Claims
- 1. A passivated porous support comprising (i) a porous polymeric matrix having interior and exterior surfaces and innate hydrophobic groups that render said matrix susceptible to undesirable non-specific interaction with one or more biological molecules, and (ii) a polymer network derived from a passivation mixture comprising a main monomer, a passivating monomer different from said main monomer, and a crosslinking agent, said mixture having been allowed to come into intimate contact with said surfaces of said matrix such that on polymerization of said mixture said innate groups of said matrix become deactivated, resulting in the substantial elimination of said undesirable non-specific interaction, said main monomer comprises a vinyl monomer having at least one polar substituent which is nonionic.
- 2. A passivated porous support comprising (i) a porous polymeric matrix having interior and exterior surfaces and innate hydrophobic groups that render said matrix susceptible to undesirable non-specific interaction with one or more biological molecules, and (ii) a polymer network derived from a passivation mixture comprising a main monomer, a passivating monomer different from said main monomer, and a crosslinking agent, said mixture having been allowed to come into intimate contact with said surfaces of said matrix such that on polymerization of said mixture said innate groups of said matrix become deactivated, resulting in the substantial elimination of said undesirable non-specific interaction, said main monomer comprises a vinyl monomer having at least one polar substituent which is positively charged.
Parent Case Info
This is a division of application Ser. No. 08/254,625, filed Jun. 6, 1994, now U.S. Pat. No. 5,445,732, which, in turn, is a continuation of Ser. No. 07/955,935, filed Oct. 5, 1992, now abandoned, which, in turn, is a continuation-in-part of Ser. No. 07/901,326, filed Jun. 19, 1992, now abandoned.
US Referenced Citations (37)
Foreign Referenced Citations (7)
Number |
Date |
Country |
2541593 |
Aug 1983 |
FRX |
50-115298 |
Sep 1975 |
JPX |
51-074694 |
Jun 1976 |
JPX |
52-054496 |
May 1977 |
JPX |
61-074644 |
Apr 1986 |
JPX |
62-286533 |
Dec 1987 |
JPX |
747513 |
Jul 1980 |
SUX |
Non-Patent Literature Citations (1)
Entry |
Snyder, Introduction to Modern Liquid Chromatography, John Wiley & Sons, Inc., New York (1979) pp. 488-489. |
Divisions (1)
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Number |
Date |
Country |
Parent |
254625 |
Jun 1994 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
955935 |
Oct 1992 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
901326 |
Jun 1992 |
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