Claims
- 1. A spray-coated powder composition for administration from a needleless syringe, said powder composition comprising seed particles coated with a pharmaceutical composition, the said coated seed particles having an average size of about 10 to 100 μm and having an envelope density ranging from about 0.1 to about 25 g/cm3 and an axis ratio of 3 or less.
- 2. The powder composition of claim 1, wherein said seed particles are crystalline particles.
- 3. The powder composition of claim 1, wherein the seed particles have an axis ratio of 2 or less.
- 4. The powder composition of claim 1, wherein the seed particles are selected from the group consisting of lactose, mannitol, trehalose, polysaccharides, starches, and biodegradable polymers.
- 5. The powder composition of claim 1, wherein said coated seed particles have an average size of about 20 to 70 μm.
- 6. The powder composition of claim 1, wherein said coated seed particles have an envelope density ranging from about 0.8 to about 1.5 g/cm3.
- 7. The powder composition of claim 1, wherein said coated seed particles have a substantially spherical aerodynamic shape.
- 8. The powder composition of claim 1, wherein said coated seed particles have a substantially uniform, nonporous surface.
- 9. The powder composition of claim 1, wherein said coated seed particles have a pharmaceutical composition loading of about 1 to 50 wt %.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is related to U.S. provisional application serial No. 60/102,726, filed Oct. 1, 1998, from which priority is claimed pursuant to 35 U.S.C. §119(e)(1) and which application is incorporated herein by reference in its entirety.
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Provisional Applications (1)
|
Number |
Date |
Country |
|
60/102726 |
Oct 1998 |
US |