PEPTIMERS TM--IMMUNOTHERAPY FOR AUTOIMMUNE DISEASE

Information

  • Research Project
  • 2540515
  • ApplicationId
    2540515
  • Core Project Number
    R43NS037272
  • Full Project Number
    1R43NS037272-01
  • Serial Number
    37272
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/30/1997 - 27 years ago
  • Project End Date
    3/29/1998 - 26 years ago
  • Program Officer Name
    KERZA-KWIATECKI, A P
  • Budget Start Date
    9/30/1997 - 27 years ago
  • Budget End Date
    3/29/1998 - 26 years ago
  • Fiscal Year
    1997
  • Support Year
    1
  • Suffix
  • Award Notice Date
    9/19/1997 - 27 years ago
Organizations

PEPTIMERS TM--IMMUNOTHERAPY FOR AUTOIMMUNE DISEASE

DESCRIPTION: (Adapted from the applicant's abstract) Peptide epitopes of autoantigens make attractive candidates for immunotherapy of autoimmune diseases because of their potential to specifically suppress autoimmune reactions. Recently, "peptide oligomers," peptide epitopes alternating with a peptide spacer of fixed length, have been shown to dramatically enhance immunopotency compared to their monomeric counterparts. We propose to utilize such peptide oligomers (Peptimers(TM)) as the basis of a novel, antigen- specific approach to the treatment of autoimmune diseases. Our initial experiments will address the production and in vitro testing of purified peptide oligomers composed of myelin basic protein (MBP) amino acid residues 84-102 and proteolipid protein amino acid residues 139-151. The former has been implicated in multiple sclerosis (MS) and the latter has been used to induce a chronic form of experimental allergic encephalomyelitis (EAE; an animal model of MS) in rodents. Peptide oligomers from 4- to 28- epitopes, joined by peptide spacers, will be tested for their potential to induce tolerance as demonstrated by in vitro assays using T-cell clones isolated from MS patients and from rodents with EAE.

IC Name
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
  • Activity
    R43
  • Administering IC
    NS
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    853
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    ZRG2
  • Study Section Name
  • Organization Name
    PEPTIMMUNE, INC.
  • Organization Department
  • Organization DUNS
  • Organization City
    CAMBRIDGE
  • Organization State
    MA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    02139
  • Organization District
    UNITED STATES