Claims
- 1. A compound according to Formula (1): wherein:R is selected from the group consisting of C1-6 alkyl, —CH2Ar, and Ar; R1 is selected from the group consisting of C1-6 alkyl, —C1-4 alkyl-Ar′, and Ar′; R2 is selected from the group consisting of hydrogen, and C1-6 alkyl; Ar is selected from the group consisting of phenyl, furyl, and thienyl, all of which are optionally substituted by one or more Z1 groups; Ar′ is selected from the group consisting of phenyl, naphthyl, furyl, pyridyl, thienyl, thiazolyl, isothiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyl, imidazolidinyl, benzofuranyl, indolyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, morpholinyl, piperidinyl, piperazinyl, pyrrolyl, and pyrimidyl; all of which are optionally substituted by one or more Z2 groups; Z1 is independently is selected from the group consisting of C1-3 alkyl, CN, F, Cl, Br, and I; Z2 is independently is selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, —(CH2) nC(O)OR2, —C(O)NRR2, —CN, —(CH2)nOH, —NO2, F, Cl, Br, I, —NRR2, and —NHC(O)R2; n is 0 to 4; or a salt, solvate, or physiologically functional derivative thereof.
- 2. A compound as claimed in claim 1, having the configuration: or a salt, solvate, or physiologically functional derivative thereof.
- 3. A compound according to claim 1 selected from the group consisting of:N-{(R)-1-[(Formyl-hydroxy-amino)methyl]-2-phenyl-ethyl}carbamic acid tert-butyl ester, N-{(S)-1-[(Formyl-hydroxy-amino)methyl]-2-phenyl-ethyl}carbamic acid tert-butyl ester, N-[(S)-1-Benzyl-2-(formyl-hydroxy-amino)-ethyl]-carbamic acid 1,1 dimethyl-propyl ester, and N-[(S)-1-Benzyl-2-(formyl-hydroxy-amino)ethyl]-carbamic acid methyl ester.
- 4. A method of treating a bacterial infection by administering to a subject in need of treatment a compound according to claim 1.
Parent Case Info
This application is the National Stage of International Application No. PCT/US02/06260 filed Mar. 1, 2002, which claims the benefit of Provisional application No. 60/272,445 filed Mar. 1, 2001.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/US02/06260 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO02/07065 |
9/12/2002 |
WO |
A |
Foreign Referenced Citations (2)
Number |
Date |
Country |
WO 0250081 |
Jun 2002 |
GB |
WO 0110834 |
Feb 2001 |
WO |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/272445 |
Mar 2001 |
US |