Claims
- 1. A percutanneous pharmaceutical preparation for external application which comprises
- (a) N-ethoxycarbonyl-3-morpholinosydnonimine; and
- (b) at least 0.01 weight part of an absorption promoter per weight part of (a) which promoter is an aliphatic monocarboxylic acid of 5 to 30 carbons.
- 2. A percutaneous pharmaceutical preparation claimed in claim 1, wherein the proportion of N-ethoxyoarbonyl-3morpholinosydnonimine and the absorption promoter to the whole preparation are 0.1 to 40% by weight and more than 0.1% by weight, respectively.
- 3. A percutaneous pharmaceutical preparation for external application of claim 1 wherein said absorption prometer is oleic acid.
- 4. A percutaneous pharmaceutical drug delivery system which comprises a support material having adhered or deposited thereon a preparation for external application which comprises
- (a) N-ethoxycarbonyl-3-morpholinosydnonimine; and
- (b) at least 0.01 weight part of an absorption propmoter per weight part of (a) which promoter is an aliphatic monocarboxylic acid of 5 to 30 carbons.
- 5. A method of percutaneously administering a vasodilator effect to a patient which comprises the percutaneous administration of N-ethoxycarbonyl-3-morpholinosydnonimine as 0.01 weight part absorption promoter per part of said vasodilator, said absorption promoter being an aliphatic monocarboxylic acid of 5 to 30 carbons.
Priority Claims (2)
Number |
Date |
Country |
Kind |
58-93153 |
May 1983 |
JPX |
|
59-56923 |
Mar 1984 |
JPX |
|
Parent Case Info
This application is a continuation of U.S. application Ser. No. 874,703, filed Aug. 1, 1986, which is a continuation of Ser. No. 611,540, filed May 17, 1984, both abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4420470 |
Otsuka et al. |
Dec 1983 |
|
4421737 |
Ito et al. |
Dec 1983 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
059356 |
Sep 1982 |
EPX |
3231400 |
Mar 1983 |
DEX |
81902 |
Feb 1980 |
LUX |
Non-Patent Literature Citations (3)
Entry |
Merck, p. 815, No. 6120, 9th ed., 1976. |
Chem. Absts., 73:25485g, 1970. |
Chemical Abstracts, vol. 69, No. 20, 11th Nov. 1968, p. 7512, No. 80150m, Columbus, Ohio, US; J. Miyazaki et al.: "Corticosteriod Ointments, III Solubilities of Corticosteriods in Some Alkylol Amides and Alkyl Amides", & Yakuzaigaku 1966, 26(3), 196-199. |
Continuations (2)
|
Number |
Date |
Country |
Parent |
874703 |
Aug 1986 |
|
Parent |
611540 |
May 1984 |
|