Claims
- 1. A sustained release formulation comprising pellets
- (a) containing acemetacin and at least, one binder, one weighting agent and one disintegrant,
- (b) coated with a lacquer which is resistant to gastric juice or granulated in the presence of a lacquer which is resistant to gastric juice, and
- (c) having an apparent density of 1.4 to 2.4 and having a diameter of 0.2 to 1.8 mm and an initial dose of acemetacin which comprises 10 to 60% by weight, based on the total weight of the acemetacin of the pellet in free form.
- 2. A sustained release formulation according to claim 1, wherein the pellets contain 0.1 to 80% by weight of acemetacin, 20 to 98% by weight of weighting agent and binder to make up 100% by weight, based on the pellet excluding lacquer.
- 3. A sustained released formulation according to claim 1, containing at least one of TiO.sub.2, BaSO.sub.4, iron oxide and ferrum redactum as the weighting agent.
- 4. A sustained released formulation according to claim 1, containing 40 to 70% weighting agent, based upon the pellet excluding lacquer.
- 5. A sustained release formulation according to claim 1, wherein the pellets have an apparent density of 1.5 to 1.8.
- 6. Capsules or tablets made up of the sustained release formulation according to claim 1.
- 7. Capsules or tablets according to claim 1, each containing 60 to 200 mg of acemetacin.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3431861 |
Aug 1984 |
DEX |
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Parent Case Info
This is a continuation of Ser. No. 919,744, filed 10/16/86, now abandoned, which is a divisional of Ser. No. 765,907, filed 8/14/85, now abandoned.
US Referenced Citations (10)
Foreign Referenced Citations (7)
Number |
Date |
Country |
0080341 |
Jun 1983 |
EPX |
42-25410 |
Dec 1967 |
JPX |
44-10799 |
May 1969 |
JPX |
44-27839 |
Nov 1969 |
JPX |
48-24246 |
Jul 1973 |
JPX |
49-30526 |
Mar 1974 |
JPX |
54-138128 |
Oct 1979 |
JPX |
Non-Patent Literature Citations (1)
Entry |
Bechgaard Distribution of Pellets in the Gastrointestinal Tract, the Influence on Transit Time Exerted by the Density or Diameter of Pellets. J. Pharmac., 1978, 30, 690 to 692. |
Divisions (1)
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Number |
Date |
Country |
Parent |
765907 |
Aug 1985 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
919744 |
Oct 1986 |
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