Claims
- 1. The peptide
- HBenv183-191 (Seq. ID No. 1)
- Phe-Leu-Leu-Thr-Arg-Ile-Leu-Thr-Ile or a fragment thereof wherein said peptide or fragment binds with an HLA-A2 molecule to form a complex recognized by cytotoxic T cells which T cells recognize a native HBV antigen.
- 2. An immunogenic composition comprising an immunogenic lipid carrier and the peptide HBenv183-191 (Seq. ID No. 1) Phe-Leu-Leu-Thr-Arg-Ile-Leu-Thr-Ile or a fragment thereof wherein said peptide or fragment binds with an HLA-A2 molecule to form a complex recognized by cytotoxic T cells which T cells recognize a native HBV antigen.
- 3. The immunogenic composition of claim 2 wherein the peptide is conjugated to the lipid carrier.
- 4. The immunogenic composition of claim 2, wherein the lipid carrier enhances a human T-lymphocyte response.
- 5. An immunogenic composition comprising a first peptide HBenv183-191 (Seq. ID No. 1) Phe-Leu-Leu-Thr-Arg-Ile-Leu-Thr-Ile or a fragment thereof and a second immunogenic peptide wherein said first peptide or fragment binds with an HLA-A2 molecule to form a complex recognized by cytotoxic T cells which T cells recognize a native HBV antigen.
- 6. The immunogenic composition of claim 5 wherein the first peptide or fragment is joined to the second immunogenic peptide to form a heteropolymer.
- 7. The immunogenic composition of claim 5 wherein the second immunogenic peptide elicits a immune response specific for hepatitis B virus.
- 8. The immunogenic composition of claim 5 wherein the second immunogenic peptide elicits a T-helper cell mediated response.
RELATED APPLICATIONS
The present application is a divisional of U.S. Ser. No. 08/396,283, filed Feb. 27, 1995, which is a continuation of U.S. Ser. No. 08/024,120, filed Feb. 26, 1993.
This is a Division of application Ser. No. 08/396,283, filed Feb. 27, 1995.
GOVERNMENT SUPPORT
The U.S. Government may have certain rights in this invention pursuant to grants awarded by the National Institutes of Health.
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 9420127 |
Sep 1994 |
WOX |
Divisions (1)
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Number |
Date |
Country |
Parent |
396283 |
Feb 1995 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
24120 |
Feb 1993 |
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