Claims
- 1. A method of inhibiting cell proliferation comprising administering an effective amount of a peptide of the formula I:
- X--A--D--Trp--Y (I)
- wherein X is selected from the group comprising hydrogen, glycine, alanine, leucine, isoleucine, valine, N-valine, proline, tyrosine, phenylalanine, tryptophan, D-alanine, D-leucine, D-isoleucine, D-valine, D-N-valine, D-proline, D-tyrosine, D-phenylalanine, D-tryptophan, .gamma.-aminobutyric acid, and .xi.-aminocaproic acid; A is selected from the group comprising D-glutamic acid and D-iso-glutamic acid; and Y is selected from the group comprising glycine, alanine, leucine, isoleucine, valine, N-valine, proline, tyrosine, phenylalanine, tryptophan, D-alanine, D-leucine, D-isoleucine, D-valine, D-N-valine, D-proline, D-tyrosine, D-phenylalanine, D-tyrptophan, .gamma.-aminobutyric acid, .xi.-aminocaproic acid, hydroxyl and an amide group, to a person or cell in need thereof.
- 2. A method according to claim 1 wherein X is hydrogen, A is D-i-glutamic acid, and Y is selected from the group consisting of hydroxyl and an amide group substituted with a C1-C3 alkyl group.
- 3. A method according to claim 1 wherein the peptide has the sequence H-D-iGlu-Trp-OH.
- 4. A method according to claim 1 wherein the peptide is administered in a dose from about 1 .mu.g to about 10 g per kilogram of weight of the patient.
- 5. A method according to claim 1 wherein the peptide is administered in dose from about 0.1 g to about 10 g per kilogram of weight of the patient.
- 6. A method according to claim 1 wherein cell proliferation is hematopoietic cell proliferation.
- 7. A method according to claim 1 wherein cell proliferation is immune system cell proliferation.
Parent Case Info
This application is a continuation-in-part of United States application Ser. No. 08/657,888 that was filed on Jun. 7, 1996, now U.S. Pat. No. 5,736,519.
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
657888 |
Jun 1996 |
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