Claims
- 1. A method for administering a topically or systemically active agent with increased penetration, said method comprising: topically administering to a mammal a composition comprising:a) an active agent having a concentration of about 0.1% to about 2%, wherein said active agent is a member selected from the group consisting of testosterone, estradiol, derivatives thereof and the mixture thereof; b) a penetration-enhancing system consisting essentially of (i) a membrane fluidizer comprising oleic acid; (ii) a C1-C4 alcohol; and (iii) a glycol said composition having a pH value of between about 4 to about 8, thereby administering a topically or systemically active agent with increased penetration.
- 2. A method in accordance with claim 1, wherein said penetration-enhancing system further comprises (iv) a gelling agent.
- 3. A method in accordance with claim 1, wherein said active agent is testosterone.
- 4. A method in accordance with claim 1, wherein said active agent is testosterone propionate.
- 5. A method for reducing inflammation associated with topical application of a topically or systemically active agent, said method comprising: topically administering to a mammal a composition comprising: a) an active agent having a concentration of about 0.1% to about 2%, wherein said active agent is a member selected from the group consisting of testosterone, estradiol, derivatives thereof and the mixture thereof; b) a penetration-enhancing system consisting essentially: (i) a membrane fluidizer comprising oleic acid; (ii) a C1-C4 alcohol; and (iii) a glycol said composition having a pH value of between about 4 to about 8, thereby reducing inflammation associated with a topical application of a topically or systemically active agent.
- 6. A method in accordance with claim 5, wherein said penetration-enhancing system further comprises (iv) a gelling agent.
- 7. A method in accordance with claim 6, wherein said active agent is a member selected from the group consisting of testosterone, testosterone propionate and mixtures thereof.
- 8. A method in accordance with claim 7, wherein said active agent is testosterone propionate.
- 9. A method in accordance with claim 1, wherein said pH value is between about 4.5 to about 6.5.
- 10. A method in accordance with claim 1, wherein said active agent is present in a concentration selected from the group consisting of 0.5%, 1.00%, 1.25%, 1.50% and 2.00% weight to weight of said composition.
- 11. A method in accordance with claim 1, wherein said C1-C4 alcohol is isopropanol.
- 12. A method in accordance with claim 1, wherein said glycol is propylene glycol.
- 13. A method in accordance with claim 1, wherein said gelling agent is Carbopol 1342.
- 14. A method in accordance with claim 1, wherein said penetration enhancing system fmal urther comprises an irritation reducing agent.
- 15. A method in accordance with claim 1, wherein said active agent is a mixture of testosterone and estradiol.
- 16. A method in accordance with claim 5, wherein said active agent is testosterone.
- 17. A method in accordance with claim 5, wherein said active agent is a mixture of testosterone and estradiol.
- 18. A method in accordance with claim 5, wherein said penetration enhancing system further comprises an iritation reducing agent.
- 19. A method for administering a topically or systemically active agent with increased penetration, said method comprising: topically administering to a mammal a composition comprising:a) testosterone or a derivative thereof having a concentration of about 0.1% to about 2%; b) a penetration-enhancing system comprising: (i) oleic acid; (ii) a C3 alcohol; and (iii) propylene glycol thereby administering a topically or systemically active agent with increased penetration.
- 20. A method in accordance with claim 19, wherein testosterone or a derivative thereof is present in a concentration selected from the group consisting of 0.5%, 1.00%, 1.25%, 1.50% and 2.00% weight to weight of said composition.
- 21. A method in accordance with claim 19, wherein said penetration-enhancing system further comprises (iv) a gelling agent.
- 22. A method for administering a topically or systemically active agent with increased penetration, said method comprising: topically administering to a mammal a composition comprising:a) estradiol or a derivative thereof having a concentration of about 0.1% to about 10%; b) a penetration-enhancing system comprising: (i) oleic acid; (ii) a C3 alcohol; and (iii) propylene glycol, thereby administering a topically or systemically active agent with increased penetration.
- 23. A method in accordance with claim 22, wherein estradiol or a derivative thereof is present from about 0.1% to about 5% weight to weight of said composition.
- 24. A method in accordance with claim 22, wherein estradiol or a derivative thereof is present from about 1% to about 2% weight to weight of said composition.
- 25. A method in accordance with claim 22, wherein estradiol or a derivative thereof is present in a concentration selected from the group consisting of 0.5%, 1.00%, 1.25%, 1.50% and 2.00% weight to weight of said composition.
- 26. A method in accordance with claim 22, wherein said penetration-enhancing system further comprises (iv) a gelling agent.
Parent Case Info
This application claims benefit of Provisional No. 60/064,980 filed Nov. 10, 1997.
US Referenced Citations (8)
Foreign Referenced Citations (2)
Number |
Date |
Country |
0 043 738 B1 |
Jan 1982 |
EP |
0 043 738 A2 |
Jan 1982 |
EP |
Non-Patent Literature Citations (1)
Entry |
Bronaugh, R.L., et al., “Methods for In Vitro Percutaneous Absorption Studies VII: Use of Excised Human Skin” J. Pharm. Sci. 75(11):1094-1097. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/064980 |
Nov 1997 |
US |