the particle beam from the accelerator is also made.
In the hybrid scanning irradiation method, while its basic way of irradiating a planned position with the particle beam by a planned amount is the same as with the spot scanning irradiation method, the particle beam is scanned not with the irradiation being stopped but with the irradiation being continued when shifted to a next irradiation position (refer to Non-Patent Document 1).
In a particle beam scanning irradiation system, the particle beam is shifted while an irradiation position is being changed. A dose during the shift of the particle beam influences a dose distribution in an actual irradiation. In Non-Patent Document 1, by incorporating contribution of a dose during the particle beam shift into an optimum calculation of the therapy planning, influence of the in-shift dose to a final dose distribution is reduced. This method needs preliminary determination of the in-shift dose contribution.
Since the contribution of the in-shift dose in an actual irradiation depends on time variation of intensity of the particle beam extracted from the accelerator during the particle beam irradiation, the method requires the incorporation of an average value of the in-shift dose contribution into the optimum calculation of the therapy planning. When a beam current waveform I(t) extracted from the accelerator varies largely with time, it is difficult to take the contribution of the in-shift particle beam into account with high accuracy. Furthermore, the average of the in-shift dose contribution needs to be taken into account in the optimum therapy-planning calculation. This relatively complicates creation of the therapy planning.
The present invention is made to resolve the above problems, and aims at reducing the difference between a dose distribution at an actual irradiation and a planned irradiating particle count at each of irradiation spots (irradiation positions) determined in accordance with a therapy plan.
A particle beam scanning irradiation method according to the present invention includes a first step of calculating a planned irradiating particle count of a particle beam for each of irradiation spots, on the basis of a relative amount of particle beam irradiation and a prescription particle-beam dose that are determined from a particle-beam therapy plan; a second step of simulating an irradiation process of the particle beam at each irradiation spot, on the basis of the planned irradiating particle count and a beam current waveform of the particle beam, and of calculating a particle count of the particle beam irradiating the diseased portion during a scan shift of the particle beam; a third step of correcting the planned irradiating particle count for each irradiation spot by using the irradiating particle count during the scan shift; a fourth step of converting the corrected planned-irradiation particle count into a count value used in a dose monitor; and a fifth step of irradiating the irradiation spot with the particle beam, on the basis of the converted count value.
According to a particle beam scanning irradiation system of the present invention, a dose distribution at an actual irradiation can be approximated, with a simple correction method, to a planned irradiating particle count at each of irradiation spots (irradiation positions) determined in accordance with a therapy plan.
The therapy planning unit 4 is for creating a therapy plan and simulates a dose calculation on the basis of the therapy plan. The therapeutic control unit 6 controls the particle beam irradiation device 30 to emit the particle beam in accordance with conditions specified by the therapy plan acquired from the irradiation data management unit 2. An actual dose of the particle beam is measured by the therapeutic control unit 6. The measurement result is transmitted to the therapeutic planned data management unit 1. The therapeutic planned data management unit 1 manages data created by the planned irradiating particle count correction unit 3, the therapy planning unit 4, and the scanning irradiation simulation unit 5. The irradiation data management unit 2 manages data, therapy records, measurement records, and the like used in the therapeutic control unit 6, the component control unit 7, and the positioning unit 8.
In a particle beam therapy, since a tumor is scanned so that the Bragg peak position is kept coincident with its three-dimensional shape, a diseased portion is cut into virtual thin slices in the depth direction in accordance with a therapy plan.
Next, the order of the particle beam irradiation in a scanning irradiation is described with reference to
Next, a particle beam scanning irradiation method according to Embodiment 1 of the present invention is described with reference to the flow diagram shown in
A beam current waveform I(t) is stored in the irradiation data management unit 2 and updated day by day on an as-needed basis to reflect a latest measurement result.
An operation of the particle beam scanning irradiation system 100 according to Embodiment 1 of the present invention will be described next with reference to
Next, the therapy planning unit 4 calculates the planned irradiating particle count Ni on the basis of the prescription dose DO and the therapy plan. For the calculation of the planned irradiating particle count Ni, the relative irradiating particle count for each spot included in the therapy plan and measurement information on an absolute value of a dose distribution in water are utilized. The planned irradiating particle count Ni and the beam current waveform I(t) for each irradiation spot are input to the scanning irradiation simulation unit 5.
The scanning irradiation simulation unit 5 is constituted with simulation software and a computer. When the scanning irradiation is carried out, the scanning irradiation simulation unit 5 calculates a beam particle count ΔNi (i=1, 2, 3, . . . , Nspot-1) irradiating the diseased portion while the particle beam is shifting from an irradiation spot (i) to the irradiation spot (i+1). The simulation of the scanning irradiation process takes into account the time responses and the operations of the dose monitor, the scanning power supply, a scanning controller, and the like.
The scanning irradiation simulation unit 5 integrates the beam current waveform I(t) in intervals of several microseconds. When the current integral value reaches the planned irradiating particle count Ni for an irradiation spot (i), the irradiation position of the particle beam is changed to the irradiation spot (1+1) taking response times of the various components into account. The beam current waveform I(t) is integrated further for the irradiation spot (1+1), and when the current integral value reaches the planned irradiating particle count Ni+i, the irradiation position is changed to the irradiation spot (1+2). In this way, by simulating the process of irradiating with the particle all irradiation spots beam from the irradiation spot (i=1) to the irradiation spot (i=Nspot), a beam particle count (in-shift particle count ΔNi) irradiating the diseased portion while the beam shifts between the irradiation spots can be calculated. The in-shift particle count ΔN1 is not taken into account in calculating the planned irradiating particle count Ni. In actual irradiation, however, since the beam starts shifting after an irradiating particle count reaches the planned irradiating particle count Ni, the diseased portion is irradiated excessively with the particle beam until the particle beam shifts the next irradiation spot (see
Next, the planned irradiating particle count correction unit 3 corrects the planned irradiating particle count Ni for an irradiation spot (i) using the in-shift particle count ΔNi. The in-shift particle count ΔNi is an irradiating particle count during the shift between the irradiation spots (i) and the irradiation spot (i+1). Specifically, a corrected planned-irradiating particle count Ni
Ni
Note that an in-shift particle count ΔNi−1 is a particle count irradiating during the shift between the irradiation spots (i−1) and (i) (1<i<Nspot). The correction equations for the irradiation spots (1) and (Nspot) change to Ni−ΔNi/2 and Ni−1−ΔNi−1/2, respectively.
The corrected planned-irradiating particle count Ni
The amount of particle beam actually irradiating the irradiation spot (i) is controlled on the basis of the planned count value MUi.
As has been described above, a particle beam scanning irradiation system described in Embodiment 1 of the present invention takes into account, at the scanning irradiation, influence of the in-shift particle beam to the dose distribution of a target irradiated during the shift between spots. The in-shift particle count ΔNi is calculated before irradiation by using the scanning irradiation simulation unit capable of simulating an actual irradiation timing and the corrected planned-irradiating particle count Ni
An operation of the particle beam scanning irradiation system is described next according to Embodiment 2 of the present invention. Embodiment 2 has a feature in that a beam current waveform whose fast fluctuation components are removed as shown in
The beam current waveform I(t) shown in
An operation of the particle beam scanning irradiation system is described next according to Embodiment 3 of the present invention. While a large beam current can cause irradiation time to shorten, it is conceivable that a corrected planned-irradiating particle count Ni
In Embodiment 3, in order to prevent a corrected planned-irradiating particle count Ni
To be specific, a maximum value of the beam current waveform IN (a maximum beam current at a certain time), which is used for irradiation of each slice, is preliminarily determined in the simulation of the scanning irradiation so that half (ΔNi/2) an in-shift particle count ΔNi does not exceed a planned irradiating particle count Ni for an irradiation spot (i) and a planned irradiating particle count Ni+1 for the irradiation spot (i+1). In irradiating a slice, while using a larger beam current can cause irradiation time to shorten, it is better, as a guideline, to irradiate the slice with a beam current equal to or less than half the maximum beam current calculated here.
In Embodiment 3, since a preliminarily limited maximum value of the beam current is used in irradiating each slice, a range of the beam current used in irradiating each slice can be properly set. This eliminates a corrected planned-irradiating particle count Ni
An operation of the particle beam scanning irradiation system is described next according to Embodiment 4 of the present invention.
In Embodiment 4, attention is focused on a spot-to-spot shift connecting between adjoining irradiation spots and a spot-to-spot shift connecting between non-adjoining irradiation spots. In the case of the shift between adjoining spots, the correction is made as described in Embodiment 1. When a shift occurs between non-adjoining spots, however, the correction method according to Embodiment 1 leads a large error. For that reason, in Embodiment 4, the planned irradiating particle count correction unit 3 preliminarily checks whether a shift is between spots or between non-adjoining spots. Only for a shift between adjoining spots, performed is the correction calculations of subtracting half the in-shift particle count ΔNi from the planned irradiating particle count Ni for an irradiation spot (i) before the shift and from the planned irradiating particle count Ni+1 for the irradiation spot (i+1) after the shift.
According to Embodiment 4, the correction calculation of subtracting half the in-shift particle count ΔN1 from the planned irradiation particle count Ni is performed only when the particle beam shifts between adjoining spots. Since no correction is made when the particle beam shifts between non-adjoining spots, an error due to the correction calculation does not occur. In practice, the case when the particle beam shifts between non-adjoining spots much less occurs than the case when the particle beam shifts between adjoining spots. The case-by-case correction calculation achieves the scanning irradiation with higher accuracy.
An operation of the particle beam scanning irradiation system is described next according to Embodiment 5 of the present invention. In Embodiment 5, the particle beam scanning irradiation system performs, using the planned irradiating particle count correction unit 3, different planned irradiating particle count correction calculations for the respective cases of shifting between adjoining spots (scan shift) and of shifting between non-adjoining spots (blank shift) shown in
For the case of shifting between non-adjoining spots, a shift path is determined first. Then, all spots (i=ik, k=1, 2, 3, . . . , nk; where nk is the number of all spots, and i1=i, ink=i+1), which are substantially spot-size apart from each other, are determined from the determined shift-path. The number of spots determined is defined as the number of blank spots nk. Next, the in-shift particle count ΔNi is divided by the number of blank spots nk, to perform respective corrections of subtracting ΔNi/nk from a planned irradiating particle count N for the spot (i) before the shift, from that for the spot (i+1) after the shift, and from those for the blank spots involved in the shift.
According to the embodiment, an in-shift particle count can be corrected more accurately also for the case of shifting between non-adjoining spots. Therefore, accuracy of the scanning irradiation can be further increased in comparison with Embodiment 4. Note that, in the above embodiments, the scanning irradiation simulation unit, the therapy planning unit, and the planned irradiating particle count correction unit are shown and described as individual components. Actually, installing in one unit a computer code that represents the same functions of these units or installing on a computer the same functions as those of these units also brings about the same effects as those described above. This allows influence of a dose due to the in-shift particle beam to be taken into account with high accuracy using the simple method having been described above.
In the present invention, each embodiment may be freely combined, and/or appropriately modified and/or omitted within the scope and spirit of the invention.
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/JP2012/057182 | 3/21/2012 | WO | 00 | 9/19/2014 |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2013/140547 | 9/26/2013 | WO | A |
| Number | Name | Date | Kind |
|---|---|---|---|
| 7102144 | Matsuda et al. | Sep 2006 | B2 |
| 20060102856 | Matsuda et al. | May 2006 | A1 |
| 20120001085 | Fujimoto et al. | Jan 2012 | A1 |
| 20140046113 | Fujimoto et al. | Feb 2014 | A1 |
| Number | Date | Country |
|---|---|---|
| 2006-145213 | Jun 2006 | JP |
| 2008-136523 | Jun 2008 | JP |
| 2009-066106 | Apr 2009 | JP |
| 2010-251106 | Nov 2010 | JP |
| 2011-156340 | Aug 2011 | JP |
| 2012-010821 | Jan 2012 | JP |
| Entry |
|---|
| International Search Report (PCT/ISA/210) mailed on Jun. 5, 2012, by the Japanese Patent Office as the International Searching Authority for International Application No. PCT/JP2012/057182. |
| T. Inaniwa et al., “Optimization for fast-scanning irradiation in particle therapy”, Medical Physics, Aug. 2007, pp. 3302-3311, vol. 34, No. 8. |
| Japanese Office Action dated Feb. 3, 2015 issued in corresponding Japanese Patent Appl. No. 2014-505878, with English translation (5 pages). |
| Partial Translation of Japanese Office Action dated Feb. 3, 2015 issued in corresponding Japanese Patent Appl. No. 2014-505878 (3 pages). |
| Number | Date | Country | |
|---|---|---|---|
| 20150038766 A1 | Feb 2015 | US |
