Claims
- 1. A synthetic blood composition comprising a mammalian blood substitute aqueous emulsion containing an effective amount of perfluoro-N,N-dimethylcyclohexylmethylamine.
- 2. A composition as defined in claim 1 further comprising an emulsifying agent a nonionic surfactant having a molecular weight of 5,000 to 15,000.
- 3. A composition as defined in claim 1 further comprising as emulsifying agent a polyoxyethylene-polyoxypropylene copolymer, wherein the particle size is predominantly less than 0.3 microns.
- 4. A composition as defined in claim 1 wherein said emulsion comprises electrolyte in quantity sufficient to adjust the osmolality to about 290 mOs.
- 5. The method of preparing a stable emulsion, which comprises subjecting to sonication an aqueous mixture of perflouro-N-N-dimethylcyclohexylmethylamine and nonionic surfactant for a period of time sufficient to obtain a predominant particle size of less than 0.3 microns and few, if any, particles larger than 0.5 microns.
- 6. The method defined in claim 5 wherein the obtained emulsion is adjusted to an osmolality of about 290 mOs by addition of electrolyte.
- 7. An aqueous oxygen-transporting emulsion suitable for use as a blood substitute, which comprises 5 to 35% by volume of perfluoro-N,N-dimethyl-cyclohexylmethylamine emulsified in a physiologically acceptable aqueous medium with a nonionic surfactant as the emulsifying agent, said emulsion further containing water soluble electrolyte salts; the particle size of the emulsified material being substantially entirely not in excess of 0.3 micron.
Parent Case Info
This is a division, of application Ser. No. 153,235, filed May 27, 1980.
Government Interests
The invention described herein was made in the course of or under a contract with the U.S. Department of Health, Education, and Welfare.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3989843 |
Chabert et al. |
Nov 1976 |
|
Non-Patent Literature Citations (1)
Entry |
Riess et al.-Angewante Chemie Intl. Ed. in English, vol. 17, No. 9 (1978), pp. 621-633. |
Divisions (1)
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Number |
Date |
Country |
Parent |
153235 |
May 1980 |
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