Claims
- 1. A percutaneous absorbent preparation for transdermal or transmucosal absorption of a pharmaceutically active substance, comprising:
- an effective amount of pharmacopeial aspirin, or insulin; and
- an absorption accelerator selected from the group consisting of 1-O-n-octyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-dodecyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-tetradecyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-hexadecyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-octadecenyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-octadecenyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-methyl-branched isostearyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-octyl-2-O-methyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-dodecyl-2-O-methyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-dodecyl-2-O-n-butyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-dodecyl-2-O-n-octyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-tetradecyl-2-O-methyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-hexadecyl-2-O-methyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-octadecyl-2-O-methyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-octadecenyl-2-O-methyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-octadecenyl-2-O-n-butyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-methyl-branched isostearyl-2-O-methyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-methyl-branched isostearyl-2-O-n-octyl-3-O-2',3'-dihydroxypropylglycerol; 1-O-n-octyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-n-dodecyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-n-dodecyl-3-O-n-butyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-n-dodecyl-3-O-n-octyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-n-tetradecyl-3-methyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-n-hexadecyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-n-octadecyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-n-octadecenyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-n-octadecenyl-3-O-n-butyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-methyl-branched isostearyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol; 1-O-methyl-branched isostearyl-3-O-n-butyl-2-O-2',3'-dihydroxypropylglycerol; and 1-O-methyl-branched isostearyl-3-O-n-octyl-2-O-2',3'-dihydroxypropylglycerol.
- 2. The preparation of claim 1, which is in the form of a liquid, a lotion, an ointment, a cream, a gel, a sol, an aerosol, a cataplasm, a plaster, or a tape preparation.
- 3. The preparation of claim 2, which is in the form of a suppository comprising:
- (a) pharmacopeial aspirin;
- (b) 1-O-n-dodecyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol; and
- (c) a medium chain fatty acid triglyceride.
- 4. The preparation of claim 2, which is in the form of a suppository comprising:
- (a) pharmacopeial aspirin;
- (b) 1-O-n-octyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol; and
- (c) a medium chain fatty acid triglyceride.
- 5. The preparation of claim 2, which is in the form of a suppository comprising:
- (a) a solution of 100 IU of insulin in 0.5 ml of a 6% aqueous acetic acid solution;
- (b) 1-O-n-dodecyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol; and
- (c) a medium chain fatty acid triglyceride.
- 6. The preparation of claim 2, which is in the form of a spraying agent for nasal use, comprising:
- (a) a solution of 1000 IU of insulin in 2.0 ml of a 6% aqueous acetic acid solution;
- (b) 1-O-methyl-branched isostearyl-3-O-methyl-2-O-2',3'-dihydroxypropylglycerol;
- (c) ethanol; and
- (d) physiological saline solution.
Priority Claims (1)
Number |
Date |
Country |
Kind |
59-82464 |
Apr 1984 |
JPX |
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Parent Case Info
This application is a divisional of copending application Ser. No. 227,777 filed Aug. 3, 1988 now U.S. Pat. No. 4,559,696, which is a continuation of Ser. No. 047,513 filed on May 6, 1987, now abandoned, which is a continuation of Ser. No. 726,320 filed on Apr. 23, 1985, now abandoned.
US Referenced Citations (11)
Foreign Referenced Citations (4)
Number |
Date |
Country |
1142969 |
Mar 1983 |
CAX |
0071019 |
Feb 1983 |
EPX |
2069334 |
Aug 1981 |
GBX |
1539625 |
Jan 1989 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Holford et al., "Transdermal Systems in Principle and Practice", Current Therapeutics, Jan. 1984, leading article. |
Divisions (1)
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Number |
Date |
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Parent |
227777 |
Aug 1988 |
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Continuations (2)
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Number |
Date |
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Parent |
47513 |
May 1987 |
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Parent |
726320 |
Apr 1985 |
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